Effects of Aerobic Exercise Protocol on Genes Related to Insulin Resistance and Inflammation in the Pancreas of ob/ob Mice with NAFLD

References

• Townsend S, Newsome PN. Non-alcoholic fatty liver disease in 2016. Br Med Bull. 2016;119(1):143. doi:10.1093/bmb/ldw031
   Web of Science ®Google Scholar
• Harrison DM, Harrison SA. Nonalcoholic steatohepatitis and noncirrhotic hepatocellular carcinoma: fertile soil. Seminars in liver disease; 2012: Thieme Medical Publishers.
   Google Scholar
• Gaggini M, Morelli M, Buzzigoli E, DeFronzo R, Bugianesi E, Gastaldelli A. Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease. Nutrients. 2013;5(5):1544–1560. doi:10.3390/nu5051544
   PubMed Web of Science ®Google Scholar
• Lee JS, Kim SH, Jun DW, et al. Clinical implications of fatty pancreas: correlations between fatty pancreas and metabolic syndrome. World j Gastroenterol. 2009;15(15):1869. doi:10.3748/wjg.15.1869
   PubMed Web of Science ®Google Scholar
• Wang CY, Ou HY, Chen MF, Chang TC, Chang CJ. Enigmatic ectopic fat: prevalence of nonalcoholic fatty pancreas disease and its associated factors in a Chinese population. J Am Heart Assoc. 2014;3(1):e000297. doi:10.1161/JAHA.113.000297
   PubMed Web of Science ®Google Scholar
• Zhang X, Cui Y, Fang L, Li F. Chronic high-fat diets induce oxide injuries and fibrogenesis of pancreatic cells in rats. Pancreas. 2008;37(3):e31–e8. doi:10.1097/MPA.0b013e3181744b50
   PubMed Web of Science ®Google Scholar
• Hori M, Takahashi M, Hiraoka N, et al. Association of pancreatic fatty infiltration with pancreatic ductal adenocarcinoma. Clin Transl Gastroenterol. 2014;5(3):e53. doi:10.1038/ctg.2014.5
   PubMed Web of Science ®Google Scholar
• Ou H-Y, Wang C-Y, Yang Y-C, Chen M-F, Chang C-J. The association between nonalcoholic fatty pancreas disease and diabetes. PLoS One. 2013;8(5):e62561. doi:10.1371/journal.pone.0062561
   PubMed Web of Science ®Google Scholar
• Garthwaite T, Martinson D, Tseng L, Hagen T, Menahan L. A longitudinal hormonal profile of the genetically obese mouse. Endocrinology. 1980;107(3):671–676. doi:10.1210/endo-107-3-671
   Web of Science ®Google Scholar
• Mayer J, Andrus S, Silides DJ. Effect of diethyldithiocarbamate and other agents on mice with the obese-hyperglycemic syndrome. Endocrinology. 1953;53(5):572–581. doi:10.1210/endo-53-5-572
   Web of Science ®Google Scholar
• Frantz EDC, Prodel E, Braz ID, et al. Modulation of the renin–angiotensin system in white adipose tissue and skeletal muscle: focus on exercise training. Clin Sci. 2018;132(14):1487–1507. doi:10.1042/CS20180276
   Web of Science ®Google Scholar
• Lehnig AC, Stanford KI. Exercise-induced adaptations to white and brown adipose tissue. J Exp Biol. 2018;221(Suppl1):jeb161570. doi:10.1242/jeb.161570
   Web of Science ®Google Scholar
• Krause M, Rodrigues-Krause J, O’Hagan C, et al. The effects of aerobic exercise training at two different intensities in obesity and type 2 diabetes: implications for oxidative stress, low-grade inflammation and nitric oxide production. Eur J Appl Physiol. 2014;114(2):251–260. doi:10.1007/s00421-013-2769-6
   Web of Science ®Google Scholar
• Ferreira JC, Rolim NP, Bartholomeu JB, Gobatto CA, Kokubun E, Brum PC. Maximal lactate steady state in running mice: effect of exercise training. Clin Exp Pharmacol Physiol. 2007;34(8):760–765. doi:10.1111/j.1440-1681.2007.04635.x
   PubMed Web of Science ®Google Scholar
• Ashworth W. A Computational Model of Hepatic Energy Metabolism: Understanding the Role of Zonation in the Development and Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD). UCL (University College London); 2017.
