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Review

Role of the WASP and WAVE family proteins in breast cancer invasion and metastasis

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Pages 99-109 | Published online: 24 Apr 2015

References

  • JemalABrayFCenterMMFerlayJWardEFormanDGlobal cancer statisticsCA Cancer J Clin201161699021296855
  • SiegelRMaJZouZJemalACancer statisticsCA Cancer J Clin20146492924399786
  • SteegPSTumor metastasis: mechanistic insights and clinical challengesNat Med20061289590416892035
  • RidleyAJSchwartzMABurridgeKCell migration: integrating signals from front to backScience20033021704170914657486
  • LinderSWiesnerCHimmelMDegrading devices: invadosomes in proteolytic cell invasionAnnu Rev Cell Dev Biol20112718521121801014
  • RidleyAJLife at the leading edgeCell20111451012102221703446
  • InsallRHMacheskyLMActin dynamics at the leading edge: from simple machinery to complex networksDev Cell20091731032219758556
  • RaftopoulouMHallACell migration: Rho GTPases lead the wayDev Biol2004265233214697350
  • TakenawaTSuetsuguSThe WASP-WAVE protein network: connecting the membrane to the cytoskeletonNat Rev Mol Cell Biol20078374817183359
  • YamaguchiHCondeelisJRegulation of the actin cytoskeleton in cancer cell migration and invasionBiochim Biophys Acta2007177364265216926057
  • DerryJMOchsHDFranckeUIsolation of a novel gene mutated in Wiskott-Aldrich syndromeCell1994786356448069912
  • AldrichRASteinbergAGCampbellDCPedigree demonstrating a sex-linked recessive condition characterized by draining ears, eczematoid dermatitis and bloody diarrheaPediatrics19541313313913133561
  • SullivanKEMullenCABlaeseRMWinkelsteinJAA multiinstitutional survey of the Wiskott-Aldrich syndromeJ Pediatr19941258768857996359
  • OrangeJSStoneKDTurveySEKrzewskiKThe Wiskott-Aldrich syndromeCell Mol Life Sci2004612361238515378206
  • ZhuQWatanabeCLiuTWiskott-Aldrich syndrome/X-linked thrombocytopenia: WASP gene mutations, protein expression, and phenotypeBlood199790268026899326235
  • MikiHMiuraKTakenawaTN-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinasesEMBO J199615532653358895577
  • MikiHSuetsuguSTakenawaTWAVE, a novel WASP-family protein involved in actin reorganization induced by RacEMBO J199817693269419843499
  • MacheskyLMInsallRHScar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complexCurr Biol19988134713569889097
  • SuetsuguSMikiHTakenawaTIdentification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complexBiochem Biophys Res Commun199926029630210381382
  • LinardopoulouEVParghiSSFriedmanCOsbornGEParkhurstSMTraskBJHuman subtelomeric WASH genes encode a new subclass of the WASP familyPLoS Genet20073e23718159949
  • CampelloneKGWebbNJZnameroskiEAWelchMDWHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transportCell200813414816118614018
  • ZucheroJBCouttsASQuinlanMEThangueNBMullinsRDp53-cofactor JMY is a multifunctional actin nucleation factorNat Cell Biol20091145145919287377
  • TakenawaTMikiHWASP and WAVE family proteins. key molecules for rapid rearrangement of cortical actin filaments and cell movementJ Cell Sci20011141801180911329366
  • EdenSRohatgiRPodtelejnikovAVMannMKirschnerMWMechanism of regulation of WAVE1-induced actin nucleation by Rac1 and NckNature200241879079312181570
  • GautreauAHoHYLiJSteenHGygiSPKirschnerMWPurification and architecture of the ubiquitous Wave complexProc Natl Acad Sci U S A20041014379438315070726
  • StovoldCFMillardTHMacheskyLMInclusion of Scar/WAVE3 in a similar complex to Scar/WAVE1 and 2BMC Cell Biol200561115752430
  • InnocentiMZucconiADisanzaAAbi1 is essential for the formation and activation of a WAVE2 signalling complexNat Cell Biol2004631932715048123
  • RohatgiRMaLMikiHThe interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assemblyCell19999722123110219243
  • YararDToWAboAWelchMDThe Wiskott-Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2/3 complexCurr Biol1999955555810339430
  • KimASKakalisLTAbdul-MananNLiuGARosenMKAutoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome proteinNature200040415115810724160
  • MikiHSasakiTTakaiYTakenawaTInduction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASPNature199839193969422512
  • PrehodaKEScottJAMullinsRDLimWAIntegration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complexScience200029080180611052943
  • RohatgiRHoHYKirschnerMWMechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphateJ Cell Biol20001501299131010995436
  • DeriveryELombardBLoewDGautreauAThe Wave complex is intrinsically inactiveCell Motil Cytoskeleton20096677779019206172
