95
Views
14
CrossRef citations to date
0
Altmetric
Review

Cardiac risk in the treatment of breast cancer: assessment and management

&
Pages 21-35 | Published online: 16 Jan 2015

References

  • GLOBOCAN 2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012 [webpage on the Internet]LyonInternational Agency for Research on Cancer2012 Available from: http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspxAccessed October 10, 2014
  • SiegelRNaishadhamDJemalACancer statistics, 2012CA Cancer J Clin2012621102922237781
  • Early Breast Cancer Trialists’ Collaborative Group (EBCTCG)DarbySMcGalePEffect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trialsLancet201137898041707171622019144
  • RechtAEdgeSBSolinLJPostmastectomy radiotherapy: clinical practice guidelines of the American Society of Clinical OncologyJ Clin Oncol20011951539156911230499
  • EBCTCG (Early Breast Cancer Trialists’ Collaborative Group)McGalePTaylorCEffect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trialsLancet201438399352127213524656685
  • ClarkeMCollinsRDarbySEffects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trialsLancet200536695032087210616360786
  • HooningMJBotmaAAlemanBMLong-term risk of cardiovascular disease in 10-year survivors of breast cancerJ Natl Cancer Inst200799536537517341728
  • BouillonKHaddyNDelalogeSLong-term cardiovascular mortality after radiotherapy for breast cancerJ Am Coll Cardiol201157444545221251585
  • LancellottiPNkomoVTBadanoLPExpert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: a report from the European Association of Cardiovascular Imaging and the American Society of EchocardiographyEur Heart J Cardiovasc Imaging201314872174023847385
  • RoychoudhuriRRobinsonDPutchaVCuzickJDarbySMøllerHIncreased cardiovascular mortality more than fifteen years after radiotherapy for breast cancer: a population-based studyBMC Cancer20077917224064
  • DarbySCMcGalePTaylorCWPetoRLong-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: prospective cohort study of about 300,000 women in US SEER cancer registriesLancet Oncol20056855756516054566
  • HarrisEECorreaCHwangWTLate cardiac mortality and morbidity in early-stage breast cancer patients after breast-conservation treatmentJ Clin Oncol200624254100410616908933
  • DarbySCEwertzMMcGalePRisk of ischemic heart disease in women after radiotherapy for breast cancerN Engl J Med20133681198799823484825
  • TaylorCWNisbetAMcGalePDarbySCCardiac exposures in breast cancer radiotherapy: 1950s–1990sInt J Radiat Oncol Biol Phys20076951484149518035211
  • TaylorCWPovallJMMcGalePCardiac dose from tangential breast cancer radiotherapy in the year 2006Int J Radiat Oncol Biol Phys200872250150718374500
  • NilssonGHolmbergLGarmoHDistribution of coronary artery stenosis after radiation for breast cancerJ Clin Oncol201230438038622203772
  • CorreaCRLittHIHwangWTFerrariVASolinLJHarrisEECoronary artery findings after left-sided compared with right-sided radiation treatment for early-stage breast cancerJ Clin Oncol200725213031303717634481
  • http://www.dbcg.dk [homepage on the Internet]CopenhagenDanish Breast Cancer Cooperative Group Available from: http://www.dbcg.dkAccessed October 10, 2014
  • BartlettFRYarnoldJRDonovanEMEvansPMLockeIKirbyAMMultileaf collimation cardiac shielding in breast radiotherapy: Cardiac doses are reduced, but at what cost?Clin Oncol (R Coll Radiol)2013251269069624083961
  • PoortmansPSHKirkoveCBudachVIrradiation of the internal mammary and medial supraclavicular lymph nodes in stage I to III breast cancer: 10 years results of the EORTC radiation oncology and breast cancer groups phase III trial 22922/10925Eur J Cancer201347Suppl 2
  • WhelanTJOlivottoIAckermanINCIC-CTG MA.20: an intergroup trial of regional nodal irradiation in early breast cancerJ Clin Oncol201129LBA1003
  • HennequinCBossardNServagi-VernatSTen-year survival results of a randomized trial of irradiation of internal mammary nodes after mastectomyInt J Radiat Oncol Biol Phys201386586086623664327
