Hepatocellular carcinoma: natural history, current management, and emerging tools

References

• BoschFXRibesJCleriesRDiazMEpidemiology of hepatocellular carcinomaClin Liver Dis200592191211v15831268
   PubMed Web of Science ®Google Scholar
• JemalABrayFCenterMMFerlayJWardEFormanDGlobal cancer statisticsCA Cancer J Clin2011612699021296855
   PubMed Web of Science ®Google Scholar
• El-SeragHBHepatocellular carcinomaN Engl J Med2011365121118112721992124
   PubMed Web of Science ®Google Scholar
• A new prognostic system for hepatocellular carcinoma: a retrospective study of 435 patients: the Cancer of the Liver Italian Program (CLIP) investigatorsHepatology19982837517559731568
   PubMed Web of Science ®Google Scholar
• BartlettDLDi BisceglieAMDawsonLACancer of the liverDeVitaVTLawrenceTSRosenbergSACancer: Principles and Practice of Oncology8th edPhiladelphiaLippincott Williams and Wilkins200811291156
   Google Scholar
• RossettoAAdaniGLRisalitiACombined approach for spontaneous rupture of hepatocellular carcinomaWorld J Hepatol201021495121160956
   PubMedGoogle Scholar
• KassianidesCKewMCThe clinical manifestations and natural history of hepatocellular carcinomaGastroenterol Clin North Am19871645535622831150
   PubMed Web of Science ®Google Scholar
• YoonKTKimJKKim doYRole of 18F-fluorodeoxyglucose positron emission tomography in detecting extrahepatic metastasis in pretreatment staging of hepatocellular carcinomaOncology (Williston Park)200772Suppl 1104110
   Web of Science ®Google Scholar
• WudelLJJrDelbekeDMorrisDThe role of [18F]fluorodeoxyglucose positron emission tomography imaging in the evaluation of hepatocellular carcinomaAm Surg2003692117124 discussion 124–12612641351
   PubMed Web of Science ®Google Scholar
• CarriagaMTHensonDELiver, gallbladder, extrahepatic bile ducts, and pancreasCancer199575Suppl 11711908000995
   PubMed Web of Science ®Google Scholar
• KatyalSOliverJH3rdPetersonMSFerrisJVCarrBSBaronRLExtrahepatic metastases of hepatocellular carcinomaRadiology2000216369870310966697
   PubMed Web of Science ®Google Scholar
• DoddGD3rdBaronRLOliverJH3rdFederleMPBaumgartelPBEnlarged abdominal lymph nodes in end-stage cirrhosis: CT-histopathologic correlation in 507 patientsRadiology199720311271309122379
   PubMed Web of Science ®Google Scholar
• SohalDPSunWHepatocellular carcinoma: prevention and therapyCurr Oncol Rep201113318619421409527
   PubMed Web of Science ®Google Scholar
• McGlynnKALondonWTThe global epidemiology of hepatocellular carcinoma: present and futureClin Liver Dis2011152223243viix21689610
   PubMed Web of Science ®Google Scholar
• BruixJShermanMManagement of hepatocellular carcinomaHepatology20054251208123616250051
   PubMed Web of Science ®Google Scholar
• BeasleyRPHwangLYLinCCChienCSHepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in TaiwanLancet198128256112911336118576
   PubMed Web of Science ®Google Scholar
• DavilaJAMorganROShaibYMcGlynnKAEl-SeragHBHepatitis C infection and the increasing incidence of hepatocellular carcinoma: a population-based studyGastroenterology200412751372138015521006
   PubMed Web of Science ®Google Scholar
• El-SeragHBMasonACRisk factors for the rising rates of primary liver cancer in the United StatesArch Intern Med2000160213227323011088082
   PubMedGoogle Scholar
• SunCAWuDMLinCCIncidence and cofactors of hepatitis C virus-related hepatocellular carcinoma: a prospective study of 12,008 men in TaiwanAm J Epidemiol2003157867468212697571
   PubMed Web of Science ®Google Scholar
• ZanettiARVan DammePShouvalDThe global impact of vaccination against hepatitis B: a historical overviewVaccine200826496266627318848855
   PubMed Web of Science ®Google Scholar
• BefritsRHedmanMBlomquistLChronic hepatitis C in alcoholic patients: prevalence, genotypes, and correlation to liver diseaseScand J Gastroenterol19953011111311188578173
   PubMed Web of Science ®Google Scholar
• DonatoFTaggerAGelattiUAlcohol and hepatocellular carcinoma: the effect of lifetime intake and hepatitis virus infections in men and womenAm J Epidemiol2002155432333111836196
   PubMed Web of Science ®Google Scholar
• TrichopoulosDBamiaCLagiouPHepatocellular carcinoma risk factors and disease burden in a European cohort: a nested case-control studyJ Natl Cancer Inst2011103221686169522021666
