Collagen Stimulators in Body Applications: A Review Focused on Poly-L-Lactic Acid (PLLA)

References

• American Society Plastic Surgeons. 2020 national plastic surgery statistics; 2020. Available from: https://www.plasticsurgery.org/news/plastic-surgery-statistics. Accessed May 23, 2022.
   Google Scholar
• Wat H, Wu DC, Goldman MP. Noninvasive body contouring: a male perspective. Dermatol Clin. 2018;36(1):49–55. doi:10.1016/j.det.2017.09.007
   PubMed Web of Science ®Google Scholar
• Wang JV, Akintilo L, Geronemus RG. Growth of cosmetic procedures in millennials: a 4.5-year clinical review. J Cosmet Dermatol. 2020;19(12):3210–3212. doi:10.1111/jocd.13768
   PubMed Web of Science ®Google Scholar
• Christen MO, Vercesi F. Polycaprolactone: how a well-known and futuristic polymer has become an innovative collagen-stimulator in esthetics. Clin Cosmet Investig Dermatol. 2020;13:31–48. doi:10.2147/CCID.S229054
   PubMed Web of Science ®Google Scholar
• Kim JA, Van Abel D. Neocollagenesis in human tissue injected with a polycaprolactone-based dermal filler. J Cosmet Laser Ther. 2015;17(2):99–101. doi:10.3109/14764172.2014.968586
   PubMed Web of Science ®Google Scholar
• Vleggaar D, Fitzgerald R, Lorenc ZP, et al. Consensus recommendations on the use of injectable poly-L-lactic acid for facial and nonfacial volumization. JDD. 2014;13(4 Suppl):s44–51.
   PubMed Web of Science ®Google Scholar
• Vleggaar D, Fitzgerald R, Lorenc ZP. The need for consensus recommendations on the use of injectable poly-L-lactic acid for facial and nonfacial volumization. JDD. 2014;13(4 Suppl):s28.
   PubMed Web of Science ®Google Scholar
• Redaelli A, Rzany B, Eve L, et al. European expert recommendations on the use of injectable poly-L-lactic acid for facial rejuvenation. JDD. 2014;13(9):1057–1066.
   PubMed Web of Science ®Google Scholar
• Goldberg D, Guana A, Volk A, Daro-Kaftan E. Single-arm study for the characterization of human tissue response to injectable poly-L-lactic acid. Dermatol Surg. 2013;39(6):915–922. doi:10.1111/dsu.12164
   PubMed Web of Science ®Google Scholar
• de Almeida AT, Figueredo V, da Cunha ALG, et al. Consensus recommendations for the use of hyperdiluted calcium hydroxyapatite (radiesse) as a face and body biostimulatory agent. Plast Reconstr Surg Glob Open. 2019;7(3):e2160. doi:10.1097/GOX.0000000000002160
   PubMedGoogle Scholar
• Loghem JV, Yutskovskaya YA, Werschler WP. Calcium hydroxylapatite: over a decade of clinical experience. J Clin Aesthetic Dermatol. 2015;8(1):38–49.
   PubMedGoogle Scholar
• Goldie K, Peeters W, Alghoul M, et al. Global consensus guidelines for the injection of diluted and hyperdiluted calcium hydroxylapatite for skin tightening. Dermatol Surg. 2018;44(Suppl 1):S32–S41. doi:10.1097/DSS.0000000000001685
   PubMed Web of Science ®Google Scholar
• Ahn CS, Rao BK. The life cycles and biological end pathways of dermal fillers. J Cosmet Dermatol. 2014;13(3):212–223. doi:10.1111/jocd.12100
   PubMed Web of Science ®Google Scholar
• Narins RS, Baumann L, Brandt FS, et al. A randomized study of the efficacy and safety of injectable poly-L-lactic acid versus human-based collagen implant in the treatment of nasolabial fold wrinkles. J Am Acad Dermatol. 2010;62(3):448–462. doi:10.1016/j.jaad.2009.07.040
   PubMed Web of Science ®Google Scholar
• Moers-Carpi M, Christen MO, Delmar H, Brun P, Bodokh I, Kestemont P. European multicenter prospective study evaluating long-term safety and efficacy of the polycaprolactone-based dermal filler in nasolabial fold correction. Dermatol Surg. 2021;47(7):960–965. doi:10.1097/DSS.0000000000002978
   PubMed Web of Science ®Google Scholar
• Lin SL, Christen MO. Polycaprolactone-based dermal filler complications: a retrospective study of 1111 treatments. J Cosmet Dermatol. 2020;19(8):1907–1914. doi:10.1111/jocd.13518
   PubMed Web of Science ®Google Scholar
• Serra MS. Polymethyl Methacrylate for the Body. In: Costa AD, editor. Minimally Invasive Aesthetic Procedures: A Guide for Dermatologists and Plastic Surgeons. Springer International Publishing; 2020:589–592. doi:10.1007/978-3-319-78265-2_82
   Google Scholar
• De Albuquerque GC. Fillers and collagen stimulator for body rejuvenation and cellulitis. In: Issa MCA, Tamura B, editors. Botulinum Toxins, Fillers and Related Substances. Clinical Approaches and Procedures in Cosmetic Dermatology. Springer International Publishing; 2017:1–7. doi:10.1007/978-3-319-20253-2_27-1
