Treatment-Refractory Central Centrifugal Cicatricial Alopecia Responsive to a Novel Botanical Treatment

References

• Bin Saif GA, McMichael A, Kwatra SG, et al. Central centrifugal cicatricial alopecia severity is associated with cowhage-induced itch. Br J Dermatol. 2013;168(2):253–256. doi:10.1111/bjd.12043
   PubMed Web of Science ®Google Scholar
• Aguh C, McMichael A. Central centrifugal cicatricial alopecia. JAMA Dermatol. 2020;156(9):1036. doi:10.1001/jamadermatol.2020.1859
   PubMed Web of Science ®Google Scholar
• Malki L, Sarig O, Romano MT, et al. Variant PADI3 in central centrifugal cicatricial alopecia. N Engl J Med. 2019;380(9):833–841. doi:10.1056/NEJMoa1816614
   PubMed Web of Science ®Google Scholar
• Aguh C, Dina Y, Talbot CC Jr, Garza L. Fibroproliferative genes are preferentially expressed in central centrifugal cicatricial alopecia. J Am Acad Dermatol. 2018;79(5):904–912. doi:10.1016/j.jaad.2018.05.1257
   PubMed Web of Science ®Google Scholar
• Araoye EF, Thomas JAL, Aguh CU. Hair regrowth in 2 patients with recalcitrant central centrifugal cicatricial alopecia after use of topical metformin. JAAD Case Rep. 2020;6(2):106–108. doi:10.1016/j.jdcr.2019.12.008
   PubMedGoogle Scholar
• Olsen EA, Whiting D, Bergfeld W, Olsen EA, Whiting D, Bergfeld W, et al. A multicenter, randomized, placebo-controlled, double-blind clinical trial of a novel formulation of 5% minoxidil topical foam versus placebo in the treatment of androgenetic alopecia in men. J Am Acad Dermatol. 2007;57(5):767–774. doi:10.1016/j.jaad.2007.04.012
   PubMed Web of Science ®Google Scholar
• Alahmari L, Almesned R, Alhumidi A, Alkhalifah A. Lichen planopilaris with koebner phenomenon. JAAD Case Rep. 2018;4(8):848–850. doi:10.1016/j.jdcr.2018.05.009
   PubMedGoogle Scholar
• Gathers RC, Lim HW. Central centrifugal cicatricial alopecia: past, present, and future. J Am Acad Dermatol. 2009;60(4):660–668. doi:10.1016/j.jaad.2008.09.066
   PubMed Web of Science ®Google Scholar
• Callender VD, Kazemi A, Young CM, et al. Safety and efficacy of clobetasol propionate 0.05% emollient foam for the treatment of central centrifugal cicatricial alopecia. J Drugs Dermatol. 2020;19(7):719–724. doi:10.36849/JDD.2020.5201
   PubMed Web of Science ®Google Scholar
• Okereke UR, Simmons A, Callender VD. Current and emerging treatment strategies for hair loss in women of color. Int J Womens Dermatol. 2019;5(1):37–45. doi:10.1016/j.ijwd.2018.10.021
   PubMedGoogle Scholar
• Herskovitz I, Miteva M. Central centrifugal cicatricial alopecia: challenges and solutions. Clin Cosmet Investig Dermatol. 2016;9:175–181. doi:10.2147/CCID.S100816
   PubMedGoogle Scholar
• Ezekwe N, King M, Hollinger JC. The use of natural ingredients in the treatment of alopecias with an emphasis on central centrifugal cicatricial alopecia: a systematic review. J Clin Aesthet Dermatol. 2020;13(8):23–27.
   PubMedGoogle Scholar
• Umar S, Carter MJ. A multimodal hair-loss treatment strategy using a new topical phytoactive formulation: a report of five cases. Case Rep Dermatol Med. 2021;2021:6659943. doi:10.1155/2021/6659943
   PubMedGoogle Scholar
• Hu Y, Liang H, Du Y, et al. Curcumin inhibits transforming growth factor-beta activity via inhibition of smad signaling in HK-2 cells. Am J Nephrol. 2010;31(4):332–341. doi:10.1159/000287230
   PubMed Web of Science ®Google Scholar
• Shishodia S. Molecular mechanisms of curcumin action: gene expression. Biofactors. 2013;39(1):37–55. doi:10.1002/biof.1041
   PubMed Web of Science ®Google Scholar
• Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013;15(1):195–218. doi:10.1208/s12248-012-9432-8
   PubMed Web of Science ®Google Scholar
• Gu W, Yang M, Bi Q, et al. Water extract from processed polygonum multiflorum modulate gut microbiota and glucose metabolism on insulin resistant rats. BMC Complement Med Ther. 2020;20(1):107.
   PubMedGoogle Scholar
• Conic RRZ, Piliang M, Bergfeld W, Atanaskova-Mesinkovska N. Vitamin D status in scarring and nonscarring alopecia. J Am Acad Dermatol. 2021;85(2):478–480. doi:10.1016/j.jaad.2018.04.032
   PubMed Web of Science ®Google Scholar
• Jung D-H, Park H-J, Byun H-E, et al. Diosgenin inhibits macrophage-derived inflammatory mediators through downregulation of CK2, JNK, Nf-κb AND AP-1 activation. Int Immunopharmacol. 2010;10(9):1047–1054. doi:10.1016/j.intimp.2010.06.004
   PubMed Web of Science ®Google Scholar
• Subash J, Alexander T, Beamer V, McMichael A. A proposed mechanism for central centrifugal cicatricial alopecia. Exp Dermatol. 2020;29(2):190–195. doi:10.1111/exd.13664
   PubMed Web of Science ®Google Scholar
• Rinwa P, Kaur B, Jaggi AS, Singh N. Involvement of PPAR-gamma in curcumin-mediated beneficial effects in experimental dementia. Naunyn Schmiedebergs Arch Pharmacol. 2010;381(6):529–539. doi:10.1007/s00210-010-0511-z
   PubMed Web of Science ®Google Scholar
• Gautam S, Ishrat N, Yadav P, et al. 4-Hydroxyisoleucine attenuates the inflammation-mediated insulin resistance by the activation of AMPK and suppression of SOCS-3 coimmunoprecipitation with both the IR-β subunit as well as IRS-1. Mol Cell Biochem. 2016;414(1–2):95–104. doi:10.1007/s11010-016-2662-9
   PubMed Web of Science ®Google Scholar
• Zayed EA, AinShoka AA, El Shazly KA, et al. Fenugreek oil and metformin improve insulin resistance via increase of GLUT4 and PPARγ in metabolic syndrome‐induced rats. Asian J Res Rep Endocrinol. 2021;4:29–39.
