518
Views
4
CrossRef citations to date
0
Altmetric
Review

Baculoviruses in Gene Therapy and Personalized Medicine

, ORCID Icon & ORCID Icon
Pages 115-132 | Published online: 28 Apr 2021

References

  • Shahryari A, Saghaeian Jazi M, Mohammadi S, et al. Development and clinical translation of approved gene therapy products for genetic disorders. Front Genet. 2019;10:868. doi:10.3389/fgene.2019.00868
  • Rangarajan S, Walsh L, Lester W, et al. AAV5–factor VIII gene transfer in severe hemophilia A. N Engl J Med. 2017;377(26):2519–2530. doi:10.1056/NEJMoa1708483
  • Hinderer C, Katz N, Buza EL, et al. Severe toxicity in nonhuman primates and piglets following high-dose intravenous administration of an adeno-associated virus vector expressing human SMN. Hum Gene Ther. 2018;29(3):285–298. doi:10.1089/hum.2018.015
  • Kanter J, Walters MC, Hsieh MM, et al. Interim results from a Phase 1/2 clinical study of lentiglobin gene therapy for severe sickle cell disease. Blood. 2016;128(22):1176. doi:10.1182/blood.V128.22.1176.1176
  • Nyström A, Bruckner-Tuderman L. Gene therapy for epidermolysis bullosa: sticky business. Mol Ther. 2016;24(12):2035–2036. doi:10.1038/mt.2016.199
  • Vanin EF, Kaloss M, Broscius C, Nienhuis AW. Characterization of replication-competent retroviruses from nonhuman primates with virus-induced T-cell lymphomas and observations regarding the mechanism of oncogenesis. J Virol. 1994;68(7):4241–4250. doi:10.1128/JVI.68.7.4241-4250.1994
  • Kost TA, Condreay JP. Recombinant baculoviruses as mammalian cell gene-delivery vectors. Trends Biotechnol. 2002;20(4):173–180. doi:10.1016/S0167-7799(01)01911-4
  • Volkman LE, Goldsmith PA. In vitro survey of autographa californica nuclear polyhedrosis virus interaction with nontarget vertebrate host cells. Appl Environ Microbiol. 1983;45(3):1085–1093. doi:10.1128/AEM.45.3.1085-1093.1983
  • Paul A, Elias CB, Shum-Tim D, Prakash S. Bioactive baculovirus nanohybrids for stent based rapid vascular re-endothelialization. Sci Rep. 2013;3(1):2366. doi:10.1038/srep02366
  • Cheever MA, Higano CS. PROVENGE (Sipuleucel-T) in prostate cancer: the first FDA-approved therapeutic cancer vaccine. Clin Cancer Res. 2011;17(11):3520–3526. doi:10.1158/1078-0432.Ccr-10-3126
  • Monie A, Hung C-F, Roden R, Wu TC. Cervarix: a vaccine for the prevention of HPV 16, 18-associated cervical cancer. Biologics. 2008;2(1):97–105.
  • Muzzarelli RAA, El Mehtedi M, Bottegoni C, Aquili A, Gigante A. Genipin-crosslinked chitosan gels and scaffolds for tissue engineering and regeneration of cartilage and bone. Mar Drugs. 2015;13(12):7314–7338. doi:10.3390/md13127068
  • Pijlman GP, van den Born E, Martens DE, Vlak JM. Autographa californica baculoviruses with large genomic deletions are rapidly generated in infected insect cells. Virology. 2001;283(1):132–138. doi:10.1006/viro.2001.0854
  • Ishiyama S, Ikeda M. High-level expression and improved folding of proteins by using the vp39 late promoter enhanced with homologous DNA regions. Biotechnol Lett. 2010;32(11):1637–1647. doi:10.1007/s10529-010-0340-7
  • Hefferon KL, Miller LK. Reconstructing the replication complex of AcMNPV. Eur J Biochem. 2002;269(24):6233–6240. doi:10.1046/j.1432-1033.2002.03342.x
  • Whitford M, Stewart S, Kuzio J, Faulkner P. Identification and sequence analysis of a gene encoding gp67, an abundant envelope glycoprotein of the baculovirus Autographa californica nuclear polyhedrosis virus. J Virol. 1989;63(3):1393–1399. doi:10.1128/JVI.63.3.1393-1399.1989