   Google Scholar
• Fitzgerald R, Bass LM, Goldberg DJ, Graivier MH, Lorenc ZP. Physiochemical characteristics of Poly-L-Lactic Acid (PLLA). Aesthet Surg J. 2018;38(suppl_1):S13–S17. doi:10.1093/asj/sjy012
   PubMed Web of Science ®Google Scholar
• Herrmann JL, Hoffmann RK, Ward CE, Schulman JM, Grekin RC. Biochemistry, physiology, and tissue interactions of contemporary biodegradable injectable dermal fillers. Dermatol Surg. 2018;44(Suppl 1):S19–S31. doi:10.1097/DSS.0000000000001582
   PubMed Web of Science ®Google Scholar
• Lacombe V. Sculptra: a stimulatory filler. Facial Plast Surg. 2009;25(2):95–99. doi:10.1055/s-0029-1220648
   PubMed Web of Science ®Google Scholar
• Lorenc ZP. Techniques for the optimization of facial and nonfacial volumization with injectable poly-l-lactic acid. Aesthetic Plast Surg. 2012;36(5):1222–1229. doi:10.1007/s00266-012-9920-3
   PubMed Web of Science ®Google Scholar
• Vleggaar D, Fitzgerald R, Lorenc ZP. Composition and mechanism of action of poly-L-lactic acid in soft tissue augmentation. JDD. 2014;13(4 Suppl):s29–31.
   PubMed Web of Science ®Google Scholar
• Bauer U, Graivier MH. Optimizing injectable poly-L-lactic acid administration for soft tissue augmentation: the rationale for three treatment sessions. Can J Plast Surg. 2011;19(3):e22–27. doi:10.1177/229255031101900311
   PubMedGoogle Scholar
• Sickles CK, Nassereddin A, Gross GP. Poly-L-lactic acid. In: StatPearls. StatPearls Publishing; 2021.
   Google Scholar
• Jabbar A, Arruda S, Sadick N. Off face usage of poly-L-lactic acid for body rejuvenation. JDD. 2017;16(5):489–494.
   PubMed Web of Science ®Google Scholar
• Haddad A, Menezes A, Guarnieri C, et al. Recommendations on the use of injectable poly-L-lactic acid for skin laxity in off-face areas. JDD. 2019;18(9):929–935.
   PubMed Web of Science ®Google Scholar
• Lin MJ, Dubin DP, Goldberg DJ, Khorasani H. Practices in the usage and reconstitution of poly-L-lactic acid. JDD. 2019;18(9):880–886.
   PubMed Web of Science ®Google Scholar
• Li CN, Wang CC, Huang CC, Wang HH, Hsu NJ, A novel, optimized method to accelerate the preparation of injectable poly-L-lactic acid by sonication. JDD. 2018;17(8):894–898.
   PubMed Web of Science ®Google Scholar
• Bravo BSF, de Carvalho RM. Safety in immediate reconstitution of poly-l-lactic acid for facial biostimulation treatment. J Cosmet Dermatol. 2020. doi:10.1111/jocd.13597
   Web of Science ®Google Scholar
• Narins RS. Minimizing adverse events associated with poly-L-lactic acid injection. Dermatol Surg. 2008;34(Suppl 1):S100–104. doi:10.1111/j.1524-4725.2008.34250.x
   PubMed Web of Science ®Google Scholar
• Guida S, Spadafora M, Longhitano S, Pellacani G, Farnetani F. A validated photonumeric scale for the evaluation of neck skin laxity. Dermatol Surg. 2021;47(5):e188–e190. doi:10.1097/DSS.0000000000002865
   PubMed Web of Science ®Google Scholar
• Kaminer MS, Casabona G, Peeters W, et al. Validated assessment scales for skin laxity on the posterior thighs, buttocks, anterior thighs, and knees in female patients. Dermatol Surg. 2019;45(Suppl 1):S12–S21. doi:10.1097/DSS.0000000000001994
   PubMed Web of Science ®Google Scholar
• Hexsel D, Fabi SG, Sattler G, et al. Validated assessment scales for cellulite dimples on the buttocks and thighs in female patients. Dermatol Surg. 2019;45(Suppl 1):S2–S11. doi:10.1097/DSS.0000000000001993
   PubMed Web of Science ®Google Scholar
• Landau M, Geister TL, Leibou L, et al. Validated assessment scales for décolleté wrinkling and pigmentation. Dermatol Surg. 2016;42(7):842–852. doi:10.1097/DSS.0000000000000786
   PubMed Web of Science ®Google Scholar
• Fabi S, Bolton J, Goldman MP, Guiha I. The Fabi-Bolton chest wrinkle scale: a pilot validation study. J Cosmet Dermatol. 2012;11(3):229–234. doi:10.1111/j.1473-2165.2012.00628.x
   PubMed Web of Science ®Google Scholar
• Longhitano S, Galadari H, Cascini S, et al. A validated photonumeric cellulite severity scale for the area above the knees: the knee cellulite severity score. JEADV. 2020;34(9):2152–2155. doi:10.1111/jdv.16269
   Web of Science ®Google Scholar