  • MastMEvan Kempen-HarteveldLHeijenbrokMWLeft-sided breast cancer radiotherapy with and without breath-hold: does IMRT reduce the cardiac dose even further?Radiother Oncol2013108224825324044804
  • ZellarsRBravoPETryggestadESPECT analysis of cardiac perfusion changes after whole-breast/chest wall radiation therapy with or without active breathing coordinator: results of a randomized phase 3 trialInt J Radiat Oncol Biol Phys201488477878524606847
  • OsmanSOHolSPoortmansPMEssersMVolumetric modulated arc therapy and breath-hold in image-guided locoregional left-sided breast irradiationRadiother Oncol20141121172224825176
  • MastMEVredeveldEJCredoeHMWhole breast proton irradiation for maximal reduction of heart dose in breast cancer patientsBreast Cancer Res Treat20141481333925266130
  • PrescottRJKunklerIHWilliamsLJA randomised controlled trial of postoperative radiotherapy following breast-conserving surgery in a minimum-risk older population. The PRIME trialHealth Technol Assess20071131114917669280
  • KaklamaniVGGradisharWJEpirubicin versus doxorubicin: which is the anthracycline of choice for the treatment of breast cancer?Clin Breast Cancer20034Suppl 1S26S3312756076
  • SingalPKIliskovicNDoxorubicin-induced cardiomyopathyN Engl J Med19983399009059744975
  • LyuYLKerriganJELinCPTopoisomerase IIbeta mediated DNA double-strand breaks: implications in doxorubicin cardiotoxicity and prevention by dexrazoxaneCancer Res2007678839884617875725
  • EwerMSLippmanSMType II chemotherapy-related cardiac dysfunction: time to recognize a new entityJ Clin Oncol2005232900290215860848
  • SmithLACorneliusVRPlummerCJCardiotoxicity of anthracycline agents for the treatment of cancer: systematic review and meta-analysis of randomised controlled trialsBMC Cancer20101033720587042
  • LotrionteMBiondi-ZoccaiGAbbateAReview and meta-analysis of incidence and clinical predictors of anthracycline cardiotoxicityAm J Cardiol2013112121980198424075281
  • SwainSMWhaleyFSEwerMSCongestive heart failure in patients treated with doxorubicin: a retrospective analysis of three trialsCancer2003972869287912767102
  • RybergMNielsenDSkovsgaardTHansenJJensenBVDombernowskyPEpirubicin cardiotoxicity: an analysis of 469 patients with metastatic breast cancerJ Clin Oncol199816350235089817267
  • MinottiGLicataSSaponieroAAnthracycline metabolism and toxicity in human myocardium: comparisons between doxorubicin, epirubicin, and a novel disaccharide analogue with a reduced level of formation and [4Fe-4S] reactivity of its secondary alcohol metaboliteChem Res Toxicol2000131336134111123976
  • RybergMNielsenDCorteseGNielsenGSkovsgaardTAndersenPKNew insight into epirubicin cardiac toxicity: competing risks analysis of 1097 breast cancer patientsJ Natl Cancer Inst20081001058106718664656
  • van DalenECvan der PalHJCaronHNKremerLCDifferent dosage schedules for reducing cardiotoxicity in cancer patients receiving anthracycline chemotherapyCochrane Database Syst Rev20064CD00500817054232
  • GiottaFLorussoVMaielloELiposomal-encapsulated doxorubicin plus cyclophosphamide as first-line therapy in metastatic breast cancer: a phase II multicentric studyAnn Oncol200718Suppl 6vi66vi6917591836
  • BrainEGMertensCGirreVImpact of liposomal doxorubicin-based adjuvant chemotherapy on autonomy in women over 70 with hormone-receptor-negative breast carcinoma: A French Geriatric Oncology Group (GERICO) phase II multicentre trialCrit Rev Oncol Hematol201180116017021035352
  • RaysonDSuterTMJackischCCardiac safety of adjuvant pegylated liposomal doxorubicin with concurrent trastuzumab: a randomized phase II trialAnn Oncol20122371780178822056854
  • JooKIXiaoLLiuSCrosslinked multilamellar liposomes for controlled delivery of anticancer drugsBiomaterials201334123098310923375392
  • LiuYFangJKimYJWongMKWangPCodelivery of doxorubicin and paclitaxel by cross-linked multilamellar liposome enables synergistic antitumor activityMol Pharm20141151651166124673622