   Google Scholar
• Bedossa P. Pathology of non‐alcoholic fatty liver disease. Liver Int. 2017;37:85–89. doi:10.1111/liv.13301
   PubMed Web of Science ®Google Scholar
• Liang W, Menke AL, Driessen A, et al. Establishment of a general NAFLD scoring system for rodent models and comparison to human liver pathology. PLoS One. 2014;9(12):e115922. doi:10.1371/journal.pone.0115922
   Web of Science ®Google Scholar
• Evangelista FS, Muller CR, Stefano JT, et al. Physical training improves body weight and energy balance but does not protect against hepatic steatosis in obese mice. Int J Clin Exp Med. 2015;8(7):10911.
   Web of Science ®Google Scholar
• Higa TS, Bergamo FC, Mazzucatto F, Fonseca-Alaniz MH, Evangelista F. Physical training prevents body weight gain but does not modify adipose tissue gene expression. Braz J Med Biol Res. 2012;45(10):988–994. doi:10.1590/S0100-879X2012007500097
   Web of Science ®Google Scholar
• Higa TS, Spinola AV, Fonseca-Alaniz MH, Evangelista F. Remodeling of white adipose tissue metabolism by physical training prevents insulin resistance. Life Sci. 2014;103(1):41–48. doi:10.1016/j.lfs.2014.02.039
   PubMed Web of Science ®Google Scholar
• Gollisch KS, Brandauer J, Jessen N, et al. Effects of exercise training on subcutaneous and visceral adipose tissue in normal-and high-fat diet-fed rats. Am J Physiol Endocrinol Metab. 2009;297(2):E495–E504. doi:10.1152/ajpendo.90424.2008
   Web of Science ®Google Scholar
• Blundell J, Gibbons C, Caudwell P, Finlayson G, Hopkins M. Appetite control and energy balance: impact of exercise. Obesity Rev. 2015;16:67–76. doi:10.1111/obr.12257
   PubMed Web of Science ®Google Scholar
• Bouassida A, Chamari K, Zaouali M, Feki Y, Zbidi A, Tabka Z. Review on leptin and adiponectin responses and adaptations to acute and chronic exercise. Br J Sports Med. 2010;44(9):620–630. doi:10.1136/bjsm.2008.046151
   PubMed Web of Science ®Google Scholar
• McGee SL, Hargreaves M. AMPK-mediated regulation of transcription in skeletal muscle. Clin Sci. 2010;118(8):507–518. doi:10.1042/CS20090533
   Web of Science ®Google Scholar
• Fu L, Liu X, Niu Y, Yuan H, Zhang N, Lavi E. Effects of high-fat diet and regular aerobic exercise on global gene expression in skeletal muscle of C57BL/6 mice. Metabolism. 2012;61(2):146–152. doi:10.1016/j.metabol.2011.06.017
   Web of Science ®Google Scholar
• Harrison SA, Fecht W, Brunt EM, Neuschwander‐Tetri BA. Orlistat for overweight subjects with nonalcoholic steatohepatitis: a randomized, prospective trial. Hepatology. 2009;49(1):80–86. doi:10.1002/hep.22575
   PubMed Web of Science ®Google Scholar
• Musso G, Gambino R, Cassader M, Pagano G. A meta‐analysis of randomized trials for the treatment of nonalcoholic fatty liver disease. Hepatology. 2010;52(1):79–104. doi:10.1002/hep.23623
   PubMed Web of Science ®Google Scholar
• Hashida R, Kawaguchi T, Bekki M, et al. Aerobic vs. resistance exercise in non-alcoholic fatty liver disease: A systematic review. J Hepatol. 2017;66(1):142–152. doi:10.1016/j.jhep.2016.08.023
   PubMed Web of Science ®Google Scholar
• Johnson NA, Sachinwalla T, Walton DW, et al. Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss. Hepatology. 2009;50(4):1105–1112. doi:10.1002/hep.23129
   PubMed Web of Science ®Google Scholar
• Mathur A, Marine M, Lu D, et al. Nonalcoholic fatty pancreas disease. HPB. 2007;9(4):312–318. doi:10.1080/13651820701504157
   PubMedGoogle Scholar
• Goodyear LJ, Kahn BB. Exercise, glucose transport, and insulin sensitivity. Annu Rev Med. 1998;49(1):235–261. doi:10.1146/annurev.med.49.1.235
   PubMed Web of Science ®Google Scholar
• Postic C, Burcelin R, Rencurel F, et al. Evidence for a transient inhibitory effect of insulin on GLUT2 expression in the liver: studies in vivo and in vitro. Biochem J. 1993;293(1):119–124. doi:10.1042/bj2930119
