The Levels of Wnt5a and Its Receptors Frizzled5 and Frizzled2 as Immunohistochemical Biomarkers of Severity of Psoriasis

References

• Crow JM. Psoriasis uncovered. Nature. 2012;492(7429):S50–S51. doi:10.1038/492S50a
   PubMed Web of Science ®Google Scholar
• WHO. Global Report on Psoriasis. Geneva: World Health Organization; 2016. Available from: https://apps.who.int/iris/handle/10665/204417. Accessed April 29, 2021.
   Google Scholar
• Boehncke WH, Schön MP. Psoriasis. Lancet. 2015;386(9997):983–994. doi:10.1016/S0140-6736(14)61909-7
   PubMed Web of Science ®Google Scholar
• Romanowska M, Evans A, Kellock D, et al. Wnt5a exhibits layer-specific expression in adult skin, is upregulated in psoriasis, and synergizes with type 1 interferon. PLoS One. 2009;4(4):e5354. doi:10.1371/journal.pone.0005354
   Web of Science ®Google Scholar
• Gudjonsson JE, Johnston A, Stoll SW, et al. Evidence for altered Wnt signaling in psoriatic skin. J Invest Dermatol. 2010;130(7):1849–1859. doi:10.1038/jid.2010.67
   Web of Science ®Google Scholar
• Reischl J, Schwenke S, Beekman JM, Mrowietz U, Stürzebecher S, Heubach JF. Increased expression of Wnt5a in psoriatic plaques. J Invest Dermatol. 2007;127(1):163–169. doi:10.1038/sj.jid.5700488
   PubMed Web of Science ®Google Scholar
• Ng LF, Kaur P, Bunnag N, et al. WNT signaling in disease. Cells. 2019;8(8):826. doi:10.3390/cells8080826
   PubMed Web of Science ®Google Scholar
• Kumawat K, Gosens R. WNT-5A: signaling and functions in health and disease. Cell Mol Life Sci. 2016;73(3):567–587. doi:10.1007/s00018-015-2076-y
   PubMed Web of Science ®Google Scholar
• Tetreault MP, Weinblatt D, Shaverdashvili K, Yang Y, Katz JP. KLF4 transcriptionally activates non-canonical WNT5A to control epithelial stratification. Sci Rep. 2016;6:26130. doi:10.1038/srep26130
   Web of Science ®Google Scholar
• Dou J, Zhang L, Xie X, et al. Integrative analyses reveal biological pathways and key genes in psoriasis. Br J Dermatol. 2017;177(5):1349–1357. doi:10.1111/bjd.15682
   Web of Science ®Google Scholar
• Zhang Y, Tu C, Zhang D, et al. Wnt/β-Catenin and Wnt5a/Ca pathways regulate proliferation and apoptosis of keratinocytes in psoriasis lesions. Cell Physiol Biochem. 2015;36(5):1890–1902. doi:10.1159/000430158
   Google Scholar
• Pavlakis K, Messini I, Athanassiadou S, et al. Endocervical glandular lesions: a diagnostic approach combining a semi-quantitative scoring method to the expression of CEA, MIB-1 and p16. Gynecol Oncol. 2006;103(3):971–976. doi:10.1016/j.ygyno.2006.06.012
   Web of Science ®Google Scholar
• Nakajima K, Sano S. Mouse models of psoriasis and their relevance. J Dermatol. 2018;45(3):252–263. doi:10.1111/1346-8138.14112
   PubMed Web of Science ®Google Scholar
• Pashirzad M, Shafiee M, Rahmani F, et al. Role of Wnt5a in the pathogenesis of inflammatory diseases. J Cell Physiol. 2017;232(7):1611–1616. doi:10.1002/jcp.25687
   PubMed Web of Science ®Google Scholar
