References
- MikhailSAlbaneseCPishvaianMJCyclin-dependent kinase inhibitors and the treatment of gastrointestinal cancersAm J Pathol20151851185119725747534
- BeckJTPotential role for mammalian target of rapamycin inhibitors as first-line therapy in hormone receptor-positive advanced breast cancerOnco Targets Ther201583629363826675495
- HanahanDWeinbergRAHallmarks of cancer: the next generationCell2011144564667421376230
- PeyressatreMPrévelCPelleranoMMorrisMCTargeting cyclin-dependent kinases in human cancers: from small molecules to peptide inhibitorsCancers (Basel)20157117923725625291
- HamiltonEInfanteJRTargeting CDK4/6 in patients with cancerCancer Treat Rev20164512913827017286
- MalumbresMBarbacidMCell cycle, CDKs and cancer: a changing paradigmNat Rev Cancer20099315316619238148
- HanahanDWeinbergRAThe hallmarks of cancerCell20001001577010647931
- Suárez-ArroyoIJLoperena-AlvarezYRosario-AcevedoRMartínez-MontemayorMMGanoderma spp.: a promising adjuvant treatment for breast cancerMedicines (Basel)201741129
- OttoTSicinskiPCell cycle proteins as promising targets in cancer therapyNat Rev Cancer20171729311528127048
- JingYWangGGeYXuMTangSGongZAA-PMe, a novel asiatic acid derivative, induces apoptosis and suppresses proliferation, migration, and invasion of gastric cancer cellsOnco Targets Ther201691605162127073325
- LaPakKMBurdCEThe molecular balancing act of p16INK4a in cancer and agingMol Cancer Res201412216718324136988
- SherrCJCancer cell cyclesScience19962745239167216778939849
- VuHLAplinAETargeting mutant NRAS signaling pathways in melanomaPharmacol Res201610711111626987942
- FinnRSMartinMRugoHSPalbociclib and letrozole in advanced breast cancerN Engl J Med2016375201925193627959613
- HortobagyiGNStemmerSMBurrisHARibociclib as first-line therapy for HR-positive, advanced breast cancerN Engl J Med2016375181738174827717303
- YangCLiZBhattTAcquired CDK6 amplification promotes breast cancer resistance to CDK4/6 inhibitors and loss of ER signaling and dependenceOncogene2017362255226427748766
- RaspéECoulonvalKPitaJMCDK4 phosphorylation status and a linked gene expression profile predict sensitivity to palbociclibEMBO Mol Med2017981052106628566333
- LefebvreCBachelotTFilleronTMutational profile of metastatic breast cancers: a retrospective analysisPLoS Med201613e100220128027327
- XuYQinLSunTTwist1 promotes breast cancer invasion and metastasis by silencing Foxa1 expressionOncogene2017361157116627524420
- WarburtonAJBooneDNInsights from global analyses of long non-coding RNAs in breast cancerCurr Pathobiol Rep201751233428616363
- CoronaSPRavelliACretellaDCDK4/6 inhibitors in HER2-positive breast cancerCrit Rev Oncol Hematol201711220821428325261
- BoérKFulvestrant in advanced breast cancer: evidence to date and place in therapyTher Adv Med Oncol20179746547928717399
- BrufskyAMDelaying chemotherapy in the treatment of hormone receptor–positive, human epidermal growth factor receptor 2-negative advanced breast cancerClin Med Insights Oncol2015913714726793013
- MalorniLPiazzaSCianiYA gene expression signature of retinoblastoma loss-of-function is a predictive biomarker of resistance to palbociclib in breast cancer cell lines and is prognostic in patients with ER positive early breast cancerOncotarget2016742680126802227634906
- SelliCDixonJMSimsHAAccurate prediction of response to endocrine therapy in breast cancer patients: current and future biomarkersBreast Cancer Res201618111827903276
- ReinertTBarriosCHOptimal management of hormone receptor positive metastatic breast cancer in 2016Ther Adv Med Oncol20157630432026557899
- Herrera-AbreuMTPalafoxMAsgharUEarly adaptation and acquired resistance to CDK4/6 inhibition in estrogen receptor-positive breast cancerCancer Res20167682301231327020857
- SherrCJA new cell-cycle target in cancer — inhibiting cyclin D-dependent kinases 4 and 6N Engl J Med20163752019201923 Perspective27959598
- RoccaASchironeAMaltoniRProgress with palbociclib in breast cancer: latest evidence and clinical considerationsTher Adv Med Oncol2017928310528203301
- ParrishKEPokornyJMittapalliRKBakkenKSarkariaJNElmquistWFEfflux transporters at the blood-brain barrier limit delivery and efficacy of cyclin-dependent kinase 4/6 inhibitor palbociclib (PD-0332991) in an orthotopic brain tumor modelJ Pharmacol Exp Ther2015355226427126354993
- FDA. The U.S. Food and Drug Administration approved ribociclib (KISQALI, Novartis Pharmaceuticals Corp.), a cyclin-dependent kinase 4/6 inhibitor, in combination with an aromatase inhibitor as initial endocrine-based therapy for the treatment of postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer. ID: 4068375. Accessed March 13, 2017.
