Perianal Crohn’s disease: challenges and solutions

References

• SchwartzDALoftusEVJrTremaineWJThe natural history of fistulizing Crohn’s disease in Olmsted County, MinnesotaGastroenterology2002122487588011910338
   PubMed Web of Science ®Google Scholar
• TarrantKMBarclayMLFramptonCMGearryRBPerianal disease predicts changes in Crohn’s disease phenotype–results of a population-based study of inflammatory bowel disease phenotypeAm J Gastroenterol2008103123082309319086959
   PubMed Web of Science ®Google Scholar
• HellersGBergstrandOEwerthSHolmstromBOccurrence and outcome after primary treatment of anal fistulae in Crohn’s diseaseGut19802165255277429313
   PubMed Web of Science ®Google Scholar
• WilliamsDRCollerJACormanMLNugentFWVeidenheimerMCAnal complications in Crohn’s diseaseDis Colon Rectum198124122247472097
   PubMed Web of Science ®Google Scholar
• FaucheronJLSaint-MarcOGuibertLParcRLong-term seton drainage for high anal fistulas in Crohn’s disease – a sphincter-saving operation?Dis Colon Rectum19963922082118620789
   PubMed Web of Science ®Google Scholar
• HatchQChampagneBJMaykelJACrohn’s disease and pregnancy: the impact of perianal disease on delivery methods and complicationsDis Colon Rectum201457217417824401878
   PubMed Web of Science ®Google Scholar
• SandbornWJFazioVWFeaganBGHanauerSBAmerican Gastroenterological Association Clinical Practice CAGA technical review on perianal Crohn’s diseaseGastroenterology200312551508153014598268
   PubMed Web of Science ®Google Scholar
• TozerPJWhelanKPhillipsRKHartALEtiology of perianal Crohn’s disease: role of genetic, microbiological, and immunological factorsInflamm Bowel Dis200915101591159819637358
   PubMed Web of Science ®Google Scholar
• IrvineEJUsual therapy improves perianal Crohn’s disease as measured by a new disease activity index. McMaster IBD Study GroupJ Clin Gastroenterol199520127327884173
   PubMed Web of Science ®Google Scholar
• PresentDHRutgeertsPTarganSInfliximab for the treatment of fistulas in patients with Crohn’s diseaseN Engl J Med1999340181398140510228190
   PubMed Web of Science ®Google Scholar
• SchwartzDAWiersemaMJDudiakKMA comparison of endoscopic ultrasound, magnetic resonance imaging, and exam under anesthesia for evaluation of Crohn’s perianal fistulasGastroenterology200112151064107211677197
   PubMed Web of Science ®Google Scholar
• RegueiroMMardiniHTreatment of perianal fistulizing Crohn’s disease with infliximab alone or as an adjunct to exam under anesthesia with seton placementInflamm Bowel Dis2003929810312769443
   PubMed Web of Science ®Google Scholar
• RegueiroMThe role of endoscopy in the evaluation of fistulizing Crohn’s diseaseGastrointest Endosc Clin N Am200212362163312486948
   PubMedGoogle Scholar
• LawPJBartramCIAnal endosonography: technique and normal anatomyGastrointest Radiol19891443493532680741
   PubMedGoogle Scholar
• CheongDMNoguerasJJWexnerSDJagelmanDGAnal endosonography for recurrent anal fistulas: image enhancement with hydrogen peroxideDis Colon Rectum19933612115811608253014
   PubMed Web of Science ®Google Scholar
• Navarro-LunaAGarcia-DomingoMIRius-MaciasJMarco-MolinaCUltrasound study of anal fistulas with hydrogen peroxide enhancementDis Colon Rectum200447110811414719157
   PubMed Web of Science ®Google Scholar
• SiddiquiMRAshrafianHTozerPA diagnostic accuracy meta-analysis of endoanal ultrasound and MRI for perianal fistula assessmentDis Colon Rectum201255557658522513437
   PubMed Web of Science ®Google Scholar
