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CASE REPORT

Itraconazole Oral Solution for Infantile Complicated Hemangioma with Double Lesions on the Skin and One Inside the Liver

, , , & ORCID Icon
Pages 1217-1226 | Received 17 Feb 2024, Accepted 10 May 2024, Published online: 23 May 2024

References

  • Metry DW, Hebert AA. Benign cutaneous vascular tumors of infancy. Arch Dermatol. 2000;136(7):905–914. doi:10.1001/archderm.136.7.905
  • Zhang XT, Ren WD, Song G, et al. Infantile hepatic hemangiomas associated with high-output cardiac failure and pulmonary hypertension. BMC Cardiovasc Disord. 2019;19(1):216. doi:10.1186/s12872-019-1200-6
  • Burke DR, Verstandig A, Edwards O, et al. Infantile hemangioendothelioma: angiographic features and factors determining efficacy of hepatic artery embolization. Cardiovasc Intervent Radiol. 1986;9(3):154–157. doi:10.1007/BF02577927
  • Samuel M, Spitz L. Infantile hepatic hemangioendothelioma: the role of surgery. J Pediatr Surg. 1995;30(10):1425–1429. doi:10.1016/0022-3468(95)90397-6
  • Wu W, Pradhan S, Ran X, et al. Multifocal infantile hemangiomas treated by oral itraconazole: a case report. NJDVL. 2022;20(1):44–46.
  • Cavalli R, Novotna V, Buffon RB, et al. Multiple cutaneous and hepatic infantile hemangiomas having a successful response to propranolol as monotherapy at neonatal period. G Ital Dermatol Venereol. 2013;148(5):525–530.
  • Vlahovic A, Simic R, Djokic D, et al. Diffuse neonatal hemangiomatosis treatment with cyclophosphamide: a case report. J Pediatr Hematol Oncol. 2009;31:858–860. doi:10.1097/MPH.0b013e3181b536ad
  • Markiewicz-Kijewska M, Kaspryzk W, Broniszczak D, et al. Hemodynamic failure as an indication to urgent liver transplantation in infants with giant hepatic hemangiomas or vascular malformations-report of four cases. Pediatr Transplant. 2009;13:906–912. doi:10.1111/j.1399-3046.2008.01050.x
  • Schiavetti A, De Pasquale MD, Di Salvo S, et al. Recombinant interferon alfa 2a in hepatic hemangiomatosis with congestive heart failure: a case report. Pediatr Hematol Oncol. 2003;20:161–165. doi:10.1080/0880010390158676
  • Stratte EG, Tope WD, Johnson CL, et al. Multimodal management of diffuse neonatal hemangiomatosis. J Am Acad Dermatol. 1996;2(Pt2):56.
  • Kassarjian A, Zurakowski D, Dubois J, et al. Infantile Hepatic Hemangiomas: clinical and Imaging Findings and Their Correlation with Therapy. Am J Roentgenol. 2004;182(3):785–795. doi:10.2214/ajr.182.3.1820785
  • Lawley LP, Siegfried E, Todd Jane L. Propranolol treatment for hemangioma of infancy: risks and recommendations. Pediatr Dermatol. 2009;26(5):610–614. doi:10.1111/j.1525-1470.2009.00975.x
  • Ran Y, Chen S, Dai Y, et al. Successful treatment of oral itraconazole for infantile hemangiomas: a case series. J Dermatol. 2015;42(2):202–206. doi:10.1111/1346-8138.12724
  • Huang Y, Ran X, Xu X, et al. Itraconazole oral solution for a case of infantile hemangioma: monitoring the efficacy by dermoscopy and MRI. Dermatol Ther. 2021;11(5):1861–1866. doi:10.1007/s13555-021-00579-9
  • Ji Y, Chen S, Yang K, et al. Screening for infantile hepatic hemangioma in patients with cutaneous infantile hemangioma: a multicenter prospective study. J Am Acad Dermatol. 2021;84(5):1378–1384. doi:10.1016/j.jaad.2020.11.062
  • Zhu L, Xie J, Liu Z, et al. Pigment epithelium-derived factor/vascular endothelial growth factor ratio plays a crucial role in the spontaneous regression of infant hemangioma and in the therapeutic effect of propranolol. Cancer Sci. 2018;109(6):1981–1994. doi:10.1111/cas.13611