   Google Scholar
• Muraki E, Hayashi Y, Chiba H, et al. Dose-dependent effects, safety and tolerability of fenugreek in diet-induced metabolic disorders in rats. Lipids Health Dis. 2011;10:240. doi:10.1186/1476-511X-10-240
   PubMed Web of Science ®Google Scholar
• Panahi Y, Hosseini MS, Khalili N, et al. Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: a post-hoc analysis of a randomized controlled trial. Biomed Pharmacother. 2016;82:578–582. doi:10.1016/j.biopha.2016.05.037
   PubMed Web of Science ®Google Scholar
• Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009;14(2):141–153.
   PubMed Web of Science ®Google Scholar
• Abe Y, Hashimoto S, Horie T. Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages. Pharmacol Res. 1999;39(1):41–47. doi:10.1006/phrs.1998.0404
   PubMed Web of Science ®Google Scholar
• Chowdhury AA, Gawali NB, Munshi R, Juvekar AR. Trigonelline insulates against oxidative stress, proinflammatory cytokines and restores BDNF levels in lipopolysaccharide induced cognitive impairment in adult mice. Metab Brain Dis. 2018;33(3):681–691. doi:10.1007/s11011-017-0147-5
   PubMed Web of Science ®Google Scholar
• Moers-Carpi M. Influence of nutritive factors on hair growth. Aktuelle Derm. 2011;37:171–175. doi:10.1055/s-0030-1256369
   Google Scholar
• Park SY, Jin ML, Chae SY, et al. Novel compound from polygonum multiflorum inhibits inflammatory response in LPS-stimulated microglia by upregulating AMPK/Nrf2 pathways. Neurochem Int. 2016;100:21–29. doi:10.1016/j.neuint.2016.08.006
   PubMed Web of Science ®Google Scholar
• Sun YN, Li W, Song SB, et al. Nuclear factor kappa B activation and peroxisome proliferator-activated receptor transactivational effects of chemical components of the roots of polygonum multiflorum. Pharmacogn Mag. 2016;12(45):31–35. doi:10.4103/0973-1296.176019
   PubMed Web of Science ®Google Scholar
• Rangarajan S, Bone NB, Zmijewska AA, et al. Metformin reverses established lung fibrosis in a bleomycin model. Nat Med. 2018;24(8):1121–1127. doi:10.1038/s41591-018-0087-6
   PubMed Web of Science ®Google Scholar
• da Silva Morais A, Abarca-Quinones J, Guigas B, et al. Development of hepatic fibrosis occurs normally in AMPK-deficient mice. Clin Sci (Lond). 2009;118(3):411–420. doi:10.1042/CS20090293
   PubMed Web of Science ®Google Scholar
• Islam N, Garza LA. Adipose and hair function: an aPPARent connection. J Invest Dermatol. 2018;138(3):480–482. doi:10.1016/j.jid.2017.10.019
   PubMed Web of Science ®Google Scholar
• Sardella C, Winkler C, Quignodon L, et al. Delayed hair follicle morphogenesis and hair follicle dystrophy in a lipoatrophy mouse model of Pparg total deletion. J Invest Dermatol. 2018;138(3):500–510. doi:10.1016/j.jid.2017.09.024
   PubMed Web of Science ®Google Scholar
• Karnik P, Tekeste Z, McCormick TS, et al. Hair follicle stem cell-specific PPARgamma deletion causes scarring alopecia. J Invest Dermatol. 2009;129(5):1243–1257. doi:10.1038/jid.2008.369
   PubMed Web of Science ®Google Scholar
• Mirmirani P, Karnik P. Lichen planopilaris treated with a peroxisome proliferator-activated receptor gamma agonist. Arch Dermatol. 2009;145(12):1363–1366. doi:10.1001/archdermatol.2009.283
   PubMed Web of Science ®Google Scholar
• Kim T, Davis J, Zhang AJ, et al. Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells. Biochem Biophys Res Commun. 2009;388(2):377–382. doi:10.1016/j.bbrc.2009.08.018
   PubMed Web of Science ®Google Scholar
• Siddiqui AM, Cui X, Wu R, et al. The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-gamma. Crit Care Med. 2006;34(7):1874–1882. doi:10.1097/01.CCM.0000221921.71300.BF
   PubMed Web of Science ®Google Scholar
• Wang HM, Zhao YX, Zhang S, et al. PPAR gamma agonist curcumin reduces the amyloid-beta-stimulated inflammatory responses in primary astrocytes. J Alzheimers Dis. 2010;20(4):1189–1199. doi:10.3233/JAD-2010-091336
   PubMed Web of Science ®Google Scholar
• Wani SA, Kumar P. Fenugreek: a review on its nutraceutical properties and utilization in various food products. J Saudi Soc Agric Sci. 2018;17(2):97–106. doi:10.1016/j.jssas.2016.01.007
   Google Scholar