Triamcinolone acetonide intralesional injection for the treatment of keloid scars: patient selection and perspectives

References

• KraevaEHoDJagdeoJSuccessful treatment of keloid with fractionated carbon dioxide (CO2) laser and laser-assisted drug delivery for triamcinolone acetonide ointment in an African-American manJ Drugs Dermatol201716992592728915288
   PubMed Web of Science ®Google Scholar
• RoblesDTBergDAbnormal wound healing: keloidsClin Dermatol2007251263217276198
   PubMed Web of Science ®Google Scholar
• MustoeTACooterRDGoldMHInternational Advisory Panel on Scar ManagementInternational clinical recommendations on scar managementPlast Reconstr Surg2002110256057112142678
   PubMed Web of Science ®Google Scholar
• GaoZWangZShiYModulation of collagen synthesis in keloid fibroblasts by silencing Smad2 with siRNAPlast Reconstr Surg200611861328133717051103
   PubMed Web of Science ®Google Scholar
• JumperNPausRBayatAFunctional histopathology of keloid diseaseHistol Histopathol20153091033105725900252
   PubMed Web of Science ®Google Scholar
• WuWSWangFSYangKDHuangCCKuoYRDexamethasone induction of keloid regression through effective suppression of VEGF expression and keloid fibroblast proliferationJ Invest Dermatol200612661264127116575391
   PubMed Web of Science ®Google Scholar
• SalemAAssafMHelmyARole of vascular endothelial growth factor in keloids: a clinicopathologic studyInt J Dermatol200948101071107719775400
   PubMed Web of Science ®Google Scholar
• BayatAArscottGOllierWEFergusonMWMcGroutherDA“Aggressive keloid”: a severe variant of familial keloid scarringJ R Soc Med2003961155455514594967
   PubMed Web of Science ®Google Scholar
• RoblesDTMooreEDrazninMBergDKeloids: pathophysiology and managementDermatol Online J20071339
   PubMedGoogle Scholar
• SaedGMLadinDOlsonJHanXHouZFivensonDAnalysis of p53 gene mutations in keloids using polymerase chain reaction-based single-strand conformational polymorphism and DNA sequencingArch Dermatol199813489639679722726
   PubMedGoogle Scholar
• TanakaAHatokoMTadaHIiokaHNiitsumaKMiyagawaSExpression of p53 family in scarsJ Dermatol Sci2004341172414757278
   PubMed Web of Science ®Google Scholar
• ShafferJJTaylorSCCook-BoldenFKeloidal scars: a review with a critical look at therapeutic optionsJ Am Acad Dermatol2002462 suppl UnderstandingS63S9711807470
   PubMed Web of Science ®Google Scholar
• ButlerPDLongakerMTYangGPCurrent progress in keloid research and treatmentJ Am Coll Surg2008206473174118387480
   PubMed Web of Science ®Google Scholar
• Al-AttarAMessSThomassenJMKauffmanCLDavisonSPKeloid pathogenesis and treatmentPlast Reconstr Surg2006117128630016404281
   PubMed Web of Science ®Google Scholar
• AkaishiSOgawaRHyakusokuHKeloid and hypertrophic scar: neurogenic inflammation hypothesesMed Hypotheses2008711323818406540
   PubMed Web of Science ®Google Scholar
• WongT-SLiJZ-HChenSChanJY-WGaoWThe efficacy of triamcinolone acetonide in keloid treatment: a systematic review and meta-analysisFront Med (Lausanne)201637128083534
   PubMed Web of Science ®Google Scholar
• YounaiSNichterLSWelliszTReinischJNimniMETuanTLModulation of collagen synthesis by transforming growth factor-beta in keloid and hypertrophic scar fibroblastsAnn Plast Surg19943321481517979045
   PubMed Web of Science ®Google Scholar