- RubovszkyGHorváthZRecent advances in the neoadjuvant treatment of breast cancerJ Breast Cancer201720211913128690648
- FDAFDA approves abemaciclib for HR+, HER2− breast cancerCancer Discov Epub2017104
- SpringLBardiaAModiSTargeting the cyclin D–cyclin-dependent kinase (CDK)4/6–retinoblastoma pathway with selective CDK 4/6 inhibitors in hormone receptor-positive breast cancer: rationale, current status, and future directionsDiscov Med201621113657426896604
- KwapiszDCyclin-dependent kinase 4/6 inhibitors in breast cancer: palbociclib, ribociclib, and abemaciclibBreast Cancer Res Treat20171661415428741274
- AsgharUSBarrARCuttsRSingle-cell dynamics determines response to CDK4/6 inhibition in triple negative breast cancerClin Cancer Res201723185561557228606920
- GampenriederSPRinnerthalerGGreilRCDK4/6 inhibition in luminal breast cancerMemo20169768127429659
- LallemandLDuhouxFPCDK 4/6 inhibitors in the treatment of advanced breast cancerBelg J Med Oncol201711234241
- O’LearyBFinnRSTurnerNCTreating cancer with selective CDK4/6 inhibitorsNat Rev Clin Oncol2016137418430
- SuhDHKimMKimKKimHJLeeKKimJWMajor clinical research advances in gynecologic cancer in 2016: 10-year special editionJ Gynecol Oncol2017283e4528382802
- TossAVenturelliMPeterleCPiacentiniFCascinuSCortesiLMolecular biomarkers for prediction of targeted therapy response in metastatic breast cancer: trick or treat?Int J Mol Sci2017181E8528054957
- LeeMSHelmsTLFengNEfficacy of the combination of MEK and CDK4/6 inhibitors in vitro and in vivo in KRAS mutant colorectal cancer modelsOncotarget2016726395953960827167191
- Barroso-SousaRShapiroGITolaneySMClinical development of the CDK4/6 inhibitors ribociclib and abemaciclib in breast cancerBreast Care (Basel)201611316717327493615
- SpringLMZangardiMLMoyBBardiaAClinical management of potential toxicities and drug interactions related to cyclin-dependent kinase 4/6 inhibitors in breast cancer: practical considerations and recommendationsOncologist20172291039104828706010
- RaubTJWishartGNKulanthaivelPBrain exposure of two selective dual CDK4 and CDK6 inhibitors and the antitumor activity of CDK4 and CDK6 inhibition in combination with temozolomide in an intracranial glioblastoma xenograftDrug Metab Dispos20154391360137126149830
- SchröderLBMcDonaldKLCDK4/6 inhibitor PD0332991 in glioblastoma treatment: does it have a future?Front Oncol2015525926649278
- BartonKLMisuracaKCorderoFPD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem gliomaPLoS One2013810e7763924098593
- MichaudKSolomonDAOermannEPharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenograftsCancer Res20107083228323820354191
- IBRANCE® (palbociclib) capsules [prescribing information]New YorkPfizer Inc2015
- IBRANCE® (palbociclib). Fact sheetNew YorkPfizer Inc2015
- EMAAnnex 1: summary of product characteristicsEuropean Medicines Agency2015
- BeaverJAAmiri-KordestaniLCharlabRFDA approval: palbociclib for the treatment of postmenopausal patients with estrogen receptor–positive, HER2-negative metastatic breast cancerClin Cancer Res201521214760476626324739
- DicklerMNTolaneySMRugoHSMONARCH 1, a Phase 2 study of abemaciclib, a CDK4 and CDK6 inhibitor, as a single agent, in patients with refractory HR+/HER2− metastatic breast cancerClin Cancer Res201723175218522428533223
- KondoSYamamotoNTamuraKPhase 1 study of abemaciclib, a CDK 4 and 6 inhibitor, as a single agent for Japanese patients with advanced cancerEur J Cancer201551Suppl 3S59
- Eli Lilly and CompanyLilly Announces Phase 3 MONARCH 2 Breast Cancer Study of Abemaciclib Met Primary Endpoint of Progression-Free Survival Available from https://investor.lilly.com/releasedetail.cfm?ReleaseID=1017952Accessed August 16, 2017
