460
Views
49
CrossRef citations to date
0
Altmetric
Review

PI3K mutations in breast cancer: prognostic and therapeutic implications

Pages 111-123 | Published online: 15 May 2015

References

  • SørlieTPerouCMTibshiraniRGene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implicationsProc Natl Acad Sci U S A20019819108691087411553815
  • GoldhirschAWoodWCCoatesASGelberRDThurlimannBSennHJStrategies for subtypes – dealing with the diversity of breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011Ann Oncol20112281736174721709140
  • SamuelsYWangZBardelliAHigh frequency of mutations of the PIK3CA gene in human cancersScience2004304567055415016963
  • LiuPChengHRobertsTMZhaoJJTargeting the phosphoinositide 3-kinase pathway in cancerNat Rev Drug Discov20098862764419644473
  • EngelmanJATargeting PI3K signalling in cancer: opportunities, challenges and limitationsNat Rev Cancer20099855056219629070
  • ZhaoJJLiuZWangLShinELodaMFRobertsTMThe oncogenic properties of mutant p110α and p110β phosphatidylinositol 3-kinases in human mammary epithelial cellsProc Natl Acad Sci U S A200510251184431844816339315
  • IsakoffSJEngelmanJAIrieHYBreast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cellsCancer Res20056523109921100016322248
  • MiledNYanYHonWCMechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunitScience2007317583523924217626883
  • HuangCHMandelkerDSchmidt-KittlerOThe structure of a human p110α/p85α complex elucidates the effects of oncogenic PI3Kα mutationsScience200731858571744174818079394
  • Gonzalez-AnguloAMChenHKaruturiMSFrequency of mesenchymal-epithelial transition factor gene (MET) and the catalytic subunit of phosphoinositide-3-kinase (PIK3CA) copy number elevation and correlation with outcome in patients with early stage breast cancerCancer2013119171522736407
  • WuGXingMMamboESomatic mutation and gain of copy number of PIK3CA in human breast cancerBreast Cancer Res200575R609R61616168105
  • CizkovaMVacherSMeseureDPIK3R1 underexpression is an independent prognostic marker in breast cancerBMC Cancer20131354524229379
  • Cancer Genome Atlas NetworkComprehensive molecular portraits of human breast tumoursNature20124907418617023000897
  • WallaschCWeissFUNiederfellnerGJallalBIssingWUllrichAHeregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3EMBO J19951417426742757556068
  • ZhangKSunJLiuNTransformation of NIH 3T3 cells by HER3 or HER4 receptors requires the presence of HER1 or HER2J Biol Chem19962717388438908632008
  • Pinkas-KramarskiRLenferinkAEBacusSSThe oncogenic ErbB-2/ErbB-3 heterodimer is a surrogate receptor of the epidermal growth factor and betacellulinOncogene19981610124912589546426
  • AlimandiMRomanoACuriaMCCooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomasOncogene1995109181318217538656
  • HynesNELaneHAERBB receptors and cancer: the complexity of targeted inhibitorsNat Rev Cancer20055534135415864276
  • KnuefermannCLuYLiuBHER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cellsOncogene200322213205321212761490
  • JunttilaTTAkitaRWParsonsKLigand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941Cancer Cell200915542944019411071
  • Lee-HoeflichSTCrockerLYaoEA central role for HER3 in HER2-amplified breast cancer: implications for targeted therapyCancer Res200868145878588718632642
  • HennessyBTSmithDLRamPTLuYMillsGBExploiting the PI3K/AKT pathway for cancer drug discoveryNat Rev Drug Discov2005412988100416341064
  • Stemke-HaleKGonzalez-AnguloAMLluchAAn integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancerCancer Res200868156084609118676830
  • CarptenJDFaberALHornCA transforming mutation in the pleckstrin homology domain of AKT1 in cancerNature2007448715243944417611497
  • GainorJFVargheseAMOuSHALK rearrangements are mutually exclusive with mutations in EGFR or KRAS: an analysis of 1,683 patients with non-small cell lung cancerClin Cancer Res201319154273428123729361
  • SaalLHHolmKMaurerMPIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinomaCancer Res20056572554255915805248
  • Pérez-TenorioGAlkhoriLOlssonBPIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancerClin Cancer Res200713123577358417575221
  • EstevaFJGuoHZhangSPTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancerAm J Pathol201017741647165620813970
  • RazisEBobosMKotoulaVEvaluation of the association of PIK3CA mutations and PTEN loss with efficacy of trastuzumab therapy in metastatic breast cancerBreast Cancer Res Treat2011128244745621594665
  • PangBChengSSunSPPrognostic role of PIK3CA mutations and their association with hormone receptor expression in breast cancer: a meta-analysisSci Rep20144625525176561
  • MaruyamaNMiyoshiYTaguchiTTamakiYMondenMNoguchiSClinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese womenClin Cancer Res2007132 Pt 140841417202311
  • BarbareschiMButtittaFFelicioniLDifferent prognostic roles of mutations in the helical and kinase domains of the PIK3CA gene in breast carcinomasClin Cancer Res200713206064606917947469
  • KalinskyKJacksLMHeguyAPIK3CA mutation associates with improved outcome in breast cancerClin Cancer Res200915165049505919671852
  • AbramsonVGCooper LloydMBallingerTCharacterization of breast cancers with PI3K mutations in an academic practice setting using SNaPshot profilingBreast Cancer Res Treat2014145238939924722917
  • CizkovaMSusiniAVacherSPIK3CA mutation impact on survival in breast cancer patients and in ERα, PR and ERBB2-based subgroupsBreast Cancer Res2012141R2822330809
  • Ramirez-ArdilaDEHelmijrJCLookMPHotspot mutations in PIK3CA associate with first-line treatment outcome for aromatase inhibitors but not for tamoxifenBreast Cancer Res Treat20131391394923592373
  • López-KnowlesESegalCVGaoQRelationship of PIK3CA mutation and pathway activity with antiproliferative response to aro-matase inhibitionBreast Cancer Res2014163R6824981670
  • BeelenKOpdamMSeversonTMPIK3CA mutations, phosphatase and tensin homolog, human epidermal growth factor receptor 2, and insulin-like growth factor 1 receptor and adjuvant tamoxifen resistance in postmenopausal breast cancer patientsBreast Cancer Res2014161R1324467828
  • LoiSMichielsSLambrechtsDSomatic mutation profiling and associations with prognosis and trastuzumab benefit in early breast cancerJ Natl Cancer Inst20131051396096723739063
  • Gonzalez-AnguloAMStemke-HaleKPallaSLAndrogen receptor levels and association with PIK3CA mutations and prognosis in breast cancerClin Cancer Res20091572472247819276248
  • EllisMJLinLCrowderRPhosphatidyl-inositol-3-kinase alpha catalytic subunit mutation and response to neoadjuvant endocrine therapy for estrogen receptor positive breast cancerBreast Cancer Res Treat2010119237939019844788
  • LazaridisGLambakiSKarayannopoulouGPrognostic and predictive value of p-Akt, EGFR, and p-mTOR in early breast cancerStrahlenther Onkol2014190763663864064524658605
  • HashimotoKTsudaHKoizumiFActivated PI3K/AKT and MAPK pathways are potential good prognostic markers in node-positive, triple-negative breast cancerAnn Oncol201425101973197925009009
  • BozhanovSSAngelovaSGKrastevaMEAlterations in p53, BRCA1, ATM, PIK3CA, and HER2 genes and their effect in modifying clinicopathological characteristics and overall survival of Bulgarian patients with breast cancerJ Cancer Res Clin Oncol2010136111657166920177704
  • JensenJDKnoopALaenkholmAVPIK3CA mutations, PTEN, and pHER2 expression and impact on outcome in HER2-positive early-stage breast cancer patients treated with adjuvant chemotherapy and trastuzumabAnn Oncol20122382034204222172323
  • LiuYRJiangYZZuoWJYuKDShaoZMPIK3CA mutations define favorable prognostic biomarkers in operable breast cancer: a systematic review and meta-analysisOnco Targets Ther2014754355224748804
