Home phototherapy for patients with vitiligo: challenges and solutions

References

• Ezzedine K, Eleftheriadou V, Whitton M, van Geel N. Vitiligo. Lancet. 2015;386(9988):74–84. doi:10.1016/S0140-6736(15)61137-025596811
   PubMed Web of Science ®Google Scholar
• Rashighi M, Harris JE. Vitiligo pathogenesis and emerging treatments. Dermatol Clin. 2017;35(2):257–265. doi:10.1016/j.det.2016.11.01428317534
   PubMed Web of Science ®Google Scholar
• Dillon AB, Sideris A, Hadi A, Elbuluk N. Advances in vitiligo: an update on medical and surgical treatments. J Clin Aesthet Dermatol. 2017;10(1):15–28.28210378
   PubMedGoogle Scholar
• Gill L, Zarbo A, Isedeh P, Jacobsen G, Lim HW, Hamzavi I. Comorbid autoimmune diseases in patients with vitiligo: A cross-sectional study. J Am Acad Dermatol. 2016;74(2):295–302. doi:10.1016/j.jaad.2015.08.06326518171
   PubMed Web of Science ®Google Scholar
• Ezzedine K, Sheth V, Rodrigues M, et al. Vitiligo is not a cosmetic disease. J Am Acad Dermatol. 2015;73(5):883–885.26475548
   PubMed Web of Science ®Google Scholar
• Porter J, Beuf A, Nordlund JJ, Lerner AB. Personal responses of patients to vitiligo: the importance of the patient-physician interaction. Arch Dermatol. 1978;114(9):1384–1385.686757
   PubMedGoogle Scholar
• Porter JR, Beuf AH, Lerner A, Nordlund J. Psychosocial effect of vitiligo: a comparison of vitiligo patients with “normal” control subjects, with psoriasis patients, and with patients with other pigmentary disorders. J Am Acad Dermatol. 1986;15(2 Pt 1):220–224.3745526
   PubMed Web of Science ®Google Scholar
• Alikhan A, Felsten LM, Daly M, Petronic-Rosic V. Vitiligo: a comprehensive overview Part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up. J Am Acad Dermatol. 2011;65(3):473–491.21839315
   PubMed Web of Science ®Google Scholar
• Rodrigues M, Ezzedine K, Hamzavi I, Pandya AG, Harris JE. Current and emerging treatments for vitiligo. J Am Acad Dermatol. 2017;77(1):17–29.28619557
   PubMed Web of Science ®Google Scholar
• Yaghoobi R, Omidian M, Bagherani N. Vitiligo: a review of the published work. J Dermatol. 2011;38(5):419–431. doi:10.1111/j.1346-8138.2010.01139.x21667529
   PubMed Web of Science ®Google Scholar
• Whitton ME, Pinart M, Batchelor J, et al. Interventions for vitiligo. Cochrane Database Syst Rev. 2015;(2):Cd003263.25710794
   PubMed Web of Science ®Google Scholar
• Ezzedine K, Whitton M, Pinart M. Interventions for vitiligo. JAMA. 2016;316(16):1708–1709. doi:10.1001/jama.2016.1239927784078
   PubMed Web of Science ®Google Scholar
• Bordere AC, Lambert J, van Geel N. Current and emerging therapy for the management of vitiligo. Clin Cosmet Investig Dermatol. 2009;2:15–25.
   Google Scholar
• Abdelmaksoud A. Methotrexate for treatment of vitiligo. Dermatol Ther. 2017;30(6). doi:10.1111/dth.12532
   Web of Science ®Google Scholar
• Garza-Mayers AC, Kroshinsky D. Low-dose methotrexate for vitiligo. J Drugs Dermatol. 2017;16(7):705–706.28697225
   PubMed Web of Science ®Google Scholar
• Dang YP, Li Q, Shi F, Yuan XY, Liu W. Effect of topical calcineurin inhibitors as monotherapy or combined with phototherapy for vitiligo treatment: a meta-analysis. Dermatol Ther. 2016;29(2):126–133. doi:10.1111/dth.1229526460804
   PubMed Web of Science ®Google Scholar
• Callis Duffin K, Wong B, Horn EJ, Krueger GG. Psoriatic arthritis is a strong predictor of sleep interference in patients with psoriasis. J Am Acad Dermatol. 2009;60(4):604–608. doi:10.1016/j.jaad.2008.10.05919167780
   PubMed Web of Science ®Google Scholar
• Wat H, Dytoc M. Off-label uses of topical vitamin D in dermatology: a systematic review. J Cutan Med Surg. 2014;18(2):91–108. doi:10.2310/7750.2014.1402224636434
   PubMed Web of Science ®Google Scholar
• Passeron T. Medical and maintenance treatments for vitiligo. Dermatol Clin. 2017;35(2):163–170. doi:10.1016/j.det.2016.11.00728317526
   PubMed Web of Science ®Google Scholar
• Matin R. Vitiligo in adults and children: surgical interventions. BMJ Clin Evid. 2015;2015:1717.