• GecseKBBemelmanWKammMAWorld Gastroenterology Organization, International Organisation for Inflammatory Bowel Diseases IOIBD, European Society of Coloproctology and Robarts Clinical TrialsWorld Gastroenterology Organization International Organisation for Inflammatory Bowel Diseases IOIBD European Society of Coloproctology and Robarts Clinical TrialsA global consensus on the classification, diagnosis and multidisciplinary treatment of perianal fistulising Crohn’s diseaseGut20146391381139224951257
   PubMed Web of Science ®Google Scholar
• BellSJWilliamsABWieselPWilkinsonKCohenRCKammMAThe clinical course of fistulating Crohn’s diseaseAliment Pharmacol Ther20031791145115112752351
   PubMed Web of Science ®Google Scholar
• DejacoCHarrerMWaldhoerTMiehslerWVogelsangHReinischWAntibiotics and azathioprine for the treatment of perianal fistulas in Crohn’s diseaseAliment Pharmacol Ther20031811–121113112014653831
   PubMed Web of Science ®Google Scholar
• BernsteinLHFrankMSBrandtLJBoleySJHealing of perineal Crohn’s disease with metronidazoleGastroenterology1980793599
   PubMed Web of Science ®Google Scholar
• TurunenUMFarkkilaMAHakalaKLong-term treatment of ulcerative colitis with ciprofloxacin: a prospective, double-blind, placebo-controlled studyGastroenterology19981155107210789797360
   PubMed Web of Science ®Google Scholar
• BrandtLJBernsteinLHBoleySJFrankMSMetronidazole therapy for perineal Crohn’s disease: a follow-up studyGastroenterology19828323833877084615
   PubMed Web of Science ®Google Scholar
• JakobovitsJSchusterMMMetronidazole therapy for Crohn’s disease and associated fistulaeAm J Gastroenterol19847975335406741906
   PubMed Web of Science ®Google Scholar
• PearsonDCMayGRFickGHSutherlandLRAzathioprine and 6-mercaptopurine in Crohn disease: a meta-analysisAnn Intern Med199512321321427778826
   PubMed Web of Science ®Google Scholar
• HinterleitnerTAPetritschWAichbichlerBFickertPRannerGKrejsGJCombination of cyclosporine, azathioprine and prednisolone for perianal fistulas in Crohn’s diseaseZ Gastroenterol19973586036089297775
   PubMed Web of Science ®Google Scholar
• EganLJSandbornWJTremaineWJClinical outcome following treatment of refractory inflammatory and fistulizing Crohn’s disease with intravenous cyclosporineAm J Gastroenterol19989334424489517654
   PubMed Web of Science ®Google Scholar
• GuruduSRGriffelLHGialanellaRJDasKMCyclosporine therapy in inflammatory bowel disease: short-term and long-term resultsJ Clin Gastroenterol199929215115410478875
   PubMed Web of Science ®Google Scholar
• SandbornWJPresentDHIsaacsKLTacrolimus for the treatment of fistulas in patients with Crohn’s disease: a randomized, placebo-controlled trialGastroenterology2003125238038812891539
   PubMed Web of Science ®Google Scholar
• FeaganBGRochonJFedorakRNMethotrexate for the treatment of Crohn’s disease. The North American Crohn’s Study Group InvestigatorsN Engl J Med199533252922977816064
   PubMed Web of Science ®Google Scholar
• FeaganBGFedorakRNIrvineEJA comparison of methotrexate with placebo for the maintenance of remission in Crohn’s disease. North American Crohn’s Study Group InvestigatorsN Engl J Med2000342221627163210833208
   PubMed Web of Science ®Google Scholar
• AroraSKatkovWCooleyJMethotrexate in Crohn’s disease: results of a randomized, double-blind, placebo-controlled trialHepatogastroenterology199946271724172910430331
   PubMed Web of Science ®Google Scholar
• Mate-JimenezJHermidaCCantero-PeronaJMoreno-OteroR6-Mercaptopurine or methotrexate added to prednisone induces and maintains remission in steroid-dependent inflammatory bowel diseaseEur J Gastroenterol Hepatol200012111227123311111780
   PubMed Web of Science ®Google Scholar
