Recent perspectives on the medicinal potential of ginger

References

• Chrubasika S, Pittlerc MH, Roufogalis BD. Zingiberis rhizoma: a comprehensive review on the ginger effect and efficacy profiles. Phytomedicine. 2005;12:684–701.
   Web of Science ®Google Scholar
• Ali BH, Blunden G, Tanira MO, Nemmar A. Some physico-chemical, pharmacological and toxicological properties of ginger (Zingerber officinale) – a review. Food Chem Toxicol. 2008;46:409–410.
   PubMed Web of Science ®Google Scholar
• Fuhrman B, Rosenblat M, Hayek T, Coleman R, Aviram M. Ginger extract consumption reduces plasma cholesterol, inhibits LDL oxidation and attenuates development of atherosclerosis in atherosclerotic, apolipoprotein E-deficient mice. J Nutr. 2000;130(5):1124–1131.
   PubMed Web of Science ®Google Scholar
• Young HY, Liao JC, Chang YS, Luo YL, Lu MC, Peng WH. Synergistic effect of ginger and nifedipine on human platelet aggregation: a study in hypertensive patients and normal volunteers. Am J Chin Med. 2006;34(4):545–551.
   Web of Science ®Google Scholar
• Ghayur MN, Gilani AH, Janssen JL. Ginger attenuates acetylcholine-induced contraction and Ca+2 signaling in murine airway smooth muscle cells. Can J Physiol Pharmacol. 2008;86:264–271.
   PubMed Web of Science ®Google Scholar
• Butt MS, Sultan MT. Ginger and its health claims: molecular aspects. Crit Rev Food Sci Nutr. 2011;51(5):383–393.
   PubMed Web of Science ®Google Scholar
• Suekawa M, Ishige A, Yuasa K, Sudo K, Aburada M, Hosoya E. Pharmacological studies on ginger. I. Pharmacological actions of pungent constituents, (6)-gingerol and (6)-shogaol. J Pharmacobiodyn. 1984;7:836–848.
   PubMedGoogle Scholar
• Gunathilake KDPP, Pitts N, Rupasinghe HPV. Formulation and characterization of a bioactives-enriched fruit beverage designed for cardio-protection. Food Res Int. 2013;52(2):535–541.
   Google Scholar
• Gunathilake KDPP, Wang Y, Rupasinghe HPV. Hypocholesterolemic and hypotensive effects of a fruit-based functional beverage in spontaneously hypertensive rats fed with cholesterol-rich diet. J Funct Foods. 2013;5(3):1392–1401.
   Web of Science ®Google Scholar
• Wang X, Zheng Z, Guo X, Yuan J, Zheng C. Preparative separation of gingerols from Zingiber officinale by high-speed counter-current chromatography using stepwise elution. Food Chem. 2011;125: 1476–1480.
   Web of Science ®Google Scholar
• Jolad SD, Lantz RC, Solyon AM, Chen GJ, Bates RB, Timmermann BN. Fresh organically grown ginger (Zingiber officinale): composition and effects on LPS-induced PGE2 production.. Phytochemistry. 2004;65:1937–1954.
   Google Scholar
• Masuda Y, Kikuzaki H, Hisamoto M, Nakatani N. Antioxidant properties of gingerol related compounds from ginger. Biofactors. 2004;21(1–4):293–296.
   PubMed Web of Science ®Google Scholar
• Ekwenye UN, Elegalam NN. Antibacterial activity of ginger (Zingiber officinale Roscoe) and garlic (Allium sativum L) extracts on Escherichia coli and Salmonella typhi. J Mol Med Adv Sci. 2005;1(4):411–416.
   Google Scholar
• Malu SP, Obochi GO, Tawo EN, Nyong BE. Antibacterial activity and medicinal properties of ginger (Zingiber officinale). Glob J Pure Appl Sci. 2008;15(3):365–368.
   Google Scholar
• Park M, Bae J, Lee D-S. Antibacterial activity of [10]-gingerol and [12]-gingerol isolated from ginger rhizome against periodontal bacteria. Phytother Res. 2008;22(11):1446–1449.
   Web of Science ®Google Scholar
• Wang HM, Chen CY, Chen HA, et al. Zingiber officinale (ginger) compounds have tetracycline-resistance modifying effects against clinical extensively drug-resistant Acinetobacter baumannii. Phytother Res. 2010;24(12):1825–1830.
