Acute radiation dermatitis in breast cancer patients: challenges and solutions

References

• Sie gelRLMillerKDJemalACancer statistics, 2016CA Cancer J Clin201666173026742998
   PubMed Web of Science ®Google Scholar
• Early Breast Cancer Trialists’ Collaborative GroupDarbySMcGalePEffect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trialsLancet201137898041707171622019144
   PubMed Web of Science ®Google Scholar
• Early Breast Cancer Trialists’ Collaborative Group;McGalePTaylorCEffect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trialsLancet201438399352127213524656685
   PubMed Web of Science ®Google Scholar
• FowbleBParkCYuenFBreast cancerFowbleBYomSSYuenFArronSSkin Care in Radiation Oncology A Practical GuideSpringer International Publishing201693122
   Google Scholar
• RyanJLIonizing radiation: the good, the bad, and the uglyJ Invest Dermatol20121323 pt 298599322217743
   PubMed Web of Science ®Google Scholar
• ZemanEMThe biological basis of radiation oncologyGundersonLLTepperJEBogartJAClinical Radiation Oncology4th edPhiladelphia, PA2016240
   Google Scholar
• QuimbyEMaccombWFurther studies on the rate of recovery of human skin from the effects of roentgen or gamma raysRadiology193729305312
   Google Scholar
• KaplanHSHistoric milestones in radiobiology and radiation therapySemin Oncol197964479489119321
   PubMed Web of Science ®Google Scholar
• KharePNairPKhareASinghVChatterjeeRThe road to radiation protection: a rocky pathJ Clin Diagn Res2014812ZE01ZE04
   Google Scholar
• BourlandJDRadiation oncology physicsGundersonLLTepperJEBogartJAClinical Radiation Oncology4th edPhiladelphia, PA201693147
   Google Scholar
• VandergriTBergstresserPAnatomy and physiologyBologniaJJorizzoJLSchafferJVDermatology3rd edPhiladelphia, PAElsevier Saunders20124354
   Google Scholar
• HerstPMProtecting the radiation-damaged skin from friction: a mini reviewJ Med Radiat Sci201461211912526229646
   PubMedGoogle Scholar
• LiuKKasperMTrottKRChanges in keratinocyte differentiation during accelerated repopulation of the irradiated mouse epidermisInt J Radiat Biol19966967637698691028
   PubMed Web of Science ®Google Scholar
• SchmuthMSztankayAWeinlichGPermeability barrier function of skin exposed to ionizing radiationArch Dermatol200113781019102311493094
   PubMedGoogle Scholar
• TrottKRShiraziAHeasmanFModulation of accelerated repopulation in mouse skin during daily irradiationRadiother Oncol199950326126610392811
   PubMed Web of Science ®Google Scholar
• KoenigTRWolffDMettlerFAWagnerLKSkin injuries from fluoroscopically guided procedures: part 1, characteristics of radiation injuryAJR Am J Roentgenol2001177131111418388
   PubMed Web of Science ®Google Scholar
• ArchambeauJOInesAFajardoLFResponse of swine skin microvasculature to acute single exposures of X rays: quantification of endothelial changesRadiat Res198498137516718694
   PubMed Web of Science ®Google Scholar
• HopewellJCalvoWJaenkeRReinholdHRobbinsMWhitehouseEMicrovasculature and Radiation DamageHinkelbeinWBruggmoserGFrommholdHWannenmacherMAcute and Long-Term Side-Effects of Radiotherapy Biological Basis and Clinical RelevanceBerlinSpringer1993116
   Google Scholar
• MullerKMeinekeVRadiation-induced alterations in cytokine production by skin cellsExp Hematol2007354 Suppl 196104
   PubMed Web of Science ®Google Scholar
• Petit-FrereCCapulasELyonDAApoptosis and cytokine release induced by ionizing or ultraviolet B radiation in primary and immortalized human keratinocytesCarcinogenesis20002161087109510836995
   PubMed Web of Science ®Google Scholar
• BeetzAMesserGOppelTvan BeuningenDPeterRUKindPInduction of interleukin 6 by ionizing radiation in a human epithelial cell line: control by corticosteroidsInt J Radiat Biol199772133439246192
   PubMed Web of Science ®Google Scholar
• HallahanDESpriggsDRBeckettMAKufeDWWeichselbaumRRIncreased tumor necrosis factor alpha mRNA after cellular exposure to ionizing radiationProc Natl Acad Sci U S A1989862410104101072602359
   PubMed Web of Science ®Google Scholar
• MullerKMeinekeVRadiation-induced mast cell mediators differentially modulate chemokine release from dermal fibroblastsJ Dermatol Sci201161319920521292447
   PubMed Web of Science ®Google Scholar
