Bile salt receptor TGR5 is highly expressed in esophageal adenocarcinoma and precancerous lesions with significantly worse overall survival and gender differences

References

• CorleyDAKuboALevinTRRace, ethnicity, sex and temporal differences in Barrett’s oesophagus diagnosis: a large community-based study, 1994–2006Gut200958218218818978173
   PubMed Web of Science ®Google Scholar
• ChenXYangCSEsophageal adenocarcinoma: a review and perspectives on the mechanism of carcinogenesis and chemopreventionCarcinogenesis20012281119112911470739
   PubMed Web of Science ®Google Scholar
• FangYChenXBajpaiMCellular origins and molecular mechanisms of Barrett’s esophagus and esophageal adenocarcinomaAnn N Y Acad Sci2013130018719924117642
   PubMed Web of Science ®Google Scholar
• QuanteMBhagatGAbramsJABile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasiaCancer Cell2012211365122264787
   PubMed Web of Science ®Google Scholar
• DubocHTacheYHofmannAFThe bile acid TGR5 membrane receptor: from basic research to clinical applicationDig Liver Dis201446430231224411485
   PubMedGoogle Scholar
• MaruyamaTMiyamotoYNakamuraTIdentification of membrane-type receptor for bile acids (M-BAR)Biochem Biophys Res Commun2002298571471912419312
   PubMed Web of Science ®Google Scholar
• KawamataYFujiiRHosoyaMA G protein-coupled receptor responsive to bile acidsJ Biol Chem2003278119435944012524422
   PubMed Web of Science ®Google Scholar
• CaoWTianWHongJExpression of bile acid receptor TGR5 in gastric adenocarcinomaAm J Physiol Gastrointest Liver Physiol20133044G322G32723238937
   PubMed Web of Science ®Google Scholar
• HoutenSMWatanabeMAuwerxJEndocrine functions of bile acidsEMBO J20062571419142516541101
   PubMed Web of Science ®Google Scholar
• KatsumaSHirasawaATsujimotoGBile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1Biochem Biophys Res Commun2005329138639015721318
   PubMed Web of Science ®Google Scholar
• HongJBeharJWandsJRole of a novel bile acid receptor TGR5 in the development of oesophageal adenocarcinomaGut201059217018019926617
   PubMed Web of Science ®Google Scholar
• PeanNDoignonITordjmannTBile acids and liver carcinogenesis: TGR5 as a novel piece in the puzzle?Clin Res Hepatol Gastroenterol201337322622923434440
   PubMed Web of Science ®Google Scholar
• YasudaHHirataSInoueKMashimaHOhnishiHYoshibaMInvolvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cellsBiochem Biophys Rese Commun20073541154159
   Web of Science ®Google Scholar
• NagathihalliNSBeesettyYLeeWWashingtonMKChenXLockhartACMerchantNBNovel mechanistic insights into ectodomain shedding of EGFR ligands amphiregulin and TGF-alpha: impact on gastrointestinal cancers driven by secondary bile acidsCancer Res20147472062207224520077
   PubMed Web of Science ®Google Scholar
• KeitelVHaussingerDTGR5 in cholangiocytesCurr Opin Gastroenterol201329329930423429467
   PubMed Web of Science ®Google Scholar
• ChenWDYuDFormanBMHuangWWangYDDeficiency of G-protein-coupled bile acid receptor Gpbar1 (TGR5) enhances chemically induced liver carcinogenesisHepatology201357265666622911633
   PubMed Web of Science ®Google Scholar
• MatsuzakiJSuzukiHTsugawaHBile acids increase levels of microRNAs 221 and 222, leading to degradation of CDX2 during esophageal carcinogenesisGastroenterology201314561300131123933602
   PubMed Web of Science ®Google Scholar
• TamagawaYIshimuraNUnoGNotch signaling pathway and Cdx2 expression in the development of Barrett’s esophagusLab Invest201292689690922449796
   PubMed Web of Science ®Google Scholar
• MorrowDJAvissarNEToiaLPathogenesis of Barrett’s esophagus: bile acids inhibit the Notch signaling pathway with induction of CDX2 gene expression in human esophageal cellsSurgery20091464714721 discussion 721–71219789031
   PubMed Web of Science ®Google Scholar