• Zhang CJ, Zhu N, Liu Z, et al. Wnt5a/Ror2 pathway contributes to the regulation of cholesterol homeostasis and inflammatory response in atherosclerosis. Biochim Biophys Acta Mol Cell Biol Lipids. 2020;1865(2):158547. doi:10.1016/j.bbalip.2019.158547
   PubMed Web of Science ®Google Scholar
• Arderiu G, Espinosa S, Peña E, Aledo R, Badimon L. Monocyte-secreted Wnt5a interacts with FZD5 in microvascular endothelial cells and induces angiogenesis through tissue factor signaling. J Mol Cell Biol. 2014;6(5):380–393. doi:10.1093/jmcb/mju036
   Web of Science ®Google Scholar
• Wang W, Yu X, Wu C, Jin H. Differential effects of Wnt5a on the proliferation, differentiation and inflammatory response of keratinocytes. Mol Med Rep. 2018;17(3):4043–4048. doi:10.3892/mmr.2017.8358
   PubMed Web of Science ®Google Scholar
• Tönük ŞB, Yorgancıoğlu ZR. Biomechanical factors in psoriatic disease: defective repair exertion as a potential cause. Hypothesis presentation and literature review. ACR Open Rheumatol. 2019;1(7):452–461. doi:10.1002/acr2.11056
   Google Scholar
• Verma D, Ekman AK, Bivik Eding C, Enerbäck C. Genome-wide DNA methylation profiling identifies differential methylation in uninvolved psoriatic epidermis. J Invest Dermatol. 2018;138(5):1088–1093. doi:10.1016/j.jid.2017.11.036
   Web of Science ®Google Scholar
• Alrefai H, Muhammad K, Rudolf R, et al. NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells. Nat Commun. 2016;7:11724. doi:10.1038/ncomms11724
   PubMed Web of Science ®Google Scholar
• Tian F, Mauro TM, Li Z. The pathological role of Wnt5a in psoriasis and psoriatic arthritis. J Cell Mol Med. 2019;23(9):5876–5883. doi:10.1111/jcmm.14531
   Web of Science ®Google Scholar
• Sato A, Yamamoto H, Sakane H, Koyama H, Kikuchi A. Wnt5a regulates distinct signalling pathways by binding to Frizzled2. EMBO J. 2010;29(1):41–54. doi:10.1038/emboj.2009.322
   Web of Science ®Google Scholar
• Li B, Zhong L, Yang X, Andersson T, Huang M, Tang SJ. WNT5A signaling contributes to Aβ-induced neuroinflammation and neurotoxicity. PLoS One. 2011;6(8):e22920. doi:10.1371/journal.pone.0022920
   Web of Science ®Google Scholar
• Sen M, Chamorro M, Reifert J, Corr M, Carson DA. Blockade of Wnt-5A/frizzled5 signaling inhibits rheumatoid synoviocyte activation. Arthritis Rheum. 2001;44(4):772–781. doi:10.1002/1529-0131(200104)44:4<772::AID-ANR133>3.0.CO;2-L
   Web of Science ®Google Scholar
• Murphy LL, Hughes CC. Endothelial cells stimulate T cell NFAT nuclear translocation in the presence of cyclosporin A: involvement of the wnt/glycogen synthase kinase-3 beta pathway. J Immunol. 2002;169(7):3717–3725. doi:10.4049/jimmunol.169.7.3717
   Web of Science ®Google Scholar
• Nusse R, Clevers H. Wnt/β-catenin signaling, disease, and emerging therapeutic modalities. Cell. 2017;169(6):985–999. doi:10.1016/j.cell.2017.05.016
   PubMed Web of Science ®Google Scholar
• Jenei V, Sherwood V, Howlin J, et al. A t-butyloxycarbonyl-modified Wnt5a-derived hexapeptide functions as a potent antagonist of Wnt5a-dependent melanoma cell invasion. Proc Natl Acad Sci USA. 2009;106(46):19473–19478. doi:10.1073/pnas.0909409106
   Web of Science ®Google Scholar