B cells contribute to MS pathogenesis through antibody-dependent and antibody-independent mechanisms

References

• BeckCAMetzLMSvensonLWPattenSBRegional variation of multiple sclerosis prevalence in CanadaMult Scler200511551651916193887
   PubMed Web of Science ®Google Scholar
• PatyDWEbersGCClinical featuresPatyDEEbersGCMultiple Sclerosis50Philadelphia, PAFA Davis Company1997135191
   Google Scholar
• HurwitzBJThe diagnosis of multiple sclerosis and the clinical subtypesAnn Indian Acad Neurol200912422623020182569
   PubMed Web of Science ®Google Scholar
• EbersGCNatural history of multiple sclerosisJ Neurol Neurosurg Psychiatry200171Suppl 2ii16ii1911701779
   PubMed Web of Science ®Google Scholar
• OpdenakkerGVan DammeJProbing cytokines, chemokines and matrix metalloproteinases towards better immunotherapies of multiple sclerosisCytokine Growth Factor Rev2011225–635936522119009
   PubMed Web of Science ®Google Scholar
• LucchinettiCFPopescuBFBunyanRFInflammatory cortical demyelination in early multiple sclerosisN Engl J Med2011365232188219722150037
   PubMed Web of Science ®Google Scholar
• PetersonJWBoLMorkSChangATrappBDTransected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesionsAnn Neurol200150338940011558796
   PubMed Web of Science ®Google Scholar
• WegnerCEsiriMMChanceSAPalaceJMatthewsPMNeocortical neuronal, synaptic, and glial loss in multiple sclerosisNeurology200667696096717000961
   PubMed Web of Science ®Google Scholar
• VercellinoMPlanoFVottaBMutaniRGiordanaMTCavallaPGrey matter pathology in multiple sclerosisJ Neuropathol Exp Neurol200564121101110716319720
   PubMed Web of Science ®Google Scholar
• MerklerDErnstingTKerschensteinerMBruckWStadelmannCA new focal EAE model of cortical demyelination: multiple sclerosis-like lesions with rapid resolution of inflammation and extensive remyelinationBrain2006129Pt 81972198316714315
   PubMed Web of Science ®Google Scholar
• LassmannHKitzKWisniewskiHMHistogenesis of demyelinating lesions in the spinal cord of guinea pigs with chronic relapsing experimental allergic encephalomyelitisJ Neurol Sci19815011091217229654
   PubMed Web of Science ®Google Scholar
• BaranziniSEJeongMCButunoiCMurrayRSBernardCCOksenbergJRB cell repertoire diversity and clonal expansion in multiple sclerosis brain lesionsJ Immunol199916395133514410528220
   PubMed Web of Science ®Google Scholar
• QinYDuquettePZhangYIntrathecal B-cell clonal expansion, an early sign of humoral immunity, in the cerebrospinal fluid of patients with clinically isolated syndrome suggestive of multiple sclerosisLab Invest20038371081108812861047
   PubMed Web of Science ®Google Scholar
• CepokSRoscheBGrummelVShort-lived plasma blasts are the main B cell effector subset during the course of multiple sclerosisBrain2005128Pt 71667167615800022
   PubMed Web of Science ®Google Scholar
• LucchinettiCBruckWParisiJScheithauerBRodriguezMLassmannHHeterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelinationAnn Neurol200047670771710852536
   PubMed Web of Science ®Google Scholar
• MartinFChanACB cell immunobiology in disease: evolving concepts from the clinicAnnu Rev Immunol20062446749616551256
   PubMed Web of Science ®Google Scholar
• SerafiniBRosicarelliBMagliozziRStiglianoEAloisiFDetection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosisBrain Pathol200414216417415193029
   PubMed Web of Science ®Google Scholar
• MagliozziRHowellOVoraAMeningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathologyBrain2007130Pt 41089110417438020
   PubMed Web of Science ®Google Scholar
