Vonoprazan Fumarate for the Treatment of Gastric Ulcers: A Short Review on Emerging Data

References

• Martinucci I, Blandizzi C, Bodini G, et al. Vonoprazan fumarate for the management of acid related diseases. Expert Opin Pharmacother. 2017;18(11):1145–1152. doi:10.1080/14656566.2017.1346087
   PubMed Web of Science ®Google Scholar
• Savarino V, Marabotto E, Zentilin P, et al. Proton pump inhibitors: use and misuse in the clinical setting. Expert Rev Clin Pharmacol. 2018;11(11):1123–1134. doi:10.1080/17512433.2018.1531703
   PubMed Web of Science ®Google Scholar
• Savarino V, Dulbecco P, de Bortoli N, Ottonello A, Savarino E. The appropriate use of proton pump inhibitors (PPIs): need for a reappraisal. Eur J Intern Med. 2017;37:19–24. doi:10.1016/j.ejim.2016.10.007
   PubMed Web of Science ®Google Scholar
• Mori H, Suzuki H. Role of acid suppression in acid-relates diseases: proton pump inhibitor and potassium-competitive acid blocker. J Neurogastroenterol Motil. 2019;25(1):6–14. doi:10.5056/jnm18139
   PubMed Web of Science ®Google Scholar
• Savarino V, Dulbecco P, Savarino E. Are proton pump inhibitors really so dangerous? Dig Liver Dis. 2016;48(8):851–859. doi:10.1016/j.dld.2016.05.018
   PubMedGoogle Scholar
• Savarino E, Ottonello A, Martinucci I, Dulbecco P, Savarino V. Ilaprazole for the treatment of gastro-esophageal reflux. Expert Opin Pharmacother. 2016;17(15):2107–2113. doi:10.1080/14656566.2016.1232389
   PubMed Web of Science ®Google Scholar
• de Bortoli N, Martinucci I, Giacchino M, et al. The pharmacokinetics of ilaprazole for gastro-esophageal reflux treatment. Expert Opin Drug Metab Toxicol. 2013;9(10):1361–1369. doi:10.1517/17425255.2013.813018
   PubMed Web of Science ®Google Scholar
• Savarino E, Martinucci I, Furnari M, et al. Vonoprazan for treatment of gastroesophageal reflux: pharmacodynamic and pharmacokinetic considerations. Expert Opin Drug Metab Toxicol. 2016;12(11):1333–1341. doi:10.1080/17425255.2016.1214714
   PubMed Web of Science ®Google Scholar
• Miwa H, Uedo N, Watari J, et al. Randomised clinical trial: efficacy and safety of vonoprazan vs. lansoprazole in patients with gastric or duodenal ulcers - results from two Phase 3, non-inferiority randomised controlled trials. Aliment Pharmacol Ther. 2017;45:240–252. doi:10.1111/apt.13876
   PubMed Web of Science ®Google Scholar
• Mizokami Y, Oda K, Funao N, et al. Vonoprazan prevents ulcer recurrence during long-term NSAID therapy: randomised, lansoprazole-controlled non-inferiority and single-blind extension study. Gut. 2018;67(6):1042–1051. doi:10.1136/gutjnl-2017-314010
   PubMed Web of Science ®Google Scholar
• Kawai T, Oda K, Funao N, et al. Vonoprazan prevents low-dose aspirin-associated ulcer recurrence: randomised phase 3 study. Gut. 2018;67(6):1033–1041. doi:10.1136/gutjnl-2017-314852
   PubMed Web of Science ®Google Scholar
• Hosokawa K, Yoshida S. Recent advances in endoscopic mucosal resection for early gastric cancer (in Japanese with English abstract). Jpn J Cancer Chemother. 1998;25:476–483.