   Web of Science ®Google Scholar
• Sebiomo A, Awofodu AD, Awosanya AO, Awotona FE, Ajayi AJ. Comparative studies of antibacterial effect of some antibiotics and ginger (Zingiber officinale) on two pathogenic bacteria. J Microbiol Antimicrob. 2011;3(1):18–22.
   Google Scholar
• Akoachere JFTK, Ndip RN, Chenwi EB, Ndip LM, Njock TE, Anong DN. Antibacterial effects of Zingiber officinale and Garcinia kola on respiratory tract pathogens. East Afr Med J. 2002;79(11):588–592.
   PubMedGoogle Scholar
• Betoni JEC, Mantovani RP, Barbosa LN, Stasi LCD, Fernandes Junior A. Synergism between plant extract and antimicrobial drugs used on Staphylococcus aureus diseases. Mem Inst Oswaldo Cruz. 2006;101(4):387–390.
   PubMed Web of Science ®Google Scholar
• Mahady GB, Pendland SL, Yun GS, Lu Z, Stoia A. Ginger (Zingiber officinale Roscoe) and the gingerols inhibit the growth of Cag A+ strains of Helicobacter pylori. Anticancer Res. 2003;23:3699–3702.
   PubMed Web of Science ®Google Scholar
• Maizura M, Aminah A, Aida WMW. Total phenolic content and antioxidant activity of kesum (Polygonum minus), ginger (Zingiber officinale) and turmeric (Curcuma longa) extract. Int Food Res J. 2011;18(2):529–534.
   Google Scholar
• Ghasemzadeh A, Jaafar HZE, Rahmat A. Effects of solvent type on phenolics and flavonoids content and antioxidant activities in two varieties of young ginger (Zingiber officinale Roscoe) extracts. J Med Plant Res. 2011;5(7):1147–1154.
   Google Scholar
• Shirin APR, Prakesh JJ. Chemical composition and antioxidant properties of ginger root (Zingiber officinale). J Med Plants Res. 2010;4:2674–2680.
   Web of Science ®Google Scholar
• Kim JK, Kim Y, Na KM, Surh YJ, Kim TY. [6]-Gingerol prevents UVB-induced ROS production and COX-2 expression in vitro and in vivo. Free Radic Res. 2007;41(5):603–614.
   PubMed Web of Science ®Google Scholar
• Gunathilake KDPP, Rupasinghe HPV. Inhibition of human low density lipoprotein oxidation in vitro by ginger extracts. J Med Food. 2014;17(4):424–431.
   Web of Science ®Google Scholar
• Afshari AT, Alireza S, Amirabbas F, et al. The effect of ginger on diabetic nephropathy, plasma antioxidant capacity and lipid peroxidation in rats. Food Chem. 2007;101(1):148–153.
   Web of Science ®Google Scholar
• Aeschbach R, Löliger J, Scott BC, et al. Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol. Food Chem Toxicol. 1994;32:31–36.
   PubMed Web of Science ®Google Scholar
• Madamanchi NR, Vendrov A, Runge MS. Oxidative stress and vascular disease. Arterioscler Thromb Vasc Biol. 2005;25:29–38.
   PubMed Web of Science ®Google Scholar
• Katsube T, Tabata H, Ohta Y, et al. Screening for antioxidant activity in edible plant products; comparison of LDL oxidation assay, DPPH assay and FC assay. J Agric Food Chem. 2004;52:2391–2396.
   PubMed Web of Science ®Google Scholar
• Gunathilake KDPP, Rupasinghe HPV. Optimization of water based-extraction methods for the preparation of bioactive rich ginger extract using response surface methodology. Eur J Med Plants. 2014;4(8):893–906.
   Google Scholar
• Ahmed RS, Vandana S, Banerjee BD. Influence of dietary ginger (Zingiber officinale Rosc) on antioxidant defense system in rat: comparison with ascorbic acid. Indian J Exp Biol. 2000;38(6):604–606.
   PubMedGoogle Scholar
• Stoilova I, Krastanov A, Stoyanova A, Denev P, Gargova S. Antioxidant activity of a ginger extract (Zingiber officinale). Food Chem. 2007; 102(3):764–770.
   Web of Science ®Google Scholar
• Ghasemzadeh A, Jaafar HZE, Rahmat A. Antioxidant activities, total phenolics and flavonoids content in two varieties of Malaysia young ginger (Zingiber officinale Roscoe). Molecules. 2010;15(6):4324–4333.
