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ORIGINAL RESEARCH

Bioinformatic Analysis and Translational Validation of Psoriasis Candidate Genes for Precision Medicine

, , , , & ORCID Icon
Pages 1447-1458 | Received 13 Jun 2022, Accepted 22 Jul 2022, Published online: 28 Jul 2022

References

  • Boehncke WH, Schön MP. Psoriasis. Lancet. 2015;386(9997):983–994.
  • Hawkes JE, Chan TC, Krueger JG. Psoriasis pathogenesis and the development of novel targeted immune therapies. J Allergy Clin Immunol. 2017;140(3):645–653.
  • Lou F, Sun Y, Xu Z, et al. Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis. Immunity. 2020;53(1):204–216.e10.
  • Fyhrquist N, Muirhead G, Prast-Nielsen S, et al. Microbe-host interplay in atopic dermatitis and psoriasis. Nat Commun. 2019;10(1):4703.
  • Michalek IM, Loring B, John SM. A systematic review of worldwide epidemiology of psoriasis. J Eur Acad Dermatol Venereol. 2017;31(2):205–212.
  • Parisi R, Symmons DP, Griffiths CE, et al. Global epidemiology of psoriasis: a systematic review of incidence and prevalence. J Invest Dermatol. 2013;133(2):377–385.
  • Icen M, Crowson CS, McEvoy MT, et al. Trends in incidence of adult-onset psoriasis over three decades: a population-based study. J Am Acad Dermatol. 2009;60(3):394–401.
  • Tollefson MM, Crowson CS, McEvoy MT, et al. Incidence of psoriasis in children: a population-based study. J Am Acad Dermatol. 2010;62(6):979–987.
  • Kamiya K, Kishimoto M, Sugai J, et al. Risk Factors for the Development of Psoriasis. Int J Mol Sci. 2019;20(18):4347.
  • Cheng BT, Silverberg JI. Predictors of hospital readmission in United States adults with psoriasis. J Am Acad Dermatol. 2020;82(4):902–909.
  • Sbidian E, Chaimani A, Garcia-Doval I, et al. Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis. Cochrane Database Syst Rev. 2017;12(12):CD011535.
  • Al-Hammadi A, Ruszczak Z, Magariños G, et al. Intermittent use of biologic agents for the treatment of psoriasis in adults. J Eur Acad Dermatol Venereol. 2021;35(2):360–367.
  • Bilal J, Berlinberg A, Bhattacharjee S, et al. A systematic review and meta-analysis of the efficacy and safety of the interleukin (IL)-12/23 and IL-17 inhibitors ustekinumab, secukinumab, ixekizumab, brodalumab, guselkumab and tildrakizumab for the treatment of moderate to severe plaque psoriasis. J Dermatolog Treat. 2018;29(6):569–578.
  • Kamata M, Tada Y. Safety of biologics in psoriasis. J Dermatol. 2018;45(3):279–286.
  • Johnson-Huang LM, Pensabene CA, Shah KR, et al. Post-therapeutic relapse of psoriasis after CD11a blockade is associated with T cells and inflammatory myeloid DCs. PLoS One. 2012;7(2):e30308.
  • Singer J, Irmisch A, Ruscheweyh HJ, et al. Bioinformatics for precision oncology. Brief Bioinform. 2019;20(3):778–788.
  • Bigler J, Rand HA, Kerkof K, et al. Cross-study homogeneity of psoriasis gene expression in skin across a large expression range. PLoS One. 2013;8(1):e52242.
  • Russell CB, Rand H, Bigler J, et al. Gene expression profiles normalized in psoriatic skin by treatment with brodalumab, a human anti-IL-17 receptor monoclonal antibody. J Immunol. 2014;192(8):3828–3836.
  • Reischl J, Schwenke S, Beekman JM, et al. Increased expression of Wnt5a in psoriatic plaques. J Invest Dermatol. 2007;127(1):163–169.
  • Stewart TJ, Tong W, Whitfeld MJ. The associations between psychological stress and psoriasis: a systematic review. Int J Dermatol. 2018;57(11):1275–1282.