• HowellOWReevesCANicholasRMeningeal inflammation is widespread and linked to cortical pathology in multiple sclerosisBrain2011134Pt 92755277121840891
   PubMed Web of Science ®Google Scholar
• Lee-ChangCTopIZephirHPrimed status of transitional B cells associated with their presence in the cerebrospinal fluid in early phases of multiple sclerosisClin Immunol20111391122021310664
   PubMed Web of Science ®Google Scholar
• PetereitHFMoeller-HartmannWReskeDRubbertARituximab in a patient with multiple sclerosis – effect on B cells, plasma cells and intrathecal IgG synthesisActa Neurol Scand2008117639940318031564
   PubMed Web of Science ®Google Scholar
• HauserSLWaubantEArnoldDLB-cell depletion with rituximab in relapsing-remitting multiple sclerosisN Engl J Med2008358767668818272891
   PubMed Web of Science ®Google Scholar
• Martin MdelPCravensPDWingerRDepletion of B lymphocytes from cerebral perivascular spaces by rituximabArch Neurol20096681016102019667224
   PubMedGoogle Scholar
• StuveOCepokSEliasBClinical stabilization and effective B-lymphocyte depletion in the cerebrospinal fluid and peripheral blood of a patient with fulminant relapsing-remitting multiple sclerosisArch Neurol200562101620162316216948
   PubMedGoogle Scholar
• KapposLLiDCalabresiPAOcrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trialLancet201137898051779178722047971
   PubMed Web of Science ®Google Scholar
• Bar-OrAFawazLFanBAbnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS?Ann Neurol201067445246120437580
   PubMed Web of Science ®Google Scholar
• WeberMSProd’hommeTPatarroyoJCB-cell activation influences T-cell polarization and outcome of anti-CD20 B-cell depletion in central nervous system autoimmunityAnn Neurol201068336938320641064
   PubMed Web of Science ®Google Scholar
• LundFERandallTDEffector and regulatory B cells: modulators of CD4(+) T cell immunityNat Rev Immunol201010423624720224569
   PubMed Web of Science ®Google Scholar
• LundFEHollifieldMSchuerKLinesJLRandallTDGarvyBAB cells are required for generation of protective effector and memory CD4 cells in response to Pneumocystis lung infectionJ Immunol2006176106147615416670323
   PubMed Web of Science ®Google Scholar
• LundFEGarvyBARandallTDHarrisDPRegulatory roles for cytokine-producing B cells in infection and autoimmune diseaseCurr Dir Autoimmun20058255415564716
   PubMedGoogle Scholar
• LiuQLiuZRozoCTThe role of B cells in the development of CD4 effector T cells during a polarized Th2 immune responseJ Immunol200717963821383017785819
   PubMed Web of Science ®Google Scholar
• WojciechowskiWHarrisDPSpragueFCytokine-producing effector B cells regulate type 2 immunity to H. polygyrusImmunity200930342143319249230
   PubMed Web of Science ®Google Scholar
• WhitmireJKAsanoMSKaechSMRequirement of B cells for generating CD4+ T cell memoryJ Immunol200918241868187619201839
   PubMed Web of Science ®Google Scholar
• ChenLCDelgadoJCJensenPEChenXDirect expansion of human allospecific FoxP3+CD4+ regulatory T cells with allogeneic B cells for therapeutic applicationJ Immunol200918364094410219684083
   PubMed Web of Science ®Google Scholar
• TuWLauYLZhengJEfficient generation of human alloantigen-specific CD4+ regulatory T cells from naive precursors by CD40- activated B cellsBlood200811262554256218599794
   PubMed Web of Science ®Google Scholar
• ToubiEKesselASlobodinGChanges in macrophage function after rituximab treatment in patients with rheumatoid arthritisAnn Rheum Dis200766681882017148544
   PubMed Web of Science ®Google Scholar
• KesselARosnerIToubiERituximab: beyond simple B cell depletionClin Rev Allergy Immunol2008341747918240027