  • Van Der Wilk F, Van Lent JWM, Vlak JM. Immunogold detection of polyhedrin, p10 and virion antigens in Autographa californica nuclear polyhedrosis virus-infected Spodoptera frugiperda cells. J Gen Virol. 1987;68(10):2615–2623. doi:10.1099/0022-1317-68-10-2615
  • Hawtin RE, Zarkowska T, Arnold K, et al. Liquefaction of Autographa californica nucleopolyhedrovirus-infected insects is dependent on the integrity of virus-encoded chitinase and cathepsin genes. Virology. 1997;238(2):243–253. doi:10.1006/viro.1997.8816
  • Miller LK, Lingg AJ, Bulla LA. Bacterial, viral, and fungal insecticides. Science. 1983;219(4585):715–721. doi:10.1126/science.219.4585.715
  • Adang MJ, Miller LK. Molecular cloning of DNA complementary to mRNA of the baculovirus Autographa californica nuclear polyhedrosis virus: location and gene products of RNA transcripts found late in infection. J Virol. 1982;44(3):782–793. doi:10.1128/JVI.44.3.782-793.1982
  • Nasimuzzaman M, van der Loo JCM, Malik P. Production and purification of baculovirus for gene therapy application. J Vis Exp. 2018;134:57019. doi:10.3791/57019
  • Via ST, Zu Altenschildesche GM, Doerfler W. Autographa californica nuclear polyhedrosis virus (AcNPV) DNA does not persist in mass cultures of mammalian cells. Virology. 1983;125(1):107–117. doi:10.1016/0042-6822(83)90067-3
  • Boyce FM, Bucher NL. Baculovirus-mediated gene transfer into mammalian cells. Proc Natl Acad Sci. 1996;93(6):2348–2352. doi:10.1073/pnas.93.6.2348
  • Mehalko JL, Esposito D. Engineering the transposition-based baculovirus expression vector system for higher efficiency protein production from insect cells. J Biotechnol. 2016;238:1–8. doi:10.1016/j.jbiotec.2016.09.002
  • Berger I, Garzoni F, Chaillet M, Haffke M, Gupta K, Aubert A. The multiBac protein complex production platform at the EMBL. J Vis Exp. 2013;77:e50159–e50159. doi:10.3791/50159
  • Pieroni L, Maione D, La Monica N. In vivo gene transfer in mouse skeletal muscle mediated by baculovirus vectors. Hum Gene Ther. 2001;12(8):871–881. doi:10.1089/104303401750195845
  • Fabre ML, Arrías PN, Masson T, Pidre ML, Romanowski V. Baculovirus-derived vectors for immunization and therapeutic applications. Emerging and Reemerging Viral PathogensAcademic Press Elsevier; 2020:197–224.
  • Zhang Z, Yang J, Barford D. Recombinant expression and reconstitution of multiprotein complexes by the USER cloning method in the insect cell-baculovirus expression system. Methods. 2016;95:13–25. doi:10.1016/j.ymeth.2015.10.003
  • Condreay JP, Witherspoon SM, Clay WC, Kost TA. Transient and stable gene expression in mammalian cells transduced with a recombinant baculovirus vector. Proc Natl Acad Sci. 1999;96(1):127–132. doi:10.1073/pnas.96.1.127
  • Luckow VA, Lee SC, Barry GF, Olins PO. Efficient generation of infectious recombinant baculoviruses by site-specific transposon-mediated insertion of foreign genes into a baculovirus genome propagated in Escherichia coli. J Virol. 1993;67(8):4566–4579. doi:10.1128/JVI.67.8.4566-4579.1993
  • Kaba SA, Salcedo AM, Wafula PO, Vlak JM, van Oers MM. Development of a chitinase and v-cathepsin negative bacmid for improved integrity of secreted recombinant proteins. J Virol Methods. 2004;122(1):113–118. doi:10.1016/j.jviromet.2004.07.006
  • Smith GE, Fraser MJ, Summers MD. Molecular engineering of the Autographa californica nuclear polyhedrosis virus genome: deletion mutations within the polyhedrin gene. J Virol. 1983;46(2):584–593. doi:10.1128/JVI.46.2.584-593.1983
  • Hitchman RB, Possee RD, King LA. High-throughput baculovirus expression in insect cells. Methods Mol Biol. 2012;824:609-27. doi:10.1007/978-1-61779-433-9_33
