References
- KormanAJPeggsKSAllisonJPCheckpoint blockade in cancer immunotherapyAdv Immunol20069029733916730267
- HwuPTreating cancer by targeting the immune systemN Engl J Med201019363(8)77978120818880
- ChambersCAKuhnsMSEgenJGAllisonJPCTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapyAnnu Rev Immunol20011956559411244047
- LinsleyPSGreeneJLTanPCoexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytesJ Exp Med19921766159516041334116
- KrummelMFAllisonJPCD28 and CTLA-4 have opposing effects on the response of T cells to stimulationJ Exp Med199518224594657543139
- KearneyERWalunasTLKarrRWAntigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4J Immunol19951553103210367543510
- WalunasTLLenschowDJBakkerCYCTLA-4 can function as a negative regulator of T cell activationImmunity1994154054137882171
- KrummelMFSullivanTJAllisonJPSuperantigen responses and costimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivoInt Immunol1996845195238671638
- TivolEABorrielloFSchweitzerANLynchWPBluestoneJASharpeAHLoss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4Immunity199535415477584144
- WaterhousePPenningerJMTimmsELymphoproliferative disorders with early lethality in mice deficient in CTLA-4Science19952709859887481803
- ChambersCACadoDTruongTAllisonJPThymocyte development is normal in CTLA-4-deficient miceProc Natl Acad Sci U S A199794929693019256476
- WaterhousePBachmannMFPenningerJMOhashiPSMakTWNormal thymic selection, normal viability and decreased lymphopro-liferation in T cell receptor-transgenic CTLA-4-deficient miceEur J Immunol1997278188718929295023
- MeleroIHervas-StubbsSGlennieMPardollDMChenLImmunostimulatory monoclonal antibodies for cancer therapyNat Rev Cancer2007729510617251916
- ThompsonCBAllisonJPThe emerging role of CTLA-4 as an immune attenuatorImmunity1997744454509354465
- de la Cruz-MerinoLGrande-PulidoEAlbero-TamaritACodesManuel de VillenaMECancer and immune response: old and new evidence for future challengesOncologist200813121246125419056856
- AlegreMLFallarinoFMechanisms of CTLA-4-Ig in tolerance inductionCurr Pharm Des200612214916016454732
- HoosAIbrahimRKormanADevelopment of ipilimumab: contribution to a new paradigm for cancer immunotherapySemin Oncol201037553354621074069
- KrummelMFAllisonJPCTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cellsJ Exp Med19961836253325408676074
- BrunnerMCChambersCAChanFKHankeJWinotoAAllisonJPCTLA-4-Mediated inhibition of early events of T cell proliferationJ Immunol1999162105813582010229815
- YangYZouJMuJEnhanced induction of antitumor T-cell responses by cytotoxic T lymphocyte associated molecule-4 blockade: the effect is manifested only at the restricted tumor-bearing stagesCancer Res199757403640419307290
- ShrikantPKhorutsAMescherMFCTLA-4 blockade reverses CD8C T cell tolerance to tumor by a CD4CT cell and IL-2 dependent mechanismImmunity19991148349310549630
- SotomayorEMBorrelloIMTubbEAllisonJPLevitskyHIIn vivo blockade of CTLA-4 enhances the priming of responsive T-cells but fails to prevent the induction of tumor antigen-specific toleranceProc Natl Acad Sci U S A19999620114761148110500201
- LeachDRKrummelMFAllisonJPEnhancement of antitumor immunity by CTLA-4 blockadeScience19962715256173417368596936
- DranoffGJaffeeELazenbyAVaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting antitumor immunityProc Natl Acad Sci U S A199390353935438097319
- van ElsasAHurwitzAAAllisonJPCombination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentationJ Exp Med1999190335536610430624
- HurwitzAAYuTFLeachDRAllisonJPCTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinomaProc Natl Acad Sci U S A1998951710067100719707601
- HurwitzAAFosterBAKwonEDCombination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockadeCancer Res20006092444244810811122
