230
Views
0
CrossRef citations to date
0
Altmetric
Original Research

Anticarcinogenic Effects of Odorant Substances Citral, Citrathal R and Cyclovertal on Breast Cancer in vitro

, , , , , , , , , & ORCID Icon show all
Pages 659-673 | Published online: 08 Dec 2021

References

  • BrayF, FerlayJ, SoerjomataramI, SiegelRL, TorreLA, JemalA. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi:10.3322/caac.2149230207593
  • LakhaniSR; International Agency for Research on Cancer, Weltgesundheitsorganisation, editors. WHO Classification of Tumours of the Breast: Views of a Working Group That Convened for a Consensus and Editorial Meeting at the International Agency for Research on Cancer (IARC), Lyon, September 1–3, 2011. 4ed. Internat. Agency for Research on Cancer; 2012.
  • HarbeckN, GnantM. Breast cancer. Lancet Lond Engl. 2017;389(10074):1134–1150. doi:10.1016/S0140-6736(16)31891-8
  • GianniL, DafniU, GelberRD, et al. Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: a 4-year follow-up of a randomised controlled trial. Lancet Oncol. 2011;12(3):236–244. doi:10.1016/S1470-2045(11)70033-X21354370
  • GreenleeH, DuPont-ReyesMJ, BalneavesLG, et al. Clinical practice guidelines on the evidence-based use of integrative therapies during and after breast cancer treatment: integrative therapies during and after breast cancer treatment. CA Cancer J Clin. 2017;67(3):194–232. doi:10.3322/caac.2139728436999
  • LopesCM, DouradoA, OliveiraR. Phytotherapy and nutritional supplements on breast cancer. BioMed Res Int. 2017;2017:1–42. doi:10.1155/2017/7207983
  • ParmentierM, LibertF, SchurmansS, et al. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. Nature. 1992;355(6359):453–455. doi:10.1038/355453a01370859
  • FlegelC, ManteniotisS, OstholdS, HattH, GisselmannG. Expression profile of ectopic olfactory receptors determined by deep sequencing. PLoS One. 2013;8(2):e55368. doi:10.1371/journal.pone.005536823405139
  • SpehrM, GisselmannG, PoplawskiA. Identification of a testicular odorant receptor mediating human sperm chemotaxis. Science. 2003;299(5615):2054–2058. doi:10.1126/science.108037612663925
  • BusseD, KudellaP, GrüningN-M, et al. A synthetic sandalwood odorant induces wound-healing processes in human keratinocytes via the olfactory receptor OR2AT4. J Invest Dermatol. 2014;134(11):2823–2832. doi:10.1038/jid.2014.27324999593
  • NeuhausEM, ZhangW, GelisL, DengY, NoldusJ, HattH. Activation of an olfactory receptor inhibits proliferation of prostate cancer cells. J Biol Chem. 2009;284(24):16218–16225. doi:10.1074/jbc.M109.01209619389702
  • MaßbergD, HattH. Human olfactory receptors: novel cellular functions outside of the nose. Physiol Rev. 2018;98(3):1739–1763. doi:10.1152/physrev.00013.201729897292
  • SpehrJ, GelisL, OsterlohM, et al. G protein-coupled receptor signaling via src kinase induces endogenous human transient receptor potential vanilloid type 6 (TRPV6) channel activation. J Biol Chem. 2011;286(15):13184–13192. doi:10.1074/jbc.M110.18352521349844
  • GelisL, JovancevicN, VeitingerS, et al. Functional characterization of the odorant receptor 51E2 in human melanocytes. J Biol Chem. 2016;291(34):17772–17786. doi:10.1074/jbc.M116.73451727226631
  • ManteniotisS, WojcikS, BrauhoffP, et al. Functional characterization of the ectopically expressed olfactory receptor 2AT4 in human myelogenous leukemia. Cell Death Discov. 2016;2(1). doi:10.1038/cddiscovery.2015.70
  • MontellC. The TRP superfamily of cation channels. Sci STKE Signal Transduct Knowl Environ. 2005;2005(272):re3. doi:10.1126/stke.2722005re3
  • StotzSC, VriensJ, MartynD, ClardyJ, ClaphamDE. Citral sensing by TRANSient receptor potential channels in Dorsal Root Ganglion neurons. PLoS One. 2008;3(5):e2082. doi:10.1371/journal.pone.000208218461159
  • LiebmannC. G protein-coupled receptors and their signaling pathways: classical therapeutical targets susceptible to novel therapeutic concepts. Curr Pharm Des. 2004;10(16):1937–1958. doi:10.2174/138161204338436715180530