• Cohen JL, Sadick NS, Kirby MT, et al. Development and validation clinician and patient reported photonumeric scales to assess buttocks cellulite severity. Dermatol Surg. 2020;46(12):1628–1635. doi:10.1097/DSS.0000000000002756
   PubMed Web of Science ®Google Scholar
• Hexsel DM, Dal’Forno T, Hexsel CL. A validated photonumeric cellulite severity scale. JEADV. 2009;23(5):523–528. doi:10.1111/j.1468-3083.2009.03101.x
   Web of Science ®Google Scholar
• Tateo A, Siquier-Dameto G, Artzi O, et al. Development and validation of IBSA photographic scale for the assessment of neck laxity. Clin Cosmet Investig Dermatol. 2021;14:349–354. doi:10.2147/CCID.S302860
   PubMed Web of Science ®Google Scholar
• Young VL, DiBernardo BE. Comparison of cellulite severity scales and imaging methods. Aesthet Surg J. 2021;41(6):NP521–NP537. doi:10.1093/asj/sjaa226
   PubMed Web of Science ®Google Scholar
• DiBernardo BE, Sasaki GH, Katz BE, Hunstad JP, Petti C, Burns AJ. A multicenter study for cellulite treatment using a 1440-nm Nd: YAG wavelength laser with side-firing fiber. Aesthet Surg J. 2016;36(3):335–343. doi:10.1093/asj/sjv203
   PubMed Web of Science ®Google Scholar
• de Freitas VMP, Miot HA, Miot LDB, et al. Development of a clinical scale to assess the severity of striae distensae. Skin Res Technol. 2021;27(4):627–631. doi:10.1111/srt.12995
   PubMed Web of Science ®Google Scholar
• Cassuto D, Pellacani G, Tateo A, et al. Development and validation of IBSA photographic scale for the assessment of inner upper arm laxity. Clin Cosmet Investig Dermatol. 2021;14:1465–1471. doi:10.2147/CCID.S317857
   PubMed Web of Science ®Google Scholar
• Lee JH, Choi YS, Park ES, et al. A novel photonumeric hand grading scale for hand rejuvenation. Arch Plast Surg. 2019;46(4):359–364. doi:10.5999/aps.2019.00521
   PubMedGoogle Scholar
• Carruthers A, Carruthers J, Hardas B, et al. A validated hand grading scale. Dermatol Surg. 2008;34(Suppl 2):S179–183. doi:10.1111/j.1524-4725.2008.34368.x
   PubMed Web of Science ®Google Scholar
• Jones D, Donofrio L, Hardas B, et al. Development and validation of a photonumeric scale for evaluation of volume deficit of the hand. Dermatol Surg. 2016;42(Suppl 1):S195–S202. doi:10.1097/DSS.0000000000000850
   PubMed Web of Science ®Google Scholar
• Sattler G, Carruthers A, Carruthers J, et al. Validated assessment scale for neck volume. Dermatol Surg. 2012;38(2 Spec No.):343–350. doi:10.1111/j.1524-4725.2011.02253.x
   PubMed Web of Science ®Google Scholar
• Jones D, Carruthers A, Hardas B, et al. Development and validation of a photonumeric scale for evaluation of transverse neck lines. Dermatol Surg. 2016;42(Suppl 1):S235–S242. doi:10.1097/DSS.0000000000000851
   PubMed Web of Science ®Google Scholar
• Vanaman M, Fabi SG. Décolletage: regional approaches with injectable fillers. Plast Reconstr Surg. 2015;136(5Suppl):276S–281S. doi:10.1097/PRS.0000000000001832
   PubMed Web of Science ®Google Scholar
• de Melo F, Carrijo A, Hong K, et al. Minimally invasive aesthetic treatment of the face and neck using combinations of a PCL-based collagen stimulator, PLLA/PLGA suspension sutures, and cross-linked hyaluronic acid. Clin Cosmet Investig Dermatol. 2020;13:333–344. doi:10.2147/CCID.S248280
   PubMed Web of Science ®Google Scholar
• Peterson JD, Goldman MP. Rejuvenation of the aging chest: a review and our experience. Dermatol Surg. 2011;37(5):555–571. doi:10.1111/j.1524-4725.2011.01972.x
   PubMed Web of Science ®Google Scholar
• Peterson JD, Kilmer SL. Three-dimensional rejuvenation of the décolletage. Dermatol Surg. 2016;42(Suppl 2):S101–S107. doi:10.1097/DSS.0000000000000758
   PubMed Web of Science ®Google Scholar
• Vanaman M, Fabi SG, Cox SE. Neck rejuvenation using a combination approach: our experience and a review of the literature. Dermatol Surg. 2016;42(Suppl 2):S94–S100. doi:10.1097/DSS.0000000000000699
   PubMed Web of Science ®Google Scholar
• Chao YY, Chiu HH, Howell DJ. A novel injection technique for horizontal neck lines correction using calcium hydroxylapatite. Dermatol Surg. 2011;37(10):1542–1545. doi:10.1111/j.1524-4725.2011.02086.x
   PubMed Web of Science ®Google Scholar
• Yutskovskaya YA, Kogan EA. Improved neocollagenesis and skin mechanical properties after injection of diluted calcium hydroxylapatite in the neck and décolletage: a pilot study. JDD. 2017;16(1):68–74.