• MartinMLefaixJDelanianSTGF-beta1 and radiation fibrosis: a master switch and a specific therapeutic target?Int J Radiat Oncol Biol Phys200047227729010802350
   PubMed Web of Science ®Google Scholar
• PohlersDBrenmoehlJLofflerITGF-beta and fibrosis in different organs – molecular pathway imprintsBiochim Biophys Acta20091792874675619539753
   PubMed Web of Science ®Google Scholar
• MendelsohnFADivinoCMReisEDKersteinMDWound care after radiation therapyAdv Skin Wound Care200215521622412368711
   PubMedGoogle Scholar
• BrownKRRzucidloEAcute and chronic radiation injuryJ Vasc Surg2011531 Suppl15S21S20843630
   PubMed Web of Science ®Google Scholar
• HarperJLFranklinLEJenretteJMAgueroEGSkin toxicity during breast irradiation: pathophysiology and managementSouth Med J2004971098999315558927
   PubMed Web of Science ®Google Scholar
• PignolJPOlivottoIRakovitchEA multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitisJ Clin Oncol200826132085209218285602
   PubMed Web of Science ®Google Scholar
• FernandoINFordHTPowlesTJFactors affecting acute skin toxicity in patients having breast irradiation after conservative surgery: a prospective study of treatment practice at the Royal Marsden HospitalClin Oncol199684226233
   Google Scholar
• HoopferDHollowayCGabosZThree-arm randomized phase III trial: quality aloe and placebo cream versus powder as skin treatment during breast cancer radiation therapyClin Breast Cancer2015153e181e184
   Web of Science ®Google Scholar
• McQuestionMEvidence-based skin care management in radiation therapy: clinical updateSemin Oncol Nurs2011272e1e17
   Google Scholar
• PignolJPVuTTMiteraGBosnicSVerkooijenHMTruongPProspective evaluation of severe skin toxicity and pain during postmastectomy radiation therapyInt J Radiat Oncol Biol Phys201591115716425835623
   PubMed Web of Science ®Google Scholar
• FisherJScottCStevensRRandomized phase III study comparing Best Supportive Care to Biafine as a prophylactic agent for radiation-induced skin toxicity for women undergoing breast irradiation: Radiation Therapy Oncology Group (RTOG) 97-13Int J Radiat Oncol Biol Phys20004851307131011121627
   PubMed Web of Science ®Google Scholar
• BuchholzTARadiation therapy for early-stage breast cancer after breast-conserving surgeryN Engl J Med20093601637019118305
   PubMed Web of Science ®Google Scholar
• CoxJDStetzJPajakTFToxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC)Int J Radiat Oncol Biol Phys1995315134113467713792
   PubMed Web of Science ®Google Scholar
• National Cancer InstituteCommon Terminology Criteria for Adverse Events v4.0NIH2009NIH publication #09-7473 Available from: https://ctep.cancer.gov/protocolDevelopment/electronic_applications/ctc.htmAccessed July 10, 2016
   Google Scholar
• FreedmanGMLiTNicolaouNChenYMaCCAndersonPRBreast intensity-modulated radiation therapy reduces time spent with acute dermatitis for women of all breast sizes during radiationInt J Radiat Oncol Biol Phys200974368969419362779
   PubMed Web of Science ®Google Scholar
• WrightJLTakitaCReisIMZhaoWLeeEHuJJRacial variations in radiation-induced skin toxicity severity: data from a prospective cohort receiving postmastectomy radiationInt J Radiat Oncol Biol Phys201490233534325304794
   PubMed Web of Science ®Google Scholar
• TwardellaDPopandaOHelmboldIPersonal characteristics, therapy modalities and individual DNA repair capacity as predictive factors of acute skin toxicity in an unselected cohort of breast cancer patients receiving radiotherapyRadiother Oncol200369214515314643951
   PubMed Web of Science ®Google Scholar
• HindleyAZainZWoodLMometasone furoate cream reduces acute radiation dermatitis in patients receiving breast radiation therapy: results of a randomized trialInt J Radiat Oncol Biol Phys201490474875525585779
   PubMed Web of Science ®Google Scholar
• PorockDKristjansonLNikolettiSCameronFPedlerPPredicting the severity of radiation skin reactions in women with breast cancerOncol Nurs Forum1998256101910299679261
   PubMedGoogle Scholar
• Noble-AdamsRRadiation-induced skin reactions. 2: development of a measurement toolBr J Nurs19998181208121110897708
   PubMedGoogle Scholar
• DiggelmannKVZytkoviczAETuaineJMBennettNCKellyLEHerstPMMepilex Lite dressings for the management of radiation-induced erythema: a systematic inpatient controlled clinical trialBr J Radiol20108399597197820647511