• SandsBEAndersonFHBernsteinCNInfliximab maintenance therapy for fistulizing Crohn’s diseaseN Engl J Med2004350987688514985485
   PubMed Web of Science ®Google Scholar
• ParsiMALashnerBAAchkarJPConnorJTBrzezinskiAType of fistula determines response to infliximab in patients with fistulous Crohn’s diseaseAm J Gastroenterol200499344544915056083
   PubMed Web of Science ®Google Scholar
• ChoiCSBergASSangsterWCombined medical and surgical approach improves healing of septic perianal Crohn’s diseaseJ Am Coll Surg20162233506514.e127266825
   PubMed Web of Science ®Google Scholar
• KhannaRBresslerBLevesqueBGREACT Study InvestigatorsEarly combined immunosuppression for the management of Crohn’s disease (REACT): a cluster randomised controlled trialLancet2015386100061825183426342731
   PubMed Web of Science ®Google Scholar
• LeeMJHeywoodNSagarPMBrownSRFearnheadNSp CD CollaboratorsSurgical management of fistulating perianal Crohn’s disease – a UK surveyColorectal Dis Epub2016716
   Web of Science ®Google Scholar
• SolomonMJFistulae and abscesses in symptomatic perianal Crohn’s diseaseInt J Colorectal Dis19961152222268951512
   PubMed Web of Science ®Google Scholar
• HyderSATravisSPJewellDPMcCMNJGeorgeBDFistulating anal Crohn’s disease: results of combined surgical and infliximab treatmentDis Colon Rectum200649121837184117041753
   PubMed Web of Science ®Google Scholar
• KeighleyMRAllanRNCurrent status and influence of operation on perianal Crohn’s diseaseInt J Colorectal Dis1986121041073611935
   PubMed Web of Science ®Google Scholar
• BuchananGNOwenHATorkingtonJLunnissPJNichollsRJCohenCRLong-term outcome following loose-seton technique for external sphincter preservation in complex anal fistulaBr J Surg200491447648015048751
   PubMed Web of Science ®Google Scholar
• WhiteRAEisenstatTERubinRJSalvatiEPSeton management of complex anorectal fistulas in patients with Crohn’s diseaseDis Colon Rectum19903375875891694476
   PubMed Web of Science ®Google Scholar
• SchwartzDAGhaziLJRegueiroMCrohn‘s & Colitis Foundation of America IncGuidelines for the multidisciplinary management of Crohn’s perianal fistulas: summary statementInflamm Bowel Dis201521472373025751066
   PubMed Web of Science ®Google Scholar
• RitchieRDSackierJMHoddeJPIncontinence rates after cutting seton treatment for anal fistulaColorectal Dis200911656457119175623
   PubMed Web of Science ®Google Scholar
• TanakaSMatsuoKSasakiTClinical advantages of combined seton placement and infliximab maintenance therapy for perianal fistulizing Crohn’s disease: when and how were the seton drains removed?Hepatogastroenterology201057973720422862
   PubMedGoogle Scholar
• RakinicJAnal fissureClin Colon Rectal Surg200720213313720011388
   PubMedGoogle Scholar
• HalmeLSainioAPFactors related to frequency, type, and outcome of anal fistulas in Crohn’s diseaseDis Colon Rectum199538155597813346
   PubMed Web of Science ®Google Scholar
• ScottHJNorthoverJMEvaluation of surgery for perianal Crohn’s fistulasDis Colon Rectum1996399103910438797656
   PubMed Web of Science ®Google Scholar
• TaxoneraCSchwartzDAGarcia-OlmoDEmerging treatments for complex perianal fistula in Crohn’s diseaseWorld J Gastroenterol200915344263427219750568
   PubMed Web of Science ®Google Scholar
• NordgrenSFasthSHultenLAnal fistulas in Crohn’s disease: incidence and outcome of surgical treatmentInt J Colorectal Dis1992742142181293243
   PubMed Web of Science ®Google Scholar
• van TetsWFKuijpersHCContinence disorders after anal fistulotomyDis Colon Rectum19943712119411977995143
   PubMed Web of Science ®Google Scholar
