Research Progress on Ferroptosis and Nanotechnology-Based Treatment in Triple-Negative Breast Cancer

References

• Gautam N, Palte MJ, Deik AA, et al. Reviewing the significance of dendritic cell vaccines in interrupting breast cancer development. Mol Aspects Med. 2023;95(1):1617. doi:10.1016/j.mam.2023.101239
   Google Scholar
• Siegel RL, Miller KD, Wagle NS, et al. Cancer statistics. Cancer J Clinicians. 2023;73(1):17–48. doi:10.3322/caac.21763
   Web of Science ®Google Scholar
• Huang Z, Wen W, Zheng Y, et al. Breast cancer incidence and mortality: trends over 40 years among women in Shanghai, China. Ann Oncol. 2016;27(6):1129–1134. doi:10.1093/annonc/mdw069
   PubMed Web of Science ®Google Scholar
• Giaquinto AN, Sung H, Miller KD, et al. Breast cancer statistics, 2022. A Cancer J Clinicians. 2022;72(6):524–541. doi:10.3322/caac.21754
   PubMed Web of Science ®Google Scholar
• Li P, Lin Q, Sun S, et al. Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism. Cell Death Dis. 2022;13(9):808. doi:10.1038/s41419-022-05242-5
   PubMed Web of Science ®Google Scholar
• Dixon SJ, Lemberg K, Lamprecht M, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060–1072. doi:10.1016/j.cell.2012.03.042
   PubMed Web of Science ®Google Scholar
• Rennekamp AJ. The Ferrous Awakens. Cell. 2017;171(6):1225–1227. doi:10.1016/j.cell.2017.11.029
   PubMed Web of Science ®Google Scholar
• Guo Q, Chen G. Research on regulatory mechanism of ferroptosis and progress in tumorigenesis and therapy. Prog in Physiol Sci. 2019;50(2):88–93.
   Google Scholar
• Stockwell BR, Friedmann Angeli JP, Bayir H, et al. Ferroptosis: A regulated cell death nexus linking metabolism, redox biology, and disease. Cell. 2017;171(2):273–285. doi:10.1016/j.cell.2017.09.021
   PubMed Web of Science ®Google Scholar
• Hirayama T, Nagasawa H. Chemical tools for detecting fe ions. J Clin Biochem Nutr. 2017;60(1):39–48. doi:10.3164/jcbn.16-70
   PubMed Web of Science ®Google Scholar
• Liang C, Zhang X, Yang M, et al. Recent progress in ferroptosis inducers for cancer therapy. Adv Mater. 2019;31(51):e1904197. doi:10.1002/adma.201904197
   PubMed Web of Science ®Google Scholar
• Yang WS, SriRamaratnam R, Welsch M, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156(1–2):317–331. doi:10.1016/j.cell.2013.12.010
   PubMed Web of Science ®Google Scholar
• Manz DH, Blanchette NL, Paul BT, et al. Iron and cancer: recent insights. Ann N Y Acad Sci. 2016;1368(1):149–161. doi:10.1111/nyas.13008
   PubMed Web of Science ®Google Scholar
• Feng H, Schorpp K, Jin J, et al. Transferrin receptor is a specific ferroptosis marker. Cell Rep. 2020;30(10):3411–3423.e7. doi:10.1016/j.celrep.2020.02.049
   PubMed Web of Science ®Google Scholar
• Zeng J, Chen Y, Xu X. Research progress of ferroptosis-related mechanisms, regulation and diseases. Chin Pharm J. 2017;52(4):253–257.