  • SlamonDEiermannWRobertNAdjuvant trastuzumab in HER2-positive breast cancerN Engl J Med2011365141273128321991949
  • Early Breast Cancer Trialists’ Collaborative Group (EBCTCG)PetoRDaviesCComparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100,000 women in 123 randomised trialsLancet2012379981443244422152853
  • RowinskyEKMcGuireWPGuarnieriTFishermanJSChristianMCDonehowerRCCardiac disturbances during the administration of taxolJ Clin Oncol19919170417121678781
  • ShimoyamaMMurataYSumiKIHamazoeRKomuroIDocetaxel induced cardiotoxicityHeart200186221911454849
  • ArbuckSGStraussHRowinskyEA reassessment of cardiac toxicity associated with TaxolJ Natl Cancer Inst Monogr1993151171307912518
  • GianniLSalvatorelliEMinottiGAnthracycline cardiotoxicity in breast cancer patients: synergism with trastuzumab and taxanesCardiovasc Toxicol20077677117652806
  • GiordanoSHBooserDJMurrayJLA detailed evaluation of cardiac toxicity: a phase II study of doxorubicin and one- or three-hour-infusion paclitaxel in patients with metastatic breast cancerClin Cancer Res200283360336812429622
  • GennariASalvadoriBDonatiSCardiotoxicity of epirubicin/paclitaxel-containing regimens: role of cardiac risk factorsJ Clin Oncol1999173596360210550159
  • PetrelliFBorgonovoKCabidduMLonatiVBarniSMortality, leukemic risk, and cardiovascular toxicity of adjuvant anthracycline and taxane chemotherapy in breast cancer: a meta-analysisBreast Cancer Res Treat2012135233534622689092
  • Early Breast Cancer Trialists’ Collaborative Group (EBCTCG)Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trialsLancet200536594721687171715894097
  • Breast International Group (BIG) 1-98 Collaborative GroupThürlimannBKeshaviahAA comparison of letrozole and tamoxifen in postmenopausal women with early breast cancerN Engl J Med2005353262747275716382061
  • CoombesRCKilburnLSSnowdonCFSurvival and safety of exemestane versus tamoxifen after 2–3 years’ tamoxifen treatment (Intergroup Exemestane Study): a randomised controlled trialLancet2007369956155957017307102
  • HowellACuzickJBaumMResults of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years’ adjuvant treatment for breast cancerLancet20053659453606215639680
  • SmithIEDowsettMAromatase inhibitors in breast cancerN Engl J Med2003348242431244212802030
  • LinCChenLSKuoSJChenDRAdjuvant tamoxifen influences the lipid profile in breast cancer patientsBreast Care (Basel)201491353924803885
  • BraithwaiteRSChlebowskiRTLauJGeorgeSHessRColNFMeta-analysis of vascular and neoplastic events associated with tamoxifenJ Gen Intern Med2003181193794714687281
  • Arimidex, Tamoxifen, Alone or in Combination Trialists’ GroupBuzdarAHowellAComprehensive side-effect profile of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: long-term safety analysis of the ATAC trialLancet Oncol20067863364616887480
  • MouridsenHKeshaviahACoatesASCardiovascular adverse events during adjuvant endocrine therapy for early breast cancer using letrozole or tamoxifen: safety analysis of BIG 1-98 trialJ Clin Oncol200725365715572217998546
  • BlissJMKilburnLSColemanREDisease-related outcomes with long-term follow-up: an updated analysis of the intergroup exemestane studyJ Clin Oncol201230770971722042946
  • GossPEIngleJNMartinoSRandomized trial of letrozole following tamoxifen as extended adjuvant therapy in receptor-positive breast cancer: updated findings from NCIC CTG MA.17J Natl Cancer Inst200597171262127116145047
  • DawoodSBroglioKBuzdarAUHortobagyiGNGiordanoSHPrognosis of women with metastatic breast cancer by HER2 status and trastuzumab treatment: an institutional-based reviewJ Clin Oncol2010281929819933921
  • VianiGAAfonsoSLStefanoEJDe FendiLISoaresFVAdjuvant trastuzumab in the treatment of her-2-positive early breast cancer: a meta-analysis of published randomized trialsBMC Cancer2007715317686164