   PubMed Web of Science ®Google Scholar
• Fabi SG, Alhaddad M, Boen M, Goldman M. Prospective clinical trial evaluating the long-term safety and efficacy of calcium hydroxylapatite for chest rejuvenation. JDD. 2021;20(5):534–537. doi:10.36849/JDD.5680
   PubMed Web of Science ®Google Scholar
• Guida S, Longhitano S, Spadafora M, et al. Hyperdiluted calcium hydroxylapatite for the treatment of skin laxity of the neck. Dermatol Ther. 2021;34(5):e15090. doi:10.1111/dth.15090
   PubMed Web of Science ®Google Scholar
• Casabona G, Nogueira Teixeira D. Microfocused ultrasound in combination with diluted calcium hydroxylapatite for improving skin laxity and the appearance of lines in the neck and décolletage. J Cosmet Dermatol. 2018;17(1):66–72. doi:10.1111/jocd.12475
   PubMed Web of Science ®Google Scholar
• Hart DR, Fabi SG, White WM, Fitzgerald R, Goldman MP. Current concepts in the use of PLLA: clinical synergy noted with combined use of microfocused ultrasound and poly-L-lactic acid on the face, neck, and décolletage. Plast Reconstr Surg. 2015;136(5 Suppl):180S–187S. doi:10.1097/PRS.0000000000001833
   PubMed Web of Science ®Google Scholar
• Mazzuco R, Hexsel D. Poly-L-lactic acid for neck and chest rejuvenation. Dermatol Surg. 2009;35(8):1228–1237. doi:10.1111/j.1524-4725.2009.01217.x
   PubMed Web of Science ®Google Scholar
• Zac RI, Da Costa A. Poly-L-lactic acid for the neck. In: Costa AD, editor. Minimally Invasive Aesthetic Procedures. Springer International Publishing; 2020:529–532. doi:10.1007/978-3-319-78265-2_73
   Google Scholar
• Bolton J, Fabi S, Peterson JD, Goldman MP. Poly-L-lactic acid for chest rejuvenation: a retrospective study of 28 cases using a 5-point chest wrinkle scale. Cosmet Dermatol. 2011;24(6):278–284.
   Google Scholar
• Wilkerson EC, Goldberg DJ. Poly-L-lactic acid for the improvement of photodamage and rhytids of the décolletage. J Cosmet Dermatol. 2018;17(4):606–610. doi:10.1111/jocd.12447
   PubMed Web of Science ®Google Scholar
• Schulman MR, Lipper J, Skolnik RA. Correction of chest wall deformity after implant-based breast reconstruction using poly-L-lactic acid (Sculptra). Breast J. 2008;14(1):92–96. doi:10.1111/j.1524-4741.2007.00529.x
   PubMed Web of Science ®Google Scholar
• Fabi SG. Fillers for the décolletage area. Pract Dermatol. 2015;42:29–40.
   Google Scholar
• Vleggaar D. Soft-tissue augmentation and the role of poly-L-lactic acid. Plast Reconstr Surg. 2006;118(3 Suppl):46S–54S. doi:10.1097/01.prs.0000234846.00139.74
   PubMed Web of Science ®Google Scholar
• Redaelli A, Forte R. Cosmetic use of polylactic acid: report of 568 patients. J Cosmet Dermatol. 2009;8(4):239–248. doi:10.1111/j.1473-2165.2009.00459.x
   PubMed Web of Science ®Google Scholar
• Palm MD, Woodhall KE, Butterwick KJ, Goldman MP. Cosmetic use of poly-l-lactic acid: a retrospective study of 130 patients. Dermatol Surg. 2010;36(2):161–170. doi:10.1111/j.1524-4725.2009.01419.x
   PubMed Web of Science ®Google Scholar
• ISAPS. Plastic surgery statistics | Global plastic surgery statistics. ISAPS. Available from: https://www.isaps.org/medical-professionals/isaps-global-statistics/. Accessed December 27, 2021.