  • Abe T, Kaname Y, Wen X, et al. Baculovirus induces type I interferon production through toll-like receptor-dependent and -independent pathways in a cell-type-specific manner. J Virol. 2009;83(15):7629–7640. doi:10.1128/jvi.00679-09
  • Krämer OH, Göttlicher M, Heinzel T. Histone deacetylase as a therapeutic target. Trends Endocrinol Metab. 2001;12(7):294–300. doi:10.1016/S1043-2760(01)00438-6
  • Monteiro F, Bernal V, Chaillet M, Berger I, Alves PM. Targeted supplementation design for improved production and quality of enveloped viral particles in insect cell-baculovirus expression system. J Biotechnol. 2016;233:34–41. doi:10.1016/j.jbiotec.2016.06.029
  • Seo N-S, Hollister JR, Jarvis DL. Mammalian glycosyltransferase expression allows sialoglycoprotein production by baculovirus-infected insect cells. Protein Expr Purif. 2001;22(2):234–241. doi:10.1006/prep.2001.1432
  • Shi X, Jarvis DL. Protein N-glycosylation in the baculovirus-insect cell system. Curr Drug Targets. 2007;8(10):1116–1125. doi:10.2174/138945007782151360
  • Tani H, Nishijima M, Ushijima H, Miyamura T, Matsuura Y. Characterization of cell-surface determinants important for baculovirus infection. Virology. 2001;279(1):343–353. doi:10.1006/viro.2000.0699
  • Tessier DC, Thomas DY, Khouri HE, Laliberié F, Vernet T. Enhanced secretion from insect cells of a foreign protein fused to the honeybee melittin signal peptide. Gene. 1991;98(2):177–183. doi:10.1016/0378-1119(91)90171-7
  • Hollister J R, Jarvis DL. Engineering lepidopteran insect cells for sialoglycoprotein production by genetic transformation with mammalian β1, 4-galactosyltransferase and α2, 6-sialyltransferase genes. Glycobiology. 2001;11(1):1–9. doi:10.1093/glycob/11.1.1
  • Moremen KW, Ramiah A, Stuart M, et al. Expression system for structural and functional studies of human glycosylation enzymes. Nat Chem Biol. 2018;14(2):156–162. doi:10.1038/nchembio.2539
  • Yokoyama N, Hirata M, Ohtsuka K, et al. Co-expression of human chaperone Hsp70 and Hsdj or Hsp40 co-factor increases solubility of overexpressed target proteins in insect cells. Biochim Biophys Acta Gene Struct Expr. 2000;1493(1–2):119–124. doi:10.1016/S0167-4781(00)00170-6
  • Hsu T-A, Eiden JJ, Bourgarel P, Meo T, Betenbaugh MJ. Effects of co-expressing chaperone BiP on functional antibody production in the baculovirus system. Protein Expr Purif. 1994;5(6):595–603. doi:10.1006/prep.1994.1082
  • Hsu T-A, Watson S, Eiden JJ, Betenbaugh MJ. Rescue of immunoglobulins from insolubility is facilitated by PDI in the baculovirus expression system. Protein Expr Purif. 1996;7(3):281–288. doi:10.1006/prep.1996.0040
  • van Loo N-D, Fortunati E, Ehlert E, Rabelink M, Grosveld F, Scholte BJ. Baculovirus infection of nondividing mammalian cells: mechanisms of entry and nuclear transport of capsids. J Virol. 2001;75(2):961–970. doi:10.1128/jvi.75.2.961-970.2001
  • Sarkis C, Serguera C, Petres S, et al. Efficient transduction of neural cells in vitro and in vivo by a baculovirus-derived vector. Proc Natl Acad Sci U S A. 2000;97(26):14638–14643. doi:10.1073/pnas.260472897
  • Kataoka C, Kaname Y, Taguwa S, et al. Baculovirus GP64-mediated entry into mammalian cells. J Virol. 2012;86(5):2610–2620. doi:10.1128/jvi.06704-11
  • Makkonen K-E, Turkki P, Laakkonen JP, Yla-Herttuala S, Marjomaki V, Airenne KJ. 6-O- and N-Sulfated syndecan-1 promotes baculovirus binding and entry into mammalian cells. J Virol. 2013;87(20):11148–11159. doi:10.1128/jvi.01919-13
