34
Views
15
CrossRef citations to date
0
Altmetric
Review

Role of L-asparaginase in acute lymphoblastic leukemia: focus on adult patients

Pages 117-124 | Published online: 29 Jun 2012

References

  • Kidd JG. Regression of transplanted lymphomas induced in vivo by means of normal guinea pig serum. II. Studies on the nature of the active serum constituent: histological mechanism of the regression: tests for effects of guinea pig serum on lymphoma cells in vitro: discussion. J Exp Med. 1953;98:583–606.
  • Broome JD. Evidence that the L-asparaginase of guinea pig serum is responsible for its antilymphoma effects. II. Lymphoma 6C3HED cells cultured in a medium devoid of L-asparagine lose their susceptibility to the effects of guinea pig serum in vivo. J Exp Med. 1963;118:121–148.
  • Hill JM, Roberts J, Loeb E, Khan A, MacLellan A, Hill RW. L-Asparaginase therapy for leukemia and other malignant neoplasms. JAMA. 1967;202:116–122.
  • Beard MEJ, Crowther D, Galton DAG, et al. L-Asparaginase in treatment of acute leukaemia and lymphosarcoma. Br Med J. 1970;1:191–195.
  • Dolowy WC, Henson D, Cornet J, Sellin H. Toxic and antineoplastic effects of L-asparaginase, study of mice with lymphoma and normal monkeys and report on a child with leukemia. Cancer. 1966;19:1813–1819.
  • Oettgen HF, Stephenson PA, Schwartz MK, et al. Toxicity of E. coli L-asparaginase in man. Cancer. 1970;25:253–278.
  • Capizzi RL, Bertino JR, Skeel RT, et al. L-Asparaginase: clinical biochemical, pharmacological and immunological studies. Ann Intern Med. 1971;74:893–901.
  • Haskell CM, Canellos GP, Levental BG, Carbone PP, Serpick AA, Hansen HH. L-asparaginase toxicity. Cancer Res. 1969;29:974–975.
  • Haskell CM, Canellos GP, Levental BG, et al. L-asparaginase: therapeutic and toxic effects in patients with neoplastic disease. N Engl J Med. 1969;281:1028–1034.
  • Asselin BL, Whitin JC, Coppola DJ, Rupp IP, Sallan SE, Cohen HJ. Comparative pharmacokinetic studies of three asparaginase preparations. J Clin Oncol. 1993;11:1780–1786.
  • Asselin BL. The three asparaginases. Comparative pharmacology and optimal use in childhood leukemia. Adv Exp Med Biol. 1999;457:621–629.
  • Avramis VI, Panosyan EH. Pharmacokinetic/pharmacodynamic relationships of asparaginase formulations. The past, the present and recommendations for the future. Clin Pharmacokinet. 2005 ;44:367–393.
  • Fu CH, Sakamoto KM. PEG asparaginase. Expert Opin Pharmacother. 2007;8:1977–1984.
  • Kantarjian H, Thomas D, O’Brien S, et al. Long-term follow up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia. Cancer. 2004;101:2788–27801.
  • Katarjian HM, Walters RS, Keating MJ, et al. Results of the vincristine, doxorubicin, and dexamethasone regimen in adults with standard- and high-risk acute lymphocytic leukemia. J Clin Oncol. 1990;8:994–1004.
  • Linker CA, Levitt LJ, O’Donnell M, Forman SF, Ries CA. Treatment of adult acute lymphoblastic leukemia with intensive cyclical chemotherapy: a follow-up report. Blood. 1991;78:2814–2822.
  • Graham ML. Pegaspargase: a review of clinical studies. Adv Drug Deliv Rev. 2003;55:1293–1302.
  • Zeidan A, Wang ES, Wetzler M. Pegasparaginase: where do we stand? Expert Opin Biol Ther. 2009;9:111–119.
  • Tallal L, Tan C, Oettgen H, et al. E. coli L-asparaginase in the treatment of leukemia and solid tumors in 131 children. Cancer. 1970;25:306–320.