   PubMed Web of Science ®Google Scholar
• Parmar I, Rupasinghe HPV. Antioxidant capacity and anti-diabetic activity of wild berry stem infusions. Eur J Med Plants. 2015;8:11–28.
   Google Scholar
• Abdulrazaq NB, Cho MM, Win NN, Zaman R, Rahman MT. Beneficial effects of ginger (Zingiber officinale) on carbohydrate metabolism in streptozotocin-induced diabetic rats. Br J Nutr. 2012;108(7):1194–1201.
   PubMed Web of Science ®Google Scholar
• Jafri SA, Abass S, Qasim M. Hypoglycemic effect of ginger (Zingiber officinale) in alloxan induced diabetic rats (Rattus norvagicus). Pak Vet J. 2010;31(2):160–162.
   Web of Science ®Google Scholar
• Sukalingama K, Ganesana K, Ganib SB. Hypoglycemic effect of 6-gingerol, an active principle of ginger in streptozotocin induced diabetic rats. Res Rev J Pharmacol Toxicol Stud. 2013;96:660–666.
   Google Scholar
• Sattar NA, Hussain F, Iqbal T, Sheikh MA. Determination of in vitro antidiabetic effects of Zingiber officinale Roscoe. Braz J Pharm Sci. 2012;48(4):601–607.
   Web of Science ®Google Scholar
• Noipha K, Ratanachaiyavong S, Ninla-Aesong P. Enhancement of glucose transport by selected plant foods in muscle cell line L6. Diabetes Res Clin Pract. 2010;89(2):e22–e26.
   Google Scholar
• Madkor HR, Mansour SW, Ramadan G. Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocin–nicotinamide diabetic rats. Br J Nutr. 2011;105(8):1210–1217.
   PubMed Web of Science ®Google Scholar
• Saraswat M, Suryanarayana P, Reddy PY, Patil MA, Balakrishna N, Reddy GB. Antiglycating potential of Zingiber officinalis and delay of diabetic cataract in rats. Mol Vis. 2010;16:1525–1537.
   PubMed Web of Science ®Google Scholar
• Rani MP, Krishna MS, Padmakumari KP, Raghu KG, Sundaresan A. Zingiber officinale extract exhibits antidiabetic potential via modulating glucose uptake, protein glycation and inhibiting adipocyte differentiation: an in vitro study. J Sci Food Agric. 2012;92(9):1948–1955.
   Web of Science ®Google Scholar
• Mahluji S, Attari VE, Mobasseri M, Payahoo L, Ostadrahimi A, Golzari SE. Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients. Int J Food Sci Nutr. 2013;64(6):682–686.
   PubMed Web of Science ®Google Scholar
• Andallu B, Radhika B, Suryakantham V. Effect of aswagandha, ginger and mulberry on hyperglycemia and hyperlipidemia. Plant Foods Hum Nutr. 2003;58(3):1–7.
   Google Scholar
• Rani PM, Padmakumari KP, Sankarikutty B, Lijo Cherian O, Nisha VM, Raghu KG. Inhibitory potential of ginger extracts against enzymes linked to type 2 diabetes, inflammation and induced oxidative stress. Int J Food Sci Nutr. 2011;62(2):106–110.
   Web of Science ®Google Scholar
• Srivastava KC, Mustafa T. Ginger (Zingiber officinale) in rheumatism and musculoskeletal disorders. Med Hypotheses. 1992;39(4):342–348.
   PubMed Web of Science ®Google Scholar
• Grzanna R, Lindmark L, Frondoza CG. Ginger – an herbal medicinal product with broad anti-inflammatory actions. J Med Food. 2005;8(2):125–132.
   PubMed Web of Science ®Google Scholar
• Singletary K. Ginger: an overview of health benefits. Nutr Today. 2010;45:171–183.
   Google Scholar
• Ojewole JA. Analgesic, antiinflammatory and hypoglycaemic effects of ethanol extract of Zingiber officinale (Roscoe) rhizomes (Zingiberaceae) in mice and rats. Phytother Res. 2006;20(9):764–772.
   PubMed Web of Science ®Google Scholar
• Dugasani S, Pichika MR, Nadarajah VD, Balijepalli MK, Tandra S, Korlakunta JN. Comparative antioxidant and anti-inflammatory effects of [6]-gingerol,[8]-gingerol,[10]-gingerol and [6]-shogaol. J Ethnopharmacol. 2010;127(2):515–520.