   Google Scholar
• Singh D. Universal allure of the hourglass figure: an evolutionary theory of female physical attractiveness. Clin Plast Surg. 2006;33(3):359–370. doi:10.1016/j.cps.2006.05.007
   PubMed Web of Science ®Google Scholar
• Gonzalez R. Etiology, definition, and classification of gluteal ptosis. Aesthetic Plast Surg. 2006;30(3):320–326. doi:10.1007/s00266-005-0051-y
   PubMed Web of Science ®Google Scholar
• Lin MJ, Dubin DP, Khorasani H. Poly-L-lactic acid for minimally invasive gluteal augmentation. Dermatol Surg. 2020;46(3):386–394. doi:10.1097/DSS.0000000000001967
   PubMed Web of Science ®Google Scholar
• Amore R, Amuso D, Leonardi V, et al. Treatment of dimpling from cellulite. Plast Reconstr Surg Glob Open. 2018;6(5):e1771. doi:10.1097/GOX.0000000000001771
   PubMedGoogle Scholar
• Whipple LA, Fournier CT, Heiman AJ, et al. The anatomical basis of cellulite dimple formation: an ultrasound-based examination. Plast Reconstr Surg. 2021;148(3):375e–381e. doi:10.1097/PRS.0000000000008218
   PubMed Web of Science ®Google Scholar
• Sadick N. Treatment for cellulite. Int J Womens Dermatol. 2019;5(1):68–72. doi:10.1016/j.ijwd.2018.09.002
   PubMedGoogle Scholar
• Rosique RG, Rosique MJF. Augmentation gluteoplasty: a Brazilian perspective. Plast Reconstr Surg. 2018;142(4):910–919. doi:10.1097/PRS.0000000000004809
   PubMed Web of Science ®Google Scholar
• Wong WW, Motakef S, Lin Y, Gupta SC. Redefining the ideal buttocks: a population analysis. Plast Reconstr Surg. 2016;137(6):1739–1747. doi:10.1097/PRS.0000000000002192
   PubMed Web of Science ®Google Scholar
• Nteli Chatzioglou G, Govsa F, Bicer A, Ozer MA, Pinar Y. Physical attractiveness: analysis of buttocks patterns for planning body contouring treatment. Surg Radiol Anat. 2019;41(1):133–140. doi:10.1007/s00276-018-2083-4
   PubMed Web of Science ®Google Scholar
• Mendieta CG, Sood A. Classification system for gluteal evaluation: revisited. Clin Plast Surg. 2018;45(2):159–177. doi:10.1016/j.cps.2017.12.013
   PubMed Web of Science ®Google Scholar
• Cuzalina A, Retana A. Creating the ideal buttock (lifting, implanting or fat grafting). In: Aguilera A, editor. The Art of Body Contouring. IntechOpen; 2019. doi:10.5772/intechopen.84660
   Google Scholar
• Toledo LS. Gluteal augmentation with fat grafting: the Brazilian buttock technique: 30 years’ experience. Clin Plast Surg. 2015;42(2):253–261. doi:10.1016/j.cps.2014.12.004
   PubMed Web of Science ®Google Scholar
• Abboud M, Geeroms M, El Hajj H, Abboud N. Improving the female silhouette and gluteal projection: an anatomy-based, safe, and harmonious approach through liposuction, suspension loops, and moderate lipofilling. Aesthet Surg J. 2021;41(4):474–489. doi:10.1093/asj/sjaa157
   PubMed Web of Science ®Google Scholar
• Oranges CM, Tremp M, Di Summa PG, et al. Gluteal augmentation techniques: a comprehensive literature review. Aesthet Surg J. 2017;37(5):560–569. doi:10.1093/asj/sjw240
   PubMed Web of Science ®Google Scholar
• Mofid MM, Teitelbaum S, Suissa D, et al. Report on mortality from gluteal fat grafting: recommendations from the ASERF task force. Aesthet Surg J. 2017;37(7):796–806. doi:10.1093/asj/sjx004
   PubMed Web of Science ®Google Scholar
• Friedmann DP, Vick GL, Mishra V. Cellulite: a review with a focus on subcision. Clin Cosmet Investig Dermatol. 2017;10:17–23. doi:10.2147/CCID.S95830
   PubMed Web of Science ®Google Scholar
• Hexsel DM, Mazzuco R. Subcision: a treatment for cellulite. Int J Dermatol. 2000;39(7):539–544. doi:10.1046/j.1365-4362.2000.00020.x
   PubMed Web of Science ®Google Scholar
• Santaella-Sosa E. Gluteal projection and augmentation using polycaprolactone-based filler: a promising new indication. J Aesthetic Nurs. 2020;9(6):229–232. doi:10.12968/joan.2020.9.6.229
   Google Scholar
• Chacur R, Menezes HS, Chacur NMBDS, et al. Gluteal augmentation with polymethyl methacrylate: a 10-year cohort study. Plast Reconstr Surg Glob Open. 2019;7(5):e2193. doi:10.1097/GOX.0000000000002193
   PubMedGoogle Scholar
• Logas C, Kosche C, Perez M, Martinez-Diaz GJ. Biostimulatory injectables for the treatment of cellulite and gluteal enhancement. Plast Surg Mod Tech. 2018;5(4). doi:10.29011/2577-1701.100042
   Google Scholar
• Davis DS, Boen M, Fabi SG. Cellulite: patient selection and combination treatments for optimal results-a review and our experience. Dermatol Surg. 2019;45(9):1171–1184. doi:10.1097/DSS.0000000000001776