• WangXSmithPPuLLKimYJKoFRobsonMCExogenous transforming growth factor beta(2) modulates collagen I and collagen III synthesis in proliferative scar xenografts in nude ratsJ Surg Res199987219420010600349
   PubMed Web of Science ®Google Scholar
• OrienteAFedarkoNSPacochaSEHuangSKLichtensteinLMEssayanDMInterleukin-13 modulates collagen homeostasis in human skin and keloid fibroblastsJ Pharmacol Exp Ther2000292398899410688614
   PubMed Web of Science ®Google Scholar
• ChauCHClavijoCADengHTEtk/Bmx mediates expression of stress-induced adaptive genes VEGF, PAI-1, and iNOS via multiple signaling cascades in different cell systemsAm J Physiol Cell Physiol20052892C444C45415788485
   PubMed Web of Science ®Google Scholar
• GiuglianoGPasqualiDNotaroAVerapamil inhibits interleukin-6 and vascular endothelial growth factor production in primary cultures of keloid fibroblastsBr J Plast Surg200356880480914615256
   PubMedGoogle Scholar
• Trisliana PerdanasariALazzeriDSuWRecent developments in the use of intralesional injections keloid treatmentArch Plast Surg201441662062925396172
   PubMedGoogle Scholar
• RoquesCTèotLThe use of corticosteroids to treat keloids: a reviewInt J Low Extrem Wounds20087313714518611924
   PubMedGoogle Scholar
• LeventhalDFurrMReiterDTreatment of keloids and hypertrophic scars: a meta-analysis and review of the literatureArch Facial Plast Surg20068636236817116782
   PubMedGoogle Scholar
• CarrollLAHanasonoMMMikulecAAKitaMKochRJTriamcinolone stimulates bFGF production and inhibits TGF-beta1 production by human dermal fibroblastsDermatol Surg200228870470912174062
   PubMed Web of Science ®Google Scholar
• MuneuchiGSuzukiSOnoderaMItoOHataYIgawaHHLong-term outcome of intralesional injection of triamcinolone acetonide for the treatment of keloid scars in Asian patientsScand J Plast Reconstr Surg Hand Surg200640211111616537259
   PubMed Web of Science ®Google Scholar
• RahbanSGarnerWFibroproliferative scarsClin Plast Surg2003301778912636218
   PubMed Web of Science ®Google Scholar
• DarziMAChowdriNAKaulSKKhanMEvaluation of various methods of treating keloids and hypertrophic scars: a 10-year follow-up studyBr J Plast Surg1992453743791638291
   PubMedGoogle Scholar
• AcostaSUretaEYanezROlivaNSearleSGuerraCEffectiveness of intralesional triamcinolone in the treatment of keloids in childrenPediatr Dermatol2016331757926758090
   PubMed Web of Science ®Google Scholar
• FinkenMJMulDCushing’s syndrome and adrenal insufficiency after intradermal triamcinolone acetonide for keloid scarsEur J Pediatr201016991147114920186428
   PubMed Web of Science ®Google Scholar
• KumarSSinghRJReedAMLteifANCushing’s syndrome after intra-articular and intradermal administration of triamcinolone acetonide in three pediatric patientsPediatrics200411361820182415173517
   PubMed Web of Science ®Google Scholar
• LiuMFYenchaMCushing’s syndrome secondary to intralesional steroid injections of multiple keloid scarsOtolaryngol Head Neck Surg2006135696096117141094
   PubMed Web of Science ®Google Scholar
• TeelucksinghSBalkaranBGaneshmoorthiAArthurPProlonged childhood Cushing’s syndrome secondary to intralesional triamcinolone acetonideAnn Trop Paediatr2002221899111926057
   PubMed Web of Science ®Google Scholar
• EpsteinETriamcinolone and keloidsWest J Med198013332572587415179
   PubMedGoogle Scholar
• VoADoumitMRockwellGThe biomechanics and optimization of the needle-syringe system for injecting triamcinolone acetonide into keloidsJ Med Eng201620168 5162394