   PubMedGoogle Scholar
• ShermanMLlovetJMSmoking, hepatitis B virus infection, and development of hepatocellular carcinomaJ Natl Cancer Inst2011103221642164322021668
   PubMedGoogle Scholar
• WolkAGridleyGSvenssonMA prospective study of obesity and cancer risk (Sweden)Cancer Causes Control2001121132111227921
   PubMed Web of Science ®Google Scholar
• PoleselJZucchettoAMontellaMThe impact of obesity and diabetes mellitus on the risk of hepatocellular carcinomaAnn Oncol200920235335718723550
   PubMed Web of Science ®Google Scholar
• RegimbeauJMColombatMMognolPObesity and diabetes as a risk factor for hepatocellular carcinomaLiver Transpl2004102 Suppl 1S69S7314762843
   PubMedGoogle Scholar
• TakamatsuSNoguchiNKudohAInfluence of risk factors for metabolic syndrome and non-alcoholic fatty liver disease on the progression and prognosis of hepatocellular carcinomaHepatogastroenterology20085582–8360961418613418
   PubMedGoogle Scholar
• AschaMSHanounehIALopezRTamimiTAFeldsteinAFZeinNNThe incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitisHepatology20105161972197820209604
   PubMed Web of Science ®Google Scholar
• ChenCJWangLYLuSNElevated aflatoxin exposure and increased risk of hepatocellular carcinomaHepatology199624138428707279
   PubMed Web of Science ®Google Scholar
• SanyalAJYoonSKLencioniRThe etiology of hepatocellular carcinoma and consequences for treatmentOncologist201015Suppl 4142221115577
   PubMed Web of Science ®Google Scholar
• VillanuevaANewellPHoshidaYInherited hepatocellular carcinomaBest Pract Res Clin Gastroenterol201024572573420955973
   PubMed Web of Science ®Google Scholar
• FattovichGStroffoliniTZagniIDonatoFHepatocellular carcinoma in cirrhosis: incidence and risk factorsGastroenterology20041275 Suppl 1S35S5015508101
   PubMed Web of Science ®Google Scholar
• DraganiTARisk of HCC: genetic heterogeneity and complex geneticsJ Hepatol201052225225720022654
   PubMed Web of Science ®Google Scholar
• FracanzaniALConteDFraquelliMIncreased cancer risk in a cohort of 230 patients with hereditary hemochromatosis in comparison to matched control patients with non-iron-related chronic liver diseaseHepatology200133364765111230745
   PubMed Web of Science ®Google Scholar
• CaballeriaLParesACastellsAGinesABruCRodesJHepatocellular carcinoma in primary biliary cirrhosis: similar incidence to that in hepatitis C virus-related cirrhosisAm J Gastroenterol20019641160116311316164
   PubMed Web of Science ®Google Scholar
• BruixJShermanMManagement of hepatocellular carcinoma: an updateHepatology20115331020102221374666
   PubMed Web of Science ®Google Scholar
• National Comprehensive Cancer NetworkNational Comprehensive Cancer Network Clinical Practice Guidelines in Oncology: Hepatobiliary Cancers Version 22012 Available from: http://www.nccn.org/professionals/physician_gls/pdf/hepatobiliary.pdf. Accessed January 27, 2012
   Google Scholar
• ZhangBHYangBHTangZYRandomized controlled trial of screening for hepatocellular carcinomaJ Cancer Res Clin Oncol2004130741742215042359
   PubMed Web of Science ®Google Scholar
• WongLLLimmWMSeverinoRWongLMImproved survival with screening for hepatocellular carcinomaLiver Transpl20006332032510827233
   PubMed Web of Science ®Google Scholar
• ShermanMSerological surveillance for hepatocellular carcinoma: time to quitJ Hepatol201052461461520185193
   PubMed Web of Science ®Google Scholar
• BolondiLSofiaSSiringoSSurveillance programme of cirrhotic patients for early diagnosis and treatment of hepatocellular carcinoma: a cost effectiveness analysisGut200148225125911156649
   PubMed Web of Science ®Google Scholar
• ChenTHChenCJYenMFUltrasound screening and risk factors for death from hepatocellular carcinoma in a high risk group in TaiwanInt J Cancer200298225726111857416
   PubMed Web of Science ®Google Scholar
• YaoFYShould surveillance for hepatocellular carcinoma be increased in patients with cirrhosis and small liver nodules?Nat Clin Pract Gastroenterol Hepatol200631054454517008923
   PubMedGoogle Scholar
• BreedisCYoungGThe blood supply of neoplasms in the liverAm J Pathol195430596997713197542
   PubMed Web of Science ®Google Scholar
