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Review

Measuring disease activity in Crohn’s disease: what is currently available to the clinician

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Pages 151-161 | Published online: 20 May 2014

References

  • Peyrin-BirouletLLoftusEVJrColombelJFSandbornWJThe natural history of adult Crohn’s disease in population-based cohortsAm J Gastroenterol2010105228929719861953
  • CosnesJBourrierANion-LarmurierISokolHBeaugerieLSeksikPFactors affecting outcomes in Crohn’s disease over 15 yearsGut20126181140114522387526
  • ParienteBCosnesJDaneseSDevelopment of the Crohn’s disease digestive damage score, the Lémann scoreInflamm Bowel Dis20111761415142221560202
  • HommesDColombelJFEmeryPGrecoMSandbornWJChanging Crohn’s disease management: need for new goals and indices to prevent disability and improve quality of lifeJ Crohns Colitis20126Suppl 2S224S23422463929
  • ZallotCPeyrin-BirouletLDeep remission in inflammatory bowel disease: looking beyond symptomsCurr Gastroenterol Rep201315331523354742
  • BestWRBecktelJMSingletonJWKernFJrDevelopment of a Crohn’s disease activity index. National Cooperative Crohn’s Disease StudyGastroenterology19767034394441248701
  • HarveyRFBradshawJMA simple index of Crohn’s-disease activityLancet1980181675146102236
  • PapayPIgnjatovicAKarmirisKOptimising monitoring in the management of Crohn’s disease: a physician’s perspectiveJ Crohns Colitis20137865366923562672
  • TinèFRossiFSferrazzaAMeta-analysis: remission and response from control arms of randomized trials of biological therapies for active luminal Crohn’s diseaseAliment Pharmacol Ther200827121210122318346185
  • BouguenGLevesqueBGFeaganBGTreat to Target: A proposed new paradigm for the management of Crohn’s diseaseClin Gastroenterol Hepatol Epub9102013
  • SchnitzlerFFidderHFerranteMMucosal healing predicts long-term outcome of maintenance therapy with infliximab in Crohn’s diseaseInflamm Bowel Dis20091591295130119340881
  • BaertFMoortgatLVan AsscheGBelgian Inflammatory Bowel Disease Research GroupNorth-Holland Gut ClubMucosal healing predicts sustained clinical remission in patients with early-stage Crohn’s diseaseGastroenterology2010138246346819818785
  • RutgeertsPVan AsscheGSandbornWJAdalimumab induces and maintains mucosal healing in patients with Crohn’s disease: data from the EXTEND trialGastroenterology201214251102111122326435
  • CellierCSahmoudTFroguelECorrelations between clinical activity, endoscopic severity, and biological parameters in colonic or ileocolonic Crohn’s disease. A prospective multicentre study of 121 cases. The Groupe d’Etudes Thérapeutiques des Affections Inflammatoires DigestivesGut19943522312357508411
  • AllezMLemannMBonnetJCattanPJianRModiglianiRLong-term outcome of patients with active Crohn’s disease exhibiting extensive and deep ulcerations at colonoscopyAm J Gastroenterol200297494795312003431
  • AloiMViolaFD’ArcangeloGDisease course and efficacy of medical therapy in stricturing paediatric Crohn’s diseaseDig Liver Dis201345646446823465684
  • FrøslieKFJahnsenJMoumBAVatnMHIBSEN GroupMucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohortGastroenterology2007133241242217681162
  • Af BjorkestenCGNieminenUSipponenTTurunenUArkkilaPFarkkilaMMucosal healing at 3 months predicts long-term endoscopic remission in anti-TNF-treated luminal Crohn’s diseaseScand J Gastroenterol201348554355123477356
  • HanauerSBFeaganBGLichtensteinGRACCENT I Study GroupMaintenance infliximab for Crohn’s disease: the ACCENT I randomised trialLancet200235993171541154912047962
  • BenitezJMMeuwisMAReenaersCVan KemsekeCMeunierPLouisERole of endoscopy, cross-sectional imaging and biomarkers in Crohn’s disease monitoringGut201362121806181624203056