• HuYJonesCGellersenOWilliamsVAWatsonTJPetersJHPathogenesis of Barrett esophagus: deoxycholic acid up-regulates goblet-specific gene MUC2 in concert with CDX2 in human esophageal cellsArch Surg20071426540544 discussion 544–54517576890
   PubMedGoogle Scholar
• CampbellFCXuHEl-TananiMCrowePBinghamVThe yin and yang of vitamin D receptor (VDR) signaling in neoplastic progression: operational networks and tissue-specific growth controlBiochem Pharmacol20107911919737544
   PubMed Web of Science ®Google Scholar
• LuRWuSXiaYSunJThe vitamin D receptor, inflammatory bowel diseases, and colon cancerCurr Colorectal Cancer Rep201281576523814529
   PubMedGoogle Scholar
• SunJMustafiRCerdaSChumsangsriAXiaYRLiYCBissonnetteMLithocholic acid down-regulation of NF-kappaB activity through vitamin D receptor in colonic cancer cellsJ Steroid Biochem Mol Biol20081111–2374018515093
   PubMed Web of Science ®Google Scholar
• RaimondiSJohanssonHMaisonneuvePGandiniSReview and meta-analysis on vitamin D receptor polymorphisms and cancer riskCarcinogenesis20093071170118019403841
   PubMed Web of Science ®Google Scholar
• BouillonRCarmelietGVerlindenLVitamin D and human health: lessons from vitamin D receptor null miceEndocr Rev200829672677618694980
   PubMed Web of Science ®Google Scholar
• MishraDKWuYSarkissyanMVitamin D receptor gene polymorphisms and prognosis of breast cancer among African-American and Hispanic womenPLoS One201383e5796723554871
   PubMed Web of Science ®Google Scholar
• ZhouZXiaYBandlaSVitamin D receptor is highly expressed in precancerous lesions and esophageal adenocarcinoma with significant sex differenceHum Pathol20144581744175124951052
   PubMed Web of Science ®Google Scholar
• HuYBandlaSGodfreyTEHER2 amplification, overexpression and score criteria in esophageal adenocarcinomaMod Pathol201124789990721460800
   PubMed Web of Science ®Google Scholar
• ZhouZBandlaSYeJCyclin E involved in early stage carcinogenesis of esophageal adenocarcinoma by SNP DNA microarray and immunohistochemical studiesBMC Gastroenterol2014147824742107
   PubMed Web of Science ®Google Scholar
• AvissarNEToiaLHuYBile acid alone, or in combination with acid, induces CDX2 expression through activation of the epidermal growth factor receptor (EGFR)J Gastrointest Surg200913221222218854960
   PubMed Web of Science ®Google Scholar
• De GottardiADumonceauJMBruttinFExpression of the bile acid receptor FXR in Barrett’s esophagus and enhancement of apoptosis by guggulsterone in vitroMol Cancer200654817054793
   PubMed Web of Science ®Google Scholar
• TrowbridgeRMittalSKSharmaPHunterWJAgrawalDKVitamin D receptor expression in the mucosal tissue at the gastroesophageal junctionExp Mol Pathol201293224624922664272
   PubMed Web of Science ®Google Scholar
• TrowbridgeRSharmaPHunterWJAgrawalDKVitamin D receptor expression and neoadjuvant therapy in esophageal adenocarcinomaExp Mol Pathol201293114715322546272
   PubMed Web of Science ®Google Scholar
• ChangCKMulhollandHGCantwellMMVitamin d receptor gene variants and esophageal adenocarcinoma risk: a population-based case-control studyJ Gastrointest Cancer201243351251721948293
   PubMedGoogle Scholar
• GuoCSuJLiZThe G-protein-coupled bile acid receptor Gpbar1 (TGR5) suppresses gastric cancer cell proliferation and migration through antagonizing STAT3 signaling pathwayOncotarget 2720156333440234413
   Google Scholar
• GuoCQiHYuYThe G-Protein-Coupled Bile Acid Receptor Gpbar1 (TGR5) inhibits gastric inflammation through antagonizing NF-kappaB signaling pathwayFront Pharmacol2015628726696888
   PubMed Web of Science ®Google Scholar
• SongSGuhaSLiuKButtarNSBresalierRSCOX-2 induction by unconjugated bile acids involves reactive oxygen species-mediated signalling pathways in Barrett’s oesophagus and oesophageal adenocarcinomaGut200756111512152117604323
   PubMed Web of Science ®Google Scholar