   PubMed Web of Science ®Google Scholar
• FestaEDHankiewiczKKimSSerum levels of CXCL13 are elevated in active multiple sclerosisMult Scler200915111271127919805441
   PubMed Web of Science ®Google Scholar
• PiccioLNaismithRTTrinkausKChanges in B- and T- lymphocyte and chemokine levels with rituximab treatment in multiple sclerosisArch Neurol201067670771420558389
   PubMed Web of Science ®Google Scholar
• DuddyMNiinoMAdatiaFDistinct effector cytokine profiles of memory and naive human B cell subsets and implication in multiple sclerosisJ Immunol2007178106092609917475834
   PubMed Web of Science ®Google Scholar
• JoffreOvan MeerwijkJPCD4+CD25+ regulatory T lymphocytes in bone marrow transplantationSemin Immunol200618212813516458534
   PubMed Web of Science ®Google Scholar
• VenkenKHellingsNThewissenMCompromised CD4+ CD25(high) regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell levelImmunology20081231798917897326
   PubMed Web of Science ®Google Scholar
• FritzschingBHaasJKonigFIntracerebral human regulatory T cells: analysis of CD4+ CD25+ FOXP3+ T cells in brain lesions and cerebrospinal fluid of multiple sclerosis patientsPLoS One201163e1798821437244
   PubMed Web of Science ®Google Scholar
• BanksWAAre the extracellular pathways a conduit for the delivery of therapeutics to the brain?Curr Pharm Des200410121365137015134487
   PubMed Web of Science ®Google Scholar
• MinagarAOstaninDLongACSerum from patients with multiple sclerosis downregulates occludin and VE-cadherin expression in cultured endothelial cellsMult Scler20039323523812814168
   PubMed Web of Science ®Google Scholar
• ProiaPSchieraGSalemiGRagonesePSavettieriGDi LiegroINeuronal and BBB damage induced by sera from patients with secondary progressive multiple sclerosisInt J Mol Med200924674374719885613
   PubMed Web of Science ®Google Scholar
• AngelucciFMirabellaMFrisulloGCaggiulaMTonaliPABatocchiAPSerum levels of anti-myelin antibodies in relapsing-remitting multiple sclerosis patients during different phases of disease activity and immunomodulatory therapyDis Markers2005212495515920290
   PubMed Web of Science ®Google Scholar
• CrossAHWuGFMultiple sclerosis: oligoclonal bands still yield clues about multiple sclerosisNat Rev Neurol201061158858921048798
   PubMed Web of Science ®Google Scholar
• AwadAHemmerBHartungHPKieseierBBennettJLStuveOAnalyses of cerebrospinal fluid in the diagnosis and monitoring of multiple sclerosisJ Neuroimmunol20102191–21719782408
   PubMed Web of Science ®Google Scholar
• MeinlEKrumbholzMHohlfeldRB lineage cells in the inflammatory central nervous system environment: migration, maintenance, local antibody production, and therapeutic modulationAnn Neurol200659688089216718690
   PubMed Web of Science ®Google Scholar
• ObermeierBMenteleRMalotkaJMatching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosisNat Med200814668869318488038
   PubMed Web of Science ®Google Scholar
• TintoreMRoviraARioJDo oligoclonal bands add information to MRI in first attacks of multiple sclerosis?Neurology20087013 Pt 21079108317881717
   PubMed Web of Science ®Google Scholar
• VillarLMSadabaMCRoldanEIntrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MSJ Clin Invest2005115118719415630459
   PubMed Web of Science ®Google Scholar
• BrennanKMGalban-HorcajoFRinaldiSLipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosisJ Neuroimmunol20112381–2879521872346
   PubMed Web of Science ®Google Scholar
• QinYDuquettePZhangYTalbotPPooleRAntelJClonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosisJ Clin Invest19981025104510509727074