  • Armstrong AW, Harskamp CT, Dhillon JS, et al. Psoriasis and smoking: a systematic review and meta-analysis. Br J Dermatol. 2014;170(2):304–314.
  • Jensen P, Skov L. Psoriasis and Obesity. Dermatology. 2016;232(6):633–639.
  • Armstrong AW, Harskamp CT, Armstrong EJ. Psoriasis and the risk of diabetes mellitus: a systematic review and meta-analysis. JAMA Dermatol. 2013;149(1):84–91.
  • Armstrong AW, Harskamp CT, Armstrong EJ. The association between psoriasis and hypertension: a systematic review and meta-analysis of observational studies. J Hypertens. 2013;31(3):433–442.
  • Masson Regnault M, Konstantinou MP, Khemis A, et al. Early relapse of psoriasis after stopping brodalumab: a retrospective cohort study in 77 patients. J Eur Acad Dermatol Venereol. 2017;31(9):1491–1496.
  • Wei JA, Han L, Lu CJ, et al. Formula PSORI-CM01 eliminates psoriasis by inhibiting the expression of keratinocyte cyclin B2. BMC Complement Altern Med. 2016;16:255.
  • Li YJ, Zhou T, Zhang J, et al. Clinical trait-connected network analysis reveals transcriptional markers of active psoriasis treatment with Liangxue-Jiedu decoction. J Ethnopharmacol. 2021;25(268):113551.
  • Zhang YJ, Sun YZ, Gao XH, et al. Integrated bioinformatic analysis of differentially expressed genes and signaling pathways in plaque psoriasis. Mol Med Rep. 2019;20(1):225–235.
  • Zanet J, Freije A, Ruiz M, et al. A mitosis block links active cell cycle with human epidermal differentiation and results in endoreplication. PLoS One. 2010;5(12):e15701.
  • Sitry-Shevah D, Kaisari S, Teichner A, et al. Role of ubiquitylation of components of mitotic checkpoint complex in their dissociation from anaphase-promoting complex/cyclosome. Proc Natl Acad Sci U S A. 2018;115(8):1777–1782.
  • Chen Z, Yu Y, Fu D, et al. Functional roles of PC-PLC and Cdc20 in the cell cycle, proliferation, and apoptosis. Cell Biochem Funct. 2010;28(4):249–257.
  • Quek LS, Grasset N, Jasmen JB, et al. Dual Role of the Anaphase Promoting Complex/Cyclosome in Regulating Stemness and Differentiation in Human Primary Keratinocytes. J Invest Dermatol. 2018;138(8):1851–1861.
  • Zhang Q, Huang H, Liu A, et al. Cell division cycle 20 (CDC20) drives prostate cancer progression via stabilization of β-catenin in cancer stem-like cells. EBioMedicine. 2019;42:397–407.
  • Teixeira JH, Silva P, Faria J, et al. Clinicopathologic significance of BubR1 and Mad2 overexpression in oral cancer. Oral Dis. 2015;21(6):713–720.
  • Li Y, Bai W, Zhang J. MiR-200c-5p suppresses proliferation and metastasis of human hepatocellular carcinoma (HCC) via suppressing MAD2L1. Biomed Pharmacother. 2017;92:1038–1044.
  • Ying H, Xu Z, Chen M, et al. Overexpression of Zwint predicts poor prognosis and promotes the proliferation of hepatocellular carcinoma by regulating cell-cycle-related proteins. Onco Targets Ther. 2018;Feb(11):689–702.
  • Pasquali L, Srivastava A, Meisgen F, et al. The Keratinocyte Transcriptome in Psoriasis: pathways Related to Immune Responses, Cell Cycle and Keratinization. Acta Derm Venereol. 2019;99(2):196–205.
  • Jia J, Li C, Yang J, et al. Yes-associated protein promotes the abnormal proliferation of psoriatic keratinocytes via an amphiregulin dependent pathway. Sci Rep. 2018;8(1):14513.
  • Yang XG, Jiang BW, Jing QQ, et al. Nitidine chloride induces S phase cell cycle arrest and mitochondria-dependent apoptosis in HaCaT cells and ameliorates skin lesions in psoriasis-like mouse models. Eur J Pharmacol. 2019;15(863):172680.
