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Biologics: Targets and Therapy Volume 15, 2021 - Issue
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Original Research

Sensitivity Assessment of Wilms Tumor Gene (WT1) Expression in Glioblastoma using qPCR and Immunohistochemistry and its Association with IDH1 Mutation and Recurrence Interval

Maher Kurdi1 Department of Pathology, Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah, Kingdom of Saudi ArabiaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-8979-3849View further author information
ORCID Icon,
Nadeem Shafique Butt2 Department of Family and Community Medicine, Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah, Kingdom of Saudi ArabiaORCID Iconhttps://orcid.org/0000-0002-0473-4920View further author information
ORCID Icon,
Saleh Baeesa3 Division of Neurosurgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi ArabiaORCID Iconhttps://orcid.org/0000-0002-3053-7912View further author information
ORCID Icon,
Abudukadeer Kuerban4 Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Kingdom of Saudi ArabiaORCID Iconhttps://orcid.org/0000-0001-8768-9426View further author information
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Yazid Maghrabi5 Department of Neuroscience, King Faisal Specialist Hospital and Research Center, Jeddah, Kingdom of Saudi ArabiaORCID Iconhttps://orcid.org/0000-0003-0749-7307View further author information
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Anas Bardeesi5 Department of Neuroscience, King Faisal Specialist Hospital and Research Center, Jeddah, Kingdom of Saudi ArabiaORCID Iconhttps://orcid.org/0000-0003-3154-8688View further author information
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Rothaina Saeedi3 Division of Neurosurgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi ArabiaView further author information
,
Badrah S Alghamdi6 Department of Physiology, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi ArabiaORCID Iconhttps://orcid.org/0000-0002-9411-3609View further author information
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Ahmed I Lary7 Section of Neurosurgery, Department of Surgery, King Abdulaziz Medical City, Jeddah, Kingdom of Saudi ArabiaORCID Iconhttps://orcid.org/0000-0001-7137-9992View further author information
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Fawaz Mohamed1 Department of Pathology, Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah, Kingdom of Saudi ArabiaORCID Iconhttps://orcid.org/0000-0002-4905-4558View further author information
ORCID Icon &
Sahar Hakamy8 Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Kingdom of Saudi ArabiaView further author information
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Pages 289-297 | Published online: 24 Jul 2021

References

  • Pritchard‑Jones K. The Wilms tumor gene, WT1, in normal and abnormal nephrogenesis. Pediatr Nephrol. 1999;13:620–625. doi:10.1007/s004670050757
  • Call KM, Glaser T, Ito CY, et al. Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms’ tumor locus. Cell. 1990;60:509–520. doi:10.1016/0092-8674(90)90601-A
  • Nakatsuka S, Oji Y, Horiuchi T, et al. Immunohistochemical detection of WT1 protein in a variety of cancer cells. Mod Pathol. 2006;19:804–814. doi:10.1038/modpathol.3800588
  • Schittenhelm J, Beschorner R, Simon P, et al. Diagnostic value of WT1 in neuroepithelial tumor. Neuropathol Appl Neurobiol. 2009;35:69–81. doi:10.1111/j.1365-2990.2008.00957.x
  • Clark AJ, Ware JL, Chen MY, et al. Effect of WT1 gene silencing on the tumorigenicity of human glioblastoma multiforme cells. J Neurosurg. 2010;112:18–25. doi:10.3171/2008.11.JNS08368
  • Kijima N, Hosen N, Kagawa N, et al. Wilms’ tumor 1 is involved in tumorigenicity of glioblastoma by regulating cell proliferation and apoptosis. Anticancer Res. 2014;34:61–67.
  • Somasundaram A, Ardanowski N, Opalak CF, et al. Wilms tumor 1 gene, CD97, and the emerging biogenetic profile of glioblastoma. Neurosurg Focus. 2014;37:1–4. doi:10.3171/2014.9.FOCUS14506
  • Izumoto S, Tsuboi A, Oka Y, et al. Phase II clinical trial of Wilms tumor 1 peptide vaccination for patients with recurrent glioblastoma multiforme. J Neurosurg. 2008;108:963–971. doi:10.3171/JNS/2008/108/5/0963
  • Manocha A, Jain S. WT1 in astrocytomas: comprehensive evaluation of immunohistochemical expression and its potential utility in different histological grades. Indian J Cancer. 2019;56:197–201. doi:10.4103/ijc.IJC_51_18
  • Rauscher J, Beschorner R, Gierke M, et al. WT1 expression increases with malignancy and indicates unfavourable outcome in astrocytoma. J Clin Pathol. 2014;67:556–561. doi:10.1136/jclinpath-2013-202114

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