   Google Scholar
• Tawfik YM, Abd Elazim NE, Abdel-Motaleb AA, Mohammed RAA, Tohamy AMA. The effect of NB-UVB on noncultured melanocyte and keratinocyte transplantation in treatment of generalized vitiligo using two different donor-to-recipient ratios. J Cosmet Dermatol. 2018;18(2):638–646. . doi:10.1111/jocd.12759
   Web of Science ®Google Scholar
• Lu N, Xu A, Wu X. Follow-up study of vitiligo patients treated with autologous epidermal sheet transplants. J Dermatolog Treat. 2014;25(3):200–204. doi:10.3109/09546634.2012.67191222390674
   PubMed Web of Science ®Google Scholar
• Khodadadi L, Shafieyan S, Sotoudeh M, et al. Intraepidermal injection of dissociated epidermal cell suspension improves vitiligo. Arch Dermatol Res. 2010;302(8):593–599. doi:10.1007/s00403-010-1034-720364383
   PubMed Web of Science ®Google Scholar
• Orouji Z, Bajouri A, Ghasemi M, et al. A single-arm open-label clinical trial of autologous epidermal cell transplantation for stable vitiligo: A 30-month follow-up. J Dermatol Sci. 2018;89(1):52–59. doi:10.1016/j.jdermsci.2017.10.00729103774
   PubMed Web of Science ®Google Scholar
• Jin Y, Xu A, Wang P, Song X, Liu X. Long-term follow-up and correlated factors of vitiligo following autologous epidermal transplantation. Cutis. 2011;87(3):137–141.21488571
   PubMed Web of Science ®Google Scholar
• Ezz-Eldawla R, Abu El-Hamd M, Saied SM, Hassanien SH. A comparative study between suction blistering graft, mini punch graft, and hair follicle transplant in treatment of patients with stable vitiligo. J Dermatolog Treat. 2018;1–6. doi:10.1080/09546634.2018.1528329
   Web of Science ®Google Scholar
• Mohamed Mohamed EE, Younes AK, Osmand A, Mohamed R, Makki M, Younis M. Punch graft versus follicular hair transplantation in the treatment of stable vitiligo. J Cosmet Laser Ther. 2017;19(5):290–293. doi:10.1080/14764172.2017.130317028272910
   PubMed Web of Science ®Google Scholar
• Linthorst Homan MW, Spuls PI, Nieuweboer-Krobotova L, et al. A randomized comparison of excimer laser versus narrow-band ultraviolet B phototherapy after punch grafting in stable vitiligo patients. J Eur Acad Dermatol Venereol. 2012;26(6):690–695. doi:10.1111/j.1468-3083.2011.04147.x21711467
   PubMed Web of Science ®Google Scholar
• Cohen BE, Elbuluk N, Mu EW, Orlow SJ. Alternative systemic treatments for vitiligo: a review. Am J Clin Dermatol. 2015;16(6):463–474. doi:10.1007/s40257-015-0153-526329814
   PubMed Web of Science ®Google Scholar
• Lim HW, Grimes PE, Agbai O, et al. Afamelanotide and narrowband UV-B phototherapy for the treatment of vitiligo: a randomized multicenter trial. JAMA Dermatol. 2015;151(1):42–50. doi:10.1001/jamadermatol.2014.187525230094
   PubMed Web of Science ®Google Scholar
• Kapoor R, Phiske MM, Jerajani HR. Evaluation of safety and efficacy of topical prostaglandin E2 in treatment of vitiligo. Br J Dermatol. 2009;160(4):861–863. doi:10.1111/j.1365-2133.2008.08923.x19014395
   PubMed Web of Science ®Google Scholar
• Craiglow BG, King BA. Tofacitinib citrate for the treatment of vitiligo: a pathogenesis-directed therapy. JAMA Dermatol. 2015;151(10):1110–1112. doi:10.1001/jamadermatol.2015.152026107994
   PubMed Web of Science ®Google Scholar
