References
- Walport LJ, Hopkinson RJ, Vollmar M et al. Human UTY (KDM6C) is a male-specific Nϵ-methyl lysyl demethylase. J. Biol. Chem. 289(26), 18302–18313 (2014).
- Grbavec D, Lo R, Liu Y, Greenfield A, Stifani S. Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms. Biochem. J. 337(1), 13–17 (1999).
- Seenundun S, Rampalli S, Liu QC et al. UTX mediates demethylation of H3K27me3 at muscle-specific genes during myogenesis. EMBO J. 29(8), 1401–1411 (2010).
- Levanon D, Goldstein RE, Bernstein Y et al. Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors. Proc. Natl Acad. Sci. USA 95(20), 11590–11595 (1998).
- Chen MJ, Yokomizo T, Zeigler BM, Dzierzak E, Speck NA. Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter. Nature 457(7231), 887–891 (2009).
- Klaus A, Birchmeier W. Wnt signalling and its impact on development and cancer. Nat. Rev. Cancer 8(5), 387–398 (2008).
- Sood R, Kamikubo Y, Liu P. Role of RUNX1 in hematological malignancies. Blood J. Am. Soc. Hematol. 129(15), 2070–2082 (2017).
- Dao T, Xiong G, Mun SS et al. Dual-receptor T cell platform with Ab-TCR and costimulatory receptor achieves specificity and potency against AML. Blood 143(6), 507–521 (2024).
- von Boehmer H, Fehling HJ. Structure and function of the pre-T cell receptor. Annu. Rev. Immunol. 15(1), 433–452 (1997).
- Abdel-Hafiz HA, Schafer JM, Chen X et al. Y chromosome loss in cancer drives growth by evasion of adaptive immunity. Nature 619, 624–631 (2023).
- Lin S, Mulloy JC, Goyama S. RUNX1-ETO Leukemia. Adv Exp Med Biol. 962, 151–173 (2017).
- Gažová I, Lengeling A, Summers KM. Lysine demethylases KDM6A and UTY: the X and Y of histone demethylation. Mol. Genet. Metabol. 127(1), 31–44 (2019).
- Riz I, Hawley TS, Luu TV, Lee NH, Hawley RG. TLX1 and NOTCH coregulate transcription in T cell acute lymphoblastic leukemia cells. Mol. Cancer 9(1), 1–17 (2010).
- Vogt MH, Goulmy E, Kloosterboer FM et al. UTY gene codes for an HLA-B60–restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: characterization of the critical polymorphic amino acid residues for T-cell recognition. Blood, J. Am. Soc. Hematol. 96(9), 3126–3132 (2000).
- Greenlee RT, Hill-Harmon MB, Murray T, Thun M. Cancer statistics, 2001. CA Cancer J. Clin. 51(1), 15–36 (2001).
- Greenfield A, Carrel L, Pennisi D et al. The UTX gene escapes X inactivation in mice and humans. Hum. Mol. Genet. 7(4), 737–742 (1998).
- Marks P, Soave A, Shariat SF, Fajkovic H, Fisch M, Rink M. Female with bladder cancer: what and why is there a difference?. Translat. Androl. Urol. 5(5), 668 (2016).
- Zhang Y, Huang Y, Dong Y et al. Unique patterns of H3K4me3 and H3K27me3 in 2-cell-like embryonic stem cells. Stem Cell Reports 16(3), 458–469 (2021).
- Shrestha BR, Wu L, Goodrich LV. Runx1 controls auditory sensory neuron diversity in mice. Developmental Cell 58(4), 306–319 (2023).
- Zhang C, Wang D, Wang J et al. Escape of hair follicle stem cells causes stem cell exhaustion during aging. Nat. Ag. 1(10), 889–903 (2021).