206
Views
11
CrossRef citations to date
0
Altmetric
Review

CCR9 antagonism: potential in the treatment of Inflammatory Bowel Disease

&
Pages 119-130 | Published online: 07 Apr 2015

References

  • LoftusEVJRClinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influencesGastroenterology200412661504151715168363
  • MolodeckyNASoonISRabiDMIncreasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic reviewGastroenterology20121421465422001864
  • AbrahamCChoJHInflammatory bowel diseaseN Engl J Med2009361212066207819923578
  • WhiteGEIqbalAJGreavesDRCC chemokine receptors and chronic inflammation – therapeutic opportunities and pharmacological challengesPharmacol Rev2013651478923300131
  • CharoIFRansohoffRMThe many roles of chemokines and chemokine receptors in inflammationN Engl J Med2006354661062116467548
  • AhmadTArmuzziABunceMThe molecular classification of the clinical manifestations of Crohn’s diseaseGastroenterology2002122485486611910336
  • FreemanHJGranuloma-positive Crohn’s diseaseCan J Gastroenterol200721958358717853953
  • OberhuberGStanglPCVogelsangHSchoberEHerbstFGascheCSignificant association of strictures and internal fistula formation in Crohn’s diseaseVirchows Arch2000437329329711037350
  • KobayashiTOkamotoSHisamatsuTIL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn’s diseaseGut200857121682168918653729
  • FussIJNeurathMBoirivantMDisparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel diseaseJ Immunol19961573126112708757634
  • ParronchiPRomagnaniPAnnunziatoFType 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn’s diseaseAm J Pathol199715038238329060820
  • FaisSCapobianchiMRPalloneFSpontaneous release of interferon gamma by intestinal lamina propria lymphocytes in Crohn’s disease. Kinetics of in vitro response to interferon gamma inducersGut19913244034071902808
  • BreeseEBraeggerCPCorriganCJWalker-SmithJAMacDonaldTTInterleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosaImmunology19937811271318436398
  • MonteleoneGBianconeLMarascoRInterleukin 12 is expressed and actively released by Crohn’s disease intestinal lamina propria mononuclear cellsGastroenterology19971124116911789098000
  • OkazawaAKanaiTWatanabeMTh1-mediated intestinal inflammation in Crohn’s disease may be induced by activation of lamina propria lymphocytes through synergistic stimulation of interleukin-12 and interleukin-18 without T cell receptor engagementAm J Gastroenterol200297123108311712492197
  • SwainSLMckinstryKKStruttTMExpanding roles for CD4+ T cells in immunity to virusesNat Rev Immunol201212213614822266691
  • FussIJHellerFBoirivantMNonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitisJ Clin Invest2004113101490149715146247
  • HellerFFlorianPBojarskiCInterleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitutionGastroenterology2005129255056416083712
  • NeurathMFFinottoSGlimcherLHThe role of Th1/Th2 polarization in mucosal immunityNat Med20028656757312042806
  • FujinoSAndohABambaSIncreased expression of interleukin 17 in inflammatory bowel diseaseGut2003521657012477762
  • OuyangWKollsJKZhengYThe biological functions of T helper 17 cell effector cytokines in inflammationImmunity200828445446718400188
  • DuerrRHTaylorKDBrantSRA genome-wide association study identifies IL23R as an inflammatory bowel disease geneScience200631458041461146317068223
  • SatsangiJSilverbergMSVermeireSColombelJFThe Montreal classification of inflammatory bowel disease: controversies, consensus, and implicationsGut200655674975316698746
  • CummingsJRKeshavSTravisSPMedical management of Crohn’s diseaseBMJ200833676521062106618467414
  • KaneSVHorstSSandbornWJNatalizumab for moderate to severe Crohn’s disease in clinical practice: the Mayo Clinic Rochester experienceInflamm Bowel Dis201218122203220822419661
  • Van AsscheGVan RanstMSciotRProgressive multifocal leukoencephalopathy after natalizumab therapy for Crohn’s diseaseN Engl J Med2005353436236815947080