  • Chang LC, Haggstrom AN, Drolet BA, et al. Growth characteristics of infantile hemangiomas: implications for management. Pediatrics. 2008;122(2):360–367. doi:10.1542/peds.2007-2767
  • Bauland CG, Luning TH, Smit JM, et al. Untreated hemangiomas: growth pattern and residual lesions. Plast Reconstr Surg. 2011;127(4):1643–1648. doi:10.1097/PRS.0b013e318208d2ac
  • Isaacs H. Fetal and neonatal hepatic tumors. J Pediatr Surg. 2007;42(11):1797–1803. doi:10.1016/j.jpedsurg.2007.07.047
  • North PE, Waner M, Mizeracki A, et al. GLUT1: a newly discovered immunohistochemical marker for juvenile hemangiomas. Hum Pathol. 2000;31(1):11–22. doi:10.1016/S0046-8177(00)80192-6
  • Mo JQ, Dimashkieh HH, Bove KE. GLUT1 endothelial reactivity distinguishes hepatic infantile hemangioma from congenital hepatic vascular malformation with associated capillary proliferation. Hum Pathol. 2004;35(2):200–209. doi:10.1016/j.humpath.2003.09.017
  • Christison-Lagay ER, Burrows PE, Alomari A, et al. Hepatic hemangiomas: subtype classification and development of a clinical practice algorithm and registry. J Pediatr Surg. 2007;42(1):62–67. doi:10.1016/j.jpedsurg.2006.09.041
  • Selby DM, Stocker JT, Waclawiw MA, et al. Infantile hemangioendothelioma of the liver. Hepatology. 1994;20(1 Pt 1):39–45. doi:10.1016/0270-9139(94)90132-5
  • Boon LM, Burrows PE, Paltiel HJ, et al. Hepatic vascular anomalies in infancy: a twenty-seven-year experience. J Pediatr. 1996;129(3):346–354. doi:10.1016/S0022-3476(96)70065-3
  • Rialon KL, Murillo R, Fevurly RD, et al. Risk factors for mortality in patients with multifocal and diffuse hepatic hemangiomas. J Pediatr Surg. 2015;50(5):837–841. doi:10.1016/j.jpedsurg.2014.09.056
  • Mazereeuw-Hautier J, Hoeger PH, Benlahrech S, et al. Efficacy of propranolol in hepatic Infantile hemangiomas with diffuse neonatal hemangiomatosis. J Pediatr. 2010;157(2):340–342. doi:10.1016/j.jpeds.2010.04.003
  • Grant SM, Clissold SP. Itraconazole: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in superficial and systemic mycoses. Drugs. 1989;37(3):310–344. doi:10.2165/00003495-198937030-00003
  • Chen S, Sun KY, Feng XW, et al. Efficacy and safety of itraconazole use in infants. World J Pediatr. 2016;12(4):399–407. doi:10.1007/s12519-016-0034-x
  • Del Carratore R, Carpi A, Beffy P, et al. Itraconazole inhibits HMEC-1 angiogenesis. Biomed Pharmacother. 2012;66(4):312–317. doi:10.1016/j.biopha.2011.11.004
  • Nacev B, Grassi P, Dell A, et al. The antifungal drug itraconazole inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells. J Biol Chem. 2011;286(51):44045–44056. doi:10.1074/jbc.M111.278754
  • Bessar H, Kandil AH, Nasr NM, et al. Itraconazole versus propranolol: therapeutic and pharmacologic effect on serum angiopoietin-2 in patients with infantile hemangioma. J DermatolTreat. 2022;33(1):105–110. doi:10.1080/09546634.2019.1687822
  • Chen S, Zhuang K, Sun K, et al. Itraconazole induces regression of infantile hemangioma via downregulation of the platelet derived growth factor-D/PI3K/Akt/mTOR pathway. J Invest Dermatol. 2019;139(7):1574–1582. doi:10.1016/j.jid.2018.12.028
  • Mhanna A, Franklin WH, Mancini AJ. Hepatic infantile hemangiomas treated with oral propranolol-a case series. Pediatr Dermatol. 2011;28(1):39–45. doi:10.1111/j.1525-1470.2010.01355.x