   PubMed Web of Science ®Google Scholar
• CatterallMRogersCThomlinsonRHFieldSBAn investigation into the clinical effects of fast neutrons. Methods and early observationsBr J Radiol1971445246036114997649
   PubMed Web of Science ®Google Scholar
• SprangersMAGroenvoldMArrarasJIThe European Organization for Research and Treatment of Cancer breast cancer-specific quality-of-life questionnaire module: first results from a three-country field studyJ Clin Oncol19961410275627688874337
   PubMed Web of Science ®Google Scholar
• BradyMJCellaDFMoFReliability and validity of the functional assessment of cancer therapy-breast quality-of-life instrumentJ Clin Oncol19971539749869060536
   PubMed Web of Science ®Google Scholar
• BackMGuerrieriMWrattenCSteiglerAImpact of radiation therapy on acute toxicity in breast conservation therapy for early breast cancerClin Oncol20041611216
   Web of Science ®Google Scholar
• RutterCQinLHigginsSMoranMEvansSDosimetric and clinical predictors of the development of moist desquamation in breast cancer irradiationJ Radiat Oncol201432147152
   Google Scholar
• MacmillanMSWellsMMacBrideSRaabGMMunroAMacDougallHRandomized comparison of dry dressings versus hydrogel in management of radiation-induced moist desquamationInt J Radiat Oncol Biol Phys200768386487217363185
   PubMed Web of Science ®Google Scholar
• PollardJMGattiRAClinical radiation sensitivity with DNA repair disorders: an overviewInt J Radiat Oncol Biol Phys20097451323133119616740
   PubMed Web of Science ®Google Scholar
• ChenMFChenWCLaiCHHungCHLiuKCChengYHPredictive factors of radiation-induced skin toxicity in breast cancer patientsBMC Cancer20101050820860847
   PubMed Web of Science ®Google Scholar
• HarsoliaAKestinLGrillsIIntensity-modulated radiotherapy results in significant decrease in clinical toxicities compared with conventional wedge-based breast radiotherapyInt J Radiat Oncol Biol Phys20076851375138017544598
   PubMed Web of Science ®Google Scholar
• DonovanEBleakleyNDenholmEBreast Technology GroupRandomised trial of standard 2D radiotherapy (RT) versus intensity modulated radiotherapy (IMRT) in patients prescribed breast radiotherapyRadiother Oncol200782325426417224195
   PubMed Web of Science ®Google Scholar
• MulliezTSpeleersBMadaniIDe GersemWVeldemanLDe NeveWWhole breast radiotherapy in prone and supine position: is there a place for multi-beam IMRT?Radiat Oncol2013815123800109
   PubMed Web of Science ®Google Scholar
• KachnicLAPowellSNIMRT for breast cancer – balancing outcomes, patient selection, and resource utilizationJ Natl Cancer Inst20111031077777921525436
   PubMedGoogle Scholar
• WangEHMougalianSSSoulosPRAdoption of hypofractionated whole-breast irradiation for early-stage breast cancer: a National Cancer Data Base analysisInt J Radiat Oncol Biol Phys2014905993100025149661
   PubMed Web of Science ®Google Scholar
• Start Trialists’ GroupBentzenSMAgrawalRKThe UK Standardisation of Breast Radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trialLancet Oncol20089433134118356109
   PubMed Web of Science ®Google Scholar
• Start Trialists’ GroupBentzenSMAgrawalRKThe UK Standardisation of Breast Radiotherapy (START) Trial B of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trialLancet200837196181098110718355913
   PubMed Web of Science ®Google Scholar
• WhelanTJPignolJPLevineMNLong-term results of hypofractionated radiation therapy for breast cancerN Engl J Med2010362651352020147717
   PubMed Web of Science ®Google Scholar
• ShaitelmanSFSchlembachPJArzuIAcute and short-term toxic effects of conventionally fractionated vs hypofractionated whole-breast irradiation: a randomized clinical trialJAMA Oncol20151793194126247543
   PubMed Web of Science ®Google Scholar
• BolderstonALloydNSWongRKHoldenLRobb-BlendermanLSupportive Care Guidelines Group of Cancer Care Ontario Program in Evidence-Based CThe prevention and management of acute skin reactions related to radiation therapy: a systematic review and practice guidelineSupport Care Cancer200614880281716758176
   PubMed Web of Science ®Google Scholar
• BoströmALindmanHSwartlingCBerneBBerghJPotent corticosteroid cream (mometasone furoate) significantly reduces acute radiation dermatitis: results from a double-blind, randomized studyRadiother Oncol200159325726511369066
