The Role of TROP2 in BCC and Cutaneous SCC: A Clinical and Immunohistochemical Study

References

• Garcovich S, Colloca G, Sollena P, et al. Skin cancer epidemics in the elderly as an emerging issue in geriatric oncology. Aging Dis. 2017;8(5):643–644. doi:10.14336/AD.2017.0503
   PubMed Web of Science ®Google Scholar
• Rogers HW, Weinstock MA, Harris AR, et al. Incidence estimate of nonmelanoma skin cancer in the United States, 2006. Arch Dermatol. 2010;146(3):283–287. doi:10.1001/archdermatol.2010.19
   PubMed Web of Science ®Google Scholar
• Ibrahim AS, Khaled HM, Mikhail NN, Baraka H, Kamel H. Cancer incidence in Egypt: results of the national population-based cancer registry program. J Cancer Epidemiol. 2014;4(1):5–6.
   Google Scholar
• Hussein MR, Al-Badaiwy ZH, Guirguis MN. Analysis of p53 and bcl-2 protein expression in the nontumorigenic, pretumorigenic, and tumorigenic keratinocytic hyperproliferative lesions. J Cutan Pathol. 2004;31(10):643–651. doi:10.1111/j.0303-6987.2004.00244.x
   PubMed Web of Science ®Google Scholar
• Fania L, Didona D, Morese R, et al. Basal cell carcinoma: from pathophysiology to novel therapeutic approaches. Biomedicines. 2020;8(11):449. doi:10.3390/biomedicines8110449
   PubMed Web of Science ®Google Scholar
• Apalla Z, Nashan D, Weller RB, Castellsagué X. Skin cancer: epidemiology, disease burden, pathophysiology, diagnosis, and therapeutic approaches. Dermatol Ther (Heidelb). 2017;7(1):5–19. doi:10.1007/s13555-016-0165-y
   Web of Science ®Google Scholar
• Lee KJ, Soyer HP. Cutaneous keratinocyte cancers of the head and neck: epidemiology, risk factors and clinical, dermoscopic and reflectance confocal microscopic features. Oral Oncol. 2019;98:109–117. doi:10.1016/j.oraloncology.2019.09.019
   Web of Science ®Google Scholar
• Paolino G, Donati M, Didona D, Mercuri SR, Cantisani C. Histology of non-melanoma skin cancers: an update. Biomedicines. 2017;5(4):71. doi:10.3390/biomedicines5040071
   PubMed Web of Science ®Google Scholar
• Voiculescu V, Calenic B, Ghita M, et al. From normal skin to squamous cell carcinoma: a quest for novel biomarkers. Dis Markers. 2016;2(1):3–4.
   Google Scholar
• Kang JK, Yun BM, Song JK, Shin MS. Non-melanocytic skin cancers of the head and neck: a clinical study in Jeju Province. Arch Plast Surg. 2017;44(4):313. doi:10.5999/aps.2017.44.4.313
   Google Scholar
• Baruah B, Sengupta S, Kesari SP, Ilapakurty B. Pattern of nonmelanoma skin cancers in Sikkim, India: a 3-year clinicopathological Review. Indian J Otolaryngol Head Neck Surg. 2013;65(1):160–162. doi:10.1007/s12070-013-0652-8
   Web of Science ®Google Scholar
• Lipinski M, Parks DR, Rouse RV, Herzenberg LA. Human trophoblast cell-surface antigens defined by monoclonal antibodies. Proc Natl Acad Sci U S A. 1981;78(8):5147–5150. doi:10.1073/pnas.78.8.5147
   PubMed Web of Science ®Google Scholar
• Linnenbach AJ, Wojcierowski J, Wu SA, et al. Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733. Proc Natl Acad Sci. 1989;86(1):27–31. doi:10.1073/pnas.86.1.27
   PubMed Web of Science ®Google Scholar
• Lenárt S, Lenárt P, Šmarda J, Remšík J, Souček K, Beneš P. Trop2: jack of all trades, master of none. Cancers. 2020;12(11):3328. doi:10.3390/cancers12113328
   PubMed Web of Science ®Google Scholar
• Ning S, Guo S, Xie J, et al. TROP2 correlates with microvessel density and poor prognosis in hilar cholangiocarcinoma. J Gastrointest Surg. 2013;17(2):360–368. doi:10.1007/s11605-012-2105-1
   Web of Science ®Google Scholar
• Zeng P, Chen MB, Zhou LN, Tang M, Liu CY, Lu PH. Impact of TROP2 expression on prognosis in solid tumors: a systematic review and meta-analysis. Sci Rep. 2016;6(1):33658. doi:10.1038/srep33658
   PubMed Web of Science ®Google Scholar
• Rapani E, Sacchetti A, Corda D, Alberti S. Human Trop‐2 is a tumor‐associated calcium signal transducer. Int J Cancer. 1998;76(5):671–676. doi:10.1002/(SICI)1097-0215(19980529)76:5<671:AID-IJC10>3.0.CO;2-7