  • SandbornWJFeaganBGRutgeertsPVedolizumab as induction and maintenance therapy for Crohn’s diseaseN Engl J Med2013369871172123964933
  • SandbornWJGasinkCGaoLLUstekinumab induction and maintenance therapy in refractory Crohn’s diseaseN Engl J Med2012367161519152823075178
  • GreenfieldSMPunchardNATeareJPThompsonRPReview article: the mode of action of the aminosalicylates in inflammatory bowel diseaseAliment Pharmacol Ther1993743693838105984
  • FordACBernsteinCNKhanKJGlucocorticosteroid therapy in inflammatory bowel disease: systematic review and meta-analysisAm J Gastroenterol2011106459059921407179
  • RamadasAVGuneshSThomasGAWilliamsGTHawthorneABNatural history of Crohn’s disease in a population-based cohort from Cardiff (1986–2003): a study of changes in medical treatment and surgical resection ratesGut20105991200120620650924
  • NielsenOHVainerBRask-MadsenJReview article: the treatment of inflammatory bowel disease with 6-mercaptopurine or azathioprineAliment Pharmacol Ther200115111699170811683683
  • SaibeniSVirgilioTD’IncaRThe use of thiopurines for the treatment of inflammatory bowel diseases in clinical practiceDig Liver Dis2008401081482018479986
  • DaneseSColombelJFPeyrin-BirouletLRutgeertsPReinischWReview article: the role of anti-TNF in the management of ulcerative colitis – past, present and futureAliment Pharmacol Ther201337985586623489068
  • FeaganBGRutgeertsPSandsBEVedolizumab as induction and maintenance therapy for ulcerative colitisN Engl J Med2013369869971023964932
  • TravisSPReview article: the management of mild to severe acute ulcerative colitisAliment Pharmacol Ther200420Suppl 4889215352901
  • LaharieDBourreilleABrancheJCiclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trialLancet201238098571909191523063316
  • ShaleMSchieringCPowrieFCD4(+) T-cell subsets in intestinal inflammationImmunol Rev2013252116418223405904
  • LeeJCLyonsPAMcKinneyEFGene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitisJ Clin Invest2011121104170417921946256
  • FellJMWalker-SmithJASpencerJMacDonaldTTThe distribution of dividing T cells throughout the intestinal wall in inflammatory bowel disease (IBD)Clin Exp Immunol199610422802858625521
  • FengTWangLSchoebTRElsonCOCongYMicrobiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitisJ Exp Med201020761321133220498021
  • MottetCUhligHHPowrieFCutting edge: cure of colitis by CD4+CD25+ regulatory T cellsJ Immunol200317083939394312682220
  • DutraRCClaudinoRFBentoAFPreventive and therapeutic euphol treatment attenuates experimental colitis in micePloS One2011611e2712222073270
  • WeberCAlonRMoserBSpringerTASequential regulation of alpha 4 beta 1 and alpha 5 beta 1 integrin avidity by CC chemokines in monocytes: implications for transendothelial chemotaxisJ Cell Biol19961344106310738769427
  • LeyKLaudannaCCybulskyMINoursharghSGetting to the site of inflammation: the leukocyte adhesion cascade updatedNat Rev Immunol20077967868917717539
  • RobertCKupperTSInflammatory skin diseases, T cells, and immune surveillanceN Engl J Med1999341241817182810588968
  • CampbellJJHaraldsenGPanJThe chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cellsNature1999400674677678010466728
  • IwataMHirakiyamaAEshimaYKagechikaHKatoCSongSYRetinoic acid imprints gut-homing specificity on T cellsImmunity200421452753815485630
  • ArihiroSOhtaniHSuzukiMDifferential expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in ulcerative colitis and Crohn’s diseasePathol Int2002525–636737412100519
  • ConnorEMEppihimerMJMoriseZGrangerDNGrishamMBExpression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in acute and chronic inflammationJ Leukoc Biol199965334935510080539
  • ArijsIDe HertoghGMachielsKMucosal gene expression of cell adhesion molecules, chemokines, and chemokine receptors in patients with inflammatory bowel disease before and after infliximab treatmentAm J Gastroenterol2011106474876121326222