  • Morris TD, Miller LK. Promoter influence on baculovirus-mediated gene expression in permissive and nonpermissive insect cell lines. J Virol. 1992;66(12):7397–7405. doi:10.1128/JVI.66.12.7397-7405.1992
  • Hofmann C, Strauss M. Baculovirus-mediated gene transfer in the presence of human serum or blood facilitated by inhibition of the complement system. Gene Ther. 1998;5(4):531–536. doi:10.1038/sj.gt.3300607
  • Ge J, Huang Y, Hu X, Zhong J. A surface-modified baculovirus vector with improved gene delivery to B-lymphocytic cells. J Biotechnol. 2007;129(3):367–372. doi:10.1016/j.jbiotec.2007.01.037
  • Hu L, Li Y, Deng F, Hu Z, Wang H, Wang M. Improving baculovirus transduction of mammalian cells by incorporation of thogotovirus glycoproteins. Virol Sin. 2019;34(4):454–466. doi:10.1007/s12250-019-00133-0
  • Borg J, Nevsten P, Wallenberg R, et al. Amino-terminal anchored surface display in insect cells and budded baculovirus using the amino-terminal end of neuraminidase. J Biotechnol. 2004;114(1–2):21–30. doi:10.1016/j.jbiotec.2004.05.014
  • Martyn JC, Cardin AJ, Wines BD, et al. Surface display of IgG Fc on baculovirus vectors enhances binding to antigen-presenting cells and cell lines expressing Fc receptors. Arch Virol. 2009;154(7):1129–1138. doi:10.1007/s00705-009-0423-8
  • Yu IL, Lin YC, Robinson JH, Lung O. Transduction of vertebrate cells with Spodoptera exigua multiple nucleopolyhedrovirus F protein-pseudotyped gp64-null Autographa californica multiple nucleopolyhedrovirus. J Gen Virol. 2009;90(\(Pt 9)):2282–2287. doi:10.1099/vir.0.012138-0
  • Lee HJ, Park N, Cho HJ, et al. Development of a novel viral DNA vaccine against human papillomavirus: acHERV-HP16L1. Vaccine. 2010;28(6):1613–1619. doi:10.1016/j.vaccine.2009.11.044
  • Barsoum J, Brown R, McKee M, Boyce FM. Efficient transduction of mammalian cells by a recombinant baculovirus having the vesicular stomatitis virus G glycoprotein. Hum Gene Ther. 1997;8(17):2011–2018. doi:10.1089/hum.1997.8.17-2011
  • Mäkelä AR, Matilainen H, White DJ, Ruoslahti E, Oker-Blom C. Enhanced baculovirus-mediated transduction of human cancer cells by tumor-homing peptides. J Virol. 2006;80(13):6603–6611. doi:10.1128/JVI.00528-06
  • Räty JK, Airenne KJ, Marttila AT, et al. Enhanced gene delivery by avidin-displaying baculovirus. Mol Ther. 2004;9(2):282–291. doi:10.1016/j.ymthe.2003.11.004
  • Chen HZ, Wu CP, Chao YC, Liu CY. Membrane penetrating peptides greatly enhance baculovirus transduction efficiency into mammalian cells. Biochem Biophys Res Commun. 2011;405(2):297–302. doi:10.1016/j.bbrc.2011.01.032
  • Tamura T, Kawabata C, Matsushita S, Sakaguchi M, Yoshida S. Malaria sporozoite protein expression enhances baculovirus-mediated gene transfer to hepatocytes. J Gene Med. 2016;18(4–6):75–85. doi:10.1002/jgm.2879
  • Jarvis DL, Fleming J-AGW, Kovacs GR, Summers MD, Guarino LA. Use of early baculovirus promoters for continuous expression and efficient processing of foreign gene products in stably transformed lepidopteran cells. Bio/Technology. 1990;8(10):950–955. doi:10.1038/nbt1090-950
  • López-Vidal J, Gómez-Sebastián S, Sánchez-Ramos I, Escribano JM. Characterization of a Trichoplusia ni hexamerin-derived promoter in the AcMNPV baculovirus vector. J Biotechnol. 2013;165(3):201–208. doi:10.1016/j.jbiotec.2013.03.012
  • Sprick G, Weidner T, Salzig D, Czermak P. Baculovirus-induced recombinant protein expression in human mesenchymal stromal stem cells: a promoter study. N Biotechnol. 2017;39:161–166. doi:10.1016/j.nbt.2017.08.006