• LindseyISmilgin-HumphreysMMCunninghamCMortensenNJGeorgeBDA randomized, controlled trial of fibrin glue vs. conventional treatment for anal fistulaDis Colon Rectum200245121608161512473883
   PubMed Web of Science ®Google Scholar
• LoungnarathRDietzDWMutchMGBirnbaumEHKodnerIJFleshmanJWFibrin glue treatment of complex anal fistulas has low success rateDis Colon Rectum200447443243614978618
   PubMed Web of Science ®Google Scholar
• GrimaudJCMunoz-BongrandNSiproudhisLGroupe d’Etude Thérapeutique des Affections Inflammatoires du Tube DigestifFibrin glue is effective healing perianal fistulas in patients with Crohn’s diseaseGastroenterology20101387227522812281 e227120178792
   PubMed Web of Science ®Google Scholar
• ChampagneBJO’ConnorLMFergusonMOrangioGRSchertzerMEArmstrongDNEfficacy of anal fistula plug in closure of cryptoglandular fistulas: long-term follow-upDis Colon Rectum200649121817182117082891
   PubMed Web of Science ®Google Scholar
• SenejouxASiproudhisLAbramowitzLGroupe d’Etude Thérapeutique des Affections Inflammatoires du tube Digestif [GETAID]Fistula plug in fistulising ano-perineal Crohn’s disease: a randomised controlled trialJ Crohns Colitis201610214114826351393
   PubMed Web of Science ®Google Scholar
• RojanasakulAPattanaarunJSahakitrungruangCTantiphlachivaKTotal anal sphincter saving technique for fistula-in-ano; the ligation of intersphincteric fistula tractJ Med Assoc Thai200790358158617427539
   PubMedGoogle Scholar
• Zirak-SchmidtSPerdawoodSKManagement of anal fistula by ligation of the intersphincteric fistula tract – a systematic reviewDan Med J20146112A497725441733
   PubMed Web of Science ®Google Scholar
• GingoldDSMurrellZAFleshnerPRA prospective evaluation of the ligation of the intersphincteric tract procedure for complex anal fistula in patients with Crohn’s diseaseAnn Surg201426061057106124374520
   PubMed Web of Science ®Google Scholar
• ParthasarathiRGomesRMRajapandianSLigation of the intersphincteric fistula tract for the treatment of fistula-in-ano: experience of a tertiary care centre in South IndiaColorectal Dis201618549650226476011
   PubMed Web of Science ®Google Scholar
• KobayashiHSugiharaKSuccessful management of rectovaginal fistula treated by endorectal advancement flap: report of two cases and literature reviewSpringerPlus201542125694858
   PubMedGoogle Scholar
• van KoperenPJBemelmanWAGerhardsMFThe anal fistula plug treatment compared with the mucosal advancement flap for cryptoglandular high transsphincteric perianal fistula: a double-blinded multicenter randomized trialDis Colon Rectum201154438739321383557
   PubMed Web of Science ®Google Scholar
• MarchesaPHullTLFazioVWAdvancement sleeve flaps for treatment of severe perianal Crohn’s diseaseBr J Surg19988512169516989876077
   PubMed Web of Science ®Google Scholar
• GrantDRCohenZMcLeodRSLoop ileostomy for anorectal Crohn’s diseaseCan J Surg198629132353940583
   PubMed Web of Science ®Google Scholar
• ZelasPJagelmanDGLoop illeostomy in the management of Crohn’s colitis in the debilitated patientAnn Surg198019121641687362285
   PubMed Web of Science ®Google Scholar
• HarperPHTrueloveSCLeeECKettlewellMGJewellDPSplit ileostomy and ileocolostomy for Crohn’s disease of the colon and ulcerative colitis: a 20 year surveyGut19832421061136852621
   PubMed Web of Science ®Google Scholar
• YamamotoTAllanRNKeighleyMREffect of fecal diversion alone on perianal Crohn’s diseaseWorld J Surg2000241012581262 discussion 1262–126311071472
   PubMed Web of Science ®Google Scholar
• LeeESplit ileostomy in the treatment of Crohn’s disease of the colonAnn R Coll Surg Engl1975562941021119787