  • IsmailAMPadrickSBChenBUmetaniJRosenMKThe WAVE regulatory complex is inhibitedNat Struct Mol Biol20091656156319363480
  • LebensohnAMKirschnerMWActivation of the WAVE complex by coincident signals controls actin assemblyMol Cell20093651252419917258
  • OikawaTYamaguchiHItohTPtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodiaNat Cell Biol2004642042615107862
  • SuetsuguSKurisuSOikawaTYamazakiDOdaATakenawaTOptimization of WAVE2 complex-induced actin polymerization by membrane-bound IRSp53, PIP(3), and RacJ Cell Biol200617357158516702231
  • DeriveryEGautreauAGeneration of branched actin networks: assembly and regulation of the N-WASP and WAVE molecular machinesBioessays20103211913120091750
  • EuteneuerUSchliwaMPersistent, directional motility of cells and cytoplasmic fragments in the absence of microtubulesNature198431058616377086
  • NemethovaMAuingerSSmallJVBuilding the actin cytoskeleton: filopodia contribute to the construction of contractile bundles in the lamellaJ Cell Biol20081801233124418362182
  • GalbraithCGYamadaKMGalbraithJAPolymerizing actin fibers position integrins primed to probe for adhesion sitesScience200731599299517303755
  • WelchMDMullinsRDCellular control of actin nucleationAnnu Rev Cell Dev Biol20021824728812142287
  • ChhabraESHiggsHNThe many faces of actin: matching assembly factors with cellular structuresNat Cell Biol200791110112117909522
  • LommelSBeneschSRottnerKFranzTWehlandJKuhnRActin pedestal formation by enteropathogenic Escherichia coli and intracellular motility of Shigella flexneri are abolished in N-WASP-defective cellsEMBO Rep2001285085711559594
  • LorenzMYamaguchiHWangYSingerRHCondeelisJImaging sites of N-wasp activity in lamellipodia and invadopodia of carcinoma cellsCurr Biol20041469770315084285
  • KawamuraKTakanoKSuetsuguSN-WASP and WAVE2 acting downstream of phosphatidylinositol 3-kinase are required for myogenic cell migration induced by hepatocyte growth factorJ Biol Chem2004279548625487115496413
  • Le ClaincheCSchlaepferDFerrariAIQGAP1 stimulates actin assembly through the N-WASP-Arp2/3 pathwayJ Biol Chem200728242643517085436
  • SnapperSBTakeshimaFAntonIN-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motilityNat Cell Biol2001389790411584271
  • InnocentiMGerbothSRottnerKAbi1 regulates the activity of N-WASP and WAVE in distinct actin-based processesNat Cell Biol2005796997616155590
  • RogersSLWiedemannUStuurmanNValeRDMolecular requirements for actin-based lamella formation in Drosophila S2 cellsJ Cell Biol20031621079108812975351
  • SuetsuguSYamazakiDKurisuSTakenawaTDifferential roles of WAVE1 and WAVE2 in dorsal and peripheral ruffle formation for fibroblast cell migrationDev Cell2003559560914536061
  • KrauseMGautreauASteering cell migration: lamellipodium dynamics and the regulation of directional persistenceNat Rev Mol Cell Biol20141557759025145849
  • YamazakiDSuetsuguSMikiHWAVE2 is required for directed cell migration and cardiovascular developmentNature200342445245612879075
  • KurisuSSuetsuguSYamazakiDYamaguchiHTakenawaTRac-WAVE2 signaling is involved in the invasive and metastatic phenotypes of murine melanoma cellsOncogene2005241309131915608687
  • KheirWAGevreyJCYamaguchiHIsaacBCoxDA WAVE2-Abi1 complex mediates CSF-1-induced F-actin-rich membrane protrusions and migration in macrophagesJ Cell Sci20051185369537916280551
  • FriedlPWolfKTumor-cell invasion and migration: diversity and escape mechanismsNat Rev Cancer2003336237412724734
  • TangHLiABiJLoss of Scar/WAVE complex promotes N-WASP- and FAK-dependent invasionCurr Biol20132310711723273897
  • BuccioneROrthJDMcNivenMAFoot and mouth: podosomes, invadopodia and circular dorsal rufflesNat Rev Mol Cell Biol2004564765715366708
  • YamaguchiHLorenzMKempiakSMolecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilinJ Cell Biol200516844145215684033
  • OserMYamaguchiHMaderCCCortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturationJ Cell Biol200918657158719704022
  • MizutaniKMikiHHeHMarutaHTakenawaTEssential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblastsCancer Res20026266967411830518
  • GligorijevicBWyckoffJYamaguchiHWangYRoussosETCondeelisJN-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumorsJ Cell Sci201212572473422389406
  • CoopmanPJDoMTThompsonEWMuellerSCPhagocytosis of cross-linked gelatin matrix by human breast carcinoma cells correlates with their invasive capacityClin Cancer Res199845075159516943