• MillerGSchwartzLHD’AngelicaMThe use of imaging in the diagnosis and staging of hepatobiliary malignanciesSurg Oncol Clin N Am200716234336817560517
   PubMed Web of Science ®Google Scholar
• FornerAVilanaRAyusoCDiagnosis of hepatic nodules 20 mm or smaller in cirrhosis: prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinomaHepatology20084719710418069697
   PubMed Web of Science ®Google Scholar
• YehJJUemuraMHepatocellular carcinomaN Engl J Med2012366192 author reply 92–9322216856
   PubMed Web of Science ®Google Scholar
• WeeAFine needle aspiration biopsy of hepatocellular carcinoma and hepatocellular nodular lesions: role, controversies and approach to diagnosisCytopathology201122528730521762411
   PubMed Web of Science ®Google Scholar
• PawlikTMGleisnerALAndersRAAssumpcaoLMaleyWChotiMAPreoperative assessment of hepatocellular carcinoma tumor grade using needle biopsy: implications for transplant eligibilityAnn Surg2007245343544217435551
   PubMed Web of Science ®Google Scholar
• SilvaMAHegabBHydeCGuoBBuckelsJAMirzaDFNeedle track seeding following biopsy of liver lesions in the diagnosis of hepatocellular cancer: a systematic review and meta-analysisGut200857111592159618669577
   PubMed Web of Science ®Google Scholar
• TorzilliGMinagawaMTakayamaTAccurate preoperative evaluation of liver mass lesions without fine-needle biopsyHepatology199930488989310498639
   PubMed Web of Science ®Google Scholar
• LevyIGreigPDGallingerSLangerBShermanMResection of hepatocellular carcinoma without preoperative tumor biopsyAnn Surg2001234220620911505066
   PubMed Web of Science ®Google Scholar
• LokASLaiCLalpha-Fetoprotein monitoring in Chinese patients with chronic hepatitis B virus infection: role in the early detection of hepatocellular carcinomaHepatology1989911101152461890
   PubMed Web of Science ®Google Scholar
• LokASSterlingRKEverhartJEDes-gamma-carboxy prothrombin and alpha-fetoprotein as biomarkers for the early detection of hepatocellular carcinomaGastroenterology2010138249350219852963
   PubMed Web of Science ®Google Scholar
• MarreroJAFengZWangYAlpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinomaGastroenterology2009137111011819362088
   PubMed Web of Science ®Google Scholar
• SangiovanniAManiniMAIavaroneMThe diagnostic and economic impact of contrast imaging techniques in the diagnosis of small hepatocellular carcinoma in cirrhosisGut201059563864419951909
   PubMed Web of Science ®Google Scholar
• BruixJCastellsABoschJSurgical resection of hepatocellular carcinoma in cirrhotic patients: prognostic value of preoperative portal pressureGastroenterology19961114101810228831597
   PubMed Web of Science ®Google Scholar
• LlovetJMFusterJBruixJIntention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: resection versus transplantationHepatology19993061434144010573522
   PubMed Web of Science ®Google Scholar
• KubotaKMakuuchiMKusakaKMeasurement of liver volume and hepatic functional reserve as a guide to decision-making in resectional surgery for hepatic tumorsHepatology1997265117611819362359
   PubMed Web of Science ®Google Scholar
• ShoupMGonenMD’AngelicaMVolumetric analysis predicts hepatic dysfunction in patients undergoing major liver resectionJ Gastrointest Surg20037332533012654556
   PubMed Web of Science ®Google Scholar
• AbdallaEKHicksMEVautheyJNPortal vein embolization: rationale, technique and future prospectsBr J Surg200188216517511167863
   PubMed Web of Science ®Google Scholar
• FargesOBelghitiJKianmaneshRPortal vein embolization before right hepatectomy: prospective clinical trialAnn Surg2003237220821712560779
   PubMed Web of Science ®Google Scholar
• VautheyJNDixonEAbdallaEKPretreatment assessment of hepatocellular carcinoma: expert consensus statementHPB (Oxford)201012528929920590901
   PubMed Web of Science ®Google Scholar
• PawlikTMPoonRTAbdallaEKCritical appraisal of the clinical and pathologic predictors of survival after resection of large hepatocellular carcinomaArch Surg20051405450457 discussion 457–45815897440
   PubMedGoogle Scholar
• ChokKSNgKKPoonRTLoCMFanSTImpact of postoperative complications on long-term outcome of curative resection for hepatocellular carcinomaBr J Surg2009961818719065644
   PubMed Web of Science ®Google Scholar