   PubMed Web of Science ®Google Scholar
• HurstRDGottliebLJCrucittiPMelisMRubinMMichelassiFPrimary closure of complicated perineal wounds with myocutaneous and fasciocutaneous flaps after proctectomy for Crohn’s diseaseSurgery20011304767772 discussion 772–77311602910
   PubMed Web of Science ®Google Scholar
• SagarPMDozoisRRWolffBGLong-term results of ileal pouch-anal anastomosis in patients with Crohn’s diseaseDis Colon Rectum19963988938988756845
   PubMed Web of Science ®Google Scholar
• PatsourasDYassinNAPhillipsRKClinical outcomes of colo-anal pull-through procedure for complex rectal conditionsColorectal Dis201416425325824344638
   PubMed Web of Science ®Google Scholar
• PoggioliGLauretiSPierangeliFLocal injection of infliximab for the treatment of perianal Crohn’s diseaseDis Colon Rectum200548476877415768185
   PubMed Web of Science ®Google Scholar
• TonelliFGiudiciFAsteriaCREffectiveness and safety of local adalimumab injection in patients with fistulizing perianal Crohn’s disease: a pilot studyDis Colon Rectum201255887087522810472
   PubMed Web of Science ®Google Scholar
• SoltaniAKaiserAMEndorectal advancement flap for cryptoglandular or Crohn’s fistula-in-anoDis Colon Rectum201053448649520305451
   PubMed Web of Science ®Google Scholar
• CassonDHEltumiMTomlinSWalker-SmithJAMurchSHTopical tacrolimus may be effective in the treatment of oral and perineal Crohn’s diseaseGut200047343644010940284
   PubMed Web of Science ®Google Scholar
• HartALPlamondonSKammMATopical tacrolimus in the treatment of perianal Crohn’s disease: exploratory randomized controlled trialInflamm Bowel Dis200713324525317206671
   PubMed Web of Science ®Google Scholar
• Garcia-OlmoDGarcia-ArranzMHerrerosDPascualIPeiroCRodriguez-MontesJAA phase I clinical trial of the treatment of Crohn’s fistula by adipose mesenchymal stem cell transplantationDis Colon Rectum20054871416142315933795
   PubMed Web of Science ®Google Scholar
• ChoYBLeeWYParkKJKimMYooHWYuCSAutologous adipose tissue-derived stem cells for the treatment of Crohn’s fistula: a phase I clinical studyCell Transplant201322227928523006344
   PubMed Web of Science ®Google Scholar
• CiccocioppoRBernardoMESgarellaAAutologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn’s diseaseGut201160678879821257987
   PubMed Web of Science ®Google Scholar
• LeeWYParkKJChoYBAutologous adipose tissue-derived stem cells treatment demonstrated favorable and sustainable therapeutic effect for Crohn’s fistulaStem Cells201331112575258123404825
   PubMed Web of Science ®Google Scholar
• de la PortillaFAlbaFGarcia-OlmoDHerreriasJMGonzalezFXGalindoAExpanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn’s disease: results from a multi-center phase I/IIa clinical trialInt J Colorectal Dis201328331332323053677
   PubMed Web of Science ®Google Scholar
• ChoYBParkKJYoonSNLong-term results of adipose-derived stem cell therapy for the treatment of Crohn’s fistulaStem Cells Translat Med201545532537
   PubMed Web of Science ®Google Scholar
• Garcia-OlmoDGuadalajaraHRubio-PerezIHerrerosMDde-la-QuintanaPGarcia-ArranzMRecurrent anal fistulae: limited surgery supported by stem cellsWorld J Gastroenterol201521113330333625805941
   PubMed Web of Science ®Google Scholar
• MolendijkIBonsingBARoelofsHAllogeneic bone marrow-derived mesenchymal stromal cells promote healing of refractory perianal fistulas in patients with Crohn’s diseaseGastroenterology20151494918927e626116801
   PubMed Web of Science ®Google Scholar
• HobbissJHSchofieldPFManagement of perianal Crohn’s diseaseJ Royal Soc Med1982756414417
   PubMed Web of Science ®Google Scholar