  • Gwak W-S, Kim H-S, Bae J-S, Kim T-H, Bae S-M, Woo S-D. Development of a novel enhanced baculovirus expression vector via promoter combination. J Asia Pac Entomol. 2020;23(4):909–914. doi:10.1016/j.aspen.2020.07.016
  • Hu YC, Tsai CT, Chang YJ, Huang JH. Enhancement and prolongation of baculovirus-mediated expression in mammalian cells: focuses on strategic infection and feeding. Biotechnol Prog. 2003;19(2):373–379. doi:10.1021/bp025609d
  • Hoare J, Waddington S, Thomas HC, Coutelle C, McGarvey MJ. Complement inhibition rescued mice allowing observation of transgene expression following intraportal delivery of baculovirus in mice. J Gene Med. 2005;7(3):325–333. doi:10.1002/jgm.671
  • Hüser A, Rudolph M, Hofmann C. Incorporation of decay-accelerating factor into the baculovirus envelope generates complement-resistant gene transfer vectors. Nat Biotechnol. 2001;19(5):451–455. doi:10.1038/88122
  • Kaikkonen MU, Maatta AI, Ylä-Herttuala S, Airenne KJ. Screening of complement inhibitors: shielded baculoviruses increase the safety and efficacy of gene delivery. Mol Ther. 2010;18(5):987–992. doi:10.1038/mt.2010.25
  • Kawai Y, Kawabata C, Sakaguchi M, Tamura T. Protection of baculovirus vectors expressing complement regulatory proteins against serum complement attack. Biol Pharm Bull. 2018;41(10):1600–1605. doi:10.1248/bpb.b18-00451
  • Liu X, Li Y, Hu X, Yi Y, Zhang Z. Gene delivery and gene expression in vertebrate using baculovirus Bombyx mori nucleopolyhedrovirus vector. Oncotarget. 2017;8(62):106017–106025. doi:10.18632/oncotarget.22522
  • Steele KH, Stone BJ, Franklin KM, et al. Improving the baculovirus expression vector system with vankyrin-enhanced technology. Biotechnol Prog. 2017;33(6):1496–1507. doi:10.1002/btpr.2516
  • Palombo F, Monciotti A, Recchia A, Cortese R, Ciliberto G, La Monica N. Site-specific integration in mammalian cells mediated by a new hybrid baculovirus–adeno-associated virus vector. J Virol. 1998;72(6):5025–5034. doi:10.1128/JVI.72.6.5025-5034.1998
  • Luo WY, Shih YS, Hung CL, et al. Development of the hybrid sleeping beauty-baculovirus vector for sustained gene expression and cancer therapy. Gene Ther. 2012;19(8):844–851. doi:10.1038/gt.2011.129
  • Wang Z, Li M, Ji Y, et al. Development of a novel bivalent baculovirus vectors for complement resistance and sustained transgene expression and its application in anti-angiogenesis gene therapy. Biomed Pharmacother. 2020;123:109765. doi:10.1016/j.biopha.2019.109765
  • Lo W-H, Hwang S-M, Chuang C-K, Chen C-Y, Hu Y-C. Development of a hybrid baculoviral vector for sustained transgene expression. Mol Ther. 2009;17(4):658–666. doi:10.1038/mt.2009.13
  • Whitlow J, Pacelli S, Walston T, Paul A. Bioactive hydrogel platforms for spatiotemporal delivery of baculoviruses in biomedical applications. Adv Ther. 2020;3(1):1900103. doi:10.1002/adtp.201900103
  • Georgopoulos LJ, Elgue G, Sanchez J, et al. Preclinical evaluation of innate immunity to baculovirus gene therapy vectors in whole human blood. Mol Immunol. 2009;46(15):2911–2917. doi:10.1016/j.molimm.2009.07.008
  • López-Vidal J, Gómez-Sebastián S, Bárcena J, et al. Improved production efficiency of virus-like particles by the baculovirus expression vector system. PLoS One. 2015;10(10):e0140039. doi:10.1371/journal.pone.0140039
  • Shang Y, Wang M, Xiao G, et al. Construction and rescue of a functional synthetic baculovirus. ACS Synth Biol. 2017;6(7):1393–1402. doi:10.1021/acssynbio.7b00028
  • Weissmann F, Petzold G, VanderLinden R, et al. biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes. Proc Natl Acad Sci. 2016;113(19):E2564. doi:10.1073/pnas.1604935113
