References
- SEER Cancer Statistics Factsheets: Breast CancerBethesda, MDNational Cancer Institute2015
- OrtmanJMVelkoffVAHowardHAn aging nation: the older population in the United StatesWashington, DCUS Census Bureau2014
- SmithBDSmithGLHurriaAHortobagyiGNBuchholzTAFuture of cancer incidence in the United States: burdens upon an aging, changing nationJ Clin Oncol200927172758276519403886
- LavelleKToddCMoranAHowellABundredNCampbellMNon-standard management of breast cancer increases with age in the UK: a population based cohort of women > or =65 yearsBr J Cancer20079681197120317387342
- GiordanoSHHortobagyiGNKauSWTheriaultRLBondyMLBreast cancer treatment guidelines in older womenJ Clin Oncol200523478379115681522
- HershmanDLShaoTKushiLHEarly discontinuation and non-adherence to adjuvant hormonal therapy are associated with increased mortality in women with breast cancerBreast Cancer Res Treat2011126252953720803066
- BouchardyCRapitiEFiorettaGUndertreatment strongly decreases prognosis of breast cancer in elderly womenJ Clin Oncol200321193580358712913099
- DiabSGElledgeRMClarkGMTumor characteristics and clinical outcome of elderly women with breast cancerJ Natl Cancer Inst200092755055610749910
- BiganzoliLWildiersHOakmanCManagement of elderly patients with breast cancer: updated recommendations of the International Society of Geriatric Oncology (SIOG) and European Society of Breast Cancer Specialists (EUSOMA)Lancet Oncol2012134e148e16022469125
- OwusuCLashTLSillimanRAEffectiveness of adjuvant tamoxifen therapy among older women with early stage breast cancerBreast J200713437438217593042
- ColleoniMGiobbie-HurderAReganMMAnalyses adjusting for selective crossover show improved overall survival with adjuvant letrozole compared with tamoxifen in the BIG 1–98 studyJ Clin Oncol20112991117112421321298
- ForbesJFCuzickJBuzdarAHowellATobiasJSBaumMEffect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trialLancet Oncol200891455318083636
- GossPEIngleJNMartinoSRandomized trial of letrozole following tamoxifen as extended adjuvant therapy in receptor-positive breast cancer: updated findings from NCIC CTG MA.17J Natl Cancer Inst200597171262127116145047
- MussHBTuDIngleJNEfficacy, toxicity, and quality of life in older women with early-stage breast cancer treated with letrozole or placebo after 5 years of tamoxifen: NCIC CTG intergroup trial MA.17J Clin Oncol200826121956196418332474
- AmirESerugaBNiraulaSCarlssonLOcanaAToxicity of adjuvant endocrine therapy in postmenopausal breast cancer patients: a systematic review and meta-analysisJ Nati Cancer Inst20111031712991309
- SenkusEKyriakidesSPenault-LlorcaFPrimary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and followupAnn Oncol201324Suppl 6vi7vi2323970019
- ZillerVKalderMAlbertUSAdherence to adjuvant endocrine therapy in postmenopausal women with breast cancerAnn Oncol200920343143619150950
- SestakICuzickJSapunarFRisk factors for joint symptoms in patients enrolled in the ATAC trial: a retrospective, exploratory analysisLancet Oncol20089986687218703382
- BaumMBudzarAUCuzickJAnastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trialLancet200235993242131213912090977
- NeunerJMYenTWSparapaniRALaudPWNattingerABFracture risk and adjuvant hormonal therapy among a population-based cohort of older female breast cancer patientsOsteoporosis Int2011221128472855
- EidtmannHde BoerRBundredNEfficacy of zoledronic acid in postmenopausal women with early breast cancer receiving adjuvant letrozole: 36-month results of the ZO-FAST StudyAnn Oncol201021112188219420444845
- KoopalCJanssen-HeijnenMLvan de WouwAJvan den BerghJPFracture incidence in pre- and postmenopausal women after completion of adjuvant hormonal therapy for breast cancerBreast201524215315825618224
- ColemanRPowlesTPatersonAAdjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from randomised trialsLancet2015386100011353136126211824
- GnantMPfeilerGDubskyPCAdjuvant denosumab in breast cancer (ABCSG-18): a multicentre, randomised, double-blind, placebo-controlled trialLancet2015386999243344326040499
- HindDWyldLBeverleyCBReedMWSurgery versus primary endocrine therapy for operable primary breast cancer in elderly women (70 years plus)Cochrane Database Syst Rev2006251CD00427216437480
