Assessment of oral toxicity and safety profile of cyanidin: acute and subacute studies on anthocyanin

References

• Suresh S, Begum RF, Singh SA, Vellapandian C. Anthocyanin as a therapeutic in Alzheimer's disease: a systematic review of preclinical evidences. Ageing Res. Rev. 76, 101595 (2022).
   PubMed Web of Science ®Google Scholar
• Winter AN, Bickford PC. Anthocyanins and their metabolites as therapeutic agents for neurodegenerative disease. Antioxidants 8(9), 333 (2019).
   Web of Science ®Google Scholar
• Bentivegna SS, Whitney KM. Subchronic 3-month oral toxicity study of grape seed and grape skin extracts. Food Chem. Toxicol. 40(12), 1731–1743 (2002).
   PubMed Web of Science ®Google Scholar
• Barcelo RC, Jonathan MB, Rosuman PF et al. Preliminary In vivo evaluation of the acute toxicity of Dillenia philippinensis (Rolfe) fruit extract, anthocyanins and polyphenols in Mice (Mus musculus). Int. J. Biosci. 10(05), 51–65 (2017).
   Google Scholar
• Hong M, Lu M, Qian Y et al. A 90-day sub-chronic oral toxicity assessment of mulberry extract in Sprague Dawley rats. Inquiry (United States) 58, 00469580211056044 (2021).
   PubMed Web of Science ®Google Scholar
• Harlinda K, Rosiarto AM, Putri AS et al. Antioxidant and toxicity properties of anthocyanin extracted from red flower of four tropical shrubs. Nisantara Biosci. 8(2), 135–140 (2016).
   Google Scholar
• Yang X, Sun H, Tu L et al. Investigation of acute, subacute and subchronic toxicities of anthocyanin derived acylation reaction products and evaluation of their antioxidant activities in vitro. Food Funct. 11(12), 10954–10967 (2020).
   PubMed Web of Science ®Google Scholar
• Aguilar F, Crebelli R, Dusemund B et al. Scientific Opinion on the re-evaluation of anthocyanins (E 163) as a food additive. EFSA J. 11(4), 3145 (2013).
   Google Scholar
• Alexandra Pazmio-Durán E, Giusti MM, Wrolstad RE et al. Anthocyanins from banana bracts (Musa X paradisiaca) as potential food colorants. Food Chem. 73(3), 327–332 (2001).
   Web of Science ®Google Scholar
• Chiang SH, Yang KM, Lai YC et al. Evaluation of the in vitro biological activities of Banana flower and bract extracts and their bioactive compounds. Int. J. Food Prop. 24(1), 1–16 (2021).
   Web of Science ®Google Scholar
• Sujithra S, Manikkandan TR. Extraction of anthocyanin from banana (Musa paradisiaca) flower bract and analysis of phytochemicals, antioxidant activities and anthocyanin content. J. Chem. Pharmaceut. Sci. 12(3), 102–104 (2019).
   Google Scholar
• Susaritha R, Prakash A, Vadivel V. Utilization of anthocyanins-rich extract from banana bract in the green synthesis of AgNPs with anti-proliferative potential. Proc. Natl Acad. Sci. India Sect. B – Biol. Sci. 91(2), 397–406 (2021).
   Google Scholar
• Begum YA, Deka SC. Ultrasound-assisted extracted dietary fiber from culinary banana bract as matrices for anthocyanin: its preparation, characterization and storage stability. J. Food Sci. Technol. 57(6), 2354–2363 (2020).
   PubMed Web of Science ®Google Scholar
• Preethi P, Balakrishnamurthy G. Assessment of banana cultivars for pigment extraction from bracts, its suitability and stability as food colourant. Internat. J. Proc. & Post Harvest Technol. 2(2), 98–101 (2011).
   Google Scholar
• Rosalina Y, Warsiki E, Fauzi AM et al. Study of anthocyanin extraction from red banana (Musa sapientum L. var Rubra) waste and characteristics of light effects. Sci. Technol. Indonesia 7(4), 522–529 (2022).
   Google Scholar
• Suresh S, Vellapandian C. Cyanidin ameliorates bisphenol a-induced Alzheimer's disease pathology by restoring Wnt/β-catenin signaling cascade: an in vitro study. Mol. Neurobiol. 1, 1–17 (2023).
   Google Scholar
• Suresh S, Vellapandian C. Restoring impaired neurogenesis and alleviating oxidative stress by cyanidin against bisphenol a-induced neurotoxicity: in vivo and in vitro evidence. Curr. Drug Discov. Technol. doi:10.2174/0115701638280481231228064532 (2024) ( Online ahead of print).