• Vu M, Heyes C, Robertson SJ, Varigos GA, Ross G. Oral tofacitinib: a promising treatment in atopic dermatitis, alopecia areata and vitiligo. Clin Exp Dermatol. 2017;42(8):942–944. doi:10.1111/ced.2017.42.issue-829034491
   PubMed Web of Science ®Google Scholar
• Rothstein B, Joshipura D, Saraiya A, et al. Treatment of vitiligo with the topical Janus kinase inhibitor ruxolitinib. J Am Acad Dermatol. 2017;76(6):1054–1060.e1051. doi:10.1016/j.jaad.2017.02.04928390737
   PubMed Web of Science ®Google Scholar
• Esmat S, Mostafa W, Hegazy RA, et al. Phototherapy: the vitiligo management pillar. Clin Dermatol. 2016;34(5):594–602. doi:10.1016/j.clindermatol.2016.05.00927638438
   PubMed Web of Science ®Google Scholar
• Mohammad TF, Al-Jamal M, Hamzavi IH, et al. The Vitiligo Working Group recommendations for narrowband ultraviolet B light phototherapy treatment of vitiligo. J Am Acad Dermatol. 2017;76(5):879–888. doi:10.1016/j.jaad.2016.12.04128216034
   PubMed Web of Science ®Google Scholar
• Mohammad TF, Silpa-Archa N, Griffith JL, Lim HW, Hamzavi IH. Home phototherapy in vitiligo. Photodermatol Photoimmunol Photomed. 2017;33(5):241–252. doi:10.1111/phpp.2017.33.issue-528620923
   PubMed Web of Science ®Google Scholar
• Yones SS, Palmer RA, Garibaldinos TM, Hawk JL. Randomized double-blind trial of treatment of vitiligo: efficacy of psoralen-UV-A therapy vs Narrowband-UV-B therapy. Arch Dermatol. 2007;143(5):578–584.17519217
   PubMedGoogle Scholar
• Sapam R, Agrawal S, Dhali TK. Systemic PUVA vs. narrowband UVB in the treatment of vitiligo: a randomized controlled study. Int J Dermatol. 2012;51(9):1107–1115. doi:10.1111/j.1365-4632.2011.05454.x22909369
   PubMed Web of Science ®Google Scholar
• Parsad D, Kanwar AJ, Kumar B. Psoralen-ultraviolet A vs. narrow-band ultraviolet B phototherapy for the treatment of vitiligo. J Eur Acad Dermatol Venereol. 2006;20(2):175–177. doi:10.1111/j.1468-3083.2006.01413.x16441626
   PubMed Web of Science ®Google Scholar
• Bhatnagar A, Kanwar AJ, Parsad D, De D. Comparison of systemic PUVA and NB-UVB in the treatment of vitiligo: an open prospective study. J Eur Acad Dermatol Venereol. 2007;21(5):638–642. doi:10.1111/j.1468-3083.2006.02088.x17447977
   PubMed Web of Science ®Google Scholar
• Kwok YK, Anstey AV, Hawk JL. Psoralen photochemotherapy (PUVA) is only moderately effective in widespread vitiligo: a 10-year retrospective study. Clin Exp Dermatol. 2002;27(2):104–110.11952699
   PubMed Web of Science ®Google Scholar
• Wind BS, Kroon MW, Beek JF, et al. Home vs. outpatient narrowband ultraviolet B therapy for the treatment of nonsegmental vitiligo: a retrospective questionnaire study. Br J Dermatol. 2010;162:1142–1144.20199553
   PubMed Web of Science ®Google Scholar
• Njoo MD, Westerhof W. Vitiligo. Pathogenesis and treatment. Am J Clin Dermatol. 2001;2(3):167–181. doi:10.2165/00128071-200102030-0000611705094
   PubMedGoogle Scholar
• Westerhof W, Nieuweboer-Krobotova L. Treatment of vitiligo with UV-B radiation vs topical psoralen plus UV-A. Arch Dermatol. 1997;133(12):1525–1528. doi:10.1001/archderm.1997.038904800450069420536
   PubMed Web of Science ®Google Scholar