- DixonJMRenshawLMacaskillEJIncrease in response rate by prolonged treatment with neoadjuvant letrozoleBreast Cancer Res Treat2009113114515118264759
- ChatzidakiPMellosCBrieseVMylonasIPerioperative complications of breast cancer surgery in elderly women (>/=80 years)Ann Surg Oncol201118492393121107743
- HindDWyldLReedMWSurgery, with or without tamoxifen, vs tamoxifen alone for older women with operable breast cancer: Cochrane reviewBr J Cancer20079671025102917285133
- ChristiansenPBjerreKEjlertsenBMortality rates among early-stage hormone receptor-positive breast cancer patients: a population-based cohort study in DenmarkJ Natl Cancer Inst2011103181363137221881042
- SchlenkEADunbar-JacobJEngbergSMedication non-adherence among older adults: a review of strategies and interventions for improvementJ Gerontol Nurs2004307334315287325
- HershmanDLKushiLHShaoTEarly discontinuation and non-adherence to adjuvant hormonal therapy in a cohort of 8,769 early-stage breast cancer patientsJ Clin Oncol201028274120412820585090
- GuthUMyrickMEKandlerCVetterMThe use of adjuvant endocrine breast cancer therapy in the oldest oldBreast201322586386823541734
- RavdinPMSiminoffLADavisGJComputer program to assist in making decisions about adjuvant therapy for women with early breast cancerJ Clin Oncol200119498099111181660
- WishartGCBajdikCDDicksEPREDICT Plus: development and validation of a prognostic model for early breast cancer that includes HER2Br J Cancer2012107580080722850554
- PaikSShakSTangGA multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancerN Engl J Med2004351272817282615591335
- FanCOhDSWesselsLConcordance among gene-expression-based predictors for breast cancerN Engl J Med2006355656056916899776
- Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trialsLancet200536594721687171715894097
- JonesSHolmesFAO’ShaughnessyJDocetaxel with cyclophosphamide is associated with an overall survival benefit compared with doxorubicin and cyclophosphamide: 7-year follow-up of US Oncology Research Trial 9735J Clin Oncol20092781177118319204201
- MartinMRodriguez-LescureARuizARandomized phase 3 trial of fluorouracil, epirubicin, and cyclophosphamide alone or followed by Paclitaxel for early breast cancerJ Natl Cancer Inst20081001180581418505968
- SparanoJAWangMMartinoSWeekly paclitaxel in the adjuvant treatment of breast cancerN Engl J Med2008358161663167118420499
- MussHBBerryDACirrincioneCTAdjuvant chemotherapy in older women with early-stage breast cancerN Engl J Med2009360202055206519439741
- PooleCJEarlHMHillerLEpirubicin and cyclophosphamide, methotrexate, and fluorouracil as adjuvant therapy for early breast cancerN Engl J Med2006355181851186217079759
- MussHBWoolfSBerryDAdjuvant chemotherapy in older and younger women with lymph node-positive breast cancerJAMA200529391073108115741529
- DoyleJJNeugutAIJacobsonJSGrannVRHershmanDLChemotherapy and cardiotoxicity in older breast cancer patients: a population-based studyJ Clin Oncol200523348597860516314622
- WolffACBlackfordALVisvanathanKRisk of marrow neoplasms after adjuvant breast cancer therapy: the national comprehensive cancer network experienceJ Clin Oncol201533434034825534386
- HowardRAGilbertESChenBELeukemia following breast cancer: an international population-based study of 376,825 womenBreast Cancer Res Treat2007105335936817221155
- FargeotPBonneterreJRocheHDisease-free survival advantage of weekly epirubicin plus tamoxifen versus tamoxifen alone as adjuvant treatment of operable, node-positive, elderly breast cancer patients: 6-year follow-up results of the French adjuvant study group 08 trialJ Clin Oncol200422234622463015505276
- KornblithABLanLArcherLQuality of life of older patients with early-stage breast cancer receiving adjuvant chemotherapy: a companion study to cancer and leukemia group B 49907J Clin Oncol20112981022102821300923
- PerroneFNuzzoFDi RellaFWeekly docetaxel versus CMF as adjuvant chemotherapy for older women with early breast cancer: final results of the randomized phase III ELDA trialAnn Oncol201526467568225488686
- von MinckwitzGConradBReimerTA randomized phase 2 study comparing EC or CMF versus nab-paclitaxel plus capecitabine as adjuvant chemotherapy for nonfrail elderly patients with moderate to high-risk early breast cancer (ICE II-GBG 52)Cancer2015121203639364826111104