   PubMed Web of Science ®Google Scholar
• MillerRCSchwartzDJSloanJAMometasone furoate effect on acute skin toxicity in breast cancer patients receiving radiotherapy: a phase III double-blind, randomized trial from the North Central Cancer Treatment Group N06C4Int J Radiat Oncol Biol Phys20117951460146620800381
   PubMed Web of Science ®Google Scholar
• OmidvariSSabooriHMohammadianpanahMTopical betamethasone for prevention of radiation dermatitisIndian J Dermatol Venereol Leprol2007733209
   PubMedGoogle Scholar
• UlffEMarotiMSerupJFalkmerUA potent steroid cream is superior to emollients in reducing acute radiation dermatitis in breast cancer patients treated with adjuvant radiotherapy. A randomised study of betamethasone versus two moisturizing creamsRadiother Oncol2013108228729223827771
   PubMed Web of Science ®Google Scholar
• UlffEMarotiMSerupJNilssonMFalkmerUProphylactic treatment with a potent corticosteroid cream ameliorates radiodermatitis, independent of radiation schedule: a randomized double blinded studyRadiother Oncol20171221505327913066
   PubMed Web of Science ®Google Scholar
• WellsMMacmillanMRaabGDoes aqueous or sucralfate cream affect the severity of erythematous radiation skin reactions? A randomised controlled trialRadiother Oncol200473215316215542162
   PubMed Web of Science ®Google Scholar
• WilliamsMSBurkMLoprinziCLPhase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicityInt J Radiat Oncol Biol Phys19963623453498892458
   PubMed Web of Science ®Google Scholar
• HeggieSBryantGPTripconyLA Phase III study on the efficacy of topical aloe vera gel on irradiated breast tissueCancer Nurs200225644245112464836
   PubMed Web of Science ®Google Scholar
• PinnixCPerkinsGHStromEATopical hyaluronic acid vs. standard of care for the prevention of radiation dermatitis after adjuvant radiotherapy for breast cancer: single-blind randomized phase III clinical trialInt J Radiat Oncol Biol Phys20128341089109422172912
   PubMed Web of Science ®Google Scholar
• KirovaYMFromantinIDe RyckeYCan we decrease the skin reaction in breast cancer patients using hyaluronic acid during radiation therapy? Results of phase III randomised trialRadiother Oncol2011100220520921624699
   PubMed Web of Science ®Google Scholar
• HematiSAsnaashariOSarvizadehMTopical silver sulfadiazine for the prevention of acute dermatitis during irradiation for breast cancerSupport Care Cancer20122081613161822006502
   PubMed Web of Science ®Google Scholar
• PommierPGomezFSunyachMPD’HombresACarrieCMontbarbonXPhase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancerJ Clin Oncol20042281447145315084618
   PubMed Web of Science ®Google Scholar
• SharpLFinnilaKJohanssonHAbrahamssonMHatschekTBergenmarMNo differences between Calendula cream and aqueous cream in the prevention of acute radiation skin reactions – results from a randomised blinded trialEur J Oncol Nurs201317442943523245940
   PubMed Web of Science ®Google Scholar
• GrahamPBrowneLCappARandomized, paired comparison of no-sting barrier film versus sorbolene cream (10% glycerine) skin care during postmastectomy irradiationInt J Radiat Oncol Biol Phys200458124124614697444
   PubMed Web of Science ®Google Scholar
• HerstPMBennettNCSutherlandAEPeszynskiRIPatersonDBJasperseMLProphylactic use of Mepitel Film prevents radiation-induced moist desquamation in an intra-patient randomised controlled clinical trial of 78 breast cancer patientsRadiother Oncol2014110113714324486117
   PubMed Web of Science ®Google Scholar
• GrahamPHPlantNGrahamJLA paired, double-blind, randomized comparison of a moisturizing durable barrier cream to 10% glycerine cream in the prophylactic management of postmastectomy irradiation skin care: trans Tasman Radiation Oncology Group (TROG) 04.01Int J Radiat Oncol Biol Phys2013861455023414763
   PubMed Web of Science ®Google Scholar
• GauglerMHVereycken-HollerVSquibanCVandammeMVozenin-BrotonsMCBenderitterMPravastatin limits endothelial activation after irradiation and decreases the resulting inflammatory and thrombotic responsesRadiat Res2005163547948715850408
   PubMed Web of Science ®Google Scholar
• HollerVBuardVGauglerMHPravastatin limits radiation-induced vascular dysfunction in the skinJ Invest Dermatol200912951280129119212344