• YangLYFangFOuDPWuWZengZJWuFSolitary large hepatocellular carcinoma: a specific subtype of hepatocellular carcinoma with good outcome after hepatic resectionAnn Surg2009249111812319106686
   PubMed Web of Science ®Google Scholar
• TjandraJJFanSTWongJPeri-operative mortality in hepatic resectionAust N Z J Surg19916132012061848427
   PubMedGoogle Scholar
• AriiSYamaokaYFutagawaSResults of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: a retrospective and nationwide survey in Japan. The Liver Cancer Study Group of JapanHepatology20003261224122911093728
   PubMed Web of Science ®Google Scholar
• ShiMGuoRPLinXJPartial hepatectomy with wide versus narrow resection margin for solitary hepatocellular carcinoma: a prospective randomized trialAnn Surg20072451364317197963
   PubMed Web of Science ®Google Scholar
• KianmaneshRRegimbeauJMBelghitiJSelective approach to major hepatic resection for hepatocellular carcinoma in chronic liver diseaseSurg Oncol Clin N Am2003121516312735129
   PubMedGoogle Scholar
• SasakiAIwashitaYShibataKOhtaMKitanoSMoriMPreoperative transcatheter arterial chemoembolization reduces long-term survival rate after hepatic resection for resectable hepatocellular carcinomaEur J Surg Oncol200632777377916797156
   PubMed Web of Science ®Google Scholar
• OnoTYamanoiANazmy El AssalOKohnoHNagasueNAdjuvant chemotherapy after resection of hepatocellular carcinoma causes deterioration of long-term prognosis in cirrhotic patients: metaanalysis of three randomized controlled trialsCancer200191122378238511413528
   PubMed Web of Science ®Google Scholar
• PrintzCClinical trials of note. Sorafenib as adjuvant treatment in the prevention of disease recurrence in patients with hepatocellular carcinoma (HCC) (STORM)Cancer200911520464619806596
   PubMedGoogle Scholar
• MazzaferroVRegaliaEDociRLiver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosisN Engl J Med1996334116936998594428
   PubMed Web of Science ®Google Scholar
• MartinAPBartelsMHaussJFangmannJOverview of the MELD score and the UNOS adult liver allocation systemTransplant Proc200739103169317418089345
   PubMed Web of Science ®Google Scholar
• JonasSBechsteinWOSteinmullerTVascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosisHepatology20013351080108611343235
   PubMed Web of Science ®Google Scholar
• FiguerasJIbanezLRamosESelection criteria for liver transplantation in early-stage hepatocellular carcinoma with cirrhosis: results of a multicenter studyLiver Transpl200171087788311679986
   PubMed Web of Science ®Google Scholar
• DuffyJPVardanianABenjaminELiver transplantation criteria for hepatocellular carcinoma should be expanded: a 22-year experience with 467 patients at UCLAAnn Surg20072463502509 discussion 509–51117717454
   PubMed Web of Science ®Google Scholar
• YaoFYFerrellLBassNMBacchettiPAscherNLRobertsJPLiver transplantation for hepatocellular carcinoma: comparison of the proposed UCSF criteria with the Milan criteria and the Pittsburgh modified TNM criteriaLiver Transpl20028976577412200775
   PubMed Web of Science ®Google Scholar
• LeeSGHwangSMoonDBExpanded indication criteria of living donor liver transplantation for hepatocellular carcinoma at one large-volume centerLiver Transpl200814793594518581465
   PubMed Web of Science ®Google Scholar
• YaoFYFerrellLBassNMLiver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survivalHepatology20013361394140311391528
   PubMed Web of Science ®Google Scholar
• HsuHCWuTTWuMZSheuJCLeeCSChenDSTumor invasiveness and prognosis in resected hepatocellular carcinoma. Clinical and pathogenetic implicationsCancer19886110209520992834037
   PubMed Web of Science ®Google Scholar
• LlovetJMBruixJGoresGJSurgical resection versus transplantation for early hepatocellular carcinoma: clues for the best strategyHepatology20003141019102110733561
   PubMed Web of Science ®Google Scholar
• PoonRTOptimal initial treatment for early hepatocellular carcinoma in patients with preserved liver function: transplantation or resection?Ann Surg Oncol200714254154717103069
   PubMed Web of Science ®Google Scholar
• LencioniRLlovetJMModified RECIST (mRECIST) assessment for hepatocellular carcinomaSemin Liver Dis2010301526020175033
   PubMed Web of Science ®Google Scholar
