233
Views
17
CrossRef citations to date
0
Altmetric
Review

New frontiers in oncolytic viruses: optimizing and selecting for virus strains with improved efficacy

Pages 43-60 | Published online: 09 Feb 2018

References

  • LundstromKBoulikasTViral and non-viral vectors in gene therapy: technology development and clinical trialsTechnol Cancer Res Treat2003247148614529313
  • RaperSEChirmuleNLeeFSFatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transferMol Genet Metab20038014815814567964
  • McCormackMPRabbittsTHActivation of the T-cell oncogene LMO2 after gene therapy for X-linked severe combined immunodeficiencyN Engl J Med200435091392214985489
  • Hacein-Bey-AbinaSGarrigueAWangGPInsertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1J Clin Invest20081183132314218688285
  • TsengJCDanielsGMerueloDControlled propagation of replication-competent Sindbis viral vector using suicide gene strategyGene Ther20091629129618818670
  • LundstromKLatest trends in cancer therapy applying viral vectorsFuture Virol201712667684
  • LinYZhangHLiangJIdentification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancersProc Natl Acad Sci U S A2014111E4504E451225288727
  • LinENemunaitisJOncolytic viral therapiesCancer Gene Ther20041164366415286681
  • KaufmanHLKohlhappFJZlozaAOncolytic viruses: a new class of immunotherapy drugsNat Rev Drug Discov20151464266226323545
  • YoungBASpencerJFYingBTollefsonAETothKWoldWSThe role of cyclophosphamide in enhancing antitumor efficacy of an adenovirus oncolytic vector in subcutaneous Syrian hamster tumorsCancer Gene Ther20132052153023928731
  • LiJMKaoKCLiLFMicroRNA-145 regulates oncolytic herpes simplex virus-1 for selective killing of human non-small lung cancer cellsVirol J20131024123876001
  • MurphyAMBesmerDMMoerdyk-SchauweckerMVesicular stomatitis virus as an oncolytic agent against pancreatic ductal adenocarcinomaJ Virol2012863073308722238308
  • ZhaoLLiuHNewcastle disease virus: a promising agent for tumor immunotherapyClin Exp Pharmacol Physiol20123972573022211810
  • EhrigKKilincMOChenNGGrowth inhibition of different human colorectal cancer xenografts after a single intravenous injection of oncolytic vaccinia virus GLV-1h68J Transl Med2013117923531320
  • LundstromKNew era in gene therapySinghMSalnikovaMNovel Approaches and Strategies for Biologics, Vaccines and Cancer TherapiesLondonAcademic Press20151337
  • LundstromKOncolytic alphaviruses in cancer immunotherapyVaccines201759
  • LiDXuDWangZImmunogenicity evaluation of modified adenovirus vaccines expressing porcine circovirus type 2 capsid protein in pigsViral Immunol20173011111927996636
  • GriegerJCSamulskiRJPackaging capacity of adeno-associated virus serotypes: impact of larger genomes on infectivity and post-entry stepsJ Virol2005799933994416014954
  • FountzilasCPatelSMahalingamDReview: oncolytic virotherapy, updates and future directions2017 Available from: http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=18309&path[]=58706Accessed November 23, 2017
  • AlainTKimTSLunXProteolytic disassembly is a critical determinant for reovirus oncolysisMol Ther2007151512152117519890
  • MarcatoPShmulevitzMPanDStoltzDLeePWRas transformation mediates reovirus oncolysis by enhancing virus uncoating, particle infectivity, and apoptosis-dependent releaseMol Ther2007151522153017457318
  • StrongJECoffeyMCTangDSabininPLeePWThe molecular basis of viral oncolysis: usurpation of the Ras signaling pathway by reovirusEMBO J199817335133629628872
  • JamiesonATGentryGASubak-SharpeJHInduction of both thymidine and deoxycytidine kinase activity by herpes virusesJ Gen Virol1974244654804372299
  • VerheijeMHRottierPJRetargeting of viruses to generate oncolytic agentsAdv Virol2012201279852622312365
  • PrestwichRJErringtonFIlettEJTumor infection by oncolytic reovirus primes adaptive antitumor immunityClin Cancer Res2008147358736619010851
  • TodaMRabkinSDKojimaHMartuzaRLHerpes simplex virus as an in situ cancer vaccine for the induction of specific anti-tumor immunityHum Gene Ther19991038539310048391