   PubMed Web of Science ®Google Scholar
• OkunieffPXuJHuDCurcumin protects against radiation-induced acute and chronic cutaneous toxicity in mice and decreases mRNA expression of inflammatory and fibrogenic cytokinesInt J Radiat Oncol Biol Phys200665389089816751071
   PubMed Web of Science ®Google Scholar
• XiaoZSuYYangSProtective effect of esculentoside A on radiation-induced dermatitis and fibrosisInt J Radiat Oncol Biol Phys200665388288916751070
   PubMed Web of Science ®Google Scholar
• FahlWEComplete prevention of radiation-induced dermatitis using topical adrenergic vasoconstrictorsArch Dermatol Res20163081075175727704205
   PubMed Web of Science ®Google Scholar
• FeightDBaneyTBruceSMcQuestionMPutting evidence into practiceClin J Oncol Nurs201115548149221951735
   PubMed Web of Science ®Google Scholar
• WongRKBensadounRJBoers-DoetsCBClinical practice guidelines for the prevention and treatment of acute and late radiation reactions from the MASCC Skin Toxicity Study GroupSupport Care Cancer201321102933294823942595
   PubMed Web of Science ®Google Scholar
• CampbellIRIllingworthMHCan patients wash during radiotherapy to the breast or chest wall? A randomized controlled trialClin Oncol1992427882
   Google Scholar
• RoyIFortinALarochelleMThe impact of skin washing with water and soap during breast irradiation: a randomized studyRadiother Oncol200158333333911230896
   PubMed Web of Science ®Google Scholar
• D’HaeseSVan RoyMBateTBijdekerkePVinh-HungVManagement of skin reactions during radiotherapy in Flanders (Belgium): a study of nursing practice before and after the introduction of a skin care protocolEur J Oncol Nurs201014536737219944645
   PubMed Web of Science ®Google Scholar
• FroschPJKligmanAMThe soap chamber test. A new method for assessing the irritancy of soapsJ Am Acad Dermatol1979113541500863
   PubMed Web of Science ®Google Scholar
• BurchSEParkerSAVannAMArazieJCMeasurement of 6-MV X-ray surface dose when topical agents are applied prior to external beam irradiationInt J Radiat Oncol Biol Phys19973824474519226334
   PubMed Web of Science ®Google Scholar
• WatsonLCGiesDThompsonEThomasBRandomized control trial: evaluating aluminum-based antiperspirant use, axilla skin toxicity, and reported quality of life in women receiving external beam radiotherapy for treatment of Stage 0, I, and II breast cancerInt J Radiat Oncol Biol Phys2012831e29e3422516385
   PubMed Web of Science ®Google Scholar
• ThebergeVHarelFDagnaultAUse of axillary deodorant and effect on acute skin toxicity during radiotherapy for breast cancer: a prospective randomized noninferiority trialInt J Radiat Oncol Biol Phys20097541048105219327906
   PubMed Web of Science ®Google Scholar
• BennettCAn investigation into the use of a non-metallic deodorant during radiotherapy treatment: a randomised controlled trialJ Radiother Pract20098139
   Google Scholar
• GeeAMoffittDChurnMErringtonRA randomised controlled trial to test a non-metallic deodorant used during a course of radiotherapyJ Radiother Pract200014205212
   Google Scholar
• AistarsJThe validity of skin care protocols followed by women with breast cancer receiving external radiationClin J Oncol Nurs200610448749216927902
   PubMedGoogle Scholar
• MeeganMHaycocksTAn investigation into the management of acute skin reactions from tangential breast irradiationCan J Med Radiat Technol19972943169173
   Google Scholar
• WinterGDFormation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pigNature196219329329414007593
   PubMed Web of Science ®Google Scholar
• GollinsSGaffneyCSladeSSwindellRRCT on gentian violet versus a hydrogel dressing for radiotherapy-induced moist skin desquamationJ Wound Care200817626827027227426518666721
   PubMedGoogle Scholar
• MakSSMolassiotisAWanWMLeeIYChanESThe effects of hydrocolloid dressing and gentian violet on radiation-induced moist desquamation wound healingCancer Nurs200023322022910851773
   PubMed Web of Science ®Google Scholar
• BC Cancer Agency [webpage on the Internet]Symptom Management Guidelines: Radiation Dermatitis Available from: http://www.bccancer.bc.ca/health-professionals/professional-resources/nursing/symptom-managementAccessed November 8, 2016
   Google Scholar