   Google Scholar
• DoongHDissanayakeSGowrishankarTRLaBarberaMCLeeRCThe 1996 Lindberg award. Calcium antagonists alter cell shape and induce procollagenase synthesis in keloid and normal human dermal fibroblastsJ Burn Care Rehabil1996176 pt 14975148951536
   PubMedGoogle Scholar
• BoggioRFFreitasVMCassiolaFMUrabayashiMMachado-SantelliGMEffect of a calcium-channel blocker (verapamil) on the morphology, cytoskeleton and collagenase activity of human skin fibroblastsBurns201137461662520800972
   PubMed Web of Science ®Google Scholar
• AhujaRBChatterjeePComparative efficacy of intralesional verapamil hydrochloride and triamcinolone acetonide in hypertrophic scars and keloidsBurns201440458358824182692
   PubMed Web of Science ®Google Scholar
• DanielsenPLReaSMWoodFMVerapamil is less effective than triamcinolone for prevention of keloid scar recurrence after excision in a randomized controlled trialActa Derm Venereol201696677477826911400
   PubMed Web of Science ®Google Scholar
• KantSBvan den KerckhoveECollaCTuinderSvan der HulstRRWJPiatkowski de GrzymalaAAA new treatment of hypertrophic and keloid scars with combined triamcinolone and verapamil: a retrospective studyEur J Plast Surg2018411698029398785
   PubMed Web of Science ®Google Scholar
• GhoshalKJacobSTAn alternative molecular mechanism of action of 5-fluorouracil, a potent anti-cancer drugBiochem Pharmacol19975311156915759264308
   PubMed Web of Science ®Google Scholar
• BlumenkranzMSClaflinAHajekASSelection of the therapeutic agents for intraocular proliferative disease: cell culture evaluationArch Ophthalmol198410245986046704019
   PubMedGoogle Scholar
• WendlingJMarchandAMauvielAVerrecchiaF5-Fluorouracil blocks transforming growth factor-beta-induced alpha 2 type I collagen gene (COL1A2) expression in human fibroblasts via c-Jun NH2-terminal kinase⁄activator protein-1 activationMol Pharmacol200364370771312920208
   PubMed Web of Science ®Google Scholar
• SahaAKMukhopadhyayMA comparative clinical study on role of 5-flurouracil versus triamcinolone in the treatment of keloidsIndian J Surg201274432632923904725
   PubMed Web of Science ®Google Scholar
• SadeghiniaASadeghiniaSComparison of the efficacy of intralesional triamcinolone acetonide and 5 fluorouracil tattooing for the treatment of keloidsDermatol Surg201238110410922093096
   PubMed Web of Science ®Google Scholar
• FitzpatrickRETreatment of inflamed hypertrophic scars using intralesional 5-FUDermatol Surg199925322423210193972
   PubMed Web of Science ®Google Scholar
• KhanMABashirMMKhanFAIntralesional triamcinolone alone and in combination with 5-fluorouracil for the treatment of keloid and hypertrophic scarsJ Pak Med Assoc20146491003100725823177
   PubMed Web of Science ®Google Scholar
• DavisonSPDayanJHClemensMWSonniSWangACraneAEfficacy of intralesional 5-fluorouracil and triamcinolone in the treatment of keloidsAesthet Surg J2009291404619233005
   PubMed Web of Science ®Google Scholar
• GuptaSSharmaVKStandard guidelines of care: keloids and hypertrophic scarsIndian J Dermatol Venereol Leprol20117719410021220896
   PubMed Web of Science ®Google Scholar
• NandaSReddyBSIntralesional 5-fluorouracil as a treatment modality of keloidsDermatol Surg20043015456 discussion 56–5714692928
   PubMed Web of Science ®Google Scholar
• ApikianMGoodmanGIntralesional 5-fluorouracil in the treatment of keloid scarsAustralas J Dermatol200445214014315068466