  • SeidmanAHudisCPierriMKCardiac dysfunction in the trastuzumab clinical trials experienceJ Clin Oncol20022051215122111870163
  • OnitiloAAEngelJMStankowskiRVCardiovascular toxicity associated with adjuvant trastuzumab therapy: prevalence, patient characteristics, and risk factorsTher Adv Drug Saf20145415416625083270
  • MojaLTagliabueLBalduzziSTrastuzumab containing regimens for early breast cancerCochrane Database Syst Rev20124CD00624322513938
  • BowlesEJWellmanRFeigelsonHSRisk of heart failure in breast cancer patients after anthracycline and trastuzumab treatment: a retrospective cohort studyJ Natl Cancer Inst2012104171293130522949432
  • NaumannDRusiusVMargiottaCFactors predicting trastuzumab-related cardiotoxicity in a real-world population of women with HER2+ breast cancerAnticancer Res20133341717172023564821
  • ZhaoYYSawyerDRBaligaRRNeuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytesJ Biol Chem19982731710261102699553078
  • De KeulenaerGWDoggenKLemmensKThe vulnerability of the heart as a pluricellular paracrine organ: Lessons from unexpected triggers of heart failure in targeted erbb2 anticancer therapyCirc Res20101061354620056944
  • FarolfiAMelegariEAquilinaMTrastuzumab-induced cardiotoxicity in early breast cancer patients: a retrospective study of possible risk and protective factorsHeart201399963463923349345
  • RussoGCioffiGDi LenardaARole of renal function on the development of cardiotoxicity associated with trastuzumab-based adjuvant chemotherapy for early breast cancerIntern Emerg Med20127543944622714882
  • CochetAQuilichiniGDygai-CochetIBaseline diastolic dysfunction as a predictive factor of trastuzumab-mediated cardiotoxicity after adjuvant anthracycline therapy in breast cancerBreast Cancer Res Treat2011130384585421918836
  • ValachisAMauriDPolyzosNPChlouverakisGMavroudisDGeorgouliasVTrastuzumab combined to neoadjuvant chemotherapy in patients with HER2-positive breast cancer: a systematic review and meta-analysisBreast201120648549021784637
  • SchneeweissAChiaSHickishTPertuzumab plus trastuzumab in combination with standard neoadjuvant anthracycline-containing and anthracycline-free chemotherapy regimens in patients with HER2-positive early breast cancer: a randomized phase II cardiac safety study (TRYPHAENA)Ann Oncol20132492278228423704196
  • BuzdarAUSumanVJMeric-BernstamFFluorouracil, epirubicin, and cyclophosphamide (FEC-75) followed by paclitaxel plus trastuzumab versus paclitaxel plus trastuzumab followed by FEC-75 plus trastuzumab as neoadjuvant treatment for patients with HER2-positive breast cancer (Z1041): a randomised, controlled, phase 3 trialLancet Oncol201314131317132524239210
  • PerezEASumanVJDavidsonNECardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trialJ Clin Oncol20082681231123818250349
  • ChenJLongJBHurriaAOwusuCSteingartRMGrossCPIncidence of heart failure or cardiomyopathy after adjuvant trastuzumab therapy for breast cancerJ Am Coll Cardiol201260242504251223158536
  • SerranoCCortésJDe Mattos-ArrudaLTrastuzumab-related cardiotoxicity in the elderly: a role for cardiovascular risk factorsAnn Oncol201223489790221828361
  • BeauclairSFormentoPFischelJLRole of the HER2 [Ile655Val] genetic polymorphism in tumorogenesis and in the risk of trastuzumab-related cardiotoxicityAnn Oncol20071881335134117693647
  • LemieuxJDiorioCCôtéMAAlcohol and HER2 polymorphisms as risk factor for cardiotoxicity in breast cancer treated with trastuzumabAnticancer Res20133362569257623749910
  • RocaLDiérasVRochéHCorrelation of HER2, FCGR2A, and FCGR3A gene polymorphisms with trastuzumab related cardiac toxicity and efficacy in a subgroup of patients from UNICANCER-PACS 04 trialBreast Cancer Res Treat2013139378980023780683
  • GeyerCEForsterJLindquistDLapatinib plus capecitabine for HER2-positive advanced breast cancerN Engl J Med20063552733274317192538
  • BaselgaJCortésJKimSBPertuzumab plus trastuzumab plus docetaxel for metastatic breast cancerN Engl J Med201236610911922149875
  • GianniLPienkowskiTImYHEfficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trialLancet Oncol2012131253222153890
  • ValachisANearchouALindPMauriDLapatinib, trastuzumab or the combination added to preoperative chemotherapy for breast cancer: a meta-analysis of randomized evidenceBreast Cancer Res Treat2012135365566222875745
  • BlackwellKLBursteinHJStornioloAMOverall survival benefit with lapatinib in combination with trastuzumab for patients with human epidermal growth factor receptor 2-positive metastatic breast cancer: final results from the EGF104900 StudyJ Clin Oncol201230212585259222689807
  • ValachisANearchouAPolyzosNPLindPCardiac toxicity in breast cancer patients treated with dual HER2 blockadeInt J Cancer201313392245225223629633
  • CuriglianoGCardinaleDSuterTCardiovascular toxicity induced by chemotherapy, targeted agents and radiotherapy: ESMO Clinical Practice GuidelinesAnn Oncol201223Suppl 7vii155vii16622997448
  • PlanaJCGalderisiMBaracAExpert consensus for multi-modality imaging evaluation of adult patients during and after cancer therapy: a report from the American Society of Echocardiography and the European Association of Cardiovascular ImagingEur Heart J Cardiovasc Imaging201415101063109325239940
  • FloydJMorganJPCardiotoxicity of anthracycline-like chemotherapy agentsUpToDateSavareseDFMUpToDateWaltham, MAAccessed on September 8, 2014
  • PerezEAMorganJPCardiotoxicity of trastuzumab and other HER2-targeted agentsUpToDateSavareseDFMUpToDateWaltham, MAAccessed on September 15, 2014
  • MarksLBConstineLSJacob AdamsMCardiotoxicity of radiation therapy for malignancyUpToDateRossMEUpToDateWaltham, MAAccessed on September 1, 2014
  • RomondEHJeongJHRastogiPSeven-year follow-up assessment of cardiac function in NSABP B-31, a randomized trial comparing doxorubicin and cyclophosphamide followed by paclitaxel (ACP) with ACP plus trastuzumab as adjuvant therapy for patients with node-positive, human epidermal growth factor receptor 2-positive breast cancerJ Clin Oncol201230313792379922987084
  • AltenaRPerikPJvan VeldhuisenDJde VriesEGGietemaJACardiovascular toxicity caused by cancer treatment: strategies for early detectionLancet Oncol200910439139919341970
  • EwerMSAliMKMackayBA comparison of cardiac biopsy grades and ejection fraction estimations in patients receiving AdriamycinJ Clin Oncol1984221121176699662
  • JensenBVSkovsgaardTNielsenSLFunctional monitoring of anthracycline cardiotoxicity: a prospective, blinded, long-term observational study of outcome in 120 patientsAnn Oncol200213569970912075737
  • EwerMSLenihanDJLeft ventricular ejection fraction and cardiotoxicity: is our ear really to the ground?J Clin Oncol20082681201120318227525
  • ThavendiranathanPGrantADNegishiTPlanaJCPopovićZBMarwickTHReproducibility of echocardiographic techniques for sequential assessment of left ventricular ejection fraction and volumes: application to patients undergoing cancer chemotherapyJ Am Coll Cardiol2013611778423199515
  • LangRMMor-AviVDentJMKramerCMThree-dimensional echocardiography: is it ready for everyday clinical use?JACC Cardiovasc Imaging20092111411719356542
  • LorenziniCCorsiCAquilinaMEarly detection of cardiotoxicity in chemotherapy-treated patients from real-time 3D echocardiographyComputing in Cardiology Conference (CinC)2013249252
  • JurcutRWildiersHGanameJStrain rate imaging detects early cardiac effects of pegylated liposomal doxorubicin as adjuvant therapy in elderly patients with breast cancerJ Am Soc Echocardiogr200821121283128919041569
  • HareJLBrownJKLeanoRJenkinsCWoodwardNMarwickTHUse of myocardial deformation imaging to detect preclinical myocardial dysfunction before conventional measures in patients undergoing breast cancer treatment with trastuzumabAm Heart J2009158229430119619708