  • Clarkson B, Gaynor J, Franza RB, Furth M. Recent advances in the treatment of acute lymphoblastic leukemia in adults and future prospects. Trans Am Clim Climatol Assoc. 1985;96:41–55.
  • Asselin B. The three asparaginases. comparative pharmacology and optimal use in childhood leukemia. Adv Exp Med Biol. 1999;457:621–629.
  • Riccardi R, Holcenberg JS, Glaubiger DL, Wood JH, Poplack DG. L-Asparaginase pharmacokinetics and asparagine levels in cerebrospinal fluid of rhesus monkeys and humans. Cancer Res. 1981;41(11 Pt 1):4554–4558.
  • Ahlke E, Nowak-Gottl U, Schulze-Westhoff P. Dose reduction of asparaginase under pharmacokinetic and pharmacodynamic control during induction therapy in children with acute lymphoblastic leukaemia. Br J Haematol. 1997;96:675–681.
  • Pieters R, Hunger SP, Boos J, et al. L-asparaginase treatment in acute lymphoblastic leukemia: a focus on Erwinia asparaginase. Cancer. 2011;117:238–249.
  • Boos J, Werber G, Ahlke E, et al. Monitoring of asparaginase activity and asparagine levels in children on different asparaginase preparations. Eur J Cancer. 1996;32A:1544–1550.
  • Panosyan EH, Seibel NL, Martin-Aragon S, et al. Asparaginase antibody and asparaginase activity in children with higher risk acute lymphoblastic leukemia: Children’s Cancer Group Study CCG-1961. J Pediatr Hematol Oncol. 200426:333–335.
  • Armstrong JK, Hempel G, Koling S, et al. Antibody against poly(ethylene glycol) adversely affects PEG-asparaginase therapy in acute lymphoblastic leukemia patients. Cancer. 2007;110:103–111.
  • Schauer P, Arlin ZA, Mertelsmann R, et al. Treatment of acute lymphoblastic leukemia in adults: results of the L-10 and L-10M protocols. J Clin Oncol. 1983;1:462–470.
  • Lister TA, Whitehouse JMA, Beard MEJ, et al. Combination chemotherapy for acute lymphoblastic leukaemia in adults. Br Med J. 1978;1:199–203.
  • Marcus RE, Catovsky D, Johnson SA, et al. Adult acute lymphoblastic leukaemia: a study of prognostic features and response to treatment over a ten-year period. Br J Cancer. 1986;53:175–180.
  • Hoelzer D, Thiel E, Loffler H, et al. Intensified therapy in acute lymphoblastic and acute undifferentiated leukemia in adults. Blood. 1984;64:38–47.
  • Durrant IJ, Richards SM. Results of Medical Research Council trial UKALL IX in acute lymphoblastic leukaemia in adults: report from the Medical Research Council Working Party on Adult Leukaemia. Br J Haematol. 1993;85:84–92.
  • Radford JE, Jones MP, Gigrich RD, et al. Adult acute lymphoblastic leukemia: results of the Iowa HOP-L protocol. J Clin Oncol. 1989;7:58–66.
  • Hoelzer D, Thiel H, Loffler H, et al. Prognostic factors in a multicenter study for treatment of acute lymphoblastic leukemia in adults. Blood. 1988;71:123–131.
  • Ellison RR, Mick R, Cuttner J, et al. The effects of postinduction intensification treatment with cytarabine and daunorubicin in adult acute lymphocytic leukemia: a prospective randomized clinical trial by Cancer and Leukemia Group B. J Clin Oncol. 1991;9:2002–2015.
  • Hussein KK, Dahlberg S, Head D, et al. Treatment of acute lymphoblastic leukemia in adults with intensive induction, consolidation, and maintenance chemotherapy. Blood. 1989;73:57–63.
  • Ludwig WD, Rieder H, Bartram CR, et al. Immunopheotypic and genotypic features, clinical characteristics and treatment outcome of adult pro-B acute lymphoblastic leukemia: results of the German multicenter trials GMALL 03/87 and 04/89. Blood. 1998;92:1898–1909.