  • De CruzPKammMAPrideauxLAllenPBMooreGMucosal healing in Crohn’s disease: a systematic reviewInflamm Bowel Dis201319242944422539420
  • MazzuoliSGuglielmiFWAntonelliESalemmeMBassottiGVillanacciVDefinition and evaluation of mucosal healing in clinical practiceDig Liver Dis2013451296997723932331
  • MaryJYModiglianiRDevelopment and validation of an endoscopic index of the severity for Crohn’s disease: a prospective multicentre study. Groupe d’Etudes Therapeutiques des Affections Inflammatoires du Tube Digestif (GETAID)Gut19893079839892668130
  • DapernoMD’HaensGVan AsscheGDevelopment and validation of a new, simplified endoscopic activity score for Crohn’s disease: the SES-CDGastrointest Endosc200460450551215472670
  • RutgeertsPGeboesKVantrappenGBeylsJKerremansRHieleMPredictability of the postoperative course of Crohn’s diseaseGastroenterology19909949569632394349
  • SipponenTNuutinenHTurunenUFärkkiläMEndoscopic evaluation of Crohn’s disease activity: comparison of the CDEIS and the SES-CDInflamm Bowel Dis201016122131213620848462
  • FerranteMColombelJFSandbornWJInternational Organization for the Study of Inflammatory Bowel DiseasesValidation of endoscopic activity scores in patients with Crohn’s disease based on a post hoc analysis of data from SONICGastroenterology2013145597898623954314
  • RutgeertsPGeboesKVantrappenGKerremansRCoenegrachtsJLCoremansGNatural history of recurrent Crohn’s disease at the ileocolonic anastomosis after curative surgeryGut19842566656726735250
  • RutgeertsPReview article: recurrence of Crohn’s disease after surgery – the need for treatment of new lesionsAliment Pharmacol Ther200624Suppl 3293216961741
  • VillanacciVAntonelliEGeboesKCasellaGBassottiGHistological healing in inflammatory bowel disease: a still unfulfilled promiseWorld J Gastroenterol201319796897823467585
  • D’HaensGVan DeventerSVan HogezandREndoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies in Crohn’s disease: a European multicenter trialGastroenterology199911651029103410220494
  • SmithJPBingamanSIRuggieroFTherapy with the opioid antagonist naltrexone promotes mucosal healing in active Crohn’s disease: a randomized placebo-controlled trialDig Dis Sci20115672088209721380937
  • BourreilleAIgnjatovicAAabakkenLWorld Organization of Digestive Endoscopy (OMED) and the European Crohn’s and Colitis Organisation (ECCO)Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED-ECCO consensusEndoscopy200941761863719588292
  • EliakimRFischerDSuissaAWireless capsule video endoscopy is a superior diagnostic tool in comparison to barium follow-through and computerized tomography in patients with suspected Crohn’s diseaseEur J Gastroenterol Hepatol200315436336712655255
  • AlbertJGMartinyFKrummenerlADiagnosis of small bowel Crohn’s disease: a prospective comparison of capsule endoscopy with magnetic resonance imaging and fluoroscopic enteroclysisGut200554121721172716020490
  • Pons BeltránVNosPBastidaGEvaluation of postsurgical recurrence in Crohn’s disease: a new indication for capsule endoscopy?Gastrointest Endosc200766353354017725942
  • EfthymiouAViazisNMantzarisGDoes clinical response correlate with mucosal healing in patients with Crohn’s disease of the small bowel? A prospective, case-series study using wireless capsule endoscopyInflamm Bowel Dis200814111542154718521929
  • YangLGeZZGaoYJAssessment of capsule endoscopy scoring index, clinical disease activity, and C-reactive protein in small bowel Crohn’s diseaseJ Gastroenterol Hepatol201328582983323425203
  • NivYIlaniSLeviZValidation of the Capsule Endoscopy Crohn’s Disease Activity Index (CECDAI or Niv score): a multicenter prospective studyEndoscopy2012441212622125196