   Google Scholar
• Sun X, Ou Z, Xie M, et al. HSPB1 as a novel regulator of ferroptotic cancer cell death. Oncogene. 2015;34(45):5617–5625. doi:10.1038/onc.2015.32
   PubMed Web of Science ®Google Scholar
• Kastenhuber ER, Lowe SW. Putting p53 in context. Cell. 2017;170(6):1062–1078. doi:10.1016/j.cell.2017.08.028
   PubMed Web of Science ®Google Scholar
• Mello SS, Attardi LD. Deciphering p53 signaling in tumor suppression. Curr Opin Cell Biol. 2018;51:65–72. doi:10.1016/j.ceb.2017.11.005
   PubMed Web of Science ®Google Scholar
• Jiang L, Kon N, Li T, et al. Ferroptosis as a p53-mediated activity during tumour suppression. Nature. 2015;520(7545):57–62. doi:10.1038/nature14344
   PubMed Web of Science ®Google Scholar
• Doll S, Proneth B, Tyurina YY, et al. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol. 2017;13(1):91–98. doi:10.1038/nchembio.2239
   PubMed Web of Science ®Google Scholar
• Yang WS, Kim KJ, Gaschler MM, et al. Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. Proc Natl Acad Sci USA. 2016;113(34):E4966–75. doi:10.1073/pnas.1603244113
   PubMed Web of Science ®Google Scholar
• Zou Y, Henry WS, Ricq EL, et al. Plasticity of ether lipids promotes ferroptosis susceptibility and evasion. Nature. 2020;585(7826):603–608. doi:10.1038/s41586-020-2732-8
   PubMed Web of Science ®Google Scholar
• Bersuker K, Hendricks JM, Li Z, et al. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature. 2019;575(7784):688–692. doi:10.1038/s41586-019-1705-2
   PubMed Web of Science ®Google Scholar
• Doll S, Freitas FP, Shah R, et al. FSP1 is a glutathione-independent ferroptosis suppressor. Nature. 2019;575(7784):693–698. doi:10.1038/s41586-019-1707-0
   PubMed Web of Science ®Google Scholar
• Mishima E, Ito J, Wu Z, et al. A non-canonical vitamin K cycle is a potent ferroptosis suppressor. Nature. 2022;608(7924):778–783. doi:10.1038/s41586-022-05022-3
   PubMed Web of Science ®Google Scholar
• Yang X, Wang Z, Zandkarimi F, et al. Regulation of VKORC1L1 is critical for p53-mediated tumor suppression through vitamin K metabolism. Cell Metab. 2023;35(8):1474–1490.e8. doi:10.1016/j.cmet.2023.06.014
   PubMed Web of Science ®Google Scholar
• Liu X, Zhuang L, Gan B. Unleashing ferroptosis for cancer therapy with warfarin. Trends Endocrinol Metab. 2023;34(11):683–684. doi:10.1016/j.tem.2023.08.008
   PubMed Web of Science ®Google Scholar
• Yagoda N, Von Rechenberg M, Zaganjor E, et al. RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature. 2007;447(7146):864–868. doi:10.1038/nature05859
   PubMed Web of Science ®Google Scholar
• Dent R, Trudeau M, Pritchard KI, et al. Triple-negative breast cancer: Clinical features and patterns of recurrence. Clin Cancer Res. 2007;13(15 Pt 1):4429–4434. doi:10.1158/1078-0432.CCR-06-3045
   PubMed Web of Science ®Google Scholar
• Verma N, Vinik Y, Saroha A, et al. Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis. Sci Adv. 2020;6(34). doi:10.1126/sciadv.aba8968.
   Web of Science ®Google Scholar
• Chen MS, Wang S-F, Hsu C-Y, et al. CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway. Oncotarget. 2017;8(70):114588–114602. doi:10.18632/oncotarget.23055
   PubMedGoogle Scholar
• Wang Y, Sun Y, Wang F, et al. Ferroptosis induction via targeting metabolic alterations in triple-negative breast cancer. Biomed Pharmacother. 2023;169:115866. doi:10.1016/j.biopha.2023.115866
   PubMed Web of Science ®Google Scholar
• Tu Y. The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine. Nat Med. 2011;17(10):1217–1220. doi:10.1038/nm.2471
   PubMed Web of Science ®Google Scholar
• Zhang J, Zhou K, Lin J,et al. Ferroptosis-enhanced chemotherapy for triple-negative breast cancer with magnetic composite nanoparticles. Biomaterials. 2023;303:122395.
   PubMed Web of Science ®Google Scholar
• Bai X, Ni J, Beretov J, et al. THOC2 and THOC5 regulate stemness and radioresistance in triple-negative breast cancer. Adv Sci. 2021;8(24):e2102658. doi:10.1002/advs.202102658
   Web of Science ®Google Scholar
• Lang X, Green MD, Wang W, et al. Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11. Cancer Discov. 2019;9(12):1673–1685. doi:10.1158/2159-8290.CD-19-0338
   PubMed Web of Science ®Google Scholar
• Gao Y, Li Y, Cao H, et al. Hypertoxic self-assembled peptide with dual functions of glutathione depletion and biosynthesis inhibition for selective tumor ferroptosis and pyroptosis. J Nanobiotechnol. 2022;20(1):390. doi:10.1186/s12951-022-01604-5
   PubMed Web of Science ®Google Scholar
• Zeng L, Ding S, Cao Y, et al. A MOF-based potent ferroptosis inducer for enhanced radiotherapy of triple negative breast cancer. ACS Nano. 2023;17(14):13195–13210. doi:10.1021/acsnano.3c00048
   PubMed Web of Science ®Google Scholar
• Chen X, Kang R, Kroemer G, et al. Broadening horizons: the role of ferroptosis in cancer. Nat Rev Clin Oncol. 2021;18(5):280–296. doi:10.1038/s41571-020-00462-0
   PubMed Web of Science ®Google Scholar
• Burnell ES. Drugs targeting mitochondrial functions, in Antimalarial Agents; 2020:375–402.
   Google Scholar
• Ashton TM, Fokas E, Kunz-Schughart LA, et al. The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia. Nat Commun. 2016;7(1):12308. doi:10.1038/ncomms12308
   PubMedGoogle Scholar
• Zhou TJ. Glutathione depletion and dihydroorotate dehydrogenase inhibition actuated ferroptosis-augment to surmount triple-negative breast cancer. Biomaterials. 2024;2:305.