- GregorPDWolchokJDFerroneCRCTLA-4 blockade in combination with xenogeneic DNA vaccines enhances T-cell responses, tumor immunity and autoimmunity to self antigens in animal and cellular model systemsVaccine20042213–141700170815068853
- DavilaEKennedyRCelisEGeneration of antitumor immunity by cytotoxic T lymphocyte epitope peptide vaccination, CpG-oligodeoxynucleotide adjuvant, and CTLA-4 blockadeCancer Res200363123281328812810660
- ChambersCASullivanTJAllisonJPLymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cellsImmunity1997768858959430233
- ChambersCASullivanTJTruongTAllisonJPSecondary but not primary T cell responses are enhanced in CTLA-4-deficient CD8+ T cellsEur J Immunol19982810313731439808182
- McCoyKDHermansIFFraserJHLe GrosGRoncheseFCytotoxic T lymphocyte-associated antigen 4 (CTLA-4) can regulate dendritic cell-induced activation and cytotoxicity of CD8(+) T cells independently of CD4(+) T cell helpJ Exp Med199918971157116210190907
- PeggsKSQuezadaSAChambersCAKormanAJAllisonJPBlockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodiesJ Exp Med200920681717172519581407
- KaehlerKCPielSLivingstoneESchillingBHauschildASchadendorfDUpdate on immunologic therapy with anti-CTLA-4 antibodies in melanoma: identification of clinical and biological response patterns, immune-related adverse events, and their managementSemin Oncol201037548549821074064
- RibasAClinical development of the anti-CTLA-4 antibody tremelimumabSemin Oncol201037545045421074059
- CamachoLHAntoniaSSosmanJPhase I/II trial of tremelimumab in patients with metastatic melanomaJ Clin Oncol20092771075108119139427
- WeberJIpilimumab: controversies in its development, utility and autoimmune adverse eventsCancer Immunol Immunother200958582383019198837
- AttiaPPhanGQMakerAVAutoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4J Clin Oncol200523256043605316087944
- MakerAVYangJCSherryRMIntrapatient dose escalation of anti-CTLA-4 antibody in patients with metastatic melanomaJ Immunother200629445546316799341
- WeberJSO’DaySUrbaWPhase I/II study of ipilimumab for patients with metastatic melanomaJ Clin Oncol200826365950595619018089
- HodiFSButlerMObleDAImmunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patientsProc Natl Acad Sci U S A200810583005301018287062
- WolchokJDKlugerHCallahanMKNivolumab plus ipilimumab in advanced melanomaN Engl J Med2013369212213323724867
- TopalianSLHodiFSBrahmerJRSafety, activity, and immune correlates of anti-PD-1 antibody in cancerN Engl J Med20123662443245422658127
- WolchokJDNeynsBLinetteGIpilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging studyLancet Oncol201011215516420004617
- O’DaySJMaioMChiarion-SileniVEfficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: a multicenter single-arm phase II studyAnn Oncol20102181712171720147741
- WeberJThompsonJAHamidOA randomized, double-blind, placebo-controlled, phase II study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patients with unresectable stage III or IV melanomaClin Cancer Res200915175591559819671877
- KornELLiuPYLeeSJMeta-analysis of phase II cooperative group trials in metastatic stage IV melanoma to determine progression-free and overall survival benchmarks for future phase II trialsJ Clin Oncol200826452753418235113
- MargolinKErnstoffMSHamidOIpilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trialLancet Oncol201213545946522456429
- Di GiacomoAMAsciertoPAPillaLIpilimumab and fotemustine in patients with advanced melanoma (NIBIT-M1): an open-label, single-arm phase 2 trialLancet Oncol201213987988622894884
- HodiFSO’DaySJMcDermottDFImproved survival with ipilimumab in patients with metastatic melanomaN Engl J Med2010363871172320525992