  • Ribera JM, Ortega JJ, Oriol A, et al. Late intensification chemotherapy has not improved the results of intensive chemotherapy in adult acute lymphoblastic leukemia. Results of a prospective multicenter randomized trial (PETHEMA ALL-89). Haematologica. 1998;83:222–230.
  • Rowe JM, Buck G, Burnett AK, et al. Induction therapy for adults with acute lymphoblastic leukemia: results of more than 1500 patients from the international ALL trial: MRC UKALL XII/ECOG E2993. Blood. 2005;106:3760–3767.
  • Nagura E, Kimura K, Yamada K, et al. Nation-wide randomized comparative study of doxorubicin, vincristine and prednisolone combination therapy with and without L-asparaginase for adult acute lymphoblastic leukemia. Cancer Chemother Pharmacol. 1994;33:359–365.
  • Rijneveld AW, van der Holt B, Daenen SM, et al. Intensified chemotherapy inspired by a pediatric regimen combined with allogeneic transplantation in adult patients with acute lymphoblastic leukemia up to the age of 40. Leukemia. 2011;25:1697–1703.
  • Huguet F, Leguay T, Raffoux E, et al. Pediatric-inspired theraphy in adults with Philadelphia chromosome-negative acute lymphoblastic leukemia: the GRALL-2003 study. J Clin Oncol. 2009;27:911–918.
  • Ribera JM, Oriol A, Sanz MA, et al. Comparison of the results of the treatment of adolescents and young adults with standard-risk acute lymphoblastic leukemia with the Programa Espanol de Tratamiento Hematologia pediatric-based protocol ALL-96. J Clin Oncol. 2008;26:1843–1849.
  • Labar B, Suciu S, Willemze R, et al. Dexamethasone compared to prednisolone for adults with acute lymphoblastic leukemia or lymphoblastic lymphoma: final results of the ALL-4 randomized, Phase III trial of the EORTC Leukemia Group. Haematologica. 2010;95:1489–1495.
  • Park Young K, Abuchowski A, Davis S, Davis F. Pharmacology of Escherichia coli L-asparaginase polyethylene glycol adduct. Anticancer Res. 1981;1:373–376.
  • Keating MJ, Holmes R, Lerner S, Ho DH. L-Asparaginase and PEG asparaginase-Padt, present, and future. Leuk Lymphoma. 1993;10:153–157.
  • Ettinger LJ, Kurtzberg J, Voute PA, Jurgens H, Halpern SL. An open-label, multicenter study of polyethylene glycol-L-asparaginase for the treatment of acute lymphoblastic leukemia. Cancer. 1995;75:1176–1181.
  • Wetzler M, Sandord BL, Kurtzberg J, et al. Effective asparagine depletion with pegylated asparaginase results in improved outcomes in adult acute lymphoblastic leukemia: Cancer and Leukemia Group B study 9511. Blood. 2007;109:4164–4167.
  • Aguayo A, Cortes J, Thomas D, Pierce S, Keating MJ, Kantarjian H. Combination therapy with methotrexate, vincristine, polyethylene- glycol conjugated-asparaginase, and prednisone in the treatment of patients with refractory or recurrent acute lymphoblastic leukemia. Cancer. 1997;86:1203–1209.
  • Rosen O, Muller HJ, Gokbuget N, et al. Pegylated asparaginase in combination with high-dose methotrexate for consolidation in adult acute lymphoblastic leukemia in first remission: a pilot study. Br J Hematol. 2003;123:836–841.
  • Douer D, Yampolsky H, Cohen LJ, Watkins K, Periclou AP, Avramis VI. Pharmacodynamics and safety of intravenous pegaspargase during remission induction in adults aged 55 years or younger with newly diagnosed acute lymphoblastic leukemia. Blood. 2007;109:2744–2750.
  • Rytting M, Earl M, Douer D, Muriera B, Advani A, Bleyer A. Toxicities in adults with acute lymphoblastic leukemia (ALL) treated with regimens using pegasparaginase. Blood. 2008;112:Abstract 1924.