   Google Scholar
• Adams S, Gatti-Mays ME, Kalinsky K, et al. Current landscape of immunotherapy in breast cancer: A review. JAMA Oncol. 2019;5(8):1205–1214. doi:10.1001/jamaoncol.2018.7147
   PubMed Web of Science ®Google Scholar
• Fu F, Wang W, Wu L, et al. Inhalable biomineralized liposomes for cyclic Ca(2+)-burst-centered endoplasmic reticulum stress enhanced lung cancer ferroptosis therapy. ACS Nano. 2023;17(6):5486–5502. doi:10.1021/acsnano.2c10830
   PubMed Web of Science ®Google Scholar
• Zhu P, Pu Y, Wang M, et al. Correction to “MnOOH-Catalyzed autoxidation of glutathione for reactive oxygen species production and nanocatalytic tumor innate immunotherapy”. J Am Chem Soc. 2023;145(18):10441–10442. doi:10.1021/jacs.3c03717
   PubMed Web of Science ®Google Scholar
• Sun X, Zhang Y, Li J, et al. Amplifying STING activation by cyclic dinucleotide-manganese particles for local and systemic cancer metalloimmunotherapy. Nat Nanotechnol. 2021;16(11):1260–1270. doi:10.1038/s41565-021-00962-9
   PubMed Web of Science ®Google Scholar
• Deng X, Liu T, Zhu Y, et al. Ca & Mn dual-ion hybrid nanostimulator boosting anti-tumor immunity via ferroptosis and innate immunity awakening. Bioact Mater. 2024;33:483–496. doi:10.1016/j.bioactmat.2023.11.017
   PubMed Web of Science ®Google Scholar
• Zhang C, Bu W, Ni D, et al. Synthesis of iron nanometallic glasses and their application in cancer therapy by a localized Fenton reaction. Angew Chem Int Ed Engl. 2016;55(6):2101–2106. doi:10.1002/anie.201510031
   PubMed Web of Science ®Google Scholar
• Wang C, Xue F, Wang M, et al. 2D Cu-Bipyridine MOF nanosheet as an agent for colon cancer therapy: A three-in-one approach for enhancing chemodynamic therapy. ACS Appl Mater Interfaces. 2022;14(34):38604–38616. doi:10.1021/acsami.2c11999
   PubMedGoogle Scholar
• Wang N. A chemo/chemodynamic nanoparticle based on hyaluronic acid induces ferroptosis and apoptosis for triple-negative breast cancer therapy. Carbohydr Polym. 2024;2:329.
   Google Scholar
• Cao C. Ferulic acid orchestrates anti-oxidative properties of danggui buxue tang, an ancient herbal decoction: Elucidation by chemical knock-out approach. PLoS One. 2016;11(11):1.
   Web of Science ®Google Scholar
• Ganesan K, Ramkumar KM, Xu B. Vitexin restores pancreatic β-cell function and insulin signaling through Nrf2 and NF-κB signaling pathways. Eur J Pharmacol. 2020;888:173606. doi:10.1016/j.ejphar.2020.173606
   PubMedGoogle Scholar
• Yang J, Mo J, Dai J, et al. Cetuximab promotes RSL3-induced ferroptosis by suppressing the Nrf2/HO-1 signalling pathway in KRAS mutant colorectal cancer. Cell Death Dis. 2021;12(11):1079. doi:10.1038/s41419-021-04367-3
   PubMed Web of Science ®Google Scholar
• Cheng Y, Gao Y, Li J, et al. TrkB agonist N-acetyl serotonin promotes functional recovery after traumatic brain injury by suppressing ferroptosis via the PI3K/Akt/Nrf2/Ferritin H pathway. Free Radic Biol Med. 2023;194:184–198. doi:10.1016/j.freeradbiomed.2022.12.002
   PubMed Web of Science ®Google Scholar
• Gong G. Danggui buxue tang improves therapeutic efficacy of doxorubicin in triple negative breast cancer via ferroptosis. J Ethnopharmacol. 2024;3:323.
   Google Scholar
• Son SR, Yoon Y-S, Hong J-P, et al. Chemical constituents of the roots of polygala tenuifolia and their anti-inflammatory effects. Plants. 2022;11(23):3307. doi:10.3390/plants11233307
   Google Scholar
• Hao K-X, Shen C-Y, Jiang J-G. Sedative and hypnotic effects of polygala tenuifolia willd. Saponins on insomnia mice and their targets. J Ethnopharmacol. 2024;323:117618. doi:10.1016/j.jep.2023.117618
   PubMed Web of Science ®Google Scholar
• Li X, et al. Studies on Paris saponin promoting iron death in triple negative breast cancer cells through p53/SLC7A11 signal axis. Med J Chin People Liber. 2023;48(1):58–63.
   Google Scholar