   PubMedGoogle Scholar
• MamalisADLev-TovHNguyenDHJagdeoJRLaser and light-based treatment of Keloids – a reviewJ Eur Acad Dermatol Venereol201428668969924033440
   PubMed Web of Science ®Google Scholar
• BassLSMoazamiNPocsidioJOzMCLoGerfoPTreatMRChanges in type I collagen following laser weldingLasers Surg Med19921255005051406002
   PubMed Web of Science ®Google Scholar
• SchoberRUrlichFSanderTDurselenHHesselSLaser induced alteration of collagen substructure allows microsurgical tissue weldingScience19862324756142114223715454
   PubMed Web of Science ®Google Scholar
• DierickxCGoldmannMPFitzpatrickRELaser treatment of erythematous/hypertrophic and pigmented scars in 26 patientsPlast Reconstr Surg19959518490 discussion 91–927809272
   PubMed Web of Science ®Google Scholar
• NouriKVidulichKRivasMPLasers for scars: a reviewJ Cosmet Dermatol200651142217173567
   PubMedGoogle Scholar
• DriscollBTreating keloids with carbon dioxide lasersArch Otolaryngol Head Neck Surg20011279114511556871
   PubMedGoogle Scholar
• SternJCLucenteFECarbon dioxide laser excision of ear lobule keloidArch Otolaryngol Head Neck Surg19891159110711112765229
   PubMedGoogle Scholar
• ApfelbergDBMaserMRWhiteDNLashHFailure of carbon dioxide laser excision of keloidsLasers Surg Med1989943823882503668
   PubMed Web of Science ®Google Scholar
• NorrisJEThe effect of carbon dioxide laser surgery on the recurrence of keloidsPlast Reconstr Surg19918714449 discussion 50–531898535
   PubMed Web of Science ®Google Scholar
• VermaKKGargTRajTCarbon dioxide laser for the treatment of keloidsIndian J Dermatol20024729193
   Google Scholar
• KumarKKapoorBSRaiPShuklaHSIn situ irradiation of keloid scars with Nd:YAG laserJ Wound Care20009521321511933330
   PubMedGoogle Scholar
• RossiALuRFreyMKKubotaTSmithLAPerezMThe use of the 300 microsecond 1064 nm Nd:YAG laser in the treatment of keloidsJ Drugs Dermatol201312111256126224196333
   PubMed Web of Science ®Google Scholar
• KassabANEl KharbotlyAManagement of ear lobule keloids using 980-nm diode laserEur Arch Otorhinolaryngol2012269241942321630062
   PubMed Web of Science ®Google Scholar
• SinghalMDel Río-SanchoSSonajeKKaliaYNFractional laser ablation for the cutaneous delivery of triamcinolone acetonide from cryomilled polymeric microparticles: creating intraepidermal drug depotsMol Pharm201613250051126731121
   PubMed Web of Science ®Google Scholar
• PerkinsKDaveyRBWalisKASilicone gel: a new treatment for burns and contracturesBurns19829406410
   Web of Science ®Google Scholar
• GoldMHA controlled clinical trial of topical silicone gel sheeting in the treatment of hypertrophic scars and keloidsJ Am Acad Dermatol19943035065078113473
   PubMed Web of Science ®Google Scholar
• WoodLCEliasPMSequeira-MartinSMCarlGFeingoldKROcclusion lowers cytokine mRNA levels in essential fatty acid-deficient and normal mouse epidermis, but not after acute barrier disruptionJ Invest Dermatol199410368348387798624
   PubMed Web of Science ®Google Scholar
• DuncanMRBemanBStimulation of connective tissue related biosynthetic functions of cultured human adult dermal fibroblasts by recombinant human interleukin 6J Invest Dermatol19919746866921940439
   PubMed Web of Science ®Google Scholar
• FultonJEJrSilicone gel sheeting for the prevention and management of evolving hypertrophic and keloid scarsDermatol Surg199521119479517582832