   PubMed Web of Science ®Google Scholar
• OwensGPKrausHBurgoonMPSmith-JensenTDevlinMEGildenDHRestricted use of VH4 germline segments in an acute multiple sclerosis brainAnn Neurol19984322362439485065
   PubMed Web of Science ®Google Scholar
• RitchieAMGildenDHWilliamsonRAComparative analysis of the CD19+ and CD138+ cell antibody repertoires in the cerebrospinal fluid of patients with multiple sclerosisJ Immunol2004173164965615210828
   PubMed Web of Science ®Google Scholar
• StorchMKPiddlesdenSHaltiaMIivanainenMMorganPLassmannHMultiple sclerosis: in situ evidence for antibody- and complement- mediated demyelinationAnn Neurol19984344654719546327
   PubMed Web of Science ®Google Scholar
• KeeganMKonigFMcClellandRRelation between humoral pathological changes in multiple sclerosis and response to therapeutic plasma exchangeLancet2005366948557958216099294
   PubMed Web of Science ®Google Scholar
• CalabreseMFederleLBernardiVThe association of intrathecal immunoglobulin synthesis and cortical lesions predicts disease activity in clinically isolated syndrome and early relapsing-remitting multiple sclerosisMult Scler201218217418021868488
   PubMed Web of Science ®Google Scholar
• RommerPSPatejdlRWinkelmannABeneckeRZettlUKRituximab for secondary progressive multiple sclerosis: a case seriesCNS Drugs201125760761321699272
   PubMed Web of Science ®Google Scholar
• WeinerHLDauPCKhatriBODouble-blind study of true vs sham plasma exchange in patients treated with immunosuppression for acute attacks of multiple sclerosisNeurology1989399114311492549450
   PubMed Web of Science ®Google Scholar
• ZettlUKHartungHPPahnkeABrueckWBeneckeRPahnkeJLesion pathology predicts response to plasma exchange in secondary progressive MSNeurology20066781515151617060593
   PubMed Web of Science ®Google Scholar
• WeinshenkerBGO’BrienPCPettersonTMA randomized trial of plasma exchange in acute central nervous system inflammatory demyelinating diseaseAnn Neurol199946687888610589540
   PubMed Web of Science ®Google Scholar
• RejdakKJacksonSGiovannoniGMultiple sclerosis: a practical overview for cliniciansBr Med Bull20109517910420603280
   PubMed Web of Science ®Google Scholar
• LennonVAWingerchukDMKryzerTJA serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosisLancet200436494512106211215589308
   PubMed Web of Science ®Google Scholar
• LennonVAKryzerTJPittockSJVerkmanASHinsonSRIgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channelJ Exp Med2005202447347716087714
   PubMed Web of Science ®Google Scholar
• WarnerHBCarpRIMultiple sclerosis and Epstein–Barr virusLancet19812825812906118702
   PubMed Web of Science ®Google Scholar
• AscherioAMungerKLEpstein–Barr virus infection and multiple sclerosis: a reviewJ Neuroimmune Pharmacol20105327127720369303
   PubMed Web of Science ®Google Scholar
• JaquieryEJilekSSchluepMIntrathecal immune responses to EBV in early MSEur J Immunol201040387888720017197
   PubMed Web of Science ®Google Scholar
• FarrellRAAntonyDWallGRHumoral immune response to EBV in multiple sclerosis is associated with disease activity on MRINeurology2009731323819458321
   PubMed Web of Science ®Google Scholar
• JafariNvan NieropGPVerjansGMOsterhausADMiddeldorpJMHintzenRQNo evidence for intrathecal IgG synthesis to Epstein Barr virus nuclear antigen-1 in multiple sclerosisJ Clin Virol2010491263120638898
   PubMed Web of Science ®Google Scholar
• SimonKCO’ReillyEJMungerKLFinertySMorganAJAscherioAEpstein–Barr virus neutralizing antibody levels and risk of multiple sclerosisMult Scler20121 [Epub ahead of print.]
