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Original Research

Real-World Economic Outcomes of Brexpiprazole and Extended-Release Quetiapine Adjunctive Use in Major Depressive Disorder

ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 741-755 | Published online: 04 Dec 2019

References

  • World Health Organization. Depression and other common mental disorders-global health estimates. 2017; Available from: http://apps.who.int/iris/bitstream/10665/254610/1/WHO-MSD-MER-2017.2-eng.pdf. Accessed 529, 2019.
  • Rai D, Zitko P, Jones K, Lynch J, Araya R. Country-and individual-level socioeconomic determinants of depression: multilevel cross-national comparison. Br J Psychiatry. 2013;202(3):195–203. doi:10.1192/bjp.bp.112.11248223349294
  • Greenberg PE, Fournier -A-A, Sisitsky T, Pike CT, Kessler RC. The economic burden of adults with major depressive disorder in the United States (2005 and 2010). J Clin Psychiatry. 2015;76(2):155–162. doi:10.4088/JCP.14m0929825742202
  • Ferrari AJ, Charlson FJ, Norman RE, et al. Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010. PLoS Med. 2013;10(11):e1001547. doi:10.1371/journal.pmed.100154724223526
  • Vos T, Abajobir AA, Abate KH, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390(10100):1211–1259. doi:10.1016/S0140-6736(17)32154-228919117
  • Merikangas KR, Ames M, Cui L, et al. The impact of comorbidity of mental and physical conditions on role disability in the US adult household population. Arch Gen Psychiatry. 2007;64(10):1180–1188. doi:10.1001/archpsyc.64.10.118017909130
  • Gelenberg AJ, Freeman MP, Markowitz JC, et al. Practice guideline for the treatment of patients with major depressive disorder third edition. Am J Psychiatry. 2010;167(10):1.20068118
  • Trivedi MH, Rush AJ, Wisniewski SR, et al. Evaluation of outcomes with citalopram for depression using measurement-based care in STAR* D: implications for clinical practice. Am J Psychiatry. 2006;163(1):28–40. doi:10.1176/appi.ajp.163.1.2816390886
  • Rush AJ, Trivedi MH, Wisniewski SR, et al. Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression. N Engl J Med. 2006;354(12):1231–1242. doi:10.1056/NEJMoa05296316554525
  • National Institute of Mental Health. Questions and answers about the NIMH Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study – all medication levels. 2006; Available from: https://www.nimh.nih.gov/funding/clinical-research/practical/stard/allmedicationlevels.shtml. Accessed 5 29, 2019.
  • Mauskopf JA, Simon GE, Kalsekar A, Nimsch C, Dunayevich E, Cameron A. Nonresponse, partial response, and failure to achieve remission: humanistic and cost burden in major depressive disorder. Depress Anxiety. 2009;26(1):83–97. doi:10.1002/da.v26:118833573
  • Knoth RL, Bolge SC, Kim E, Tran Q-V. Effect of inadequate response to treatment in patients with depression. Am J Manag Care. 2010;16(8):e188–e196.20690785
  • Russell JM, Hawkins K, Ozminkowski RJ, et al. The cost consequences of treatment-resistant depression. J Clin Psychiatry. 2004;65(3):341–347. doi:10.4088/JCP.v65n030915096073
  • Suppes T, Silva R, Cucchiaro J, et al. Lurasidone for the treatment of major depressive disorder with mixed features: a randomized, double-blind, placebo-controlled study. Am J Psychiatry. 2015;173(4):400–407. doi:10.1176/appi.ajp.2015.1506077026552942
  • Thase ME, Youakim JM, Skuban A, et al. Efficacy and safety of adjunctive brexpiprazole 2 mg in major depressive disorder: a phase 3, randomized, placebo-controlled study in patients with inadequate response to antidepressants. J Clin Psychiatry. 2015;76(9):1224–1231. doi:10.4088/JCP.14m0968826301701
  • Wang P, Si T. Use of antipsychotics in the treatment of depressive disorders. Shanghai Arch Psychiatry. 2013;25(3):134.24991148
  • Shelton RC, Papakostas GI. Augmentation of antidepressants with atypical antipsychotics for treatment‐resistant major depressive disorder. Acta Psychiatr Scand. 2008;117(4):253–259. doi:10.1111/acp.2008.117.issue-418190674
  • Papakostas GI, Shelton RC, Smith J, Fava M. Augmentation of antidepressants with atypical antipsychotic medications for treatment-resistant major depressive disorder: a meta-analysis. J Clin Psychiatry. 2007;68:826–831. doi:10.4088/JCP.v68n060217592905
  • Nelson JC, Papakostas GI. Atypical antipsychotic augmentation in major depressive disorder: a meta-analysis of placebo-controlled randomized trials. Am J Psychiatry. 2009;166(9):980–991. doi:10.1176/appi.ajp.2009.0903031219687129
  • Komossa K, Depping AM, Gaudchau A, Kissling W, Leucht S. Second‐generation antipsychotics for major depressive disorder and dysthymia. Cochrane Database Syst Rev. 2010;(12):CD008121.21154393
  • Chen J, Gao K, Kemp DE. Second-generation antipsychotics in major depressive disorder: update and clinical perspective. Curr Opin Psychiatry. 2011;24(1):10–17. doi:10.1097/YCO.0b013e328341350521088586