  • Fallah-RadNWalkerJRWassefAThe utility of cardiac biomarkers, tissue velocity and strain imaging, and cardiac magnetic resonance imaging in predicting early left ventricular dysfunction in patients with human epidermal growth factor receptor II-positive breast cancer treated with adjuvant trastuzumab therapyJ Am Coll Cardiol201157222263227021616287
  • ErvenKJurcutRWeltensCAcute radiation effects on cardiac function detected by strain rate imaging in breast cancer patientsInt J Radiat Oncol Biol Phys20117951444145120605341
  • KavousiMElias-SmaleSRuttenJHEvaluation of newer risk markers for coronary heart disease risk classification: a cohort studyAnn Intern Med2012156643844422431676
  • ThavendiranathanPWinterspergerBJFlammSDMarwickTHCardiac MRI in the assessment of cardiac injury and toxicity from cancer chemotherapy: a systematic reviewCirc Cardiovasc Imaging2013661080109124254478
  • CardinaleDSandriMTColomboAPrognostic value of troponin I in cardiac risk stratification of cancer patients undergoing high-dose chemotherapyCirculation2004109222749275415148277
  • SawayaHSebagIAPlanaJCEarly detection and prediction of cardiotoxicity in chemotherapy-treated patientsAm J Cardiol201110791375138021371685
  • CardinaleDColomboATorrisiRTrastuzumab-induced cardiotoxicity: clinical and prognostic implications of troponin I evaluationJ Clin Oncol201028253910391620679614
  • SawayaHSebagIAPlanaJCAssessment of echocardiography and biomarkers for the extended prediction of cardiotoxicity in patients treated with anthracyclines, taxanes, and trastuzumabCirc Cardiovasc Imaging20125559660322744937
  • KuttehLAHobdayTJaffeAA correlative study of cardiac biomarkers and left ventricular ejection fraction (LVEF) from N9831, a phase III randomized trial of chemotherapy and trastuzumab as adjuvant therapy for HER2-positive breast cancerJ Clin Oncol20072518S57917242396
  • RadererMKornekGWeinländerGKastnerJSerum troponin T levels in adults undergoing anthracycline therapyJ Natl Cancer Inst19978921718998187
  • LenihanDJMasseyMRBaysingerKBSuperior Detection of Cardiotoxicity during Chemotherapy Using BiomarkersJ Card Fail200713S151
  • RomanoSFratiniSRicevutoESerial measurements of NT-proBNP are predictive of not-high-dose anthracycline cardiotoxicity in breast cancer patientsBr J Cancer2011105111663166822068815
  • SkovgaardDHasbakPKjaerABNP predicts chemotherapy-related cardiotoxicity and death: comparison with gated equilibrium radionuclide ventriculographyPLoS One201495e9673624800827
  • DodosFHalbsguthTErdmannEHoppeUCUsefulness of myocardial performance index and biochemical markers for early detection of anthracycline-induced cardiotoxicity in adultsClin Res Cardiol200897531832618193371
  • KnoblochKTepeJLichtinghagenRLuckHJVogtPMMonitoring of cardiotoxicity during immunotherapy with Herceptin using simultaneous continuous wave Doppler depending on N-terminal pro-brain natriuretic peptideClin Med200771888917348585
  • KnoblochKTepeJRossnerDCombined NT-pro-BNP and CW-Doppler ultrasound cardiac output monitoring (USCOM) in epirubicin and liposomal doxorubicin therapyInt J Cardiol2008128331632517707098
  • DamrotJNubelTEpeBRoosWPKainaBFritzGLovastatin protects human endothelial cells from the genotoxic and cytotoxic effects of the anticancer drugs doxorubicin and etoposideBr J Pharmacol2006149898899717088865
  • RanXZRanXZongZWProtective effect of atorvastatin on radiation-induced vascular endothelial cell injury in vitroJ Radiat Res201051552753320921821
  • SeiceanSSeiceanAPlanaJCBuddGTMarwickTHEffect of statin therapy on the risk for incident heart failure in patients with breast cancer receiving anthracycline chemotherapy: an observational clinical cohort studyJ Am Coll Cardiol201260232384239023141499
  • AcarZKaleATurgutMEfficiency of atorvastatin in the protection of anthracycline-induced cardiomyopathyJ Am Coll Cardiol201158998898921851890
  • AsanumaHMinaminoTSanadaSBeta-adrenoceptor blocker carvedilol provides cardioprotection via an adenosine-dependent mechanism in ischemic canine heartsCirculation2004109222773277915148268