- Eli Lilly and CompanyLilly Builds Upon Body of Data for Abemaciclib with Phase 3 MONARCH 2 Data Demonstrating Superior Progression-Free Survival in Advanced Breast Cancer Available from https://www.newswire.com/news/lilly-builds-upon-body-of-data-for-abemaciclib-with-phase-3-monarch-2-dataAccessed August 16, 2017
- SledgeGWJrToiMNevenPMONARCH 2: abemaciclib in combination with fulvestrant in women with HR+/HER2− advanced breast cancer who had progressed while receiving endocrine therapyJ Clin Oncol201735252875288428580882
- KISQALI® (ribociclib) tablets [prescribing information]East Hanover, NJNovartis Pharmaceuticals Corporation2017
- ChoyMPharmaceutical approval updateP T201742636637128579722
- CuriglianoGGómez PardoPMeric-BernstamFRibociclib plus letrozole in early breast cancer: a presurgical, window-of-opportunity studyBreast20162819119827336726
- CareyLAPerouCMPalbociclib — taking breast-cancer cells out of gearN Engl J Med2015373327327426176385
- TurnerNCRoJAndréFPALOMA3 Study GroupPalbociclib in hormone-receptor-positive advanced breast cancerN Engl J Med2015373320921926030518
- TurnerNCHuang BartlettCCristofanilliMPalbociclib in hormone-receptor–positive advanced breast cancerN Engl J Med20153731716721673
- Eli Lilly and CompanyFDA Grants Priority Review for Lilly’s Abemaciclib for the Treatment of Advanced Breast Cancer2017 Available from https://investor.lilly.com/releasedetail.cfm?ReleaseID=1032523Accessed October 18, 2017
- WolffACCDK4 and CDK6 inhibition in breast cancer — a new standardN Engl J Med2016375201993199527959592
- MurphyCGDicklerMNThe role of CDK4/6 inhibition in breast cancerOncologist201520548349025876993
- TripathyDBardiaASellersWRRibociclib (LEE011): mechanism of action and clinical impact of this selective cyclin-dependent kinase 4/6 inhibitor in various solid tumorsClin Cancer Res201723133251326228351928
- WoodACKrytskaKRylesHTDual ALK and CDK4/6 inhibition demonstrates synergy against neuroblastomaClin Cancer Res201723112856286827986745
- RaderJRussellMRHartLSDual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastomaClin Cancer Res201319226173618224045179
- HartLSRaderJRamanPPreclinical therapeutic synergy of MEK1/2 and CDK4/6 inhibition in neuroblastomaClin Cancer Res20172371785179627729458
- ZhangYXSicinskaECzaplinskiJTAntiproliferative effects of CDK4/6 inhibition in CDK4-amplified human liposarcoma in vitro and in vivoMol Cancer Ther20141392184219325028469
- PablaNGibsonAABuegeMMitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functionsProc Natl Acad Sci U S A2015112165231523625848011
- O’SullivanCCOvercoming endocrine resistance in hormone-receptor positive advanced breast cancer – the emerging role of CDK4/6 inhibitorsInt J Cancer Clin Res201524 pii:029
- InfanteJRCassierPAGerecitanoJFA Phase I study of the cyclin-dependent kinase 4/6 inhibitor ribociclib (LEE011) in patients with advanced solid tumors and lymphomasClin Cancer Res201622235696570527542767
- SonkeGSHartLLCamponeMEfficacy and safety of ribociclib (LEE011) + letrozole in elderly patients with hormone receptor-positive (HR+), HER2-negative (HER2−) advanced breast cancer (ABC) in MONALEESA-2Eur J Cancer201772Suppl 1S1S2
- SyedYYRibociclib: first global approvalDrugs201777779980728417244
- O’SullivanCCCDK4/6 inhibitors for the treatment of advanced hormone receptor positive breast cancer and beyond: 2016 updateExpert Opin Pharmacother201617121657166727322766
- GeoergerBBourdeautFDuBoisSGA Phase I study of the CDK4/6 inhibitor ribociclib (LEE011) in pediatric patients with malignant rhabdoid tumors, neuroblastoma, and other solid tumorsClin Cancer Res201723102433244128432176
- López-TarruellaSJerezYMárquez-RodasIEchavarriaIMartinMRibociclib for the treatment of advanced hormone receptor-positive, HER2-negative breast cancerFuture Oncol201713242137214928758424