   Web of Science ®Google Scholar
• Kim J-W, Kim Y-K, Ahn Y-H. A mechanism of differential expression of GLUT2 in hepatocyte and pancreatic β-cell line. Exp Mol Med. 1998;30(1):15. doi:10.1038/emm.1998.2
   Web of Science ®Google Scholar
• Brichard S, Ongemba L, Henquin J-C. Oral vanadate decreases muscle insulin resistance in obese fa/fa rats. Diabetologia. 1992;35(6):522–527. doi:10.1007/BF00400479
   Web of Science ®Google Scholar
• Burcelin R, Eddouks M, Kande J, Assan R, Girard J. Evidence that GLUT-2 mRNA and protein concentrations are decreased by hyperinsulinaemia and increased by hyperglycaemia in liver of diabetic rats. Biochem J. 1992;288(2):675–679. doi:10.1042/bj2880675
   Web of Science ®Google Scholar
• Oka Y, Asano T, Shibasaki Y, et al. Increased liver glucose-transporter protein and mRNA in streptozocin-induced diabetic rats. Diabetes. 1990;39(4):441–446. doi:10.2337/diab.39.4.441
   Web of Science ®Google Scholar
• Yamamoto T, Fukumoto H, Koh G, et al. Liver and muscle-fat type glucose transporter gene expression in obese and diabetic rats. Biochem Biophys Res Commun. 1991;175(3):995–1002. doi:10.1016/0006-291X(91)91663-W
   Web of Science ®Google Scholar
• Silva AD. O Diabetes Altera a Expressão Do RNAm Do GLUT2 Em Fígado e Rim: Participação Dos Fatores Transcricionais Hepatic Nuclear Factor-(HNF-) 1a, 3b e 4a. Universidade de São Paulo; 2011.
   Google Scholar
• Kurauti MA, Costa-Júnior JM, Ferreira SM, et al. Interleukin-6 increases the expression and activity of insulin-degrading enzyme. Sci Rep. 2017;7(1):46750. doi:10.1038/srep46750
   Web of Science ®Google Scholar
• Ellingsgaard H, Hojman P, Pedersen BK. Exercise and Health–emerging roles of IL-6. Curr Opin Physiol. 2019;10:49–54. doi:10.1016/j.cophys.2019.03.009
   Web of Science ®Google Scholar
• Morettini M, Palumbo MC, Sacchetti M, Castiglione F, Mazza C. A system model of the effects of exercise on plasma Interleukin-6 dynamics in healthy individuals: role of skeletal muscle and adipose tissue. PLoS One. 2017;12(7):e0181224. doi:10.1371/journal.pone.0181224
   Web of Science ®Google Scholar
• Febbraio MA, Hiscock N, Sacchetti M, Fischer CP, Pedersen BK. Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction. Diabetes. 2004;53(7):1643–1648. doi:10.2337/diabetes.53.7.1643
   Web of Science ®Google Scholar
• Matthews VB, Allen T, Risis S, et al. Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance. Diabetologia. 2010;53(11):2431–2441. doi:10.1007/s00125-010-1865-y
   PubMed Web of Science ®Google Scholar
• Wallenius V, Wallenius K, Ahrén B, et al. Interleukin-6-deficient mice develop mature-onset obesity. Nat Med. 2002;8(1):75–79. doi:10.1038/nm0102-75
   PubMed Web of Science ®Google Scholar
• Wunderlich FT, Ströhle P, Könner AC, et al. Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action. Cell Metab. 2010;12(3):237–249. doi:10.1016/j.cmet.2010.06.011
   PubMed Web of Science ®Google Scholar
• Awazawa M, Ueki K, Inabe K, et al. Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway. Cell Metab. 2011;13(4):401–412. doi:10.1016/j.cmet.2011.02.010
   PubMed Web of Science ®Google Scholar
• Schmidt-Arras D, Rose-John S. IL-6 pathway in the liver: from physiopathology to therapy. J Hepatol. 2016;64(6):1403–1415. doi:10.1016/j.jhep.2016.02.004
   PubMed Web of Science ®Google Scholar
• Zhou D, Liang Z, Qin Q, Zhang M, Li S. Therapeutic efficacy and mechanisms of quercetin in a rat model of nonalcoholic fatty liver disease. Zhonghua Gan Zang Bing Za Zhi Zhonghua Ganzangbing Zazhi. 2013;21(2):134–137. doi:10.3760/cma.j.issn.1007-3418.2013.02.014
   Google Scholar
• Speretta GFF, Rosante MC, Duarte FO, et al. The effects of exercise modalities on adiposity in obese rats. Clinics. 2012;67(12):1469–1477. doi:10.6061/clinics/2012(12)19
   Web of Science ®Google Scholar