   Web of Science ®Google Scholar
• Cubas R, Zhang S, Li M, Chen C, Yao Q. Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway. Mol Cancer. 2010;9(1):253. doi:10.1186/1476-4598-9-253
   PubMed Web of Science ®Google Scholar
• Yang J, Zhu Z, Wang H, Li F, Du X, Ma RZ. Trop2 regulates the proliferation and differentiation of murine compact-bone derived MSCs. Int J Oncol. 2013;43(3):859–867. doi:10.3892/ijo.2013.1987
   Web of Science ®Google Scholar
• Balzar M, Briaire-de Bruijn IH, Rees-Bakker HA, et al. Epidermal growth factor-like repeats mediate lateral and reciprocal interactions of Ep-CAM molecules in homophilic adhesions. Mol Cell Biol. 2001;21(7):2570–2580. doi:10.1128/MCB.21.7.2570-2580.2001
   PubMed Web of Science ®Google Scholar
• Sawanyawisuth K, Tantapotinan N, Kraiklang R, et al. Suppression of trophoblast cell surface antigen 2 enhances proliferation and migration in liver fluke-associated cholangiocarcinoma. Ann Hepatol. 2016;15(1):71–81. doi:10.5604/16652681.1184223
   Web of Science ®Google Scholar
• Jiang A, Gao X, Zhang D, Zhang L, Lu H. Expression and clinical significance of the Trop-2 gene in advanced non-small cell lung carcinoma. Oncol Lett. 2013;6(2):375–380. doi:10.3892/ol.2013.1368
   PubMed Web of Science ®Google Scholar
• Liu T, Liu Y, Bao X, Tian J, Liu Y, Yang X. Overexpression of TROP2 predicts poor prognosis of patients with cervical cancer and promotes the proliferation and invasion of cervical cancer cells by regulating ERK signaling pathway. PLoS One. 2013;8(9):e75864. doi:10.1371/journal.pone.0075864
   Web of Science ®Google Scholar
• Tang G, Tang Q, Jia L, et al. High expression of TROP2 is correlated with poor prognosis of oral squamous cell carcinoma. Pathol Res Pract. 2018;214(10):1606–1612. doi:10.1016/j.prp.2018.07.017
   PubMed Web of Science ®Google Scholar
• Zhang B, Gao S, Li R, et al. Tissue mechanics and expression of TROP2 in oral squamous cell carcinoma with varying differentiation. BMC Cancer. 2020;20(1):1–2.
   Web of Science ®Google Scholar
• Elston DM, Stratman EJ, Miller SJ. Skin biopsy: biopsy issues in specific diseases. J Am Acad Dermatol. 2016;74(1):P1–16.
   PubMed Web of Science ®Google Scholar
• De Giorgi V, Savarese I, Gori A, et al. Advanced basal cell carcinoma: when a good drug is not enough. J Dermatolog Treat. 2020;31(6):552–553. doi:10.1080/09546634.2018.1542481
   PubMed Web of Science ®Google Scholar
• Dalal AJ, Ingham J, Collard B, Merrick G. Review of outcomes of 500 consecutive cases of non-melanoma skin cancer of the head and neck managed in an oral and maxillofacial surgical unit in a District General Hospital. Br J Oral Maxillofac Surg. 2018;56(9):805–809. doi:10.1016/j.bjoms.2018.08.015
   Web of Science ®Google Scholar
• Higgins S, Nazemi A, Chow M, Wysong A. Review of nonmelanoma skin cancer in African Americans, Hispanics, and Asians. Dermatol Surg. 2018;44(7):903–910. doi:10.1097/DSS.0000000000001547
   Web of Science ®Google Scholar
• Shvartsur A, Bonavida B. Trop2 and its overexpression in cancers: regulation and clinical/ therapeutic implications. Genes & Cancer. 2015;6(3–4):84. doi:10.18632/genesandcancer.40
   PubMedGoogle Scholar
• Stepan LP, Trueblood ES, Hale K, Babcook J, Borges L, Sutherland CL. Expression of Trop2 cell surface glycoprotein in normal and tumor tissues: potential implications as a cancer therapeutic target. J Histochem Cytochem. 2011;59(7):701–710. doi:10.1369/0022155411410430
   PubMed Web of Science ®Google Scholar
• Fong D, Spizzo G, Gostner JM, et al. TROP2: a novel prognostic marker in squamous cell carcinoma of the oral cavity. Mod Pathol. 2008;21(2):186–191. doi:10.1038/modpathol.3801001
   PubMed Web of Science ®Google Scholar
• Cubas R, Li M, Chen C, Yao Q. Trop 2: a possible therapeutic target for late stage epithelial carcinomas. Biochimica et biophysica acta. 2009;1796(2):309–314.