  • GralnekIMDefranchisRSeidmanELeightonJALegnaniPLewisBSDevelopment of a capsule endoscopy scoring index for small bowel mucosal inflammatory changeAliment Pharmacol Ther200827214615417956598
  • KoulaouzidisADouglasSPlevrisJNLewis score correlates more closely with fecal calprotectin than Capsule Endoscopy Crohn’s Disease Activity IndexDig Dis Sci201257498799322057284
  • PanesJBouhnikYReinischWImaging techniques for assessment of inflammatory bowel disease: joint ECCO and ESGAR evidence-based consensus guidelinesJ Crohns Colitis20137755658523583097
  • PanesJBouzasRChaparroMSystematic review: the use of ultrasonography, computed tomography and magnetic resonance imaging for the diagnosis, assessment of activity and abdominal complications of Crohn’s diseaseAliment Pharmacol Ther201134212514521615440
  • MaconiGRadiceEGrecoSBianchi PorroGBowel ultrasound in Crohn’s diseaseBest Pract Res Clin Gastroenterol20062019311216473803
  • Di MizioRMaconiGRomanoSD’AmarioFBianchi PorroGGrassiRSmall bowel Crohn disease: sonographic featuresAbdom Imaging2004291233515160749
  • ParenteFGrecoSMolteniMOral contrast enhanced bowel ultrasonography in the assessment of small intestine Crohn’s disease. A prospective comparison with conventional ultrasound, x-ray studies, and ileocolonoscopyGut200453111652165715479688
  • BruCSansMDefelittoMMHydrocolonic sonography for evaluating inflammatory bowel diseaseAJR Am J Roentgenol200117719910511418406
  • MigaledduVScanuAMQuaiaEContrast-enhanced ultrasonographic evaluation of inflammatory activity in Crohn’s diseaseGastroenterology20091371435219422826
  • RipollesTMartinezMJParedesJMBlancEFlorsLDelgadoFCrohn disease: correlation of findings at contrast enhanced US with severity at endoscopyRadiology2009253124124819635834
  • De FrancoAMarzoMFeliceCIleal Crohn’s disease: CEUS determination of activityAbdom Imaging201237335936822223202
  • CalabreseEZorziFZuzziSDevelopment of a numerical index quantitating small bowel damage as detected by ultrasonography in Crohn’s diseaseJ Crohns Colitis20126885286022398077
  • ParkMJLimJSComputed tomography enterography for evaluation of inflammatory bowel diseaseClin Endosc201346432736623964329
  • FiorinoGBonifacioCPeyrin-BirouletLProspective comparison of computed tomography enterography and magnetic resonance enterography for assessment of disease activity and complications in ileocolonic Crohn’s diseaseInflamm Bowel Dis20111751073108021484958
  • WuYWTangYHHaoNXTangCYMiaoFCrohn’s disease: CT enterography manifestations before and after treatmentEur J Radiol2012811525921185142
  • SiddikiHAFidlerJLFletcherJGProspective comparison of state-of-the-art MR enterography and CT enterography in small-bowel Crohn’s diseaseAJR Am J Roentgenol2009193111312119542402
  • LeeSSKimAYYangSKCrohn disease of the small bowel: comparison of CT enterography, MR enterography, and small-bowel follow-through as diagnostic techniquesRadiology2009251375176119276325
  • MasselliGGualdiGCT and MR enterography in evaluating small bowel diseases: when to use which modality?Abdom Imaging201338224925923011551
  • CraigOO’NeillSO’NeillFDiagnostic accuracy of computed tomography using lower doses of radiation for patients with Crohn’s diseaseClin Gastroenterol Hepatol201210888689222469992
  • LeeSJParkSHKimAYA prospective comparison of standard-dose CT enterography and 5 0% reduced-dose CT enterography with and without noise reduction for evaluating Crohn diseaseAJR Am J Roentgenol20111971505721701010
  • CiprianoLELevesqueBGZaricGSLoftusEVJrSandbornWJCost-effectiveness of imaging strategies to reduce radiation-induced cancer risk in Crohn’s diseaseInflamm Bowel Dis20121871240124821928375
  • FeuerbachSMRI enterography: the future of small bowel diagnostics?Dig Dis201028343343820926869