  • ThorneSHContagCHIntegrating the biological characteristics of oncolytic viruses and immune cells can optimize therapeutic benefits of cell-based deliveryGene Ther20081575375818356814
  • DiaconuICerulloVHirvinenMLImmune response is an important aspect of the antitumor effect produced by a CD40L-encoding oncolytic adenovirusCancer Res2012722327233822396493
  • MiyamotoSInoueHNakamuraTCoxsackievirus B3 is an oncolytic virus with immunostimulatory properties that is active against lung adenocarcinomaCancer Res2012722609262122461509
  • DonnellyOGErrington-MaisFSteeleLMeasles virus causes immunogenic cell death in human melanomaGene Ther20132071522170342
  • CassadyKAHaworthKBJacksonJMarkertJMCripeTPTo infection and beyond: the multi-prolonged anti-cancer mechanisms of oncolytic virusesViruses2016843
  • ChioccaEAThe host response to cancer virotherapyCurr Opin Mol Ther200810384518228180
  • HuangJHZhangSNChoiKJTherapeutic and tumor-specific immunity induced by combination of dendritic cells and oncolytic adenovirus expressing IL-12 and 4-1BBLMol Ther20101826427419738604
  • MelchjorsenJSørensenLNPaludanSRExpression and function of chemokines during viral infections: from molecular mechanisms to in vivo functionJ Leukoc Biol20037433134312949236
  • WickhamSLuBAshJCarrDJChemokine receptor deficiency is associated with increased chemokine expression in the peripheral and central nervous systems and increased resistance to herpetic encephalitisJ Neuroimmunol2005162515915833359
  • AghiMChouTCSulingKBreakefieldXOChioccaEAMultimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapiesCancer Res1999593861386510463570
  • BeugSTTangVALaCasseECSmac mimetics and innate immune stimuli synergize to promote tumor deathNat Biotechnol20143218219024463573
  • WongRJPatelSGKimSCytokine gene transfer enhances herpes oncolytic therapy in murine squamous cell carcinomaHum Gene Ther20011225326511177562
  • ChoiIKLeeJSZhangSNOncolytic adenovirus co-expressing IL-12 and IL-18 improves tumor-specific immunity via differentiation of T cells expressing IL-12Rβ2 or IL-18RαGene Ther20111889890921451575
  • ParkerJNMelethSHughesKBGillespieGYWhitleyRJMarkertJMEnhanced inhibition of syngeneic murine tumors by combinatorial therapy with genetically engineered HSV-1 expressing CCL2 and IL-12Cancer Gene Ther20051235936815678154
  • MillerCGFraserNWRequirement of an integrated immune response for successful neuroattenuated HSV-1 therapy in an intracranial metastatic melanoma modelMol Ther2003774174712788647
  • ChioccaEAThe host response to cancer virotherapyCurr Opin Mol Ther200810384518228180
  • WatersAMJohnstonJMReddyATRationale and design of a phase 1 clinical trial to evaluate HSV G207 alone or with a single radiation dose in children with progressive or recurrent malignant supratentorial brain tumorsHum Gene Ther Clin Dev20172871628319448
  • MatthewsKSAlvarezRDCurielDTAdvancements in adenoviral-based virotherapy for ovarian cancerAdv Drug Deliv Rev20096183684119422865
  • EkbladMHaldenGAdenovirus-based therapy for prostate cancerCurr Opin Mol Ther200912421431
  • ZhangYZhangBCZhangARCo-transduction of ribosomal protein L23 enhances the therapeutic efficacy of adenoviral-mediated p53 gene transfer in human gastric cancerOncol Rep2013301989199523933826
  • FuYJDuJYangRJYinLTLiangAHPotential adenovirus-mediated gene therapy of glioma cancerBiotechnol Lett201032111819784809
  • FujiwaraTA novel molecular therapy using bioengineered adenovirus for human gastrointestinal cancerActa Med Okoyama201165151162
  • ShapiraSShapiraAKazanovDHevroniGKrausSArberNSelective eradication of cancer cells by delivery of adenovirus-based toxinsOncotarget20178385813859128445136
  • ZhouWDaiSZhuHTelomerase-specific oncolytic adenovirus expressing TRAIL suppresses peritoneal dissemination of gastric cancerGene Ther20172419920728075429