   Web of Science ®Google Scholar
• SchwarzMSpectorLGortlerMSerum anti-Glc(alpha1,4) Glc(alpha) antibodies as a biomarker for relapsing-remitting multiple sclerosisJ Neurol Sci20062441–2596816480743
   PubMed Web of Science ®Google Scholar
• LolliFMulinacciBCarotenutoAAn N-glucosylated peptide detecting disease-specific autoantibodies, biomarkers of multiple sclerosisProc Natl Acad Sci U S A200510229102731027816014416
   PubMed Web of Science ®Google Scholar
• WilliamsonRABurgoonMPOwensGPAnti-DNA antibodies are a major component of the intrathecal B cell response in multiple sclerosisProc Natl Acad Sci U S A20019841793179811172030
   PubMed Web of Science ®Google Scholar
• ReindlMLiningtonCBrehmUAntibodies against the myelin oligodendrocyte glycoprotein and the myelin basic protein in multiple sclerosis and other neurological diseases: a comparative studyBrain1999122Pt 112047205610545390
   PubMed Web of Science ®Google Scholar
• SchmidtSHaaseCGBezmanLSerum autoantibody responses to myelin oligodendrocyte glycoprotein and myelin basic protein in X-linked adrenoleukodystrophy and multiple sclerosisJ Neuroimmunol20011191889411525804
   PubMed Web of Science ®Google Scholar
• ZhouDSrivastavaRNesslerSIdentification of a pathogenic antibody response to native myelin oligodendrocyte glycoprotein in multiple sclerosisProc Natl Acad Sci U S A200610350190571906217142321
   PubMed Web of Science ®Google Scholar
• LalivePHMengeTDelarasseCAntibodies to native myelin oligodendrocyte glycoprotein are serologic markers of early inflammation in multiple sclerosisProc Natl Acad Sci U S A200610372280228516461459
   PubMed Web of Science ®Google Scholar
• KarniABakimer-KleinerRAbramskyOBen-NunAElevated levels of antibody to myelin oligodendrocyte glycoprotein is not specific for patients with multiple sclerosisArch Neurol199956331131510190821
   PubMedGoogle Scholar
• LampasonaVFranciottaDFurlanRSimilar low frequency of anti-MOG IgG and IgM in MS patients and healthy subjectsNeurology200462112092209415184621
   PubMed Web of Science ®Google Scholar
• von BudingenHCHarrerMDKuenzleSMeierMGoebelsNClonally expanded plasma cells in the cerebrospinal fluid of MS patients produce myelin-specific antibodiesEur J Immunol20083872014202318521957
   PubMed Web of Science ®Google Scholar
• OwensGPBennettJLLassmannHAntibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluidAnn Neurol200965663964919557869
   PubMed Web of Science ®Google Scholar
• ZhangYDaRRGuoWAxon reactive B cells clonally expanded in the cerebrospinal fluid of patients with multiple sclerosisJ Clin Immunol200525325426415981091
   PubMed Web of Science ®Google Scholar
• ScottJKSmithGPSearching for peptide ligands with an epitope libraryScience199024949673863901696028
   PubMed Web of Science ®Google Scholar
• CorteseITafiRGrimaldiLMMartinoGNicosiaACorteseRIdentification of peptides specific for cerebrospinal fluid antibodies in multiple sclerosis by using phage librariesProc Natl Acad Sci U S A1996932011063110678855309
   PubMed Web of Science ®Google Scholar
• SomersVGovartsCSomersKHuppertsRMedaerRStinissenPAutoantibody profiling in multiple sclerosis reveals novel antigenic candidatesJ Immunol200818063957396318322204
   PubMed Web of Science ®Google Scholar
• RandKHHouckHDenslowNDHeilmanKMMolecular approach to find target(s) for oligoclonal bands in multiple sclerosisJ Neurol Neurosurg Psychiatry199865148559667560
   PubMed Web of Science ®Google Scholar
• CepokSZhouDSrivastavaRIdentification of Epstein-Barr virus proteins as putative targets of the immune response in multiple sclerosisJ Clin Invest200511551352136015841210
   PubMed Web of Science ®Google Scholar
• QuintanaFJFarezMFVigliettaVAntigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosisProc Natl Acad Sci U S A200810548188891889419028871
   PubMed Web of Science ®Google Scholar
• QuintanaFJFarezMFIzquierdoGLucasMCohenIRWeinerHLAntigen microarrays identify CNS-produced autoantibodies in RRMSNeurology201278853253922262743
   PubMed Web of Science ®Google Scholar
• MatheyEKDerfussTStorchMKNeurofascin as a novel target for autoantibody-mediated axonal injuryJ Exp Med2007204102363237217846150
   PubMed Web of Science ®Google Scholar