   Google Scholar
• Ono H, Kondo H, Gotoda T, et al. Endoscopic mucosal resection for treatment of early gastric cancer. Gut. 2001;48(2):225–229. doi:10.1136/gut.48.2.225
   PubMed Web of Science ®Google Scholar
• Ohkuwa M, Hosokawa N, Boku N, Ohtsu H, Tajiri S, Yoshida S. New endoscopic treatment technique for intratumoural gastric tumours using an insulated-tip diathermic knife. Endoscopy. 2001;33:221–226. doi:10.1055/s-2001-12805
   PubMed Web of Science ®Google Scholar
• Muto M, Miyamoto S, Hosokawa A, et al. Endoscopic mucosal resection in the stomach using the insulated-tip needle-knife. Endoscopy. 2005;37:182. doi:10.1055/s-2004-826194
   Web of Science ®Google Scholar
• Kakushima N, Yahagi N, Fujishiro M, et al. The healing process of artificial ulcers after endoscopic submucosal dissection. Dig Endosc. 2004;16:327–331. doi:10.1111/j.1443-1661.2004.00413.x
   Google Scholar
• Kakushima N, Fujishiro M, Yahagi N, Kodashima S, Nakamura M, Omata M. Helicobacter pylori status and the extent of gastric atrophy do not affect ulcer healing after endoscopic submucosal dissection. J Gastroenterol Hepatol. 2006;21(10):1586–1589. doi:10.1111/j.1440-1746.2006.04321.x
   PubMed Web of Science ®Google Scholar
• Ichida T, Ueyama S, Eto T, Kusano F, Sakai Y. Randomized controlled trial comparing the effects of vonoprazan plus rebamipide and esomeprazole plus rebamipide on gastric ulcer healing induced by endoscopic submucosal dissection. Intern Med. 2019;58(2):159–166. doi:10.2169/internalmedicine.1146-18
   PubMed Web of Science ®Google Scholar
• Hamada K, Uedo N, Tonai Y, et al. Efficacy of vonooprazan in prevention of bleeding from endoscopic submucosal dissection-induced gastric ulcers: a prospective randomized Phase II study. J Gastroenterol. 2019;54(2):122–130. doi:10.1007/s00535-018-1487-6
   PubMed Web of Science ®Google Scholar
• Komori H, Ueyama H, Nagahara A, et al. A prospective randomized trial of a potassium competitive acid blocker vs proton pump inhibitors on the effect of ulcer healing after endoscopic submucosal dissection of gastric neoplasia. J Int Med Res. 2019;47(4):1441–1452. doi:10.1177/0300060519828514
   Web of Science ®Google Scholar
• Kakushima N, Ono H, Takizawa K, et al. Incidence of delayed bleeding among patients continuing antithrombotics during gastric endoscopic submucosal dissection. Intern Med. 2019;58(19):2759–2766. doi:10.2169/internalmedicine.2754-19
   PubMed Web of Science ®Google Scholar
• Kim EH, Park SW, Nam E, Lee JG, Park CH. Comparative efficacy of various anti-ulcer medications after gastric endoscopic submucosal dissection: a systematic review and network meta-analysis. Surg Endosc. 2019;33(4):1271–1283. doi:10.1007/s00464-018-6409-4
   PubMed Web of Science ®Google Scholar
• Jaruvongvanich V, Poonsombudlert K, Ungprasert P. Vonoprazan versus proton-pump inhibitors for gastric endoscopic submucosal dissection-induced ulcers: a systematic review and meta analysis. Eur J Gastroenterol Hepatol. 2018;30(12):1416–1421. doi:10.1097/MEG.0000000000001204
   PubMed Web of Science ®Google Scholar
• HS, Li BY, Chen QT, Song CY, Shi J, Shi B. Comparison of the use of vonoprazan and proton pump inhibitors for the treatment of peptic ulcers resulting from endoscopic submucosal dissection: a systematic review and meta-analysis. Med Sci Monit. 2019;25:1169–1176. doi:10.12659/MSM.911886
   Web of Science ®Google Scholar
• Kang H, Kim BJ, Choi G, Kim JG. Vonoprazan versus proton pump inhibitors for the management of gastric endoscopic submucosal dissection-induced artificial ulcer. A systematic review with meta-analysis. Medicine (Baltimore). 2019;98(24):e15860. doi:10.1097/MD.0000000000015860
   PubMed Web of Science ®Google Scholar
• Martin YZ, Meng CX, Takagi T, Tian YS. Vonoprazan versus proton pump inhibitors in treating post-endoscopic submucosal dissection ulcers and preventing bleeding. Medicine (Baltimore). 2019;98(8):e14381. doi:10.1097/MD.0000000000014381
   Web of Science ®Google Scholar
• Martin YZ, Meng CX, Takagi T, Tian YS. Vonoprazan vs proton pump inhibitors in treating post-endoscopic submucosal dissection ulcers and preventing bleeding: a meta-analysis of randomized controlled trials and observational studies. Medicine (Baltimore). 2020;99(9):e19357. doi:10.1097/MD.0000000000019357
   Web of Science ®Google Scholar