  • ChoiJWLeeJSKimSWEvolution of oncolytic adenoviruses for cancer treatmentAdv Drug Deliv Rev20126472072922212901
  • ChenJGaoPYuanSOncolytic adenovirus complexes coated with lipids and calcium phosphate for cancer therapyACS Nano201610115481156027977128
  • LiYZhuoBYinYAnti-cancer effect of oncolytic adenovirus-armed shRNA targeting MYCN gene on doxorubicin-resistant neuroblastoma cellsBiochem Biophys Res Commun201749113413928711493
  • ZhangJLaiWLiQA novel oncolytic adenovirus targeting Wnt signaling effectively inhibits cancer-stem like cell growth via metastasis, apoptosis and autophagy in HCC modelsBiochem Biophys Res Commun201749146947728698142
  • Sato-DahlmanMMiuraYHuangJLCD133-targeted oncolytic adenovirus demonstrates anti-tumor effect in colorectal cancerOncotarget20178760447605629100290
  • LiuZYangYZhangXAn oncolytic adenovirus encoding decorin and GM-CSF inhibits tumor growth in a colorectal tumor model by targeting pro-tumorigenic signals and via immune-activationHum Gene Ther20172866768028530155
  • ShihCSLaurieNHolzmacherJAAV-mediated local delivery of interferon-β for the treatment of retinoblastoma in preclinical modelsNeuromolecular Med200911435219306089
  • LuLLuoSTShiHSAAV2-mediated gene transfer of VEGF-Trap with potent suppression of primary breast tumor growth and spontaneous pulmonary metastases by long-term expressionOncol Rep2012281332133822824831
  • LingCLuYChengBHigh efficiency transduction of liver cancer cells by recombinant adeno-associated virus serotype 3 vectorsJ Vis Exp201149e2538
  • YuanLZhaoHZhangLLiuXThe efficacy of combination therapy using adeno-associated virus co-expression of apoptin and interleukin-24 on hepatocellular carcinomaTumour Biol2013343027303423907578
  • SuHChangJCXuSMKanYWSelective killing of AFP positive hepatocellular carcinoma cells by adeno-associated virus transfer of the herpes simplex virus thymidine kinase geneHum Gene Ther199674634708800740
  • SteeleJCDi PasqualeGRamloganCAPatelVChioriniJAMorrisJCOral vaccination with adeno-associated virus vectors expressing the Neu inhibits the growth of murine breast cancerMol Ther20132168068723295951
  • SunATangJTerranovaPFZhangXThrasherJBLiBAdeno-associated virus-delivered short hairpin-structured RNA for androgen receptor gene silencing induces tumor eradication of prostate cancer xenografts in nude mice: a preclinical studyInt J Cancer201012676477419642108
  • CrommentuijnMHKantarRNoskeDPSystemically administered AAV9-sTRAIL combats invasive glioblastoma in a patient-derived orthotopic xenograft modelMol Ther Oncolytics201631601727382645
  • ZhenZYangKYeLYouZChenRLiuYDecorin gene upregulation mediated by an adeno-associated virus vector increases intratumoral uptake of nab-paclitaxel in neuroblastoma via inhibition of stabilin-1Invest New Drugs Epub2017620
  • MeshiiNTakahashiGOkunagaSEnhancement of systemic tumor immunity for squamous cell carcinoma cells from oncolytic herpes simplex virusCancer Gene Ther20132049349823887644
  • LiHNakashimaHDeckleverTDNaceRARussellSJHSV-NIS, an oncolytic herpes simplex virus type 1 encoding the human sodium iodine symporter for preclinical prostate cancer radiovirotherapyCancer Gene Ther20132047848523868101
  • ChenCYWangPYHutzenBCooperation of oncolytic herpes virotherapy and blockade in murine rhabdomyosarcoma modelsSci Rep20177239628539588
  • YinLZhaoCHanJAntitumor effects of oncolytic herpes simplex virus type 2 against colorectal cancer in vitro and in vivoTher Clin Risk Manag20171311713028223815
  • DelwarZMLiuGKuoYTumour-specific triple-regulated oncolytic herpes virus to target gliomaOncotarget20167286582866927070093
  • EsakiSRabkinSDMartuzaRLWakimotoHTransient fasting enhances replication of oncolytic herpes simplex virus in glioblastomaAm J Cancer Res2016630031127186404
  • KharePDLiaoSHiroseYTumor growth suppression by a retroviral vector displaying scFv antibody to CEA and carrying the iNOS geneAnticancer Res2002222443244612174941
