References
- FarberHWLoscalzoJPulmonary arterial hypertensionN Engl J Med2004351161655166515483284
- GalieNRubinLHoeperMTreatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trialLancet200837196302093210018572079
- GalieNBarberaJAFrostAEInitial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial HypertensionN Engl J Med2015373983484426308684
- McLaughlinVChannickRNGhofraniHABosentan added to sildenafil therapy in patients with pulmonary arterial hypertensionEur Respir J201546240541326113687
- Selexipag (Uptravi) for pulmonary arterial hypertensionMed Lett Drugs Ther2016581488212326859660
- PulidoTAdzerikhoIChannickRNSERAPHIN InvestigatorsMacitentan and morbidity and mortality in pulmonary arterial hypertensionN Engl J Med2013369980981823984728
- SitbonOChannickRChinKMSelexipag for the treatment of pulmonary arterial hypertensionN Engl J Med2015373262522253326699168
- Centers for Medicare & Medicaid ServicesNational Health Expenditure Data: Projected2017 Available from: https://www.cms.gov/Research-Statistics-Data-and-Systems/Statistics-Trends-and-Reports/NationalHealthExpendData/NationalHealthAccountsProjected.htmlAccessed August 24, 2017
- Express ScriptsDrug Trend Report 2016: Express Scripts2016 Available from: https://lab.express-scripts.com/lab/drug-trend-reportAccessed Aug 24, 2017
- McLaughlinVVArcherSLBadeschDBACCF/AHA 2009 expert consensus document on pulmonary hypertension a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians; American Thoracic Society, Inc.; and the Pulmonary Hypertension AssociationJ Am Coll Cardiol200953171573161919389575
- GalieNHumbertMVachieryJL2015ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT)Eur Heart J20163716711926320113
- SimonneauGGatzoulisMAAdatiaIUpdated clinical classification of pulmonary hypertensionJ Am Coll Cardiol201362(25 Suppl):D34D4124355639
- HuismanAMVreugdenhilSAvan PaassenHCTreatment of pulmonary arterial hypertensionN Engl J Med20053523308309 author reply 308–30915659740
- EnderbyCYBurgerCMedical treatment update on pulmonary arterial hypertensionTher Adv Chronic Dis20156526427226336595
- HoeperMMMcLaughlinVVBarberaJAInitial combination therapy with ambrisentan and tadalafil and mortality in patients with pulmonary arterial hypertension: a secondary analysis of the results from the randomised, controlled AMBITION studyLancet Respir Med201641189490127745818
- GalieNJansaPPulidoTSERAPHIN haemodynamic substudy: the effect of the dual endothelin receptor antagonist macitentan on haemodynamic parameters and NT-proBNP levels and their association with disease progression in patients with pulmonary arterial hypertensionEur Heart J201738151147115528329315
- BrudererSHurstNRemenovaTDingemanseJClinical pharmacology, efficacy, and safety of selexipag for the treatment of pulmonary arterial hypertensionExpert Opin Drug Saf201716674375128494686
- GhofraniHAGalieNGrimmingerFRiociguat for the treatment of pulmonary arterial hypertensionN Engl J Med2013369433034023883378
- CoghlanJGGalieNBarberaJAInitial combination therapy with ambrisentan and tadalafil in connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH): subgroup analysis from the AMBITION trialAnn Rheum Dis20177671219122728039187
- ChannickRNDelcroixMGhofraniHAEffect of macitentan on hospitalizations: results from the SERAPHIN trialJACC Heart Fail2015311825457902
- LiuHLChenXYLiJREfficacy and safety of pulmonary arterial hypertension-specific therapy in pulmonary arterial hypertension: a meta-analysis of randomized controlled trialsChest2016150235336627048870
- LajoieACLauziereGLegaJCCombination therapy versus monotherapy for pulmonary arterial hypertension: a meta-analysisLancet Respir Med20164429130526935844
- JainSKheraRGirotraSComparative effectiveness of pharmacologic interventions for pulmonary arterial hypertension: a systematic review and network meta-analysisChest201715119010527615023
- BenzaRLMillerDPGomberg-MaitlandMPredicting survival in pulmonary arterial hypertension: insights from the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL)Circulation2010122216417220585012
- BenzaRLGomberg-MaitlandMMillerDPThe REVEAL Registry risk score calculator in patients newly diagnosed with pulmonary arterial hypertensionChest2012141235436221680644
- BurgerCDOzbayBRiehleELenhartGWhiteRJTreatment Patterns After Initial Therapy Among Pulmonary Arterial Hypertension Patients In The United States [Abstract]Am J Respir Crit Care Med2016193A3987
- BurgerCDLongPKShahMRCharacterization of first-time hospitalizations in patients with newly diagnosed pulmonary arterial hypertension in the REVEAL registryChest201414651263127324901386
- FrantzRPSchilzRJChakinalaMMHospitalization and survival in patients using epoprostenol for injection in the PROSPECT observational studyChest2015147248449425320967
- BurkeJPHunscheERegulierENagaoMBuzinecPDrake IiiWCharacterizing pulmonary hypertension-related hospitalization costs among Medicare Advantage or commercially insured patients with pulmonary arterial hypertension: a retrospective database studyAm J Manag Care2015213 Suppls47s5825734573
- Medicare Payment Advisory Commission USDOH, Human SMedicare Payment Advisory Commission report to the Congress, March 2010J Pain Palliat Care Pharmacother201024330230520718654
- PopaABosentan (Tracleer), a New Agent for the Treatment of Pulmonary Arterial HypertensionPharmacotherapy Update2002V(2).
- SikiricaMIorgaSRBancroftTPotashJThe economic burden of pulmonary arterial hypertension (PAH) in the US on payers and patientsBMC Health Serv Res20141467625539602
- GuSHuHDongHSystematic Review of the economic burden of pulmonary arterial hypertensionPharmacoeconomics201634653355026714685
- JohnsonSDelateTBokaAShawPZagerCCharacterizing the financial burden of pulmonary arterial hypertension within an integrated healthcare delivery systemJ Med Econ201316121414142224074226
- OudizRJMathaiSWhiteRJacobsenMWeyckerDBurgerCCost consequences of initial combination treatment of pah with ambrisentan and tadalafilAm J Respir Crit Care Med2016193A2953
- BeaudetATsangYHunscheEDrakeWBilirSPBudget impact model for selexipag: taking a US payer perspectiveValue Health2016193A243A244
- LiHHighlandKColeMMinimizing burden of disease-related hospitalization among pulmonary arterial hypertension patients [Abstract]J Manag Care Spec Pharm20162210-a SupplS57
- BergerAEdelsbergJTealSMychaskiwMAOsterGChanges in healthcare utilization and costs associated with sildenafil therapy for pulmonary arterial hypertension: a retrospective cohort studyBMC Pulm Med2012127523231890
- VaidyaBGuptaVNovel therapeutic approaches for pulmonary arterial hypertension: Unique molecular targets to site-specific drug deliveryJ Control Release201521111813326036906
- GeraciMWBullTMTuderRMGenomics of pulmonary arterial hypertension: implications for therapyHeart Fail Clin20106110111419945066
- KjellstromBFrantzRPBenzaRLBennettTBourgeRCMcGoonMDHemodynamic ranges during daily activities and exercise testing in patients with pulmonary arterial hypertensionJ Card Fail201420748549124816520