  • AgaceWGeneration of gut-homing T cells and their localization to the small intestinal mucosaImmunol Lett20101281212319808049
  • VicariAPFigueroaDJHedrickJATECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell developmentImmunity1997722913019285413
  • ZabelBAAgaceWWCampbellJJHuman G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxisJ Exp Med199919091241125610544196
  • KunkelEJCampbellJJHaraldsenGLymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunityJ Exp Med2000192576176810974041
  • SvenssonMMarsalJEricssonACCL25 mediates the localization of recently activated CD8alphabeta(+) lymphocytes to the small-intestinal mucosaJ Clin Invest200211081113112112393847
  • StenstadHSvenssonMCucakHKotarskyKAgaceWWDifferential homing mechanisms regulate regionalized effector CD8alphabeta+ T cell accumulation within the small intestineProc Natl Acad Sci U S A200710424101221012717551016
  • Rivera-NievesJHoJBamiasGAntibody blockade of CCL25/CCR9 ameliorates early but not late chronic murine ileitisGastroen-terology2006131515181529
  • WermersJDMcNameeENWurbelMAJedlickaPRivera-NievesJThe chemokine receptor CCR9 is required for the T cell-mediated regulation of chronic ileitis in miceGastroenterology201114051526153521300065
  • WurbelMAMcIntireMGDwyerPFiebigerECCL25/CCR9 interactions regulate large intestinal inflammation in a murine model of acute colitisPloS One201161e1644221283540
  • PapadakisKAPrehnJNelsonVThe role of thymus-expressed chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune systemJ Immunol200016595069507611046037
  • PapadakisKAPrehnJMorenoSTCCR9-positive lymphocytes and thymus-expressed chemokine distinguish small bowel from colonic Crohn’s diseaseGastroenterology2001121224625411487533
  • YuCRPedenKWZaitsevaMBGoldingHFarberJMCCR9A and CCR9B: two receptors for the chemokine CCL25/TECK/Ck beta-15 that differ in their sensitivities to ligandJ Immunol200016431293130510640743
  • PapadakisKALandersCPrehnJCC chemokine receptor 9 expression defines a subset of peripheral blood lymphocytes with mucosal T cell phenotype and Th1 or T-regulatory 1 cytokine profileJ Immunol2003171115916512816994
  • BerahovichRDLaiNLWeiZLanierLLSchallTJEvidence for NK cell subsets based on chemokine receptor expressionJ Immunol2006177117833784017114454
  • WendlandMCzelothNMachNCCR9 is a homing receptor for plasmacytoid dendritic cells to the small intestineProc Natl Acad Sci U S A2007104156347635217404233
  • HadeibaHLahlKEdalatiAPlasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central toleranceImmunity201236343845022444632
  • NakamotoNEbinumaHKanaiTCCR9+ macrophages are required for acute liver inflammation in mouse models of hepatitisGastroenterology2012142236637622079594
  • LuttrellLMLefkowitzRJThe role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signalsJ Cell Sci2002115Pt 345546511861753
  • WurbelMAMalissenMGuy-GrandDMice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor gam-madelta(+) gut intraepithelial lymphocytesBlood20019892626263211675330
  • WurbelMAMalissenMGuy-GrandDMalissenBCampbellJJImpaired accumulation of antigen-specific CD8 lymphocytes in chemokine CCL25-deficient intestinal epithelium and lamina propriaJ Immunol2007178127598760617548595
  • StenstadHEricssonAJohansson-LindbomBGut-associated lymphoid tissue-primed CD4+ T cells display CCR9-dependent and -independent homing to the small intestineBlood200610793447345416391017
  • SarutaMYuQTAvanesyanAFleshnerPRTarganSRPapadakisKAPhenotype and effector function of CC chemokine receptor 9- expressing lymphocytes in small intestinal Crohn’s diseaseJ Immunol200717853293330017312180
  • EksteenBGrantAJMilesAHepatic endothelial CCL25 mediates the recruitment of CCR9+ gut-homing lymphocytes to the liver in primary sclerosing cholangitisJ Exp Med2004200111511151715557349
  • HolteKKehletHPostoperative ileus: a preventable eventBr J Surg200087111480149311091234
  • EngelDRKoscielnyAWehnerST helper type 1 memory cells disseminate postoperative ileus over the entire intestinal tractNat Med201016121407141321113155