   PubMedGoogle Scholar
• Manzoor MF, Zeng XA, Rahaman A et al. Combined impact of pulsed electric field and ultrasound on bioactive compounds and FT-IR analysis of almond extract. J. Food Sci. Technol. 56(5), 2355 (2019).
   PubMed Web of Science ®Google Scholar
• OECD. Test no. 423: acute oral toxicity – acute toxic class method. Oecd Guidel. Test. Chem. 1–14 (2002). Available from: doi:10.1787/9789264071001-en
   Google Scholar
• OECD. Test no. 407: repeated dose 28-day oral toxicity study in rodents. Oecd. Guidel. Test. Chem. (2008). Available from: doi:10.1787/9789264070684-en
   Google Scholar
• Parasuraman S, Raveendran R, Kesavan R. Blood sample collection in small laboratory animals. J. Pharmacol. Pharmacother. 1(2), 87 (2010).
   PubMedGoogle Scholar
• Zhang C, Zhang D, Wang H et al. Hyperbaric oxygen treatment improves pancreatic β-cell function and hepatic gluconeogenesis in STZ-induced type-2 diabetes mellitus model mice. Mol. Med. Rep. 25(3), 90 (2022).
   PubMed Web of Science ®Google Scholar
• Cardiff RD, Miller CH, Munn RJ. Manual hematoxylin and eosin staining of mouse tissue sections. Cold Spring Harb. Protoc. 2014(6), 655–658 (2014).
   PubMedGoogle Scholar
• Cai J, Zeng F, Zheng S et al. Preparation of lipid-soluble bilberry anthocyanins through acylation with cinnamic acids and their antioxidation activities. J. Agric. Food Chem. 68(28), 7467–7473 (2020).
   PubMed Web of Science ®Google Scholar
• Liu J, Zhuang Y, Hu Y et al. Improving the color stability and antioxidation activity of blueberry anthocyanins by enzymatic acylation with p-coumaric acid and caffeic acid. LWT 130, 109673 (2020).
   Web of Science ®Google Scholar
• Lin Y, Li C, Shao P et al. Enzymatic acylation of cyanidin-3-O-glucoside in raspberry anthocyanins for intelligent packaging: improvement of stability, lipophilicity and functional properties. Curr. Res. Food Sci. 5, 2219–2227 (2022).
   PubMedGoogle Scholar
• da Silva HR, de Assis D da C, Prada AL et al. Obtaining and characterization of anthocyanins from Euterpe oleracea (açaí) dry extract for nutraceutical and food preparations. Rev. Bras. Farmacogn. 29(5), 677–685 (2019).
   Google Scholar
• Compendium of CPCSEA. Acts, rules and guidelines: committee for the purpose of control and supervision of experiments on animals (2018). Available from: https://ccsea.gov.in/WriteReadData/userfiles/file/Compendium%20of%20CPCSEA.pdf
   Google Scholar
• Lee YM, Yoon Y, Yoon H et al. Dietary anthocyanins against obesity and inflammation. Nutrients 9(10), 1089 (2017).
   PubMed Web of Science ®Google Scholar
• Santamarina AB, Calder PC, Estadella D et al. Anthocyanins ameliorate obesity-associated metainflammation: preclinical and clinical evidence. Nutr. Res. 114, 50–70 (2023).
   PubMed Web of Science ®Google Scholar
• Zhao X, Yuan Z. Anthocyanins from Pomegranate (Punica granatum L.) and their role in antioxidant capacities in vitro. Chem. Biodivers. 18(10), e2100399 (2021).
   PubMed Web of Science ®Google Scholar
• Morais CA, de Rosso VV, Estadella D et al. Anthocyanins as inflammatory modulators and the role of the gut microbiota. J. Nutr. Biochem. 33, 1–7 (2016).
   PubMed Web of Science ®Google Scholar
• Rózańska D, Regulska-Ilow B. The significance of anthocyanins in the prevention and treatment of type 2 diabetes. Adv. Clin. Exp. Med. 27(1), 135–142 (2018).
   PubMed Web of Science ®Google Scholar
• Kim JN, Han SN, Kim HK. Anti-inflammatory and anti-diabetic effect of black soybean anthocyanins: data from a dual cooperative cellular system. Molecules 26(11), 3363 (2021).
   PubMed Web of Science ®Google Scholar
• Roy S, Rhim JW. Anthocyanin food colorant and its application in pH-responsive color change indicator films. Crit. Rev. Food Sci. Nutr. 61(14), 2297–2325 (2021).
   PubMed Web of Science ®Google Scholar
• Bagchi D, Roy S, Patel V et al. Safety and whole-body antioxidant potential of a novel anthocyanin-rich formulation of edible berries. Mol. Cell. Biochem. 281(1–2), 197–209 (2006).
   PubMed Web of Science ®Google Scholar