  • Rip J, Nierman MC, Sierts JA, et al. Gene therapy for lipoprotein lipase deficiency: working toward clinical application. Hum Gene Ther. 2005;16(11):1276–1286. doi:10.1089/hum.2005.16.1276
  • Mietzsch M, Grasse S, Zurawski C, et al. OneBac: platform for scalable and high-titer production of adeno-associated virus serotype 1–12 vectors for gene therapy. Hum Gene Ther. 2014;25(3):212–222. doi:10.1089/hum.2013.184
  • Joshi PRH, Cervera L, Ahmed I, et al. Achieving high-yield production of functional AAV5 gene delivery vectors via fedbatch in an insect cell-one baculovirus system. Mol Ther Clin Dev. 2019;13:279–289. doi:10.1016/j.omtm.2019.02.003
  • Wang J, Zhu L, Chen X, Huang R, Wang S, Dong P. Human bone marrow mesenchymal stem cells functionalized by hybrid baculovirus-adeno-associated viral vectors for targeting hypopharyngeal carcinoma. Stem Cells Dev. 2019;28(8):543–553. doi:10.1089/scd.2018.0252
  • Wu Y, Jiang L, Geng H, et al. A recombinant baculovirus efficiently generates recombinant adeno-associated virus vectors in cultured insect cells and Larvae. Mol Ther Methods Clin Dev. 2018;10:38–47. doi:10.1016/j.omtm.2018.05.005
  • Abe T, Hemmi H, Miyamoto H, et al. Involvement of the Toll-like receptor 9 signaling pathway in the induction of innate immunity by baculovirus. J Virol. 2005;79(5):2847–2858. doi:10.1128/jvi.79.5.2847-2858.2005
  • Molinari P, Crespo MI, Gravisaco MJ, Taboga O, Morón G. Baculovirus capsid display potentiates OVA cytotoxic and innate immune responses. PLoS One. 2011;6(8):e24108. doi:10.1371/journal.pone.0024108
  • Gronowski AM, Hilbert DM, Sheehan KC, Garotta G, Schreiber RD. Baculovirus stimulates antiviral effects in mammalian cells. J Virol. 1999;73(12):9944–9951. doi:10.1128/JVI.73.12.9944-9951.1999
  • Jin R, Lv Z, Chen Q, et al. Safety and immunogenicity of h5n1 influenza vaccine based on baculovirus surface display system of Bombyx mori. PLoS One. 2008;3(12):e3933. doi:10.1371/journal.pone.0003933
  • Ho Y, Lin P-H, Liu CYY, Lee S-P, Chao Y-C. Assembly of human severe acute respiratory syndrome coronavirus-like particles. Biochem Biophys Res Commun. 2004;318(4):833–838. doi:10.1016/j.bbrc.2004.04.111
  • Buonaguro L, Buonaguro FM, Tornesello ML, et al. High efficient production of Pr55gag virus-like particles expressing multiple HIV-1 epitopes, including a gp120 protein derived from an Ugandan HIV-1 isolate of subtype A. Antiviral Res. 2001;49(1):35–47. doi:10.1016/S0166-3542(00)00136-4
  • Warfield KL, Dye JM, Wells JB, et al. Homologous and heterologous protection of nonhuman primates by Ebola and Sudan virus-like particles. PLoS One. 2015;10(3):e0118881–e0118881. doi:10.1371/journal.pone.0118881
  • Warfield KL, Posten NA, Swenson DL, et al. Filovirus-like particles produced in insect cells: immunogenicity and protection in rodents. J Infect Dis. 2007;196(Supplement_2):S421–S429. doi:10.1086/520612
  • Zheng X, Liu G, Opriessnig T, Wang Z, Yang Z, Jiang Y. Development and validation of a multiplex conventional PCR assay for simultaneous detection and grouping of porcine bocaviruses. J Virol Methods. 2016;236:164–169. doi:10.1016/j.jviromet.2016.06.014
  • Deo VK, Tsuji Y, Yasuda T, et al. Expression of an RSV-gag virus-like particle in insect cell lines and silkworm larvae. J Virol Methods. 2011;177(2):147–152. doi:10.1016/j.jviromet.2011.07.012
  • Hinke SA. Diamyd, an alum-formulated recombinant human GAD65 for the prevention of autoimmune diabetes. Curr Opin Mol Ther. 2008;10(5):516–525.