• RiazARyuRKKulikLMAlpha-fetoprotein response after locoregional therapy for hepatocellular carcinoma: oncologic marker of radiologic response, progression, and survivalJ Clin Oncol200927345734574219805671
   PubMed Web of Science ®Google Scholar
• LivraghiTBolondiLLazzaroniSPercutaneous ethanol injection in the treatment of hepatocellular carcinoma in cirrhosis. A study on 207 patientsCancer19926949259291310435
   PubMed Web of Science ®Google Scholar
• KasugaiHOsakiYOkaHKudoMSekiTSevere complications of radiofrequency ablation therapy for hepatocellular carcinoma: an analysis of 3,891 ablations in 2,614 patientsOncology (Williston Park)200772Suppl 17275
   Web of Science ®Google Scholar
• EbaraMOkabeSKitaKPercutaneous ethanol injection for small hepatocellular carcinoma: therapeutic efficacy based on 20-year observationJ Hepatol200543345846416005538
   PubMed Web of Science ®Google Scholar
• BrunelloFVeltriACarucciPRadiofrequency ablation versus ethanol injection for early hepatocellular carcinoma: A randomized controlled trialScand J Gastroenterol200843672773518569991
   PubMed Web of Science ®Google Scholar
• LencioniRAAllgaierHPCioniDSmall hepatocellular carcinoma in cirrhosis: randomized comparison of radio-frequency thermal ablation versus percutaneous ethanol injectionRadiology2003228123524012759473
   PubMed Web of Science ®Google Scholar
• ShiinaSTerataniTObiSA randomized controlled trial of radiofrequency ablation with ethanol injection for small hepatocellular carcinomaGastroenterology2005129112213016012942
   PubMed Web of Science ®Google Scholar
• ChoYKKimJKKimMYRhimHHanJKSystematic review of randomized trials for hepatocellular carcinoma treated with percutaneous ablation therapiesHepatology200949245345919065676
   PubMed Web of Science ®Google Scholar
• OrlandoALeandroGOlivoMAndriulliACottoneMRadiofrequency thermal ablation vs percutaneous ethanol injection for small hepatocellular carcinoma in cirrhosis: meta-analysis of randomized controlled trialsAm J Gastroenterol2009104251452419174803
   PubMed Web of Science ®Google Scholar
• BouzaCLopez-CuadradoTAlcazarRSaz-ParkinsonZAmateJMMeta-analysis of percutaneous radiofrequency ablation versus ethanol injection in hepatocellular carcinomaBMC Gastroenterol200993119432967
   PubMed Web of Science ®Google Scholar
• LivraghiTGoldbergSNLazzaroniSMeloniFSolbiatiLGazelleGSSmall hepatocellular carcinoma: treatment with radio-frequency ablation versus ethanol injectionRadiology1999210365566110207464
   PubMed Web of Science ®Google Scholar
• MazzaferroVBattistonCPerroneSRadiofrequency ablation of small hepatocellular carcinoma in cirrhotic patients awaiting liver transplantation: a prospective studyAnn Surg2004240590090915492574
   PubMed Web of Science ®Google Scholar
• LlovetJMVilanaRBruCIncreased risk of tumor seeding after percutaneous radiofrequency ablation for single hepatocellular carcinomaHepatology20013351124112911343240
   PubMed Web of Science ®Google Scholar
• LuDSYuNCRamanSSRadiofrequency ablation of hepatocellular carcinoma: treatment success as defined by histologic examination of the explanted liverRadiology2005234395496015681691
   PubMed Web of Science ®Google Scholar
• SalaMLlovetJMVilanaRInitial response to percutaneous ablation predicts survival in patients with hepatocellular carcinomaHepatology20044061352136015565564
   PubMed Web of Science ®Google Scholar
• LivraghiTGiorgioAMarinGHepatocellular carcinoma and cirrhosis in 746 patients: long-term results of percutaneous ethanol injectionRadiology199519711011087568806
   PubMed Web of Science ®Google Scholar
• LinSMLinCJLinCCHsuCWChenYCRandomised controlled trial comparing percutaneous radiofrequency thermal ablation, percutaneous ethanol injection, and percutaneous acetic acid injection to treat hepatocellular carcinoma of 3 cm or lessGut20055481151115616009687
   PubMed Web of Science ®Google Scholar
• LivraghiTMeloniFDi StasiMSustained complete response and complications rates after radiofrequency ablation of very early hepatocellular carcinoma in cirrhosis: is resection still the treatment of choice?Hepatology2008471828918008357
   PubMed Web of Science ®Google Scholar
• ChenMSLiJQZhengYA prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinomaAnn Surg2006243332132816495695
   PubMed Web of Science ®Google Scholar