• Hegazy RA, Fawzy MM, Gawdat HI, Samir N, Rashed LA. T helper 17 and Tregs: a novel proposed mechanism for NB-UVB in vitiligo. Exp Dermatol. 2014;23(4):283–286. doi:10.1111/exd.2014.23.issue-424617827
   PubMed Web of Science ®Google Scholar
• Wu CS, Yu CL, Lan CC, Yu HS. Narrow-band ultraviolet-B stimulates proliferation and migration of cultured melanocytes. Exp Dermatol. 2004;13(12):755–763. doi:10.1111/j.0906-6705.2004.00141.x15560759
   PubMed Web of Science ®Google Scholar
• De Francesco V, Stinco G, Laspina S, Parlangeli ME, Mariuzzi L, Patrone P. Immunohistochemical study before and after narrow band (311 nm) UVB treatment in vitiligo. Eur J Dermatol. 2008;18(3):292–296.18474458
   PubMed Web of Science ®Google Scholar
• Hum M, Kalia S, Gniadecki R. Prescribing home narrowband UVB phototherapy: a review of current approaches. J Cutan Med Surg. 2018;23(1):91–96. doi:10.1177/1203475418800947.
   Web of Science ®Google Scholar
• Larko O, Swanbeck G. Home solarium treatment of psoriasis. Br J Dermatol. 1979;101(1):13–16. doi:10.1111/bjd.1979.101.issue-1
   Web of Science ®Google Scholar
• Eleftheriadou V, Ezzedine K. Portable home phototherapy for vitiligo. Clin Dermatol. 2016;34(5):603–606. doi:10.1016/j.clindermatol.2016.05.01027638439
   PubMed Web of Science ®Google Scholar
• Bhutani T, Liao W. A practical approach to home UVB phototherapy for the treatment of generalized psoriasis. Pract Dermatol. 2010;7(2):31–35.25191138
   PubMedGoogle Scholar
• Tien Guan ST, Theng C, Chang A. Randomized, parallel group trial comparing home-based phototherapy with institution-based 308 excimer lamp for the treatment of focal vitiligo vulgaris. J Am Acad Dermatol. 2015;72(4):733–735. doi:10.1016/j.jaad.2014.12.02625773416
   PubMed Web of Science ®Google Scholar
• Eleftheriadou V, Whitton ME, Gawkrodger DJ, et al. Future research into the treatment of vitiligo: where should our priorities lie? Results of the vitiligo priority setting partnership. Br J Dermatol. 2011;164(3):530–536.21128908
   PubMed Web of Science ®Google Scholar
• Koek MB, Buskens E, Steegmans PH, van Weelden H, Bruijnzeel-Koomen CA, Sigurdsson V. UVB phototherapy in an outpatient setting or at home: a pragmatic randomised single-blind trial designed to settle the discussion. The PLUTO study. BMC Med Res Methodol. 2006;6:39. doi:10.1186/1471-2288-6-3916882343
   PubMedGoogle Scholar
• Eleftheriadou V, Thomas K, Ravenscroft J, Whitton M, Batchelor J, Williams H. Feasibility, double-blind, randomised, placebo-controlled, multi-centre trial of hand-held NB-UVB phototherapy for the treatment of vitiligo at home (HI-Light trial: Home Intervention of Light therapy). Trials. 2014;15:51. doi:10.1186/1745-6215-15-5124507484
   PubMed Web of Science ®Google Scholar
• Cameron H, Yule S, Moseley H, Dawe RS, Ferguson J. Taking treatment to the patient: development of a home TL-01 ultraviolet B phototherapy service. Br J Dermatol. 2002;147(5):957–965.12410707
   PubMed Web of Science ®Google Scholar
• Haines RH, Thomas KS, Montgomery AA, et al. Home interventions and light therapy for the treatment of vitiligo (HI-Light Vitiligo Trial): study protocol for a randomised controlled trial. BMJ Open. 2018;8(4):e018649.