  • KimIMTilleyDGChenJBeta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivationProc Natl Acad Sci U S A200810538145551456018787115
  • KayaMGOzkanMGunebakmazOProtective effects of nebivolol against anthracycline-induced cardiomyopathy: a randomized control studyInt J Cardiol201316752306231022727976
  • KalayNBasarEOzdogruIProtective effects of carvedilol against anthracycline-induced cardiomyopathyJ Am Coll Cardiol200648112258226217161256
  • BoschXRoviraMSitgesMEnalapril and carvedilol for preventing chemotherapy-induced left ventricular systolic dysfunction in patients with malignant hemopathies: the OVERCOME trial (preventiOn of left Ventricular dysfunction with Enalapril and caRvedilol in patients submitted to intensive ChemOtherapy for the treatment of Malignant hEmopathies)J Am Coll Cardiol201361232355236223583763
  • EwerMSVooletichMTDurandJBReversibility of trastuzumab-related cardiotoxicity: new insights based on clinical course and response to medical treatmentJ Clin Oncol200523317820782616258084
  • OlivaSCioffiGFrattiniSItalian Cardio-Oncological NetworkAdministration of angiotensin-converting enzyme inhibitors and β-blockers during adjuvant trastuzumab chemotherapy for nonmetastatic breast cancer: marker of risk or cardioprotection in the real world?Oncologist201217791792422673631
  • TokudomeTMizushigeKNomaTPrevention of doxorubicin (adriamycin)-induced cardiomyopathy by simultaneous administration of angiotensin-converting enzyme inhibitor assessed by acoustic densitometryJ Cardiovasc Pharmacol200036336136810975594
  • Abd El-AzizMAOthmanAIAmerMEl-MissiryMAPotential protective role of angiotensin-converting enzyme inhibitors captopril and enalapril against adriamycin-induced acute cardiac and hepatic toxicity in ratsJ Appl Toxicol200121646947311746193
  • LemmensKSegersVFDemolderMDe KeulenaerGWRole of neuregulin-1/ErbB2 signaling in endothelium-cardiomyocyte crosstalkJ Biol Chem200628128194691947716698793
  • NakamaeHTsumuraKTeradaYNotable effects of angiotensin II receptor blocker, valsartan, on acute cardiotoxic changes after standard chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisoloneCancer2005104112492249816247790
  • DessìMMadedduCPirasALong-term, up to 18 months, protective effects of the angiotensin II receptor blocker telmisartan on Epirubin-induced inflammation and oxidative stress assessed by serial strain rateSpringerplus20132119823741643
  • CardinaleDColomboASandriMTPrevention of high-dose chemotherapy-induced cardiotoxicity in high-risk patients by angiotensin-converting enzyme inhibitionCirculation2006114232474248117101852
  • TofieldAACE inhibitor reduces radiation injury to myocardiumEur Heart J201334272023202424015406
  • ScottJMKhakooAMackeyJRHaykowskyMJDouglasPSJonesLWModulation of anthracycline-induced cardiotoxicity by aerobic exercise in breast cancer: current evidence and underlying mechanismsCirculation2011124564265021810673
  • HaykowskyMJMackeyJRThompsonRBJonesLWPatersonDIAdjuvant trastuzumab induces ventricular remodeling despite aerobic exercise trainingClin Cancer Res200915154963496719622583
  • HuntSAAbrahamWTChinMH2009 Focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the International Society for Heart and Lung TransplantationJ Am Coll Cardiol20095315e1e9019358937
  • CardinaleDColomboALamantiaGAnthracycline-induced cardiomyopathy: clinical relevance and response to pharmacologic therapyJ Am Coll Cardiol201055321322020117401
  • TocchettiCGRagoneGCoppolaCDetection, monitoring, and management of trastuzumab-induced left ventricular dysfunction: an actual challengeEur J Heart Fail201214213013722219501
  • SuterTMProcterMvan VeldhuisenDJTrastuzumab-associated cardiac adverse effects in the herceptin adjuvant trialJ Clin Oncol200725253859386517646669
  • MackeyJRClemonsMCotéMACardiac management during adjuvant trastuzumab therapy: recommendations of the Canadian Trastuzumab Working GroupCurr Oncol2008151243518317582