  • LiFGuoYHanLIn vitro and in vivo growth inhibition of drug-resistant ovarian carcinoma cells using a combination of cisplatin and a TRAIL-encoding retrovirusOncol Lett201241254125823205123
  • SchambachAMorganMRetroviral vectors for cancer gene therapyRecent Results Cancer Res2016209173528101685
  • LuYCChenYJYuYRReplicating retroviral vectors for oncolytic virotherapy of experimental hepatocellular carcinomaOncol Rep201228212622552490
  • LoggCRRobbinsJMJollyDJGruberHEKasaharaNRetroviral replicating vectors in cancerMethods Enzymol201250719922822365776
  • XiaoLJooKILimMWangPDendritic cell-directed vaccination with a lentivector PSCA for prostate cancer in micePLoS One20127e4886623139820
  • RavetLLulkaHGrossFCasteillaLBuscailLCordelierPUsing lentiviral vectors for efficient pancreatic cancer gene therapyCancer Gene Ther20101731532419911032
  • ZhangYWNiuJLuXMulti-target lentivirus specific to hepatocellular carcinoma: in vitro and in vivo studiesJ Hepatol20135850250823149065
  • ChenYSLiHRMiaoYLocal injection of lentivirus-delivered livin shRNA suppresses lung adenocarcinoma growth by inducing a G0/G1-phase cell cycle arrestInt J Clin Exp Pathol2012579680523071862
  • LiRYangHQHiHLFengSQinRHInhibition of CDH17 gene expression via RNA interference reduces proliferation and apoptosis of human MKN28 gastric cancer cellsInt J Oncol201750152227909714
  • YanFWangXZhuMHuXRNAi-mediated downregulation of cyclin Y to attenuate human breast cancer cell growthOncol Rep2016362793279927666310
  • TianLLiuJXiaGHChenBARNAi-mediated knockdown of MCM7 gene on CML cells and its therapeutic potential for leukemiaMed Oncol2017342128058629
  • YolamanovaMMeierCShaytanAKPeptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating virusesNat Nanotechnol2013813013623334171
  • RanzaniMCesanaDBartolomaeCCLentiviral vector-based insertional mutagenesis identifies genes associated with liver cancerNat Methods20131015516123314173
  • UhligKMSchülkeSScheupleinVALentiviral protein transfer vectors are an efficient vaccine platform and induce a strong antigen-specific cytotoxic T cell responseJ Virol2015899044906026085166
  • LiljeströmPGaroffHA new generation of animal cell expression vectors based on the Semliki Forest virus repliconBiotechnology (N Y)19919135613611370252
  • XiongCLevisRShenPSchlesingerSRiceCMHuangHVSindbis virus: an efficient, broad host range vector for gene expression in animal cellsScience1989243118811912922607
  • DavisNLWillisLVSmithJFJohnstonREIn vitro synthesis of infectious Venezuelan equine encephalitis virus RNA from a cDNA clone: analysis of a viable deletion mutantVirology19891711892042525837
  • YingHZaksTZWangRFCancer therapy using a self-replicating RNA vaccineNat Med1999582382710395329
  • MurphyAMMorris-DownesMMSheahanBJAtkinsGJInhibition of human lung carcinoma cell growth by apoptosis induction using Semliki Forest virus recombinant particlesGene Ther200071477148211001367
  • LeitnerWWHwangLNdeVeerMJAlphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathwaysNat Med20039333912496961
  • Vähä-KoskelaMJKallioJPJanssonLCOncolytic capacity of attenuated replicative Semliki Forest virus in human melanoma xenografts in severe combined immunodeficient miceCancer Res2006667185719416849565
  • KetolaAHinkkanenAYongabiFOncolytic Semliki Forest virus vector as a novel candidate against unresectable osteosarcomaCancer Res2008688342835018922906
  • MäättäAMMäkinenKKetolaAReplication competent Semliki Forest virus prolongs survival in experimental lung cancerInt J Cancer20081231704171118651570
  • AutioKPRuotsalainenJJAnttilaMOAttenuated Semliki Forest virus for cancer treatment in dogs: safety assessment in two laboratory beaglesBMC Vet Res20151117026215394
  • TsengJCLevinBHurtadoASystemic tumor targeting and killing by Sindbis viral vectorsNat Biotechnol200422707714647305
  • Rodriguez-MadozJRPrietoJSmerdouCBiodistribution and tumor infectivity of Semliki Forest virus vectors in mice: effects of re-administrationMol Ther2007152164217117667947