• LüMDKuangMLiangLJSurgical resection versus percutaneous thermal ablation for early–stage hepatocellular carcinoma: a randomized clinical trial [Chinese]Zhonghua Yi Xue Za Zhi2006861280180516681964
   PubMedGoogle Scholar
• LewandowskiRJGeschwindJFLiapiESalemRTranscatheter intraarterial therapies: rationale and overviewRadiology2011259364165721602502
   PubMed Web of Science ®Google Scholar
• BiolatoMMarroneGRaccoSTransarterial chemoembolization (TACE) for unresectable HCC: a new life begins?Eur Rev Med Pharmacol Sci201014435636220496548
   PubMed Web of Science ®Google Scholar
• VarelaMRealMIBurrelMChemoembolization of hepatocellular carcinoma with drug eluting beads: efficacy and doxorubicin pharmacokineticsJ Hepatol200746347448117239480
   PubMed Web of Science ®Google Scholar
• RaoulJLGuyaderDBretagneJFRandomized controlled trial for hepatocellular carcinoma with portal vein thrombosis: intra-arterial iodine-131-iodized oil versus medical supportJ Nucl Med19943511178217877525901
   PubMed Web of Science ®Google Scholar
• KulikLMCarrBIMulcahyMFSafety and efficacy of 90Y radiotherapy for hepatocellular carcinoma with and without portal vein thrombosisHepatology2008471718118027884
   PubMed Web of Science ®Google Scholar
• LlovetJMRealMIMontanaXArterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trialLancet200235993191734173912049862
   PubMed Web of Science ®Google Scholar
• LoCMNganHTsoWKRandomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinomaHepatology20023551164117111981766
   PubMed Web of Science ®Google Scholar
• DhanasekaranRKoobyDAStaleyCAKauhJSKhannaVKimHSComparison of conventional transarterial chemoembolization (TACE) and chemoembolization with doxorubicin drug eluting beads (DEB) for unresectable hepatocelluar carcinoma (HCC)J Surg Oncol2010101647648020213741
   PubMed Web of Science ®Google Scholar
• LammerJMalagariKVoglTProspective randomized study of doxorubicin-eluting-bead embolization in the treatment of hepatocellular carcinoma: results of the PRECISION V studyCardiovasc Intervent Radiol2010331415219908093
   PubMed Web of Science ®Google Scholar
• MalagariKPomoniMKelekisAProspective randomized comparison of chemoembolization with doxorubicin-eluting beads and bland embolization with BeadBlock for hepatocellular carcinomaCardiovasc Intervent Radiol201033354155119937027
   PubMed Web of Science ®Google Scholar
• SalemRLewandowskiRJKulikLRadioembolization results in longer time-to-progression and reduced toxicity compared with chemoembolization in patients with hepatocellular carcinomaGastroenterology2011140249750721044630
   PubMed Web of Science ®Google Scholar
• MolinariMKachuraJRDixonETransarterial chemoembolisation for advanced hepatocellular carcinoma: results from a North American cancer centreClin Oncol (R Coll Radiol)200618968469217100154
   PubMed Web of Science ®Google Scholar
• El-SeragHBMarreroJARudolphLReddyKRDiagnosis and treatment of hepatocellular carcinomaGastroenterology200813461752176318471552
   PubMed Web of Science ®Google Scholar
• MaluccioMACoveyAMPoratLBTranscatheter arterial embolization with only particles for the treatment of unresectable hepatocellular carcinomaJ Vasc Interv Radiol200819686286918503900
   PubMed Web of Science ®Google Scholar
• GishRGPortaCLazarLPhase III randomized controlled trial comparing the survival of patients with unresectable hepatocellular carcinoma treated with nolatrexed or doxorubicinJ Clin Oncol200725213069307517634485
   PubMed Web of Science ®Google Scholar
• ParikhPMFuloriaJBabuGA phase II study of gemcitabine and cisplatin in patients with advanced hepatocellular carcinomaTrop Gastroenterol200526311511816512457
   PubMedGoogle Scholar
• LlovetJMSalaMCastellsLRandomized controlled trial of interferon treatment for advanced hepatocellular carcinomaHepatology2000311545810613728
   PubMed Web of Science ®Google Scholar
• YeoWMokTSZeeBA randomized phase III study of doxorubicin versus cisplatin/interferon alpha-2b/doxorubicin/fluorouracil (PIAF) combination chemotherapy for unresectable hepatocellular carcinomaJ Natl Cancer Inst200597201532153816234567
   PubMedGoogle Scholar
• BarbareJCBoucheOBonnetainFRandomized controlled trial of tamoxifen in advanced hepatocellular carcinomaJ Clin Oncol200523194338434615994145