  • XuBGuanZShenZAssociation of phosphatase and tensin homolog low and phosphatidylinositol 3-kinase catalytic subunit alpha gene mutations on outcome in human epidermal growth factor receptor 2-positive metastatic breast cancer patients treated with first-line lapatinib plus paclitaxel or paclitaxel aloneBreast Cancer Res201416440525056500
  • BaderAGKangSVogtPKCancer-specific mutations in PIK3CA are oncogenic in vivoProc Natl Acad Sci U S A200610351475147916432179
  • ZhaoLVogtPKHelical domain and kinase domain mutations in p110α of phosphatidylinositol 3-kinase induce gain of function by different mechanismsProc Natl Acad Sci U S A200810572652265718268322
  • BernsKHorlingsHMHennessyBTA functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancerCancer Cell200712439540217936563
  • EichhornPJGiliMScaltritiMPhosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235Cancer Res200868229221923019010894
  • KataokaYMukoharaTShimadaHSaijoNHiraiMMinamiHAssociation between gain-of-function mutations in PIK3CA and resistance to HER2-targeted agents in HER2-amplified breast cancer cell linesAnn Oncol201021225526219633047
  • O’BrienNABrowneBCChowLActivated phosphoinositide 3-kinase/AKT signaling confers resistance to trastuzumab but not lapatinibMol Cancer Ther2010961489150220501798
  • CizkovaMDujaricMELehmann-CheJOutcome impact of PIK3CA mutations in HER2-positive breast cancer patients treated with trastuzumabBr J Cancer201310891807180923612454
  • Pogue-GeileKLSongNJeongJHIntrinsic Subtypes, PIK3CA Mutation, and the Degree of Benefit From Adjuvant Trastuzumab in the NSABP B-31 TrialJ Clin Oncol Epub152015
  • LoiblSvon MinckwitzGSchneeweissAPIK3CA mutations are associated with lower rates of pathologic complete response to anti-human epidermal growth factor receptor 2 (HER2) therapy in primary HER2-overexpressing breast cancerJ Clin Oncol201432293212322025199759
  • MajewskiIJNuciforoPMittempergherLPIK3CA mutations are associated with decreased benefit to neoadjuvant human epidermal growth factor receptor 2-targeted therapies in breast cancerJ Clin Oncol Epub152015
  • ToiMIwataHFujiwaraYLapatinib monotherapy in patients with relapsed, advanced, or metastatic breast cancer: efficacy, safety, and biomarker results from Japanese patients phase II studiesBr J Cancer2009101101676168219844234
  • SchneeweissAChiaSHeggREvaluating the predictive value of biomarkers for efficacy outcomes in response to pertuzumab- and tras-tuzumab-based therapy: an exploratory analysis of the TRYPHAENA studyBreast Cancer Res2014164R7325005255
  • BaselgaJCortésJKimSBPertuzumab plus trastuzumab plus docetaxel for metastatic breast cancerN Engl J Med2012366210911922149875
  • BaselgaJCortesJImSABiomarker analyses in CLEOPATRA: a phase III, placebo-controlled study of pertuzumab in human epidermal growth factor receptor 2-positive, first-line metastatic breast cancerJ Clin Oncol201432333753376125332247
  • CampbellRABhat-NakshatriPPatelNMConstantinidouDAliSNakshatriHPhosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistanceJ Biol Chem2001276139817982411139588
  • MohseniMParkBHPIK3CA and KRAS mutations predict for response to everolimus therapy: now that’s RAD001J Clin Invest201012082655265820664174
  • MillerTWRexerBNGarrettJTArteagaCLMutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancerBreast Cancer Res201113622422114931
  • JankuFWhelerJJNaingAPIK3CA mutation H1047R is associated with response to PI3K/AKT/mTOR signaling pathway inhibitors in early-phase clinical trialsCancer Res201373127628423066039
  • BaselgaJBradburyIEidtmannHLapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trialLancet2012379981663364022257673
  • BerrutiAAmorosoVGalloFPathologic complete response as a potential surrogate for the clinical outcome in patients with breast cancer after neoadjuvant therapy: a meta-regression of 29 randomized prospective studiesJ Clin Oncol201432343883389125349292