  • WeberL, MaßbergD, BeckerC, et al. Olfactory receptors as biomarkers in human breast carcinoma tissues. Front Oncol. 2018;8. doi:10.3389/fonc.2018.00033
  • MasjediS, ZwiebelLJ, GiorgioTD. Olfactory receptor gene abundance in invasive breast carcinoma. Sci Rep. 2019;9(1):13736. doi:10.1038/s41598-019-50085-431551495
  • Dhennin-DuthilleI, GautierM, FaouziM, et al. High expression of transient receptor potential channels in human breast cancer epithelial cells and tissues: correlation with pathological parameters. Cell Physiol Biochem. 2011;28(5):813–822. doi:10.1159/00033579522178934
  • GuilbertA, GautierM, Dhennin-DuthilleI, HarenN, SevestreH, Ouadid-AhidouchH. Evidence that TRPM7 is required for breast cancer cell proliferation. Am J Physiol Cell Physiol. 2009;297(3):C493–C502. doi:10.1152/ajpcell.00624.200819515901
  • WeberLV, Al-RefaeK, WölkG, et al. Expression and functionality of TRPV1 in breast cancer cells. Breast Cancer Targets Ther. 2016;8:243–252. doi:10.2147/BCTT.S121610
  • ScholzenT, GerdesJ. The Ki-67 protein: from the known and the unknown. J Cell Physiol. 2000;182(3):311–322. doi:10.1002/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-910653597
  • JuríkováM, DanihelĽ, PolákŠ, VargaI. Ki67, PCNA, and MCM proteins: markers of proliferation in the diagnosis of breast cancer. Acta Histochem. 2016;118(5):544–552. doi:10.1016/j.acthis.2016.05.00227246286
  • GreenDR, KroemerG. Cytoplasmic functions of the tumour suppressor p53. Nature. 2009;458(7242):1127–1130. doi:10.1038/nature0798619407794
  • VaziriH, DessainSK, Ng EatonE, et al. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell. 2001;107(2):149–159. doi:10.1016/s0092-8674(01)00527-x11672523
  • MitaAC, MitaMM, NawrockiST, GilesFJ. Survivin: key regulator of mitosis and apoptosis and novel target for cancer therapeutics. Clin Cancer Res. 2008;14(16):5000–5005. doi:10.1158/1078-0432.CCR-08-074618698017
  • BrumattiG, SheridanC, MartinSJ. Expression and purification of recombinant annexin V for the detection of membrane alterations on apoptotic cells. Methods. 2008;44(3):235–240. doi:10.1016/j.ymeth.2007.11.01018314054
  • ZhongZ, YeowW-S, ZouC, et al. Cyclin D1/Cyclin-dependent Kinase 4 interacts with Filamin A and affects the migration and invasion potential of breast cancer cells. Cancer Res. 2010;70(5):2105–2114. doi:10.1158/0008-5472.CAN-08-110820179208
  • Aguirre-PortolesC, BirdAW, HymanA, CanameroM, Perez de CastroI, MalumbresM. Tpx2 controls spindle integrity, genome stability, and tumor development. Cancer Res. 2012;72(6):1518–1528. doi:10.1158/0008-5472.CAN-11-197122266221
  • McCubreyJA, SteelmanLS, ChappellWH, et al. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim Biophys Acta BBA Mol Cell Res. 2007;1773(8):1263–1284. doi:10.1016/j.bbamcr.2006.10.001
  • CuendaA, RousseauS. p38 MAP-Kinases pathway regulation, function and role in human diseases. Biochim Biophys Acta BBA Mol Cell Res. 2007;1773(8):1358–1375. doi:10.1016/j.bbamcr.2007.03.010
  • O’NeillE, RushworthL, BaccariniM, KolchW. Role of the Kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1. Science. 2004;306(5705):2267–2270. doi:10.1126/science.110323315618521
  • MadsenCD, HooperS, TozluogluM, et al. STRIPAK components determine mode of cancer cell migration and metastasis. Nat Cell Biol. 2014;17(1):68–80. doi:10.1038/ncb308325531779
  • SchäggerH, von JagowG. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal Biochem. 1987;166(2):368–379. doi:10.1016/0003-2697(87)90587-22449095
  • HaanC, BehrmannI. A cost effective non-commercial ECL-solution for Western blot detections yielding strong signals and low background. J Immunol Methods. 2007;318(1–2):11–19. doi:10.1016/j.jim.2006.07.02717141265
  • LivakKJ, SchmittgenTD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods San Diego Calif. 2001;25(4):402–408. doi:10.1006/meth.2001.1262
  • Microsoft Corporation. Microsoft Excel; 2017.