- HoosAEggermontAMJanetzkiSImproved endpoints for cancer immunotherapy trialsJ Natl Cancer Inst2010102181388139720826737
- RobertCHodiFSO’DayRe-induction with ipilimumab, gp100 peptide vaccine or a combination of both in a Phase III study of previously-treated patients with advanced melanoma: update of clinical characteristic of patients35th Congress of the European Society for Medical Oncology (ESMO)October 8–10, 2010Milan, Italy
- SchwartzentruberDJLawsonDHRichardsJMgp100 peptide vaccine and interleukin-2 in patients with advanced melanomaN Engl J Med2011364222119212721631324
- PrietoPAYangJCSherryRMCTLA-4 blockade with ipilimumab: long-term follow-up of 177 patients with metastatic melanomaClin Cancer Res20121872039204722271879
- RobertCThomasLBondarenkoIIpilimumab plus dacarbazine for previously untreated metastatic melanomaN Engl J Med2011364262517252621639810
- AlmubarakMAbrahamJResearch highlights: highlights from the latest articles in cancer immunotherapyImmunotherapy20124547347522642329
- ClinicalTrialsgov [homepage on the Internet]National Institutes of Health Available from: http://www.clinicaltrials.govAccessed July 23, 2013
- RibasAChmielowskiBGlaspyJADo we need a different set of response assessment criteria for tumor immunotherapy?Clin Cancer Res200915237116711819934296
- RibasAComin-AnduixBEconomouJSIntratumoral immune cell infiltrates, FoxP3, and indoleamine 2,3-dioxygenase in patients with melanoma undergoing CTLA4 blockadeClin Cancer Res20091539039919118070
- WolchokJDHoosAO’DaySGuidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteriaClin Cancer Res2009157412742019934295
- van ElsasASutmullerRPHurwitzAAElucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapyJ Exp Med2001194448148911514604
- MakerAVPhanGQAttiaPTumor regression and autoim-munity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II studyAnn Surg Oncol200512121005101616283570
- DowneySGKlapperJASmithFOPrognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockadeClin Cancer Res20071322 Pt 16681668817982122
- KuGYYuanJPageDBSingle-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting: lymphocyte count after 2 doses correlates with survivalCancer201011671767177520143434
- YangAKendleRFGinsbergBACTLA-4 blockade with ipilimumab increases peripheral CD8+ cells: correlation with clinical outcomesJ Clin Oncol20102815s (suppl; abstract 2555)
- MarshallMARibasAHuangBEvaluation of baseline serum C-reactive protein (CRP) and benefit from tremelimumab compared to chemotherapy in first-line melanomaJ Clin Oncol20102815s (suppl; abstract 2609)
- HamidOSchmidtHNissanAA prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanomaJ Transl Med2011920422123319
- CetindereTNambiarSSantourlidisSEssmannFHassanMInduction of indoleamine 2, 3-dioxygenase by death receptor activation contributes to apoptosis of melanoma cells via mitochondrial damage-dependent ROS accumulationCell Signal201022219721119799997
- ObleDALoeweRYuPMihmMCJrFocus on TILs: prognostic significance of tumor infiltrating lymphocytes in human melanomaCancer Immun20099319338264
- LiakouCIKamatATangDNCTLA-4 blockade increases IFN-gamma-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patientsProc Natl Acad Sci U S A2008105149871499218818309
- CarthonBCWolchokJDYuanJPreoperative CTLA-4 blockade: tolerability and immune monitoring in the setting of a presurgical clinical trialClin Cancer Res201016102861267120460488
- FuTHeQSharmaPThe ICOS/ICOSL pathway is required for optimal antitumor responses mediated by anti-CTLA-4 therapyCancer Res201171165445545421708958
- VerschraegenCThe monoclonal antibody to cytotoxic T lymphocyte antigen 4, ipilimumab, in the treatment of melanomaCancer Manag Res201241822346364