  • LundstromKBoulikasTBreakthrough in cancer therapy: encapsulation of drugs and virusesCurr Drug Discov2002111923
  • YlösmäkiEMartikainenMHinkkanenASakselaKAttenuation of Semliki Forest virus neurovirulence by microRNA-mediated detargetingJ Virol20138733534423077310
  • LinYZhangHLiangJIdentification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancersProc Natl Acad Sci U S A2014111E4504E451225288727
  • ZhangHLinYLiKNaturally existing oncolytic virus M1 Is nonpathogenic for the nonhuman primates after multiple rounds of repeated intravenous injectionsHum Gene Ther20162770071127296553
  • MartikainenMRuotsalainenJTuomelaJOncolytic alphavirus SFV-VA7 efficiently eradicates subcutaneous and orthotopic human prostate tumours in miceBr J Cancer2017117515528557974
  • PijlmanGPSuhrbierAKhromykhAAKunjin virus replicons: an RNA-based, non-cytopathic viral vector system for protein production, vaccine and gene therapy applicationsExp Opin Biol Ther20066134145
  • ShiPYTilgnerMLoMKConstruction and characterization of subgenomic replicons of New York strain of West Nile virusVirology200229621923312069521
  • MolenkampRKooiEALucassenMAYellow fever virus replicons as an expression system for hepatitis C virus structural proteinsJ Virol2003771644164812502883
  • JonesMDavidsonAHibbertLDengue virus inhibits alpha interferon signaling by reducing STAT2 expressionJ Virol2005795414542015827155
  • GherkeREckerMAberleSWAllisonSLHeinzFXMandlCWIncorporation of tick-borne encephalitis virus replicons into virus-like particles by a packaging cell lineJ Virol2003778924893312885909
  • Hoang-LeDSmeenkLAnrakuIA Kunjin replicon vector encoding granulocyte macrophage colony-stimulating factor for intratumoral gene therapyGene Ther20091619019919092857
  • OsakadaFCallawayEMDesign and generation of recombinant rabies virus vectorsNat Protoc201381583160123887178
  • ItoNTakayama-ItoMYamadaKHosokawaJSugiyamaMMinamotoNImproved recovery of rabies virus from cloned cDNA using a vaccinia virus-free reverse genetics systemMicrobiol Immunol20034761361714524622
  • AnHKimGNKangCYGenetically modified VSVNJ vector is capable of accommodating a large foreign gene insert and allows high level gene expressionVirus Res201317116817723207069
  • MurphyAMBesmerDMMoerdyk-SchauweckerMVesicular stomatitis virus as an oncolytic agent against pancreatic ductal adenocarcinomaJ Virol2012863073308722238308
  • HastieEBesmerDMShahNROncolytic vesicular stomatitis virus in an immunocompetent model of MUC1-positive of MUC1-null pancreatic ductal adenocarcinomaJ Virol201387102831029423864625
  • HastieEGrdzelishviliVZVesicular stomatitis virus as a flexible platform for oncolytic virotherapy against cancerJ Gen Virol2012932529254523052398
  • FeltSAMoerdyk-SchauweckerMJGrdzelishviliVZInduction of apoptosis in pancreatic cancer cells by vesicular stomatitis virusVirology201547416317325463614
  • Le BoeufFSelmanMSonHHOncolytic Maraba virus MG1 as a treatment for sarcomaInt J Cancer20171411257126428568891
  • ZhouYWenFZhangPTangRLiQVesicular stomatitis virus is a potent agent for the treatment of malignant ascitesOncol Rep2016351573158126707610
  • RadeckeFSpielhoferPSchneiderHRescue of measles viruses from cloned DNAEMBO J199514577357848846771
  • MsaouelPIankovIDDispenzieriAGalanisEAttenuated oncolytic measles virus strains as cancer therapeuticsCurr Pharm Biotechnol2012131732174121740361
  • GroteDRussellSJCornuTILive attenuated measles virus induces regression of human lymphoma xenografts in immunodeficient miceBlood2001973746375411389012
  • HasegawaKPhamLO’ConnorMKFederspielMJRussellSJPengKWDual therapy of ovarian cancer using measles viruses expressing carcinoembryonic antigen and sodium iodide symporterClin Cancer Res2006121868187516551872
  • McDonaldCJErlichmanCIngleJNA measles virus vaccine strain derivative as a novel oncolytic agent against breast cancerBreast Cancer Res Treat20069917718416642271
  • MsaouelPIankovIDAllenCEngineered measles virus as a novel oncolytic therapy against prostate cancerProstate200969829118973133