  • R Foundation for Statistical Computing. R Core Team. R: a language and environment for statistical computing; 2020. Available from:https://www.R-project.org/. Accessed November9, 2020.
  • NigjehSE, YeapSK, NordinN, KamalideghanB, KyH, RosliR. Citral induced apoptosis in MDA-MB-231 spheroid cells. BMC Complement Altern Med. 2018;18(1). doi:10.1186/s12906-018-2115-y
  • ChaoukiW, LegerDY, LiagreB, BeneytoutJ-L, HmamouchiM. Citral inhibits cell proliferation and induces apoptosis and cell cycle arrest in MCF-7 cells. Fundam Clin Pharmacol. 2009;23(5):549–556. doi:10.1111/j.1472-8206.2009.00738.x19656204
  • PatelPB, ThakkarVR, PatelJS. Cellular effect of curcumin and citral combination on breast cancer cells: induction of apoptosis and cell cycle arrest. J Breast Cancer. 2015;18(3):225. doi:10.4048/jbc.2015.18.3.22526472972
  • KapurA, FelderM, FassL, et al. Modulation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation. Sci Rep. 2016;6(1). doi:10.1038/srep27530
  • DudaiN, WeinsteinY, KrupM, RabinskiT, OfirR. Citral is a new inducer of Caspase-3 in tumor cell lines. Planta Med. 2005;71(5):484–488. doi:10.1055/s-2005-86414615931590
  • SauerK, LehnerCF. The role of cyclin E in the regulation of entry into S phase. Prog Cell Cycle Res. 1995;1:125–139.9552358
  • PaganoM, PepperkokR, VerdeF, AnsorgeW, DraettaG. Cyclin A is required at two points in the human cell cycle. EMBO J. 1992;11(3):961–971. doi:10.1002/j.1460-2075.1992.tb05135.x1312467
  • OhtsuboS, FujitaT, MatsushitaA, KumamotoE. Inhibition of the compound action potentials of frog sciatic nerves by aroma oil compounds having various chemical structures. Pharmacol Res Perspect. 2015;3(2):e00127. doi:10.1002/prp2.12726038703
  • FazzariJ, LinH, MurphyC, UngardR, SinghG. Inhibitors of glutamate release from breast cancer cells; new targets for cancer-induced bone-pain. Sci Rep. 2015;5(1). doi:10.1038/srep08380
  • VercelliC, BarberoR, CunibertiB, et al. Transient receptor potential vanilloid 1 expression and functionality in MCF-7 cells: a preliminary investigation. J Breast Cancer. 2014;17(4):332. doi:10.4048/jbc.2014.17.4.33225548580
  • HaqueM, DesaiKV. Pathways to endocrine therapy resistance in breast cancer. Front Endocrinol. 2019;10. doi:10.3389/fendo.2019.00573
  • ThomasML, de AntuenoR, CoyleKM, et al. Citral reduces breast tumor growth by inhibiting the cancer stem cell marker ALDH1A3. Mol Oncol. 2016;10(9):1485–1496. doi:10.1016/j.molonc.2016.08.00427592281