   Web of Science ®Google Scholar
• Yentzer BA, Feldman SR. Trends in home phototherapy adoption in the US: monetary disincentives are only the tip of the iceberg. J Dermatolog Treat. 2011;22(1):27–30.20524873
   PubMed Web of Science ®Google Scholar
• Anderson KL, Huang KE, Huang WW, Feldman SR. Training for prescribing in-office and home phototherapy. Photodermatol Photoimmunol Photomed. 2015;31(6):325–332.26285141
   PubMed Web of Science ®Google Scholar
• Goyal K, Nguyen MO, Reynolds RV, et al. Perceptions of U.S. dermatology residency program directors regarding the adequacy of phototherapy training during residency. Photodermatol Photoimmunol Photomed. 2017;33(6):321–325.28857313
   PubMed Web of Science ®Google Scholar
• Koek MB, Buskens E, Bruijnzeel-Koomen CA, Sigurdsson V. Home ultraviolet B phototherapy for psoriasis: discrepancy between literature, guidelines, general opinions and actual use. Results of a literature review, a web search, and a questionnaire among dermatologists. Br J Dermatol. 2006;154(4):701–711.16536814
   PubMed Web of Science ®Google Scholar
• Ungureanu S, Arzpayma P, Edwards C, Anstey AV. Home phototherapy in the U.K.’s National Health Service: time to reach out. Br J Dermatol. 2017;176(5):1339–1340.28504385
   PubMed Web of Science ®Google Scholar
• Franken SM, Vierstra CL, Rustemeyer T. Improving access to home phototherapy for patients with psoriasis: current challenges and future prospects. Psoriasis (Auckl). 2016;6:55–64.29387594
   PubMedGoogle Scholar
• Yentzer BA, Yelverton CB, Simpson GL, et al. Paradoxical effects of cost reduction measures in managed care systems for treatment of severe psoriasis. Dermatol Online J. 2009;15(4):1.
   PubMedGoogle Scholar
• Hyde K, Cardwell LA, Stotts R, Feldman S. Psoriasis treatment cost comparison: biologics versus home phototherapy. Am J Pharm Benefits. 2018;10(1):18–21.
   Web of Science ®Google Scholar
• Koek MB, Sigurdsson V, van Weelden H, Steegmans PH, Bruijnzeel-Koomen CA, Buskens E. Cost effectiveness of home ultraviolet B phototherapy for psoriasis: economic evaluation of a randomised controlled trial (PLUTO study). BMJ. 2010;340:c1490.20406865
   PubMed Web of Science ®Google Scholar
• Yentzer BA, Gustafson CJ, Feldman SR. Explicit and implicit copayments for phototherapy: examining the cost of commuting. Dermatol Online J. 2013;19(6):18563.24011313
   PubMedGoogle Scholar
• Anderson KL, Feldman SR. A guide to prescribing home phototherapy for patients with psoriasis: the appropriate patient, the type of unit, the treatment regimen, and the potential obstacles. J Am Acad Dermatol. 2015;72(5):868–878.e861.25748310
   PubMed Web of Science ®Google Scholar
• Ibbotson SH, Bilsland D, Cox NH, et al. An update and guidance on narrowband ultraviolet B phototherapy: a British Photodermatology Group Workshop Report. Br J Dermatol. 2004;151(2):283–297.15327535
   PubMed Web of Science ®Google Scholar
• El-Zawahry BM, Esmat S, Bassiouny D, et al. Effect of procedural-related variables on melanocyte-keratinocyte suspension transplantation in nonsegmental stable vitiligo: a clinical and immunocytochemical study. Dermatol Surg. 2017;43(2):226–235.28157763
   PubMed Web of Science ®Google Scholar
• Esmat SM, El-Tawdy AM, Hafez GA, et al. Acral lesions of vitiligo: why are they resistant to photochemotherapy? J Eur Acad Dermatol Venereol. 2012;26(9):1097–1104.21851425
   PubMed Web of Science ®Google Scholar
• Rajpara AN, O’Neill JL, Nolan BV, Yentzer BA, Feldman SR. Review of home phototherapy. Dermatol Online J. 2010;16(12):2.
   Google Scholar
• Shan X, Wang C, Tian H, Yang B, Zhang F. Narrow-band ultraviolet B home phototherapy in vitiligo. Indian J Dermatol Venereol Leprol. 2014;80:336–338.25035361
   PubMed Web of Science ®Google Scholar