  • ParaskevakouGAllenCNakamuraTEpidermal growth factor receptor (EGFR)-retargeted measles virus strains effectively target EGFR- or EGFRvIII expressing gliomasMol Ther20071567768617299404
  • KleinlützumDHanauerJDMuikAEnhancing the oncolytic activity of CD133-targeted measles virus: receptor extension or chimerism with vesicular stomatitis virus are most effectiveFront Oncol2017712728695108
  • VeinaldeRGrossardtCHartmannLOncolytic measles virus encoding interleukin-12 mediates potent antitumor effects through T cell activationOncoimmunology20176e128599228507792
  • CsataryLKMossRWBeuthHTöröcsikBSzeberenyiJBakacsTBeneficial treatment of patients with advanced cancer using a Newcastle disease virus vaccine (MHT-68/H)Anticancer Res19991963563810216468
  • ZhaoLLiuHNewcastle disease virus: a promising agent for tumor immunotherapyClin Exp Pharmacol Physiol20123972573022211810
  • NiuZBaiFSunTRecombinant Newcastle disease virus expressing IL15 demonstrates promising antitumor efficiency in melanoma modelTechnol Cancer Res Treat20151460761524645750
  • ChaiZZhangPFuFOncolytic therapy of a recombinant Newcastle disease virus D90 strain for lung cancerVirol J2014118424885546
  • KumarRTiwariAKChaturvediUVelogenic Newcastle disease virus as an oncolytic virotherapeutics: in vitro characterizationAppl Biochem Biotechnol20121672005202222644640
  • WuYHeJAnYRecombinant Newcastle disease virus (NDV/ANH-IL-2) expressing human IL-2 as a potential candidate suppresses growth of hepatoma therapyJ Pharmacol Sci2016132243027174862
  • WuYHeJGengJRecombinant Newcastle disease virus expressing human TRAIL as a potential candidate for hepatoma therapyEur J Pharmacol2017802859228246027
  • ChengXWangWXuQGenetic modification of oncolytic New-castle disease virus for cancer therapyJ Virol2016905343535227009956
  • CasselWAMurrayDRA ten-year follow-up on stage II malignant melanoma patients treated postsurgically with Newcastle disease virus oncolysateMed Oncol Tumor Pharmacother199291691711342060
  • SteinerHHBonsantoMMBeckhovePAntitumor vaccination of patients with glioblastoma multiforme: a pilot study to assess feasibility, safety, and clinical benefitJ Clin Oncol2004224272428115452186
  • Herold-MendeCKarcherJDyckhoffGSchirrmacherVAntitumor immunization of head and neck squamous cell carcinoma patients with a virus-modified autologous tumor cell vaccineAdv Otorhinolaryngol20056217318315608427
  • ZehHJBartlettDLDevelopment of a replication-selective oncolytic poxvirus for the treatment of human cancersCancer Gene Ther200291001101212522439
  • MastrangeloMJLattimeECVirotherapy clinical trials for regional disease: in situ immune modulation using recombinant poxvirus vectorsCancer Gene Ther200291013102112522440
  • ChenBTimiryasovaTMHaghighatPLow-dose vaccinia virus-mediated cytokine gene therapy of gliomaJ Immunother200124465711211148
  • EhrigKKilincMOChenNGGrowth inhibition of different human colorectal cancer xenografts after a single intravenous injection of oncolytic vaccinia virus GLV-1h68J Transl Med2013117923531320
  • ChernichenkoNLinkovGLiPOncolytic vaccinia virus therapy of salivary gland carcinomaJAMA Otolaryngol Head Neck Surg201313917318223429949
  • HaddadDChenNZhangQA novel genetically modified vaccinia virus in experimental models is effective against a wide range of human cancersAnn Surg Oncol201219Suppl 3S665S67422258815
  • BinzEBerchtoldSBeilJChemovirotherapy of pancreatic adenocarcinoma by combining oncolytic vaccinia virus GLV-1h68 with nab-paclitaxel plus gemcitabineMol Ther Oncolytics20176102128607950
  • BrunJMahoneyDJLe BoeufFOncolytic vaccinia virus safely and effectively treats skin tumors in mouse models of xeroderma pigmentosumInt J Cancer201313272673122733395
  • MellLKBrumundKTDanielsGAPhase I trial of intravenous oncolytic vaccinia virus (GL-ONC1) with cisplatin and radiotherapy in patients with locoregionally advanced head and neck carcinomaClin Cancer Res2017235696570228679776