   PubMed Web of Science ®Google Scholar
• Habib SHM, Makpol S, Hamid NAA, Das S, Ngah WZW, Yusof YAM. Ginger extract (Zingiber officinale) has anti-cancer and anti-inflammatory effects on ethionine-induced hepatoma rats. Clinics (Sao Paulo). 2008;63(6):807–813.
   PubMed Web of Science ®Google Scholar
• Minghetti P, Sosa S, Cilurzo F, et al. Evaluation of the topical anti-inflammatory activity of ginger dry extracts from solutions and plasters. Planta Med. 2007;73(15):1525–1530.
   PubMed Web of Science ®Google Scholar
• Ramadan G, Al-Kahtani MA, El-Sayed WM. Anti-inflammatory and anti-oxidant properties of Curcuma longa (Turmeric) versus Zingiber officinale (Ginger) rhizomes in rat adjuvant-induced arthritis. Inflammation. 2011;34(4):291–301.
   PubMed Web of Science ®Google Scholar
• Young HY, Luo YL, Cheng HY, Hsieh WC, Liao JC, Peng WH. Analgesic and anti-inflammatory activities of [6]-gingerol. J Ethnopharmacol. 2005;96(1):207–210.
   Web of Science ®Google Scholar
• Thomson M, Al-Qattan KK, Al-Sawan SM, Alnaqeeb MA, Khan I, Ali M. The use of ginger (Zingiber officinale Rosc) as a potential anti-inflammatory and antithrombotic agent. Prostaglandins Leukot Essent Fatty Acids. 2002;67(6):475–478.
   Web of Science ®Google Scholar
• Bhandari U, Sharma JN, Zafar R. The protective action of ethanolic ginger (Zingiber officinale) extract in cholesterol fed rabbits. J Ethnopharmacol. 1998;61(2):167–171.
   Web of Science ®Google Scholar
• Singh AB, Akanksha SN, Maurya R, Srivastava AK. Anti-hyperglycaemic, lipid lowering and anti-oxidant properties of [6]-gingerol in db/db mice. Int J Med Med Sci. 2009;1(12):536–544.
   Google Scholar
• Verma SK, Singh M, Jain P, Bordia A. Protective effect of ginger, Zingiber officinale Rosc on experimental atherosclerosis in rabbits. Indian J Exp Biol. 2004;42(7):736–738.
   Google Scholar
• Nammi S, Sreemantula S, Roufogalis BD. Protective effects of ethanolic extract of Zingiber officinale rhizome on the development of metabolic syndrome in high-fat diet-fed rats. Basic Clin Pharmacol Toxicol. 2009;104(5):366–373.
   PubMed Web of Science ®Google Scholar
• Bordia A, Verma SK, Srivastava KC. Effect of ginger (Zingiber officinale Rosc) and fenugreek (Trigonella foenumgraecum L) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty Acids. 1997;56(5):379–384.
   PubMed Web of Science ®Google Scholar
• Bhandari U, Kanojia R, Pillai KK. Effect of ethanolic extract of Zingiber officinale on dyslipidaemia in diabetic rats. J Ethnopharmacol. 2005;97(2):227–230.
   PubMed Web of Science ®Google Scholar
• Heeba GH, Abd-Elghany MI. Effect of combined administration of ginger (Zingiber officinale) and atorvastatin on the liver of rats. Phytomedicine. 2010;17(14):1076–1081.
   Web of Science ®Google Scholar
• Alizadeh-Navaei R, Fatemeh R, Mehrdad S, Mehdi P, Farzad J, Moghadamnia AA. Investigation of the effect of ginger on the lipid levels. A double blind controlled clinical trial. Saudi Med J. 2008;29(9):1280–1284.
   PubMed Web of Science ®Google Scholar
• Ghayur MN, Anwarul HG, Afridi MB, Houghton PJ. Cardiovascular effects of ginger aqueous extract and its phenolic constituents are mediated through multiple pathways. Vascul Pharmacol. 2005;43(4):234–241.
   PubMed Web of Science ®Google Scholar
• Aming SN. The effect of twice a day intake of ginger tea on the blood pressure of hypertensive individuals in Barnagay La Victoria, Aurora, Zambonga Del Sur. Herdin Record #: R09-ZCHRD-12043023205433. 2006 (abstract).