   PubMed Web of Science ®Google Scholar
• Nakashima K, Shimada H, Ochiai T, et al. Serological identification of TROP2 by recombinant cDNA expression cloning using sera of patients with esophageal squamous cell carcinoma. Int J Cancer. 2004;112(6):1029–1035. doi:10.1002/ijc.20517
   Web of Science ®Google Scholar
• Calvo A, Xiao N, Kang J, et al. Alterations in gene expression profiles during prostate cancer progression: functional correlations to tumorigenicity and down-regulation of selenoprotein-P in mouse and human tumors. Cancer Res. 2012;62(18):5325–5335.
   Google Scholar
• Kowalsky CA, Faber MS, Nath A, et al. Rapid fine conformational epitope mapping using comprehensive mutagenesis and deep sequencing. J Biol Chem. 2015;290(44):26457–26470. doi:10.1074/jbc.M115.676635
   PubMed Web of Science ®Google Scholar
• Tang G, Tang Q, Jia L, et al. TROP2 increases growth and metastasis of human oral squamous cell carcinoma through activation of the PI3K/Akt signaling pathway. Int J Mol Med. 2019;44(6):2161–2170. doi:10.3892/ijmm.2019.4378
   Web of Science ®Google Scholar
• Li X, Teng S, Zhang Y, et al. TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT. Oncotarget. 2017;8(29):47052. doi:10.18632/oncotarget.16789
   Google Scholar
• Gu QZ, Nijiati A, Gao X, et al. TROP2 promotes cell proliferation and migration in osteosarcoma through PI3K/AKT signaling. Mol Med Rep. 2018;18(2):1782–1788. doi:10.3892/mmr.2018.9083
   Web of Science ®Google Scholar
• Stoyanova T, Goldstein AS, Cai H, Drake JM, Huang J, Witte ON. Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling. Genes Dev. 2012;26(20):2271–2285. doi:10.1101/gad.196451.112
   PubMed Web of Science ®Google Scholar
• Hong Y, Manoharan I, Suryawanshi A, et al. β-Catenin promotes regulatory T-cell responses in tumors by inducing vitamin A metabolism in dendritic cells. Cancer Res. 2015;75(2):656–665. doi:10.1158/0008-5472.CAN-14-2377
   Web of Science ®Google Scholar
• Xue J, Yu X, Xue L, Ge X, Zhao W, Peng W. Intrinsic β-catenin signaling suppresses CD8+ T-cell infiltration in colorectal cancer. Biomed Pharmacother. 2019;115:108921. doi:10.1016/j.biopha.2019.108921
   Web of Science ®Google Scholar
• Hou J, Lv A, Deng Q, Zhang G, Hu X, Cui H. TROP2 promotes the proliferation and metastasis of glioblastoma cells by activating the JAK2/STAT3 signaling pathway. Oncol Rep. 2019;41(2):753–764. doi:10.3892/or.2018.6859
   PubMed Web of Science ®Google Scholar
• Braakhuis BJ, Tabor MP, Kummer JA, Leemans CR, Brakenhoff RH. A genetic explanation of slaughter’s concept of field cancerization: evidence and clinical implications. Cancer Res. 2003;63(8):1727–1730.
   PubMed Web of Science ®Google Scholar
• Szeimies RM, Torezan L, Niwa A, et al. Clinical, histopathological and immunohistochemical assessment of human skin field cancerization before and after photodynamic therapy. Br J Dermatol. 2012;167(1):150–159. doi:10.1111/j.1365-2133.2012.10887.x
   Web of Science ®Google Scholar
• Ulrich M, Maltusch A, Röwert-Huber J, et al. Actinic keratoses: non-invasive diagnosis for field cancerisation. Br J Dermatol. 2007;156(Suppl 3):13–17. doi:10.1111/j.1365-2133.2007.07865.x
   Web of Science ®Google Scholar
• Bardia A, Mayer IA, Diamond JR, et al. Efficacy and safety of anti-trop-2 antibody drug conjugate sacituzumab govitecan (IMMU-132) in heavily pretreated patients with metastatic triple-negative breast cancer. J Clin Oncol. 2017;35(19):2141. doi:10.1200/JCO.2016.70.8297
   PubMed Web of Science ®Google Scholar