   PubMed Web of Science ®Google Scholar
• Mazzuco R, Sadick NS. The use of poly-L-lactic acid in the gluteal area. Dermatol Surg. 2016;42(3):441–443. doi:10.1097/DSS.0000000000000632
   PubMed Web of Science ®Google Scholar
• Mazzuco R. SubcisionTM plus poly-l-lactic acid for the treatment of cellulite associated to flaccidity in the buttocks and thighs. J Cosmet Dermatol. 2020;19(5):1165–1171. doi:10.1111/jocd.13364
   PubMed Web of Science ®Google Scholar
• Mazzuco R, Dal’Forno T, Hexsel D. Poly-L-lactic acid for nonfacial skin laxity. Dermatol Surg. 2020;46(Suppl 1):S86–S88. doi:10.1097/DSS.0000000000002390
   PubMedGoogle Scholar
• Cunha MG, da Daza F, Rezende FC, Machado Filho CDA. Poly-L-lactic acid injections in sagging body skin. Surg Cosmet Dermatol. 2016;8(4). doi:10.5935/scd1984-8773.20168404
   Google Scholar
• Durairaj KK, Devgan L, Lee A, et al. Poly-L-lactic acid for gluteal augmentation found to be safe and effective in retrospective clinical review of 60 patients. Dermatol Surg. 2020;46(Suppl 1):S46–S53. doi:10.1097/DSS.0000000000002598
   PubMed Web of Science ®Google Scholar
• Swearingen A, Medrano K, Ferzli G, Sadick N, Arruda S. Randomized, double-blind, placebo-controlled study of poly-L-lactic acid for treatment of cellulite in the lower extremities. JDD. 2021;20(5):529–533. doi:10.36849/JDD.5380
   PubMed Web of Science ®Google Scholar
• Shridharani SM, Tisch GM, Ebersole TG, Moak TN, Edwartz C. Clinical experience of poly-L-lactic acid injections for body contouring treatment. J Cosmet Dermatol. 2021;20:1655–1662. doi:10.1111/jocd.14141
   PubMed Web of Science ®Google Scholar
• Sandoval MHL. Poly-L-lactic acid for the gluteal area. In: Costa AD, editor. Minimally Invasive Aesthetic Procedures: A Guide for Dermatologists and Plastic Surgeons. Springer International Publishing; 2020:543–547. doi:10.1007/978-3-319-78265-2_76
   Google Scholar
• Harper J, Avelar L, Haddad A, et al. Expert recommendations on the use of injectable poly-L-lactic acid for contour deficiencies of the buttocks. JDD. 2022;21(1):21–26. doi:10.36849/JDD.2022.6180
   PubMed Web of Science ®Google Scholar
• Sadick NS, Arruda S. The use of poly-L-lactic acid in the abdominal area. Dermatol Surg. 2017;43(2):313–315. doi:10.1097/DSS.0000000000000881
   PubMed Web of Science ®Google Scholar
• Jerdan K, Fabi S. A noninvasive approach to off-face skin laxity and tightening: a review of the literature. Semin Cutan Med Surg. 2015;34(3):118–128. doi:10.12788/j.sder.2015.0173
   PubMed Web of Science ®Google Scholar
• Cogorno Wasylkowski V. Body vectoring technique with Radiesse(®) for tightening of the abdomen, thighs, and brachial zone. Clin Cosmet Investig Dermatol. 2015;8:267–273. doi:10.2147/CCID.S75631
   PubMedGoogle Scholar
• Lapatina NG, Pavlenko T. Diluted calcium hydroxylapatite for skin tightening of the upper arms and abdomen. JDD. 2017;16(9):900–906.
   PubMed Web of Science ®Google Scholar
• Teimourian B, Malekzadeh S. Rejuvenation of the upper arm. Plast Reconstr Surg. 1998;102(2):545–553. doi:10.1097/00006534-199808000-00041
   PubMed Web of Science ®Google Scholar
• Lee SJ, Jang HW, Kim H, Suh DH, Ryu HJ. Non-invasive cryolipolysis to reduce subcutaneous fat in the arms. J Cosmet Laser Ther. 2016;18(3):126–129. doi:10.3109/14764172.2015.1114644
   PubMed Web of Science ®Google Scholar
• Wanitphakdeedecha R, Sathaworawong A, Manuskiatti W. The efficacy of cryolipolysis treatment on arms and inner thighs. Lasers Med Sci. 2015;30(8):2165–2169. doi:10.1007/s10103-015-1781-y
   PubMed Web of Science ®Google Scholar
• McKnight B, Tobin R, Kabir Y, Moy R. Improving upper arm skin laxity using a tripollar radiofrequency device. JDD. 2015;14(12):1463–1466.
   PubMed Web of Science ®Google Scholar
• Miotto G, Ortiz-Pomales Y. Arm contouring: review and current concepts. Aesthet Surg J. 2018;38(8):850–860. doi:10.1093/asj/sjx218
   PubMed Web of Science ®Google Scholar
• Amselem M. Radiesse(®): a novel rejuvenation treatment for the upper arms. Clin Cosmet Investig Dermatol. 2016;9:9–14. doi:10.2147/CCID.S93137
   PubMedGoogle Scholar
• Coimbra D, Gutstein da Fonseca Amorim A. Poly-L-lactic acid in the rejuvenation of the medial and anterior arms. Surg Cosmet Dermatol. 2012;4(2):182–185.