  • Seetasith A, Greene M, Hartry A, Burudpakdee C. Changes in healthcare resource use and costs associated with early versus delayed initiation of atypical antipsychotic adjunctive treatment in major depressive disorder. J Med Econ. 2018;21(9):888–901. doi:10.1080/13696998.2018.148437329862860
  • Yermilov I, Greene M, Chang E, Hartry A, Yan T, Broder MS. Earlier versus later augmentation with an antipsychotic medication in patients with major depressive disorder demonstrating inadequate efficacy in response to antidepressants: a retrospective analysis of US claims data. Adv Ther. 2018;35(12):2138–2151. doi:10.1007/s12325-018-0838-230456519
  • Prescribing information for Abilify. Otsuka American Pharmaceutical, Inc., Rockville, MD.
  • Prescribing information for Seroquel XR. AstraZeneca Pharmaceuticals LP., Wilmington, DE.
  • Prescribing information for Rexulti. Otsuka American Pharmaceutical, Inc., Rockville, MD.
  • Maeda K, Lerdrup L, Sugino H, et al. Brexpiprazole II: antipsychotic-like and procognitive effects of a novel serotonin-dopamine activity modulator. J Pharmacol Exp Ther. 2014;350(3):605–614. doi:10.1124/jpet.114.21381924947464
  • Das S, Barnwal P, Winston AB, Mondal S, Saha I. Brexpiprazole: so far so good. Ther Adv Psychopharmacol. 2016;6(1):39–54. doi:10.1177/204512531561473926913177
  • Peuskens J. The management of schizophrenia: focus on extended-release quetiapine fumarate. Neuropsychiatr Dis Treat. 2011;7:549. doi:10.2147/NDT22003295
  • Austin PC. An introduction to propensity score methods for reducing the effects of confounding in observational studies. Multivariate Behav Res. 2011;46(3):399–424. doi:10.1080/00273171.2011.56878621818162
  • Brookhart MA, Wyss R, Layton JB, Stürmer T. Propensity score methods for confounding control in nonexperimental research. Circ Cardiovasc Qual Outcomes. 2013;6(5):604–611. doi:10.1161/CIRCOUTCOMES.113.00035924021692
  • Petri H, Urquhart J. Channeling bias in the interpretation of drug effects. Stat Med. 1991;10(4):577–581. doi:10.1002/(ISSN)1097-02582057656
  • Kluwer W Medi-span price Rx. Available from: https://www.wolterskluwercdi.com/price-rx/. Accessed 5 29, 2019.
  • Wu EQ, Greenberg PE, Ben-Hamadi R, Yu AP, Yang EH, Erder MH. Comparing treatment persistence, healthcare resource utilization, and costs in adult patients with major depressive disorder treated with escitalopram or citalopram. Am Health Drug Benefits. 2011;4(2):78.25126340
  • World Health Organization. Mental health of older adults. 2017; Available from: http://www.who.int/mediacentre/factsheets/fs381/en/. Accessed 529, 2019..
  • Kramer D, Allgaier A-K, Fejtkova S, Mergl R, Hegerl U. Depression in nursing homes: prevalence, recognition, and treatment. Int J Psychiatry Med. 2009;39(4):345–358. doi:10.2190/PM.39.4.a20391857
  • Richardson LP, DiGiuseppe D, Garrison M, Christakis DA. Depression in Medicaid-covered youth: differences by race and ethnicity. Arch Pediatr Adolesc Med. 2003;157(10):984–989. doi:10.1001/archpedi.157.10.98414557159
  • Centers of Medicare & Medicaid Services. Physician and mental health condition prevalence and comorbidity among fee-for-service medicare-medicaid enrollees. 2014; Available from: https://www.cms.gov/Medicare-Medicaid-Coordination/Medicare-and-Medicaid-Coordination/Medicare-Medicaid-Coordination-Office/Downloads/Dual_Condition_Prevalence_Comorbidity_2014.pdf. Accessed 529, 2019..
  • Mansournia MA, Hernán MA, Greenland S. Matched designs and causal diagrams. Int J Epidemiol. 2013;42(3):860–869. doi:10.1093/ije/dyt08323918854
  • Heinze G, Jüni P. An overview of the objectives of and the approaches to propensity score analyses. Eur Heart J. 2011;32(14):1704–1708. doi:10.1093/eurheartj/ehr03121362706
  • Schisterman EF, Cole SR, Platt RW. Overadjustment bias and unnecessary adjustment in epidemiologic studies. Epidemiology (Cambridge, Mass). 2009;20(4):488. doi:10.1097/EDE.0b013e3181a819a1
  • Porta M. A Dictionary of Epidemiology. Oxford university press; 2014.
  • Rothman KJ, Greenland S, Lash TL. Modern Epidemiology. Vol. 3 Wolters Kluwer Health/Lippincott Williams & Wilkins Philadelphia; 2008.
  • Brookhart MA, Stürmer T, Glynn RJ, Rassen J, Schneeweiss S. Confounding control in healthcare database research: challenges and potential approaches. Med Care. 2010;48(60):S114. doi:10.1097/MLR.0b013e3181dbebe320473199
  • Austin PC, Grootendorst P, Anderson GM. A comparison of the ability of different propensity score models to balance measured variables between treated and untreated subjects: a monte carlo study. Stat Med. 2007;26(4):734–753. doi:10.1002/(ISSN)1097-025816708349
  • Fewell Z, Davey Smith G, Sterne JA. The impact of residual and unmeasured confounding in epidemiologic studies: a simulation study. Am J Epidemiol. 2007;166(6):646–655. doi:10.1093/aje/kwm16517615092