   PubMed Web of Science ®Google Scholar
• KatzBESilicone gel sheeting in scar therapyCutis199556165677555106
   PubMed Web of Science ®Google Scholar
• TanEChuaSLimJTopical silicone gel sheet versus intralesional injections of triamcinolone acetonide in the treatment of keloids – a patient-controlled comparative clinical trialJ Dermatol Treat1999104251254
   Web of Science ®Google Scholar
• SproatJEDalcinAWeitauerNRobertsRSHypertrophic sternal scars: silicone gel sheet versus Kenalog injection treatmentPlast Reconstr Surg19929069889921448534
   PubMed Web of Science ®Google Scholar
• KelemenOKollárLCurrent methods of treatment and prevention of pathologic scarsMagy Seb2007602637017649846
   PubMedGoogle Scholar
• YamawakiSNaitohMIshikoTMuneuchiGSuzukiSKeloids can be forced into remission with surgical excision and radiation, followed by adjuvant therapyAnn Plast Surg201167440240621407049
   PubMed Web of Science ®Google Scholar
• KuoYRWuWSJengSFActivation of ERK and p38 kinase mediated keloid fibroblast apoptosis after flashlamp pulsed-dye laser treatmentLasers Surg Med2005361313715662632
   PubMed Web of Science ®Google Scholar
• BodokhIBrunPTreatment of keloid with intralesional bleomycin (French)Ann Dermatol Venereol1996123127917949636763
   PubMed Web of Science ®Google Scholar
• PayapvipapongKNiumpraditNPiriyanandCBuranaphalinSNakakesAThe treatment of keloids and hypertrophic scars with intralesional bleomycin in skin of colorJ Cosmet Dermatol2015141839025626920
   PubMed Web of Science ®Google Scholar
• EspanaASolanoTQuintanillaEBleomycin in the treatment of keloids and hypertrophic scars by multiple needle puncturesDermatol Surg2001271232711231236
   PubMed Web of Science ®Google Scholar
• FarahnazFNJamshidNBleomycin tattooing as a promising therapeutic modality in large keloids and hypertrophic scarsDermatol Surg200632810231029 discussion 1029–103016918564
   PubMed Web of Science ®Google Scholar
• SlempAEKirschnerREKeloids and scars: a review of keloids and scars, their pathogenesis, risk factors, and managementCurr Opin Pediatr200618439640216914994
   PubMed Web of Science ®Google Scholar
• HackertIAschoffRSebastianGThe treatment of keloidsHautarzt200354101003101514577419
   PubMed Web of Science ®Google Scholar
• SavionYSelaMSharon-BullerAPressure earring as an adjunct to surgical removal of earlobe keloidsDermatol Surg200935349049219250308
   PubMed Web of Science ®Google Scholar
• AkozTGiderogluKAkanMCombination of different techniques for the treatment of earlobe keloidsAesthetic Plast Surg200226318418812140696
   PubMed Web of Science ®Google Scholar
• ChrisostomidisCKonofaosPChrisostomidisGManagement of external ear keloids using form-pressure therapyClin Exp Dermatol200833327327518093244
   PubMed Web of Science ®Google Scholar
• NiessenFBSpauwenPHSchalkwijkJKonMOn the nature of hypertrophic scars and keloids: a reviewPlast Reconstr Surg199910451435145810513931
   PubMed Web of Science ®Google Scholar
• CarvalhaesSMPetroianuAFerreiraMAde BarrosVMLopesRVAssessment of the treatment of earlobe keloids with triamcinolone injections, surgical resection, and local pressureRev Col Bras Cir2015421913
   Google Scholar
• BranGMBromJHörmannKStuckBAAuricular keloids: combined therapy with a new pressure deviceArch Facial Plast Surg2012141202621844479
   PubMedGoogle Scholar