   Google Scholar
• Coimbra DD, Stefanello B. Poly-L-lactic acid for arms. In: Costa AD, editor. Minimally Invasive Aesthetic Procedures. Springer International Publishing; 2020:533–537. doi:10.1007/978-3-319-78265-2_74
   Google Scholar
• Vartanian E, Gould DJ, Hammoudeh ZS, Azadgoli B, Stevens WG, Macias LH. The ideal thigh: a crowdsourcing-based assessment of ideal thigh aesthetic and implications for gluteal fat grafting. Aesthet Surg J. 2018;38(8):861–869. doi:10.1093/asj/sjx191
   PubMed Web of Science ®Google Scholar
• Michaels J. Vertical medial thigh contouring. Clin Plast Surg. 2019;46(1):91–103. doi:10.1016/j.cps.2018.08.014
   PubMed Web of Science ®Google Scholar
• Okumus A. Combination of lipofilling with liposuction in the correction of pseudo genu varus deformity. Aesthet Surg J. 2020;40(3):NP94–NP100. doi:10.1093/asj/sjz305
   PubMed Web of Science ®Google Scholar
• Gold MH, Sensing W, Biron J. Use of micro-focused ultrasound with visualization to lift and tighten lax knee skin (1.). J Cosmet Laser Ther. 2014;16(5):225–229. doi:10.3109/14764172.2014.949273
   PubMed Web of Science ®Google Scholar
• Guida S, Longhitano S, Shaniko K, et al. Hyperdiluted calcium hydroxylapatite for skin laxity and cellulite of the skin above the knee: a pilot study. Dermatol Ther. 2020;33(6):e14076. doi:10.1111/dth.14076
   PubMed Web of Science ®Google Scholar
• Machado Costa GR, Mesquita AC. Poly-L-lactic acid for the knee area skin laxity treatment; 2019. Available from: https://www.wcd2019milan-dl.org/abstract-book/documents/late-breaking-abstracts/03-aesthetic-cosmetic-dermatology/poly-l-lactic-acid-for-428.pdf. Accessed May 23, 2022.
   Google Scholar
• Kollipara R, Hoss E, Boen M, Alhaddad M, Fabi SG, Randomized A. Split-body, placebo-controlled trial to evaluate the efficacy and safety of poly-L-lactic acid for the treatment of upper knee skin laxity. Dermatol Surg. 2020;46(12):1623–1627. doi:10.1097/DSS.0000000000002685
   PubMed Web of Science ®Google Scholar
• Park JA, Lee SH, Hwang SJ, Koh KS, Song WC. Anatomic, histologic, and ultrasound analyses of the dorsum of the hand for volumetric rejuvenation. JPRAS. 2021;74(7):1615–1620. doi:10.1016/j.bjps.2020.11.017
   Web of Science ®Google Scholar
• Butterwick K, Sadick N. Hand rejuvenation using a combination approach. Dermatol Surg. 2016;42(Suppl 2):S108–118. doi:10.1097/DSS.0000000000000687
   PubMed Web of Science ®Google Scholar
• Shamban AT. Combination hand rejuvenation procedures. Aesthet Surg J. 2009;29(5):409–413. doi:10.1016/j.asj.2009.08.003
   PubMed Web of Science ®Google Scholar
• Figueiredo VM. A five-patient prospective pilot study of a polycaprolactone based dermal filler for hand rejuvenation. J Cosmet Dermatol. 2013;12(1):73–77. doi:10.1111/jocd.12020
   PubMed Web of Science ®Google Scholar
• Lowe NJ, Ghanem AM. Volume restoration of hands with polycaprolactone by cannula delivery; a prospective single center consecutive case series evaluation. J Cosmet Laser. 2020;22(2):55–59. doi:10.1080/14764172.2019.1711127
   PubMed Web of Science ®Google Scholar
• de Melo F, Nicolau P, Piovano L, et al. Recommendations for volume augmentation and rejuvenation of the face and hands with the new generation polycaprolactone-based collagen stimulator (Ellansé®). Clin Cosmet Investig Dermatol. 2017;10:431–440. doi:10.2147/CCID.S145195
   PubMed Web of Science ®Google Scholar
• Kühne U, Imhof M. Treatment of the ageing hand with dermal fillers. J Cutan Aesthetic Surg. 2012;5(3):163–169. doi:10.4103/0974-2077.101369
   PubMedGoogle Scholar
• Goldman MP, Moradi A, Gold MH, et al. Calcium hydroxylapatite dermal filler for treatment of dorsal hand volume loss: results from a 12-month, multicenter, randomized, blinded trial. Dermatol Surg. 2018;44(1):75–83. doi:10.1097/DSS.0000000000001203
   PubMed Web of Science ®Google Scholar
• Graivier MH, Lorenc ZP, Bass LM, Fitzgerald R, Goldberg DJ. Calcium hydroxyapatite (CaHA) indication for hand rejuvenation. Aesthet Surg J. 2018;38(suppl_1):S24–S28. doi:10.1093/asj/sjy013
   PubMed Web of Science ®Google Scholar
• Haq S, Storck R, Baspeyras M, et al. Multinational, multipatient study of calcium hydroxylapatite for treatment of the aging hand: European cosmetic physician group on hand augmentation. Dermatol Surg. 2010;36(1):782–789. doi:10.1111/j.1524-4725.2010.01548.x