  • KuehleCAAjajWLaddSCMassingSBarkhausenJLauensteinTCHydro-MRI of the small bowel: effect of contrast volume, timing of contrast administration, and data acquisition on bowel distentionAJR Am J Roentgenol2006187W375W38516985108
  • NegaardAPaulsenVSandvikLA prospective randomized comparison between two MRI studies of the small bowel in Crohn’s disease, the oral contrast method and MR enteroclysisEur Radiol20071792294230117483955
  • MasselliGGualdiGMR imaging of the small bowelRadiology2012264233334822821694
  • MakanyangaJCTaylorSACurrent and future role of MR enterography in the management of Crohn diseaseAJR Am J Roentgenol20132011566423789658
  • Al-HawaryZimmermannEMA new look at Crohn’s disease: novel imaging techniquesCurr Opin Gastroenterol201228433434022678451
  • RimolaJOrdásIRodríguezSRicartEPanésJImaging indexes of activity and severity for Crohn’s disease: current status and future trendsAbdom Imaging201237695896622072290
  • RimolaJRodríguezSGarcía-BoschOMagnetic resonance for assessment of disease activity and severity in ileocolonic Crohn’s diseaseGut20095881113112019136510
  • RimolaJOrdásIRodríguezSMagnetic resonance imaging for evaluation of Crohn’s disease: validation of parameters of severity and quantitative index of activityInflamm Bowel Dis20111781759176821744431
  • StewardMJPunwaniSProctorINonperforating small bowel Crohn’s disease assessed by MRI enterography: derivation and histopathological validation of an MR-based activity indexEur J Radiol20128192080208821924572
  • TielbeekJAMakanyangaJCBipatSGrading Crohn Disease activity with MRI: interobserver variability of MRI features, MRI scoring of severity, and correlation with Crohn Disease Endoscopic Index of SeverityAJR Am J Roentgenol201320161220122824261360
  • SempereGAMartinez SanjuanVMedina ChuliaEMRI evaluation of inflammatory activity in Crohn’s diseaseAJR Am J Roentgenol200518461829183515908538
  • OrdàsIRimolaJRipollesTAccuracy of MRI to assess therapeutic responses and mucosal healing in Crohn’s diseaseGastroenterology2011140Suppl 1S73
  • Van AsscheGHerrmannKALouisEEffects of infliximab therapy on transmural lesions as assessed by magnetic resonance enteroclysis in patients with ileal Crohn’s diseaseJ Crohns Colitis201371295095723411006
  • LawranceICWelmanCJShipmanPMurrayKCorrelation of MRI-determined small bowel Crohn’s disease categories with medical response and surgical pathologyWorld J Gastroenterol200915273367337519610137
  • ZappaMStefanescuCCazals-HatemDWhich magnetic resonance imaging findings accurately evaluate inflammation in small bowel Crohn’s disease? A retrospective comparison with surgical pathologic analysisInflamm Bowel Dis201117498499320722053
  • ParienteBPeyrin-BirouletLCohenLGastroenterology review and perspective: the role of cross-sectional imaging in evaluating bowel damage in Crohn diseaseAMJ Am J Roentegenol201119714249
  • Van AsscheGVanbeckevoortDBielenDMagnetic resonance imaging of the effects of infliximab on perianal fistulizing Crohn’s diseaseAm J Gastroenterol200398233233912591051
  • KarmirisKBielenDVanbeckevoortDLong-term monitoring of infliximab therapy for perianal fistulizing Crohn’s disease by using magnetic resonance imagingClin Gastroenterol Hepatol20119213013621056696
  • VermeireSVan AsscheGRutgeertsPC-reactive protein as a marker for inflammatory bowel diseaseInflamm Bowel Dis200410566166515472532
  • ChamouardPRichertZMeyerNRahmiGBaumannRDiagnostic value of C-reactive protein for predicting activity level of Crohn’s diseaseClin Gastroenterol Hepatol20064788288716630759
  • KissLSPappMLovaszBDHigh-sensitivity C-reactive protein for identification of disease phenotype, active disease, and clinical relapses in Crohn’s disease: a marker for patient classification?Inflamm Bowel Dis20121891647165422081542
