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Review

Profile of crofelemer for the symptomatic treatment of diarrhea in HIV-infected persons

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Pages 21-25 | Published online: 07 Jan 2015

References

  • MacArthur RD, DuPont HL. Etiology and pharmacologic management of noninfectious diarrhea in HIV-infected individuals in the highly active antiretroviral therapy era. Clin Infect Dis. 2012;55:860–867.
  • Hill A, Balkin A. Risk factors for gastrointestinal adverse events in HIV treated and untreated patients. AIDS Rev. 2009;11:30–38.
  • MacArthur RD, Hawkins T, Brown SJ, et al. Efficacy and safety of crofelemer for noninfectious diarrhea in HIV-seropositive individuals (ADVENT Trial): a randomized, double-blind, placebo-controlled, two-stage study. HIV Clin Trials. 2013;14:261–273.
  • What is a Botanical Drug? [webpage on the Internet] Silver Spring: US Food and Drug Administration; 2010. Available from: http://www.fda.gov/aboutfda/centersoffices/officeofmedicalproductsandtobacco/cder/ucm090983.htm. Accessed December 1, 2014.
  • Dietary Supplements [webpage on the Internet]. Silver Spring: US Food and Drug Administration; 2014. Available from: http://www.fda.gov/Food/DietarySupplements/default.htm. Accessed December 1, 2014.
  • Williams JE. Review of antiviral and immunomodulating properties of plants of the Peruvian rainforest with a particular emphasis on Una de Gato and Sangre de Grado. Altern Med Rev. 2001;6:567–579.
  • Jones K. Revew of sangre de drago (Croton lechleri) – a South American tree sap in the treatment of diarrhea, inflammation, insect bites, viral infections, and wounds: traditional uses to clinical research. J Altern Complement Med. 2003;9:877–896.
  • Crutchley RD, Miller J, Garey KW. Crofelemer, a novel agent for treatment of secretory diarrhea. Ann Pharmacother. 2010;44:878–884.
  • Ubillas, R, Jolad SD, Bruening RC, et al. SP-303, an antiviral oligomeric proanthocyanidin from the latex of Croton lechleri (Sangre de Drago). Phytomedicine. 1994;1:77–106.
  • Gabriel SE, Davenport SE, Steagall RJ, Vimal V, Calson T, Rozhon EJ. A novel plant-derived inhibitor of cAMP-mediated fluid and chloride secretion. Am J Physiol. 1999;276:G58–G63.
  • Murek M, Kopic S, Geibel J. Evidence for intestinal chloride secretion. Exp Physiol. 2010;95:471–478.
  • Barrett KE, Keely SJ. Chloride secretion by the intestinal epithelium: molecular basis and regulatory aspects. Annu Rev Physiol. 2000;62:535–572.
  • Verkman AS, Galietta LJ. Chloride channels as drug targets. Nat Rev Drug Discov. 2009;8:153–171.
  • Rufo PA, Lin PW, Andrade A, et al. Diarrhea-associated HIV-1 APIs potentiate muscarinic activation of Cl- secretion by T84 cells via prolongation of cytosolic Ca2+ signaling. Am J Physiol Cell Physiol. 2004;286:C998–C1008.
  • Tradtrantip L, Namkung W, Verkman AS. Crofelemer, an antisecretory antidiarrheal proanthocyanidin oligomer extracted from Croton lechleri, targets two distinct intestinal chloride channels. Mol Pharmacol. 2010;77:69–78.
  • Bardhan P, Sharma A, Bolmall C, et al. Safety and efficacy of a novel anti-secretory anti-diarrheal agent crofelemer (NP-303), in the treatment of adult acute infectious diarrhea and cholera, with or without the use of antibiotics. Proceedings of the US–Japan CMSP: 13th International Conference on Emerging Infectious Diseases (EID) in the Pacific Rim – Focused on Enteric Diseases; April 6–9, 2009; Kolkata.
  • Holodniy M, Koch J, Mistal M, et al. A double blind, randomized, placebo-controlled phase II study to assess the safety and efficacy of orally administered SP-303 for the symptomatic treatment of diarrhea in patients with AIDS. Am J Gastroenterol. 1999;94:3267–3273.
  • Patel TS, Crutchley RD, Tucker AM, Cotteau J, Gare KW. Crofelemer for the treatment of chronic diarrhea in patients living with HIV/AIDS. HIV AIDS (Auckl). 2013;5:153–162.
  • A Possible New Drug to Treat Acute Diarrhea from Cholera and Other Conditions: Crofelemer [webpage on the Internet]. Bethesda: National Institute of Allergy and Infectious Diseases; 2013. Available from: http://www.niaid.nih.gov/topics/cholera/research/Pages/crofelemer.aspx. Accessed.