  • CrainicRCoudercTMartinAWychowskiCGirardMHoraudFAn insight into poliovirus biologyAdv Exp Med Biol198925761662482671
  • BradleySJakesADHarringtonKPandhaHMelcherAErrington-MaisFApplications of coxsackievirus A21 in oncologyOncolytic Virother20143475527512662
  • ShafrenDRAuGGNguyenTSystemic therapy of malignant human melanoma tumors by a common cold-producing enterovirus, coxsackievirus A21Clin Cancer Res200410536014734451
  • AuGGLinczLFEnnoAShafrenDROncolytic coxsackievirus A21 as a novel therapy for multiple myelomaBr J Haematol200713713314117391493
  • SkeldingKABarryRDShafrenDRSystemic targeting of metastatic human breast tumor xenografts by coxsackievirus A21Breast Cancer Res Treat2009113213018256929
  • BerryLJAuGGBarryRDPotent oncolytic activity of human enteroviruses against human prostate cancerProstate20086857758718288643
  • YeeYWChanSHQuahMYShafrenDROncolytic activity of coxsackievirus A21 (CAVATAK) in human lung cancer: a novel targeted anti-cancer strategyPoster presented at: 14th World Conference on Lung CancerJuly 3–7, 2011Amsterdam, Netherlands
  • BreitbachCJDe SilvaNSFallsTJTargeting tumor vasculature with an oncolytic virusMol Ther20111988689421364541
  • BenenciaFCourregesMCConejo-GarciaJROncolytic HSV exerts direct antiangiogenic activity in ovarian carcinomaHum Gene Ther20051676577815960607
  • BreitbachCJArulanandamRDe SilvaNOncolytic vaccinia virus disrupts tumor-associated vasculature in humansCancer Res2013731265127523393196
  • ZhangZZouWWangJSuppression of tumor growth by oncolytic adenovirus-mediated delivery of an antiangiogenic gene, soluble Flt-1Mol Ther20051155356215771958
  • GholamiSMaranoAChenNGA novel vaccinia virus with dual oncolytic and anti-angiogenic therapeutic effects against triple-negative breast cancerBreast Cancer Res Treat201414848949925391896
  • HouWZChenHRojasJSampathPThorneSHOncolytic vaccinia virus demonstrates antiangiogenic effects mediated by targeting of VEGFInt J Cancer20141351238124624474587
  • JhaBKPolyakovaIKesslerPInhibition of RNase L and RNA-dependent protein kinase (PKR) by sunitinib impairs antiviral innate immunityJ Biol Chem2011286263192632621636578
  • JhaBKDongBNguyenCTPolyakovaISilvermanRHSuppression of antiviral innate immunity by sunitinib enhances oncolytic virotherapyMol Ther2013211749175723732991
  • PassaroCBorrielloFVastoloVThe oncolytic virus dl922-947 reduces IL-8/CXCL8 and MCP-1/CCL2 expression and impairs angiogenesis and macrophage infiltration in anaplastic thyroid carcinomaOncotarget201671500151526625205
  • TaguchiSFukuharaHHommaYTodoTCurrent status of clinical trials assessing oncolytic virus therapy for urological cancersInt J Urol20172434235128326624
  • BurkeJMLammDLMengMVA first in human phase 1 study of CG0070, a GM-CSF expressing oncolytic adenovirus, for the treatment of nonmuscle invasive bladder cancerJ Urol20121882391239723088985
  • SmallEJCarducciMABurkeJMA phase I trial of intravenous CG7870, a replication-selective, prostate-specific antigen-targeted oncolytic adenovirus, for the treatment of hormone-refractory, metastatic prostate cancerMol Ther20061410711716690359
  • FreytagSOKhilMStrickerHPhase I study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancerCancer Res2002624968497612208748
  • PecoraALRizviNCohenGIPhase I trial of intravenous administration of PV701, an oncolytic virus, in patients with advanced solid cancersJ Clin Oncol2002202251226611980996
  • ParkBHHwangTLiuTCUse of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trialLancet Oncol2008953354218495536
  • KimSGHwangTHPhase 2 trial of Pexa-Vec (pexastimogene devacirepvec; JX-594), an oncolytic and immunotherapeutic vaccinia virus, in patients with metastatic, refractory renal cell carcinoma (RCC)Eur J Cancer201551S510
  • GomellaLGMastrangeloMJMcCuePAMaguireHCMulhollandSGLattimeECPhase 1 study of intravesical vaccinia virus as a vector for gene therapy of bladder cancerJ Urol20011661291129511547060