   Web of Science ®Google Scholar
• Edelson KL. Hand recontouring with calcium hydroxylapatite (Radiesse). J Cosmet Dermatol. 2009;8(1):44–51. doi:10.1111/j.1473-2165.2009.00423.x
   PubMed Web of Science ®Google Scholar
• Sadick NS, Anderson D, Werschler WP. Addressing volume loss in hand rejuvenation: a report of clinical experience. J Cosmet Laser Ther. 2008;10(4):237–241. doi:10.1080/14764170802524429
   PubMed Web of Science ®Google Scholar
• Fabi SG, Goldman MP. Hand rejuvenation: a review and our experience. Dermatol Surg. 2012;38(7 Pt 2):1112–1127. doi:10.1111/j.1524-4725.2011.02291.x
   PubMed Web of Science ®Google Scholar
• Redaelli A. Cosmetic use of polylactic acid for hand rejuvenation: report on 27 patients. J Cosmet Dermatol. 2006;5(3):233–238. doi:10.1111/j.1473-2165.2006.00259.x
   PubMedGoogle Scholar
• Sadick NS. Poly-L-lactic acid: a perspective from my practice. J Cosmet Dermatol. 2008;7(1):55–60. doi:10.1111/j.1473-2165.2008.00362.x
   PubMedGoogle Scholar
• Atamoros FMP, Lozano AA. Poly-L-lactic acid for hands. In: Costa AD, editor. Minimally Invasive Aesthetic Procedures: A Guide for Dermatologists and Plastic Surgeons. Springer International Publishing; 2020:539–542. doi:10.1007/978-3-319-78265-2_75
   Google Scholar
• Da Costa A Minimally invasive aesthetic procedures: a guide for dermatologists and plastic surgeons. Springer International Publishing; 2020. Available from: https://books.google.fr/books?id=7aDSDwAAQBAJ. Accessed May 23, 2022.
   Google Scholar
• Quezada Gaón N, Wortsman X, Apt P. Polycaprolactone for extrafacial areas. In: Costa AD, editor. Minimally Invasive Aesthetic Procedures: A Guide for Dermatologists and Plastic Surgeons. Springer International Publishing; 2020:565–573. doi:10.1007/978-3-319-78265-2_79
   Google Scholar
• Vleggaar D, Fitzgerald R, Lorenc ZP. The history behind the use of injectable poly-L-lactic acid for facial and nonfacial volumization: the positive impact of evolving methodology. JDD. 2014;13(4 Suppl):s32–34.
   PubMed Web of Science ®Google Scholar
• Palm M, Mayoral F, Rajani A, et al. Chart review presenting safety of injectable PLLA used with alternative reconstitution volume for facial treatments. JDD. 2021;20(1):118–122. doi:10.36849/JDD.5631
   PubMed Web of Science ®Google Scholar
• Duracinsky M, Leclercq P, Herrmann S, Christen MO, et al. Safety of poly-L-lactic acid (New-Fill®) in the treatment of facial lipoatrophy: a large observational study among HIV-positive patients. BMC Infect Dis. 2014;14:474. doi:10.1186/1471-2334-14-474
   PubMed Web of Science ®Google Scholar
• Lorenc ZP, Greene T, Gottschalk RW. Injectable poly-L-lactic acid: understanding its use in the current era. JDD. 2016;15(6):759–762.
   PubMed Web of Science ®Google Scholar
• Rossner F, Rossner M, Hartmann V, Erdmann R, Wiest LG, Rzany B. Decrease of reported adverse events to injectable polylactic acid after recommending an increased dilution: 8-year results from the Injectable Filler Safety study. J Cosmet Dermatol. 2009;8(1):14–18. doi:10.1111/j.1473-2165.2009.00417.x
   PubMed Web of Science ®Google Scholar
• Fabi SG, Burgess C, Carruthers A, et al. Consensus recommendations for combined aesthetic interventions using botulinum toxin, fillers, and microfocused ultrasound in the neck, décolletage, hands, and other areas of the body. Dermatol Surg. 2016;42(10):1199–1208. doi:10.1097/DSS.0000000000000869
   PubMed Web of Science ®Google Scholar
• Cohen JL, Carruthers A, Jones DH, et al. A randomized, blinded study to validate the Merz hand grading scale for use in live assessments. Dermatol Surg. 2015;41(Suppl 1):S384–S388. doi:10.1097/DSS.0000000000000553
   PubMed Web of Science ®Google Scholar
• Hexsel D, Valente-Bezerra I, Dal’Forno T, et al. Buttocks’ skin laxity severity scale. Dermatol Surg. 2022. doi:10.1097/DSS.0000000000003434
   PubMed Web of Science ®Google Scholar
• Green JB, Pavicic T, Pooth R, et al. Validated 5 – point photonumeric scales for the assessment of hand atrophy. J Cosmet Dermatol. 2022;21:933–939. doi:10.1111/jocd.14776
   PubMed Web of Science ®Google Scholar