- BalducciLAl-HalawaniHCharuVElderly cancer patients receiving chemotherapy benefit from first-cycle pegfilgrastimOncologist200712121416142418165618
- BarcenasCHNiuJZhangNRisk of hospitalization according to chemotherapy regimen in early-stage breast cancerJ Clin Oncol201432192010201724868022
- HoogerduijnJGBuurmanBMKorevaarJCGrobbeeDEde RooijSESchuurmansMJThe prediction of functional decline in older hospitalised patientsAge Ageing201241338138722378613
- ExtermannMBolerIReichRRPredicting the risk of chemotherapy toxicity in older patients: the Chemotherapy Risk Assessment Scale for High-Age Patients (CRASH) scoreCancer2012118133377338622072065
- FriedTRBradleyEHTowleVRAlloreHUnderstanding the treatment preferences of seriously ill patientsN Engl J Med2002346141061106611932474
- MolinoAGiovanniniMAuriemmaAPathological, biological and clinical characteristics, and surgical management, of elderly women with breast cancerCrit Rev Oncol Hematol200659322623316533603
- DaidoneMGCoradiniDMartelliGVeneroniSPrimary breast cancer in elderly women: biological profile and relation with clinical outcomeCrit Rev Oncol Hematol200345331332512633842
- MustacchiGCazzanigaMEPronzatoPDe MatteisADi CostanzoFFlorianiIBreast cancer in elderly women: a different reality? Results from the NORA studyAnn Oncol200718699199617351258
- EngelsCCKiderlenMBastiaannetEThe clinical value of HER-2 overexpression and PIK3CA mutations in the older breast cancer population: a FOCUS study analysisBreast Cancer Res Treat2016156236137026968397
- MussHBComing of age: breast cancer in seniorsOncologist201015Suppl 5576521138956
- BoekhoutAHBeijnenJHSchellensJHTrastuzumabOncologist201116680081021632460
- RomondEHPerezEABryantJTrastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancerN Engl J Med2005353161673168416236738
- Piccart-GebhartMJProcterMLeyland-JonesBTrastuzumab after adjuvant chemotherapy in HER2-positive breast cancerN Engl J Med2005353161659167216236737
- SlamonDEiermannWRobertNAdjuvant trastuzumab in HER2-positive breast cancerN Engl J Med2011365141273128321991949
- JoensuuHKellokumpu-LehtinenPLBonoPAdjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancerN Engl J Med2006354880982016495393
- SpielmannMRocheHDelozierTTrastuzumab for patients with axillary-node-positive breast cancer: results of the FNCLCC-PACS 04 trialJ Clin Oncol200927366129613419917839
- SmithIProcterMGelberRD2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trialLancet20073699555293617208639
- PerezEASumanVJDavidsonNESequential versus concurrent trastuzumab in adjuvant chemotherapy for breast cancerJ Clin Oncol201129344491449722042958
- TolaneySMBarryWTDangCTAdjuvant paclitaxel and trastuzumab for node-negative, HER2-positive breast cancerN Engl J Med2015372213414125564897
- Tan-ChiuEYothersGRomondEAssessment of cardiac dysfunction in a randomized trial comparing doxorubicin and cyclophosphamide followed by paclitaxel, with or without trastuzumab as adjuvant therapy in node-positive, human epidermal growth factor receptor 2-overexpressing breast cancer: NSABP B-31J Clin Oncol200523317811781916258083
- PerezEASumanVJDavidsonNECardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trialJ Clin Oncol20082681231123818250349
- RussellSDBlackwellKLLawrenceJIndependent adjudication of symptomatic heart failure with the use of doxorubicin and cyclophosphamide followed by trastuzumab adjuvant therapy: a combined review of cardiac data from the National Surgical Adjuvant breast and Bowel Project B-31 and the North Central Cancer Treatment Group N9831 clinical trialsJ Clin Oncol201028213416342120530275
- SuterTMProcterMvan VeldhuisenDJTrastuzumab-associated cardiac adverse effects in the herceptin adjuvant trialJ Clin Oncol200725253859386517646669
- GoldhirschAGelberRDPiccart-GebhartMJ2 years versus 1 year of adjuvant trastuzumab for HER2-positive breast cancer (HERA): an open-label, randomised controlled trialLancet201338298971021102823871490
- PivotXSuterTNabholtzJMCardiac toxicity events in the PHARE trial, an adjuvant trastuzumab randomised phase III studyEur J Cancer201551131660166626163096
- SawakiMTokudomeNMizunoTEvaluation of trastuzumab without chemotherapy as a post-operative adjuvant therapy in HER2-positive elderly breast cancer patients: randomized controlled trial [RESPECT (N-SAS BC07)]Jpn J Clin Oncol201141570971221355003