  • SolemCALoftusEVJrTremaineWJHarmsenWSZinsmeisterARSandbornWJCorrelation of C-reactive protein with clinical, endoscopic, histologic, and radiographic activity in inflammatory bowel diseaseInflamm Bowel Dis200511870771216043984
  • LouisEVermeireSRutgeertsPA positive response to infliximab in Crohn disease: association with a higher systemic inflammation before treatment but not with-308 TNF gene polymorphismScand J Gastroenterol200237781882412190096
  • ReinischWWangYOddensBJLinkRC-reactive protein, an indicator for maintained response or remission to infliximab in patients with Crohn’s disease: a post-hoc analysis from ACCENT IAliment Pharmacol Ther201235556857622251435
  • KissLSSzamosiTMolnarTHungarian IBD Study GroupEarly clinical remission and normalisation of CRP are the strongest predictors of efficacy, mucosal healing and dose escalation during the first year of adalimumab therapy in Crohn’s diseaseAliment Pharmacol Ther201134891192221883326
  • MagroFRodrigues-PintoESantos-AntunesJHigh C-reactive protein in Crohn’s disease patients predicts nonresponse to infliximab treatmentJ Crohns Colitis20148212913623932786
  • DenisMAReenaersCFontaineFBelaicheJLouisEAssessment of endoscopic activity index and biological inflammatory markers in clinically active Crohn’s disease with normal C-reactive protein serum levelInflamm Bowel Dis20071391100110517508418
  • CaccaroRD’IncáRSturnioloGCClinical utility of calprotectin and lactoferrin as markers of inflammation in patients with inflammatory bowel diseaseExpert Rev Clin Immunol20106455155820594128
  • CaccaroRD’IncàRPathakSSturnioloGCClinical utility of calprotectin and lactoferrin in patients with inflammatory bowel disease: is there something new from the literature?Expert Rev Clin Immunol20128657958522992152
  • SipponenTKarkkainenPSavilahtiECorrelation of faecal calprotectin and lactoferrin with an endoscopic score for Crohn’s disease and histological findingsAliment Pharmacol Ther200828101221122918752630
  • SipponenTSavilahtiEKohloKLNuutinenHTurunenUFarkkilaMCrohn’s disease activity assessed by fecal calprotectin and lactoferrin: correlation with Crohn’s disease activity index and endoscopic findingsInflamm Bowel Dis2008141404618022866
  • SchoepferAMBeglingerCStraumannAFecal calprotectin correlates more closely with the simple endoscopic score for Crohn’s disease (SES-CD) than CRP, blood leukocytes, and the CDAIAm J Gastroenterol2010105116216919755969
  • MaoRXiaoYLGaoXFecal calprotectin in predicting relapse of inflammatory bowel diseases: a meta-analysis of prospective studiesInflamm Bowel Dis201218101894189922238138
  • D’HaensGFerranteMVermeireSFecal calprotectin is a surrogate marker for endoscopic lesions in inflammatory bowel diseaseInflamm Bowel Dis201218122218222422344983
  • SipponenTBjörkestenCGFärkkiläMNuutinenHSavilahtiEKolhoKLFaecal calprotectin and lactoferrin are reliable surrogate markers of endoscopic response during Crohn’s disease treatmentScand J Gastroenterol201045332533120034360
  • LemannMColombelJFGrimaudJCFecal calprotectin and high sensitivity C-reactive protein levels to predict mucosal healing in patients with Crohn’s disease. A subanalysis of the STORI studyGut201059Suppl IIIA80
  • de SurayNSalleronJVernier-MassouilleGClose monitoring of CRP and fecal calprotectin levels to predict relapse in Crohn’s disease patients. A sub-analysis of the STORI studyJ Crohn Colitis201261P274
  • LouisEMaryJYVernier-MassouilleGGroupe D’etudes Therapeutiques Des Affections Inflammatoires DigestivesMaintenance of remission among patients with Crohn’s disease on antimetabolite therapy after infliximab therapy is stoppedGastroenterology20121421637021945953