   PubMed Web of Science ®Google Scholar
• MeliaWMJohnsonPJWilliamsRControlled clinical trial of doxorubicin and tamoxifen versus doxorubicin alone in hepatocellular carcinomaCancer Treat Rep19877112121312162446752
   PubMedGoogle Scholar
• Randomized trial of leuprorelin and flutamide in male patients with hepatocellular carcinoma treated with tamoxifenHepatology20044061361136915565568
   PubMed Web of Science ®Google Scholar
• BeckerGAllgaierHPOlschewskiMZahringerABlumHELong-acting octreotide versus placebo for treatment of advanced HCC: a randomized controlled double-blind studyHepatology200745191517187405
   PubMed Web of Science ®Google Scholar
• BarbareJCBoucheOBonnetainFTreatment of advanced hepatocellular carcinoma with long-acting octreotide: a phase III multicentre, randomised, double blind placebo-controlled studyEur J Cancer200945101788179719303768
   PubMed Web of Science ®Google Scholar
• LlovetJMRicciSMazzaferroVSorafenib in advanced hepatocellular carcinomaN Engl J Med2008359437839018650514
   PubMed Web of Science ®Google Scholar
• ChengALKangYKChenZEfficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trialLancet Oncol2009101253419095497
   PubMed Web of Science ®Google Scholar
• LiuLCaoYChenCSorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5Cancer Res20066624118511185817178882
   PubMed Web of Science ®Google Scholar
• HuynhHMolecularly targeted therapy in hepatocellular carcinomaBiochem Pharmacol201080555056020371362
   PubMed Web of Science ®Google Scholar
• RaoulJLSantoroABeaugrandAEfficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to ECOG performance status: a subanalysis from the SHARP trialJ Clin Oncol5262008Suppl 20 Abstr 4587
   Google Scholar
• ParkYNUpdate on precursor and early lesions of hepatocellular carcinomasArch Pathol Lab Med2011135670471521631263
   PubMed Web of Science ®Google Scholar
• BorzioMFargionSBorzioFImpact of large regenerative, low grade and high grade dysplastic nodules in hepatocellular carcinoma developmentJ Hepatol200339220821412873817
   PubMed Web of Science ®Google Scholar
• VillanuevaAMinguezBFornerAReigMLlovetJMHepatocellular carcinoma: novel molecular approaches for diagnosis, prognosis, and therapyAnnu Rev Med20106131732820059340
   PubMed Web of Science ®Google Scholar
• ParadisVBiecheIDargereDMolecular profiling of hepatocellular carcinomas (HCC) using a large-scale real-time RT-PCR approach: determination of a molecular diagnostic indexAm J Pathol2003163273374112875992
   PubMed Web of Science ®Google Scholar
• LlovetJMChenYWurmbachEA molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosisGastroenterology200613161758176717087938
   PubMed Web of Science ®Google Scholar
• NamSWParkJYRamasamyAMolecular changes from dysplastic nodule to hepatocellular carcinoma through gene expression profilingHepatology200542480981816175600
   PubMed Web of Science ®Google Scholar
• WurmbachEChenYBKhitrovGGenome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinomaHepatology200745493894717393520
   PubMed Web of Science ®Google Scholar
• Di TommasoLFranchiGParkYNDiagnostic value of HSP70, glypican 3, and glutamine synthetase in hepatocellular nodules in cirrhosisHepatology200745372573417326147
   PubMed Web of Science ®Google Scholar
• Di TommasoLDestroASeokJYThe application of markers (HSP70 GPC3 and GS) in liver biopsies is useful for detection of hepatocellular carcinomaJ Hepatol200950474675419231003
   PubMed Web of Science ®Google Scholar
• LiuHLiPZhaiYDiagnostic value of glypican-3 in serum and liver for primary hepatocellular carcinomaWorld J Gastroenterol201016354410441520845507
   PubMed Web of Science ®Google Scholar
• BertinoGArdiriAMCalvagnoGSBertinoNBoemiPMPrognostic and diagnostic value of des-gamma-carboxy prothrombin in liver cancerDrug News Perspect201023849850821031166
   PubMedGoogle Scholar
• ToyodaHKumadaTTadaTClinical utility of highly sensitive Lens culinaris agglutinin-reactive alpha-fetoprotein in hepatocellular carcinoma patients with alpha-fetoprotein < 20 ng/mLCancer Sci201110251025103121244578
   PubMed Web of Science ®Google Scholar
• DurazoFABlattLMCoreyWGDes-gamma-carboxyprothrombin, alpha-fetoprotein and AFP-L3 in patients with chronic hepatitis, cirrhosis and hepatocellular carcinomaJ Gastroenterol Hepatol200823101541154818422961