  • Thatikonda S, Pooladanda V, Sigalapalli DK, et al. Piperlongumine regulates epigenetic modulation and alleviates psoriasis-like skin inflammation via inhibition of hyperproliferation and inflammation. Cell Death Dis. 2020;11(1):21.
  • Lo YH, Li CS, Chen HL, et al. Galectin-8 Is Upregulated in Keratinocytes by IL-17A and Promotes Proliferation by Regulating Mitosis in Psoriasis. J Invest Dermatol. 2021;141(3):503–511.e9.
  • Wang R, Zhao Z, Zheng L, et al. MicroRNA-520a suppresses the proliferation and mitosis of HaCaT cells by inactivating protein kinase B. Exp Ther Med. 2017;14(6):6207–6212.
  • Nair RP, Duffin KC, Helms C, et al. Collaborative Association Study of Psoriasis. Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet. 2009;41(2):199–204.
  • Yao Y, Richman L, Morehouse C, et al. Type I interferon: potential therapeutic target for psoriasis? PLoS One. 2008;3(7):e2737.
  • Suárez-Fariñas M, Li K, Fuentes-Duculan J, et al. Expanding the psoriasis disease profile: interrogation of the skin and serum of patients with moderate-to-severe psoriasis. J Invest Dermatol. 2012;132(11):2552–2564.
  • Niu X, Zhang K. Dysregulated expression of inflammation-related genes in psoriatic dermis mesenchymal stem cells. Acta Biochim Biophys Sin (Shanghai). 2016;48(6):587–588.
  • Swindell WR, Xing X, Stuart PE, et al. Heterogeneity of inflammatory and cytokine networks in chronic plaque psoriasis. PLoS One. 2012;7(3):e34594.
  • Pollock RA, Abji F, Liang K, et al. Gene expression differences between psoriasis patients with and without inflammatory arthritis. J Invest Dermatol. 2015;135(2):620–623.
  • Ruano J, Suárez-Fariñas M, Shemer A, et al. Molecular and Cellular Profiling of Scalp Psoriasis Reveals Differences and Similarities Compared to Skin Psoriasis. PLoS One. 2016;11(2):e0148450.
  • Sundarrajan S, Arumugam M. Weighted gene co-expression based biomarker discovery for psoriasis detection. Gene. 2016;593(1):225–234.
  • Ruano J, Suárez-Fariñas M, Shemer A, Oliva M, Guttman-Yassky E, Krueger JG. Molecular and Cellular Profiling of Scalp Psoriasis Reveals Differences and Similarities Compared to Skin Psoriasis. PLoS One. 2017;11(2):548.
  • Damiani G, Bragazzi NL, Karimkhani Aksut C, et al. The Global, Regional, and National Burden of Psoriasis: results and Insights From the Global Burden of Disease 2019 Study. Front Med. 2021;8:743180.
  • Damiani G, Conic RRZ, de Vita V, et al. When IL-17 inhibitors fail: real-life evidence to switch from secukinumab to Adalimumab or ustekinumab. Dermatol Ther. 2019;32(2):e12793.
  • Damiani G, Odorici G, Pacifico A, et al. Secukinumab Loss of Efficacy Is Perfectly Counteracted by the Introduction of Combination Therapy (Rescue Therapy): data from a Multicenter Real-Life Study in a Cohort of Italian Psoriatic Patients That Avoided Secukinumab Switching. Pharmaceuticals. 2022;15(1):95.
  • Damiani G, Conic RRZ, Pigatto PDM, et al. From randomized clinical trials to real life data. An Italian clinical experience with ixekizumab and its management. Dermatol Ther. 2019;32(3):e12886.
  • Conic RR, Damiani G, Schrom KP, et al. Psoriasis and Psoriatic Arthritis Cardiovascular Disease Endotypes Identified by Red Blood Cell Distribution Width and Mean Platelet Volume. J Clin Med. 2020;9(1):186.
  • Damiani G, Conic RRZ, Pigatto PDM, et al. Predicting Secukinumab Fast-Responder Profile in Psoriatic Patients: advanced Application of Artificial-Neural-Networks (ANNs). J Drugs Dermatol. 2020;19(12):1241–1246.