  • Lu L, Ho Y, Kwang J. Suppression of porcine arterivirus replication by baculovirus-delivered shRNA targeting nucleoprotein. Biochem Biophys Res Commun. 2006;340(4):1178–1183. doi:10.1016/j.bbrc.2005.12.133
  • Kim Y-K, Choi JY, Yoo M-K, et al. Receptor-mediated gene delivery by folate-PEG-baculovirus in vitro. J Biotechnol. 2007;131(3):353–361. doi:10.1016/j.jbiotec.2007.07.938
  • Meysami P, Rezaei F, Marashi SM, Amiri MM, Bakker E, Mokhtari-Azad T. Antitumor effects of a recombinant baculovirus displaying anti-HER2 scFv expressing Apoptin in HER2 positive SK-BR-3 breast cancer cells. Future Virol. 2019;14(3):139–152. doi:10.2217/fvl-2018-0187
  • Ono C, Ninomiya A, Yamamoto S, et al. Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells. J Virol. 2014;88(4):2157–2167. doi:10.1128/jvi.03055-13
  • Cheshenko N, Krougliak N, Eisensmith RC, Krougliak VA. A novel system for the production of fully deleted adenovirus vectors that does not require helper adenovirus. Gene Ther. 2001;8(11):846–854. doi:10.1038/sj.gt.3301459
  • Chen HC, Sung LY, Lo WH, et al. Combination of baculovirus-expressed BMP-2 and rotating-shaft bioreactor culture synergistically enhances cartilage formation. Gene Ther. 2008;15(4):309–317. doi:10.1038/sj.gt.3303087
  • Gottardo MF, Pidre ML, Zuccato C, et al. Baculovirus-based gene silencing of Humanin for the treatment of pituitary tumors. Apoptosis. 2018;23(2):143–151. doi:10.1007/s10495-018-1444-0
  • Wang CY, Li F, Yang Y, Guo HY, Wu CX, Wang S. Recombinant baculovirus containing the diphtheria toxin A gene for malignant glioma therapy. Cancer Res. 2006;66(11):5798–5806. doi:10.1158/0008-5472.Can-05-4514
  • Balani P, Boulaire J, Zhao Y, Zeng J, Lin J, Wang S. High mobility group box2 promoter-controlled suicide gene expression enables targeted glioblastoma treatment. Mol Ther. 2009;17(6):1003–1011. doi:10.1038/mt.2009.22
  • Huang W, Tian XL, Wu YL, et al. Suppression of gastric cancer growth by baculovirus vector-mediated transfer of normal epithelial cell specific-1 gene. World J Gastroenterol. 2008;14(38):5810–5815. doi:10.3748/wjg.14.5810
  • Lin C-Y, Chang Y-H, Lin K-J, et al. The healing of critical-sized femoral segmental bone defects in rabbits using baculovirus-engineered mesenchymal stem cells. Biomaterials. 2010;31(12):3222–3230. doi:10.1016/j.biomaterials.2010.01.030
  • Paul A, Binsalamah ZM, Khan AA, et al. A nanobiohybrid complex of recombinant baculovirus and Tat/DNA nanoparticles for delivery of Ang-1 transgene in myocardial infarction therapy. Biomaterials. 2011;32(32):8304–8318. doi:10.1016/j.biomaterials.2011.07.042
  • Muñoz N, Bosch FX, de Sanjosé S, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med. 2003;348(6):518–527. doi:10.1056/NEJMoa021641
  • Ferreira V, Petry H, Salmon F. Immune responses to AAV-vectors, the glybera example from bench to bedside. Front Immunol. 2014;5:82. doi:10.3389/fimmu.2014.00082
  • Emran TB, Iyori M, Ono Y, et al. Baculovirus-induced fast-acting innate immunity kills liver-stage Plasmodium. J Immunol. 2018;201(8):2441. doi:10.4049/jimmunol.1800908
  • Fedson DS, Dunnill P. New approaches to confronting an imminent influenza pandemic. Perm J. 2007;11(3):63. doi:10.7812/TPP/07-044
  • Caballero S, Guix S, Ribes E, Bosch A, Pintó RM. Structural requirements of astrovirus virus-like particles assembled in insect cells. J Virol. 2004;78(23):13285. doi:10.1128/JVI.78.23.13285-13292.2004
  • Liu Q, Yan K, Feng Y, et al. A virus-like particle vaccine for coxsackievirus A16 potently elicits neutralizing antibodies that protect mice against lethal challenge. Vaccine. 2012;30(47):6642–6648. doi:10.1016/j.vaccine.2012.08.071
  • Metz SW, Gardner J, Geertsema C, et al. Effective chikungunya virus-like particle vaccine produced in insect cells. PLoS Negl Trop Dis. 2013;7(3):e2124. doi:10.1371/journal.pntd.0002124