  • PollheimerMJHalilbasicEFickertPTraunerMPathogenesis of primary sclerosing cholangitisBest Pract Res Clin Gastroenterol201125672773922117638
  • MolodeckyNAKareemiHParabRIncidence of primary sclerosing cholangitis: a systematic review and meta-analysisHepatology20115351590159921351115
  • WaltersMJWangYLaiNCharacterization of CCX282-B, an orally bioavailable antagonist of the CCR9 chemokine receptor, for treatment of inflammatory bowel diseaseJ Pharmacol Exp Ther20103351616920660125
  • KontoyiannisDPasparakisMPizarroTTCominelliFKolliasGImpaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunop-athologiesImmunity199910338739810204494
  • ChemoCentryxA study to evaluate the efficacy and safety of CCX282-B in subjects with moderate to severe Crohn’s disease Available from: http://clinicaltrials.gov/show/NCT00306215. NLM Identifier: NCT00306215Accessed August 2, 2014
  • KeshavSVaňásekTNivYA randomized controlled trial of the efficacy and safety of CCX282-B, an orally-administered blocker of chemokine receptor CCR9, for patients with Crohn’s diseasePloS One201383e6009423527300
  • GlaxoSmithKlineA study to investigate the efficacy and safety of GSK1605786A in the treatment of subjects with moderately-to-severely active Crohn’s disease (SHIELD-1) Available from: http://clinicaltrials.gov/show/NCT01277666. NLM Identifier: NCT01277666Accessed August 2, 2014
  • GlaxoSmithKlineGSK1605786A in the maintenance of remission in subjects with Crohn’s disease (SHIELD-2) Available from: http://clinicaltrials.gov/show/NCT01316939. NLM Identifier: NCT01316939Accessed August 2, 2014
  • GlaxoSmithKlineOpen-label extension study of GSK1605786A (SHIELD-3) Available from: http://clinicaltrials.gov/show/NCT01318993. NLM Identifier: NCT01318993Accessed August 2, 2014
  • GlaxoSmithKlineAn active treatment study to induce clinical response and/or remission with GSK1605786A in subjects with Crohn’s disease (SHIELD-4) Available from: http://clinicaltrials.gov/show/NCT01536418. NLM Identifier: NCT01536418Accessed August 2, 2014
  • EberhardsonMMaritsPJonesMTreatment of inflammatory bowel disease by chemokine receptor-targeted leukapheresisClin Immunol20131491738223892544
  • GrantAJLalorPFHubscherSGBriskinMAdamsDHMAdCAM-1 expressed in chronic inflammatory liver disease supports mucosal lymphocyte adhesion to hepatic endothelium (MAdCAM-1 in chronic inflammatory liver disease)Hepatology20013351065107211343233
  • ChemoCentryxSafety and activity study of an oral medication to treat moderate to severe Crohn’s disease Available from: http://clinicaltrials.gov/show/NCT00102921. NLM Identifier: NCT00102921Accessed August 2, 2014
  • JohanssonCAhlstedtIFurubackaSJohnssonEAgaceWWQuiding-JärbrinkMDifferential expression of chemokine receptors on human IgA+ and IgG+ B cellsClin Exp Immunol2005141227928715996192
  • KunkelEJKimCHLazarusNHCCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cellsJ Clin Invest200311171001101012671049
  • WirtzSNeufertCWeigmannBNeurathMFChemically induced mouse models of intestinal inflammationNat Protoc20072354154617406617
  • ReuterBKPizarroTTMechanisms of tight junction dysregulation in the SAMP1/YitFc model of Crohn’s disease-like ileitisAnn N Y Acad Sci2009116530130719538320
  • ApostolakiMManoloukosMRoulisMRole of beta7 inte-grin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF-dependent Crohn’s diseaseGastroenterology200813472025203518439426
  • PowrieFLeachMWMauzeSCaddleLBCoffmanRLPheno-typically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid miceInt Immunol1993511146114717903159
  • MizukamiTKanaiTMikamiYCCR9(+) macrophages are required for eradication of peritoneal bacterial infections and prevention of polymicrobial sepsisImmunol Lett20121471–2757922771342
  • WangCKangSGHogeneschHLovePEKimCHRetinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestineJ Immunol2010184105519552620400707