   PubMed Web of Science ®Google Scholar
• VandecaveyeVDe KeyzerFVerslypeCDiffusion-weighted MRI provides additional value to conventional dynamic contrast-enhanced MRI for detection of hepatocellular carcinomaEur Radiol200919102456246619440718
   PubMed Web of Science ®Google Scholar
• TanCHLowSCThngCHAPASL and AASLD Consensus Guidelines on Imaging Diagnosis of Hepatocellular Carcinoma: a reviewInt J Hepatol20112011111
   Google Scholar
• MarinDDi MartinoMGuerrisiAHepatocellular carcinoma in patients with cirrhosis: qualitative comparison of gadobenate dimeglumine-enhanced MR imaging and multiphasic 64-section CTRadiology20092511859519332848
   PubMed Web of Science ®Google Scholar
• Di MartinoMMarinDGuerrisiAIntraindividual comparison of gadoxetate disodium-enhanced MR imaging and 64-section multidetector CT in the detection of hepatocellular carcinoma in patients with cirrhosisRadiology2010256380681620720069
   PubMed Web of Science ®Google Scholar
• SunHYLeeJMShinCIGadoxetic acid-enhanced magnetic resonance imaging for differentiating small hepatocellular carcinomas (< or = 2 cm in diameter) from arterial enhancing pseudolesions: special emphasis on hepatobiliary phase imagingInvest Radiol20104529610320057319
   PubMed Web of Science ®Google Scholar
• AhnJHYuJSHwangSHChungJJKimJHKimKWNontumorous arterioportal shunts in the liver: CT and MRI findings considering mechanisms and fateEur Radiol201020238539419657644
   PubMed Web of Science ®Google Scholar
• KhanMACombsCSBruntEMPositron emission tomography scanning in the evaluation of hepatocellular carcinomaJ Hepatol200032579279710845666
   PubMed Web of Science ®Google Scholar
• KimYKLeeKWChoSYUsefulness 18F-FDG positron emission tomography/computed tomography for detecting recurrence of hepatocellular carcinoma in posttransplant patientsLiver Transpl201016676777220517911
   PubMed Web of Science ®Google Scholar
• HoCLChenSYeungDWChengTKDual-tracer PET/CT imaging in evaluation of metastatic hepatocellular carcinomaJ Nucl Med200748690290917504862
   PubMed Web of Science ®Google Scholar
• EisenhauerEATherassePBogaertsJNew response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)Eur J Cancer200945222824719097774
   PubMed Web of Science ®Google Scholar
• World Health OrganizationWHO Handbook for Reporting Results of Cancer TreatmentGenevaWHO1979
   Google Scholar
• FornerAAyusoCVarelaMEvaluation of tumor response after locoregional therapies in hepatocellular carcinoma: are response evaluation criteria in solid tumors reliable?Cancer2009115361662319117042
   PubMed Web of Science ®Google Scholar
• MannelliLKimSHajduCHBabbJSClarkTWTaouliBAssessment of tumor necrosis of hepatocellular carcinoma after chemoembolization: diffusion-weighted and contrast-enhanced MRI with histopathologic correlation of the explanted liverAJR Am J Roentgenol200919341044105219770328
   PubMed Web of Science ®Google Scholar
• ChenGMaDQHeWZhangBFZhaoLQComputed tomography perfusion in evaluating the therapeutic effect of transarterial chemoembolization for hepatocellular carcinomaWorld J Gastroenterol200814375738574318837093
   PubMed Web of Science ®Google Scholar
• MaksimovicOSchramlCHartmannJTEvaluation of response in malignant tumors treated with the multitargeted tyrosine kinase inhibitor sorafenib: a multitechnique imaging assessmentAJR Am J Roentgenol2010194151420028898
   PubMed Web of Science ®Google Scholar
• VillanuevaALlovetJMTargeted therapies for hepatocellular carcinomaGastroenterology201114051410142621406195
   PubMed Web of Science ®Google Scholar
• HoshidaYNijmanSMKobayashiMIntegrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinomaCancer Res200969187385739219723656
   PubMed Web of Science ®Google Scholar
• JiJShiJBudhuAMicroRNA expression, survival, and response to interferon in liver cancerN Engl J Med2009361151437144719812400
   PubMed Web of Science ®Google Scholar
• RoesslerSJiaHLBudhuAA unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patientsCancer Res20107024102021021221159642
   PubMed Web of Science ®Google Scholar
• KewMCPrevention of hepatocellular carcinomaAnn Hepatol20109212013220526004
   PubMed Web of Science ®Google Scholar