  • Avramis VI, Sencer S, Periclou AP, et al. A Randomized comparison of native Escherichia coli asparaginase and polyethylene glycol conjugated asparaginase for treatment of children with newly diagnosed standard-risk acute lymphoblastic leukemia: a children’s cancer group study. Blood. 2002;99:1986–1994.
  • Kearney SL, Dahlberg SE, Levy DE, Voss SD, Sallan SE, Silverman LB. Clinical course and outcome in children with acute lymphoblastic leukemia and asparaginase-associated pancreatitis. Pediatr Blood Cancer. 2009;53:162–167.
  • Freund M, Diedrich H, Ganser A, et al. Treatment of relapsed or refractory adult acute lymphocytic leukemia. Cancer. 1992;69:709–716.
  • Grace RF, Dahlberg SE, Neuberg D, et al. The frequency and management of asparaginase-related thrombosis in pediatric and adult patients with acute lymphoblastic leukemia treated on Dana-Farber Cancer Institute consortium protocols. Br J Haematol. 2011;152:452–459.
  • Appel IM, Kazemier KM, Boos J, et al. Pharmacokinetic, pharmacodynamic and intracellular effects of PEG-asparagines in newly diagnosed childhood acute lymphoblastic leukemia: results from a single agent window study. Leukemia. 2008;22:1665–1679.
  • Wenner KA, Pinheiro JP, Escherich G, et al. Asparagine concentration in plasma after 2,500 IU/m(2) PEG-asparaginase i.v. in children with acute lymphoblastic leukemia. Klin Padiatr. 2005;217:321–326. German.
  • Dinnorf PA, Gootenbert J, Cohen M, Keegan P, Pazdur R. FDA drug approval summary: Pegaspargase (Oncaspar) for the first-line treatment of children with acute lymphoblastic leukemia. Oncologist. 2007;12:991–994.
  • Nowak-Gotti U, Kenet G, Mitchell LG. Thrombosis in childhood acute lymphoblastic leukemia: epidemiology, aetiology, diagnosis, prevention and treatment. Best Pract Res Clin Haematol. 2009;22:103–114.
  • Hunault-Berger M, Chevallier P, Delain M, et al. Changes in antithrombin and fibrinogen levels during induction chemotherapy with L-asparaginase in adult patients with acute lymphoblastic leukemia or lymphoblastic lymphoma. Use of supportive coagulation therapy and clinical outcome: the CAPELAL study. Haematologica. 2008;93:1488–1494.
  • Hernández-Espinosa D, Minano A, Ordonez A, et al. Dexamethasone induces a heat-stress response that ameliorated the conformational consequences on antithrombin of L-asparagines treatment. J Thromb Haemost. 2009;7:1128–1133.
  • Durden DL, Salazar AM, Distasio JA. Kinetic analysis of hepatotoxicity associated with antieoplastic asparaginases. Cancer Res. 1983;43:1602–1605.
  • Linker C, Damon L, Ries C, Navarro W. Intensified and shortened cyclical chemotherapy for adult acute lymphoblastic leukemia. J Clin Oncol. 2002;20:2464–2471.
  • Chang J, Medlin S, Kahl B, et al. Augmented and standard BerlinFrankfurt-Munster chemotherapy for treatment of adult acute lymphoblastic leukemia. Leuk Lymphoma. 2008;49:2298–2307.
  • Larson RA, Fretzin MH, Dodge RK, Schiffer CA. Hypersensitivity reactions to L-asparaginase do not impact on the remission duration of adults with acute lymphoblastic leukemia. Leukemia. 1998;12:660–665.
  • Storring JM, Minden MD, Kao S, et al. Treatment of adults with BCR- ABL negative acute lymphoblastic leukemia with a modified pediatric regimen. Br JHematol 2009;146:76–85.
  • Vrooman LM, Supko JG, Neuberg DS, et al. Erwinia asparaginase after allergy to E. coli asparaginase in children with acute lymphoblastic leukemia. Pediatr Blood Cancer. 2010;54:199–205.