  • YangLYTaoYMOuDPWangWChangZGWuFIncreased expression of Wiskott-Aldrich syndrome protein family verprolin-homologous protein 2 correlated with poor prognosis of hepatocellular carcinomaClin Cancer Res2006125673567917020969
  • SembaSIwayaKMatsubayashiJCoexpression of actin-related protein 2 and Wiskott-Aldrich syndrome family verproline-homologous protein 2 in adenocarcinoma of the lungClin Cancer Res2006122449245416638851
  • IwayaKOikawaKSembaSCorrelation between liver metastasis of the colocalization of actin-related protein 2 and 3 complex and WAVE2 in colorectal carcinomaCancer Sci20079899299917459058
  • FernandoHSSandersAJKynastonHGJiangWGWAVE3 is associated with invasiveness in prostate cancer cellsUrol Oncol20102832032719395286
  • FernandoHSSandersAJKynastonHGJiangWGWAVE1 is associated with invasiveness and growth of prostate cancer cellsJ Urol20081801515152118710763
  • TengYRenMQCheneyRSharmaSCowellJKInactivation of the WASF3 gene in prostate cancer cells leads to suppression of tumorigenicity and metastasesBr J Cancer20101031066107520717117
  • IshiharaDDovasAHernandezLWiskott-Aldrich syndrome protein regulates leukocyte-dependent breast cancer metastasisCell Rep2013442943623911287
  • GoswamiSSahaiEWyckoffJBMacrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loopCancer Res2005655278528315958574
  • WyckoffJWangWLinEYA paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumorsCancer Res2004647022702915466195
  • ZichaDAllenWEBrickellPMChemotaxis of macrophages is abolished in the Wiskott-Aldrich syndromeBr J Haematol19981016596659674738
  • Escudero-EsparzaAJiangWGMartinTAClaudin-5 is involved in breast cancer cell motility through the N-WASP and ROCK signalling pathwaysJ Exp Clin Cancer Res2012314322559840
  • PetersonJRBickfordLCMorganDChemical inhibition of N-WASP by stabilization of a native autoinhibited conformationNat Struct Mol Biol20041174775515235593
  • MartinTAPereiraGWatkinsGManselREJiangWGN-WASP is a putative tumor suppressor in breast cancer cells, in vitro and in vivo, and is associated with clinical outcome in patients with breast cancerClin Exp Metastasis2008259710817985201
  • PichotCSArvanitisCHartigSMCdc42-interacting protein 4 promotes breast cancer cell invasion and formation of invadopodia through activation of N-WASpCancer Res2010708347835620940394
  • SanchezAMFlaminiMIBaldacciCGogliaLGenazzaniARSimonciniTEstrogen receptor-alpha promotes breast cancer cell motility and invasion via focal adhesion kinase and N-WASPMol Endocrinol2010242114212520880986
  • FernandoHSDaviesSRChhabraAExpression of the WASP verprolin-homologues (WAVE members) in human breast cancerOncology20077337638318509249
  • KimJSKangCGKimSHLeeEORhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cellsJ Nat Prod2014771135113924828286
  • KoHSKimJSChoSMUrokinase-type plasminogen activator expression and Rac1/WAVE-2/Arp2/3 pathway are blocked by pterostilbene to suppress cell migration and invasion in MDA-MB-231 cellsBioorg Med Chem Lett2014241176117924440300
  • TakahashiKSuzukiKWAVE2, N-WASP, and Mena facilitate cell invasion via phosphatidylinositol 3-kinase-dependent local accumulation of actin filamentsJ Cell Biochem20111123421342921769917
  • Sossey-AlaouiKSuGMalajERoeBCowellJKWAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastomaOncogene2002215967597412185600
  • Sossey-AlaouiKSafinaALiXDown-regulation of WAVE3, a metastasis promoter gene, inhibits invasion and metastasis of breast cancer cellsAm J Pathol20071702112212117525277
  • KulkarniSAugoffKRiveraLIncreased expression levels of WAVE3 are associated with the progression and metastasis of triple negative breast cancerPLoS One20127e4289522952619
  • Sossey-AlaouiKRanalliTALiXBakinAVCowellJKWAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expressionExp Cell Res200530813514515907837
  • TaylorMADavuluriGParvaniJGUpregulated WAVE3 expression is essential for TGF-beta-mediated EMT and metastasis of triple-negative breast cancer cellsBreast Cancer Res Treat201314234135324197660
  • SpenceHJTimpsonPTangHRInsallRHMacheskyLMScar/WAVE3 contributes to motility and plasticity of lamellipodial dynamics but not invasion in three dimensionsBiochem J2012448354222909346
  • Sossey-AlaouiKSurfing the big WAVE: insights into the role of WAVE3 as a driving force in cancer progression and metastasisSemin Cell Dev Biol20132428729723116924
  • TengYNgokaLMeiYLesoonLCowellJKHSP90 and HSP70 proteins are essential for stabilization and activation of WASF3 metastasis-promoting proteinJ Biol Chem2012287100511005922315230