  • Chung C-Y, Chen C-Y, Lin S-Y, et al. Enterovirus 71 virus-like particle vaccine: improved production conditions for enhanced yield. Vaccine. 2010;28(43):6951–6957. doi:10.1016/j.vaccine.2010.08.052
  • Mohana Subramanian B, Madhanmohan M, Sriraman R, et al. Development of foot-and-mouth disease virus (FMDV) serotype O virus-like-particles (VLPs) vaccine and evaluation of its potency. Antivir Res. 2012;96(3):288–295. doi:10.1016/j.antiviral.2012.09.019
  • Suzuki H, Tamai N, Habu Y, Chang MOO, Takaku H. Suppression of hepatitis C virus replication by baculovirus vector-mediated short-hairpin RNA expression. FEBS Lett. 2008;582(20):3085–3089. doi:10.1016/j.febslet.2008.07.056
  • Wang Y, Ouyang W, Liu X, et al. Virus-like particles of hepatitis B virus core protein containing five mimotopes of infectious bursal disease virus (IBDV) protect chickens against IBDV. Vaccine. 2012;30(12):2125–2130. doi:10.1016/j.vaccine.2012.01.040
  • Treanor JJ, El Sahly H, King J, et al. Protective efficacy of a trivalent recombinant hemagglutinin protein vaccine (FluBlok®) against influenza in healthy adults: a randomized, placebo-controlled trial. Vaccine. 2011;29(44):7733–7739. doi:10.1016/j.vaccine.2011.07.128
  • Yoshida S, Kawasaki M, Hariguchi N, Hirota K, Matsumoto M. A baculovirus dual expression system-based malaria vaccine induces strong protection against Plasmodium berghei sporozoite challenge in mice. Infect Immun. 2009;77(5):1782–1789. doi:10.1128/IAI.01226-08
  • Blazevic V, Lappalainen S, Nurminen K, Huhti L, Vesikari T. Norovirus VLPs and rotavirus VP6 protein as combined vaccine for childhood gastroenteritis. Vaccine. 2011;29(45):8126–8133. doi:10.1016/j.vaccine.2011.08.026
  • Atmar RL, Bernstein DI, Harro CD, et al. Norovirus vaccine against experimental human Norwalk Virus illness. N Engl J Med. 2011;365:2178–2187. doi:10.1056/NEJMoa1101245
  • Bernstein DI, El Sahly HM, Keitel WA, et al. Safety and immunogenicity of a candidate parvovirus B19 vaccine. Vaccine. 2011;29(43):7357–7363. doi:10.1016/j.vaccine.2011.07.080
  • Bräutigam S, Snezhkov E, Bishop DH. Formation of poliovirus-like particles by recombinant baculoviruses expressing the individual VP0, VP3, and VP1 proteins by comparison to particles derived from the expressed poliovirus polyprotein. Virology. 1993;192(2):512–524. doi:10.1006/viro.1993.1067
  • Liu L, Celma CCP, Roy P. Rift Valley fever virus structural proteins: expression, characterization and assembly of recombinant proteins. Virol J. 2008;5:82. doi:10.1186/1743-422X-5-82
  • Akinobu K, Fumio A, Makoto T, Hiroaki Y, Akihiro K, Hiroshi H. Purification and characterization of virus-like particles and pentamers produced by the expression of SV40 capsid proteins in insect cells. Biochim Biophys Acta Gen Subj. 1996;1290(1):37–45. doi:10.1016/0304-4165(95)00184-0
  • Takahama M, Fukuda M, Ohbayashi N, et al. The RAB2B-GARIL5 complex promotes cytosolic DNA-induced innate immune responses. Cell Rep. 2017;20(12):2944–2954. doi:10.1016/j.celrep.2017.08.085
  • Wang X, Ao Z, Chen L, Kobinger G, Peng J, Yao X. The cellular antiviral protein APOBEC3G Interacts with HIV-1 reverse transcriptase and inhibits its function during viral replication. J Virol. 2012;86(7):3777 LP- 3786. doi:10.1128/JVI.06594-11
  • Kool M, Voncken JW, Van Lier FLJ, Tramper J, Vlak JM. Detection and analysis of Autographa californica nuclear polyhedrosis virus mutants with defective interfering properties. Virology. 1991;183(2):739–746. doi:10.1016/0042-6822(91)91003-Y
  • Draft landscape of covid-19candidate vaccines. Available from: https://www.who.int/publications/m/item/draft-landscape-of-covid-19-candidate-vaccines. Accessed February 25, 2021.