   Google Scholar
• Nurtjahja-Tjendraputra E, Ammit AJ, Roufogalis BD, Tran VH, Duke CC. Effective anti-platelet and COX-1 enzyme inhibitors from pungent constituents of ginger. Thromb Res. 2003;111(4):259–265.
   PubMed Web of Science ®Google Scholar
• Liao Y-R, Leu Y-L, Chan Y-Y, Kuo P-C, Wu T-S. Anti-platelet aggregation and vasorelaxing effects of the constituents of the rhizomes of Zingiber officinale. Molecules. 2012;17:8928–8937.
   PubMed Web of Science ®Google Scholar
• Koo KLK, Ammit AJ, Tran VH, Duke CC, Roufogalis BC. Gingerols and related analogues inhibit arachidonic acid-induced human platelet serotonin release and aggregation. Thromb Res. 2001;103(5):387–397.
   Web of Science ®Google Scholar
• Nicoll R, Henein MY. Ginger (Zingiber officinale Roscoe): a hot remedy for cardiovascular disease? Int J Cardiol. 2009;131(3):408–409.
   PubMed Web of Science ®Google Scholar
• Baliga MS, Haniadka R, Pereira MM, et al. Update on the chemopreventive effects of ginger and its phytochemicals. Crit Rev Food Sci Nutr. 2011;51(6):499–523.
   PubMed Web of Science ®Google Scholar
• Sang S, Hong J, Wu H, et al. Increased growth inhibitory effects on human cancer cells and anti-inflammatory potency of shogaols from Zingiber officinale relative to gingerols. J Agric Food Chem. 2009;57(22):10645–10650.
   PubMed Web of Science ®Google Scholar
• Shukla Y, Singh M. Cancer preventive properties of ginger: a brief review. Food Chem Toxicol. 2007;45(5):683–690.
   PubMed Web of Science ®Google Scholar
• Akhani SP, Vishwakarma SL, Goyal RK. Anti-diabetic activity of Zingiber officinale in streptozotocin-induced type I diabetic rats. J Pharm Pharmacol. 2004;56(1):101–105.
   PubMed Web of Science ®Google Scholar
• Bode A, Dong ZG. Ginger is an effective inhibitor of HCT116 human colorectal carcinoma in vivo. Cancer Epidemiol Biomarkers Prev. 2003;12(11):1324S.
   Web of Science ®Google Scholar
• Rhode JM, Huang J, Fogoros S, Tan L, Zick S, Liu JR. Ginger induces apoptosis and autophagocytosis in ovarian cancer cells. Cancer Res. 2006;66(8 Suppl):1058.
   Google Scholar
• Nagasawa H, Watanabe K, Inatomi H. Effects of bitter melon (Momordica charantia l) or ginger rhizome (Zingiber officinale Rosc) on spontaneous mammary tumorigenesis in SHN mice. Am J Chin Med. 2002;30(2–3):195–205.
   Web of Science ®Google Scholar
• Brahmbhatt M, Gundala SR, Asif G, Shamsi SA, Aneja R. Ginger phytochemicals exhibit synergy to inhibit prostate cancer cell proliferation. Nutr Cancer. 2013;65:263–272.
   PubMed Web of Science ®Google Scholar
• Lee HS, Seo EY, Kang NE, Kim WK. [6]-Gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells. J Nutr Biochem. 2008;19(5):313–319.
   PubMed Web of Science ®Google Scholar
• Bone ME, Wilkinson DJ, Young JR, McNeil J, Charlton S. Ginger root – a new antiemetic. The effect of ginger root on postoperative nausea and vomiting after major gynaecological surgery. Anaesthesia. 1990;45(8):669–671.
   PubMed Web of Science ®Google Scholar
• Maghbooli M, Golipour F, Esfandabadi AM, Yousefi M. Comparison between the efficacy of ginger and sumatriptan in the ablative treatment of the common migraine. Phytother Res. 2014;28(3):412–415.
   Web of Science ®Google Scholar
• Al-Naqeeb MA, Thomson M, Al-Qattan K, Kamel F, Mustafa T, Ali M. Biochemical and histopathological toxicity of an aqueous extract of ginger in female rats. Kuwait J Sci Eng. 2003;30(2):35–48.
   Google Scholar
• Weidner MS, Sigwart K. The safety of a ginger extract in the rat. J Ethnopharmacol. 2000;73:513–520.
   PubMed Web of Science ®Google Scholar