  • GulleyJLHeeryCRMadanRAPhase I study of intraprostatic vaccine administration in men with locally recurrent or progressive prostate cancerCancer Immunol Immunother2013621521153123836412
  • VidalLPandhaHSYapTAA phase I study of intravenous oncolytic reovirus type 3 Dearing in patients with advanced cancerClin Cancer Res2008147127713718981012
  • NoonanAMFarrenMRGeyerSMRandomized phase 2 trial of the oncolytic virus pelareorep (Reolysin) in upfront treatment of metastatic pancreatic adenocarcinomaMol Ther2016241150115827039845
  • GalanisEMarkovicSNSumanVJPhase II trial of intravenous administration of Reolysin (reovirus serotype-3-dearing strain) in patients with metastatic melanomaMol Ther2012201998200322871663
  • KarapanaglotouEMRoulstoneVTwiggerKPhase I/II trial of carboplatin and paclitaxel chemotherapy in combination with intravenous oncolytic reovirus in patients with advanced malignanciesClin Cancer Res2012182080208922316603
  • PatelDMForemanPMNaborsLBRileyKGillespieYMarkertJDesign of a phase I clinical trial to evaluate M032, a genetically engineered HSV-1 expressing IL-12, in patients with recurrent/progressive glioblastoma multiforme, anaplastic astrocytoma, or gliosarcomaHum Gene Ther Clin Dev201627697827314913
  • RothJCCassadyKACodyJJEvaluation of the safety and biodistribution of M032 an attenuated herpes simplex virus type 1 expressing hIL-12 after intracerebral administration of Aotus nonhuman primatesHum Gene Ther Clin Dev201425162724649838
  • MarkertJMRazdanSNKuoHCA phase 1 trial of oncolytic HSV-1, G207, given in combination with radiation for recurrent GBM demonstrates safety and radiographic responsesMol Ther2014221048105524572293
  • MarkertJMLiechtyPGWangWPhase 1B trial of mutant herpes simplex virus G207 inoculated pre- and post-tumor resection for recurrent GBMMol Ther20091719920718957964
  • SlovinSFKehoeMDursoRA phase I dose escalation trial of vaccine replicon particles (VRP) expressing prostate-specific membrane antigen (PSMA) in subjects with prostate cancerVaccine20133194394923246260
  • PandhaHHarringtonKRalphCMelcherAGroseMShafrenDPhase I/II storm study: intravenous delivery of a novel oncolytic immunotherapy agent, coxsackievirus A21, in advanced cancer patientsJ Immunother Cancer20153P341
  • AndtbackaRHCurtiBDHallmeyerSPhase II calm extension study: coxsackievirus A21 delivered intratumorally to patients with advanced melanoma induces immune-cell infiltration in the tumor microenvironmentJ Immunother Cancer20153P343
  • SilkAWKaufmanHGabrielNPhase 1B study of intratumoral coxsackievirus A21 (CVA21) and systemic pembrolizumab in advanced melanoma patients: interim results of the CAPRA clinical trialCancer Res201777CT026
  • RätyJKPikkarainenJTWirthTGene therapy: the first approved gene-based medicines, molecular mechanisms and clinical indicationsCurr Mol Pharmacol20081132320021420
  • LiuTCKimDGene therapy progress and prospects cancer: oncolytic virusesGene Ther20081587788418418413
  • FukuharaHInoYTodoTOncolytic virus therapy: a new era of cancer treatment at dawnCancer Sci20161071373137927486853
  • KaufmanHLKimDWDeRaffeleGMitchamJCoffinRSKim-SchulzeSLocal and distant immunity induced by intralesional vaccination with an oncolytic herpes virus encoding GM-CSF in patients with stage IIIC and IV melanomaAnn Surg Oncol20101771873019915919
  • HeoJReidTRuoLRandomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancerNat Med20131932933623396206
  • InoYTodoTClinical development of a third-generation HSV-1 (G47δ) for malignant gliomaGene Ther Regul20105101111
  • RameshNGeYEnnistDLCG0070, a conditionally replicating granulocyte macrophage colony-stimulating factor-armed oncolytic adenovirus for the treatment of bladder cancerClin Cancer Res20061230531316397056
  • GollamudiRGhalibMHDesaiKKIntravenous administration of Reolysin, a live replication competent RNA virus is safe in patients in advanced solid tumorsInvest New Drugs20102864164919572105