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Blood and Lymphatic Cancer: Targets and Therapy Volume 11, 2021 - Issue
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Case Report

Successful Non-Transplant Treatment of Double Hit Richter Transformation with Long-Term Remission

Karan Seegobin1 Department of Hematology and Medical Oncology, Mayo Clinic Hospital, Jacksonville City, FL, 32224, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2739-7357View further author information
ORCID Icon,
Muhamad Alhaj Moustafa1 Department of Hematology and Medical Oncology, Mayo Clinic Hospital, Jacksonville City, FL, 32224, USAORCID Iconhttps://orcid.org/0000-0001-8582-1219View further author information
ORCID Icon,
Liuyan Jiang2 Department of Pathology, Mayo Clinic Hospital, Jacksonville City, FL, 32224, USAORCID Iconhttps://orcid.org/0000-0002-9851-985XView further author information
ORCID Icon &
Han W Tun1 Department of Hematology and Medical Oncology, Mayo Clinic Hospital, Jacksonville City, FL, 32224, USAORCID Iconhttps://orcid.org/0000-0002-9184-094XView further author information
ORCID Icon
Pages 67-72 | Published online: 22 Sep 2021

References

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  • Rogers TS, Gardner JA, Devitt KA. High-grade B-cell lymphoma with MYC and BCL6 rearrangements associated with Richter transformation of chronic lymphocytic leukemia. Autops Case Rep. 2019;9(3):e2019090. doi:10.4322/acr.2019.090
  • Rossi D, Spina V, Gaidano G. Biology and treatment of Richter syndrome. Blood. 2018;131(25):2761–2772. doi:10.1182/blood-2018-01-791376
  • Wang YC, Rabe KG, Bold MS, et al. The role of F-18-FDG-PET in detecting Richter transformation of chronic lymphocytic leukemia in patients receiving therapy with a B-cell receptor inhibitor. Haematologica. 2020;105(11):2675–2678. doi:10.3324/haematol.2019.240564
  • Wang YC, Ding W. Richter transformation of chronic lymphocytic leukemia in the era of novel agents. Clin Adv Hematol Onc. 2020;18(6):348–357.
  • Wang YC, Tschautscher MA, Rabe KG, et al. Clinical characteristics and outcomes of Richter transformation: experience of 204 patients from a single center. Haematologica. 2020;105(3):765–773. doi:10.3324/haematol.2019.224121
  • Rogers KA, Huang Y, Ruppert AS, et al. A single-institution retrospective cohort study of first-line R-EPOCH chemoimmunotherapy for Richter syndrome demonstrating complex chronic lymphocytic leukaemia karyotype as an adverse prognostic factor. Br J Haematol. 2018;180(2):259–266. doi:10.1111/bjh.15035
  • Ding W. Richter transformation in the era of novel agents. Hematology Am Soc Hematol Educ Program. 2018;2018(1):256–263. doi:10.1182/asheducation-2018.1.256
  • Phuoc V, Sandoval-Sus J, Chavez JC. Drug therapy for double-hit lymphoma. Drugs Context. 2019;8:1–13. doi:10.7573/dic.2019-8-1
  • Tsang M, Shanafelt TD, Call TG, et al. The efficacy of ibrutinib in the treatment of Richter syndrome. Blood. 2015;125(10):1676–1678. doi:10.1182/blood-2014-12-610782

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