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Clinical and Experimental Gastroenterology Volume 10, 2017 - Issue

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Original Research

High prevalence of subclass-specific binding and neutralizing antibodies against Clostridium difficile toxins in adult cystic fibrosis sera: possible mode of immunoprotection against symptomatic C. difficile infection

Tanya M Monaghan1 Nottingham Digestive Diseases Centre, NIHR Nottingham Digestive Diseases Biomedical Research Unit, School of Medicine, University of Nottingham, NottinghamCorrespondence[email protected]

Ola H Negm2 Breast Surgery Group, Division of Medical Sciences and Graduate Entry Medicine, School of Medicine, Queen’s Medical Centre, University of Nottingham, Nottingham, UK;3 Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Brendon MacKenzie4 Antibody Biology, UCB-New Medicines, UCB Celltech, Slough, UK

Mohamed R Hamed2 Breast Surgery Group, Division of Medical Sciences and Graduate Entry Medicine, School of Medicine, Queen’s Medical Centre, University of Nottingham, Nottingham, UK;3 Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Clifford C Shone5 Toxins Group, National Infection Service, Public Health England, Salisbury, UK

David P Humphreys4 Antibody Biology, UCB-New Medicines, UCB Celltech, Slough, UK

K Ravi Acharya6 Department of Biology and Biochemistry, University of Bath, Bath, UK

Mark H Wilcox7 Leeds Institute of Biomedical and Clinical Sciences, University of Leeds, Leeds, UK

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Pages 169-175 | Published online: 19 Jul 2017

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High prevalence of subclass-specific binding and neutralizing antibodies against Clostridium difficile toxins in adult cystic fibrosis sera: possible mode of immunoprotection against symptomatic C. difficile infection

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High prevalence of subclass-specific binding and neutralizing antibodies against Clostridium difficile toxins in adult cystic fibrosis sera: possible mode of immunoprotection against symptomatic C. difficile infection

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