Cost-Minimization Analysis of Dexmedetomidine Compared to Other Sedatives for Short-Term Sedation During Mechanical Ventilation in the United States

References

• Barrett ML, Smith MW, Elixhauser A, Leah S, Honigman, Pines JM. Statistical Brief #185: Utilization of Intensive Care Services, 2011. Healthcare Cost and Utilization Project; 2014.
   Google Scholar
• Kramer AA, Dasta JF, Kane-Gill SL. The impact of mortality on total costs within the ICU. Crit Care Med. 2017;45(9):1457–1463. doi:10.1097/CCM.0000000000002563
   PubMed Web of Science ®Google Scholar
• Dasta JF, McLaughlin TP, Mody SH, Piech CT. Daily cost of an intensive care unit day: the contribution of mechanical ventilation. Crit Care Med. 2005;33(6):1266–1271. doi:10.1097/01.CCM.0000164543.14619.00
   PubMed Web of Science ®Google Scholar
• Reade MC, Finfer S. Sedation and delirium in the intensive care unit. N Engl J Med. 2014;370(5):444–454. doi:10.1056/NEJMra1208705
   PubMed Web of Science ®Google Scholar
• Wunsch H, Wagner J, Herlim M, Chong DH, Kramer AA, Halpern SD. ICU occupancy and mechanical ventilator use in the United States. Crit Care Med. 2013;41(12):2712–2719. doi:10.1097/CCM.0b013e318298a139
   PubMed Web of Science ®Google Scholar
• Hughes CG, McGrane S, Pandharipande PP. Sedation in the intensive care setting. Clin Pharmacol. 2012;4:53–63. doi:10.2147/CPAA.S26582
   PubMedGoogle Scholar
• Devlin JW, Skrobik Y, Gelinas C, et al. Clinical practice guidelines for the prevention and management of pain, agitation/ sedation, delirium, immobility, and sleep disruption in adult patients in the ICU. Crit Care Med. 2018;46(9):e825e873. doi:10.1097/CCM.0000000000003299
   Web of Science ®Google Scholar
• Sydow M, Neumann P. Sedation for the critically Ill. Intensive Care Med. 1999;25(6):634–636. doi:10.1007/s001340050917
   Web of Science ®Google Scholar
• Zhang Z, Chen K, Ni H, Zhang X, Fan H. Sedation of mechanically ventilated adults in intensive care unit: a network meta-analysis. Sci Rep. 2017;7:44979. doi:10.1038/srep44979
   PubMed Web of Science ®Google Scholar
• Barr J, Fraser GL, Puntillo K, et al. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med. 2013;41(1):263–306. doi:10.1097/CCM.0b013e3182783b72
   PubMed Web of Science ®Google Scholar
• Kotfis K, Zegan-Barańska M, Żukowski M, Kusza K, Kaczmarczyk M, Ely EW. Multicenter assessment of sedation and delirium practices in the intensive care units in Poland-is this common practice in Eastern Europe? BMC Anesthesiol. 2017;17(1):120. doi:10.1186/s12871-017-0415-2
   Web of Science ®Google Scholar
• Morandi A, Piva S, Ely EW, et al. Worldwide Survey of the “Assessing pain, both spontaneous awakening and breathing trials, choice of drugs, delirium monitoring/management, early exercise/mobility, and family empowerment” (ABCDEF) Bundle. Crit Care Med. 2017;45(11):e1111. doi:10.1097/CCM.0000000000002640
   PubMed Web of Science ®Google Scholar
• Azeem TMA, Yosif NE, Alansary AM, Esmat IM, Mohamed AK. Dexmedetomidine vs morphine and midazolam in the prevention and treatment of delirium after adult cardiac surgery; a randomized, double-blinded clinical trial. Saudi J Anaesth. 2018;12(2):190–197. doi:10.4103/sja.SJA_303_17
   PubMed Web of Science ®Google Scholar
• Djaiani G, Silverton N, Fedorko L, et al. Dexmedetomidine versus propofol sedation reduces delirium after cardiac surgery: a randomized controlled trial. Anesthesiology. 2016;124(2):362–368. doi:10.1097/ALN.0000000000000951
   PubMed Web of Science ®Google Scholar
• Srivastava VK, Agrawal S, Kumar S, Mishra A, Sharma S, Kumar R. Comparison of dexmedetomidine, propofol and midazolam for short-term sedation in postoperatively mechanically ventilated neurosurgical patients. J Clin Diagn Res. 2014;8(9):GC0407. doi:10.7860/JCDR/2014/8797.4817
   Google Scholar
• Wan LJ, Huang QQ, Yue JX, Lin L, Li SH. Comparison of sedative effect of dexmedetomidine and midazolam for post-operative patients undergoing mechanical ventilation in surgical intensive care unit. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2011;23(9):543–546. Chinese.
   Google Scholar
• Martin E, Ramsay G, Mantz J, Sum-Ping ST. The role of the alpha2-adrenoceptor agonist dexmedetomidine in postsurgical sedation in the intensive care unit. J Intensive Care Med. 2003;18(1):29–41. doi:10.1177/0885066602239122
   Google Scholar
• Maldonado JR, Wysong A, van der Starre PJ, Block T, Miller C, Reitz BA. Dexmedetomidine and the reduction of postoperative delirium after cardiac surgery. Psychosomatics. 2009;50(3):206–217. doi:10.1176/appi.psy.50.3.206
   PubMed Web of Science ®Google Scholar
• Herr DL, Sum-Ping ST, England M. ICU sedation after coronary artery bypass graft surgery: dexmedetomidine-based versus propofol-based sedation regimens. J Cardiothorac Vasc Anesth. 2003;17(5):576–584. doi:10.1016/S1053-0770(03)00200-3
   Web of Science ®Google Scholar
• Fan H, Zhao Y, Sun M, Ye JH, Chen GD, Zhu JH. Dexmedetomidine based sedation for post-surgery critically Ill adults: a meta-analysis of randomized controlled trials. Iran J Public Health. 2017;46(12):1611–1622.
   Web of Science ®Google Scholar
• Liu H, Ji F, Peng K, Applegate RL 2nd, Fleming N. Sedation after cardiac surgery: is one drug better than another? Anesth Analg. 2017;124(4):1061–1070. doi:10.1213/ANE.0000000000001588
   Web of Science ®Google Scholar
• Cruickshank M, Henderson L, MacLennan G, et al. Alpha-2 agonists for sedation of mechanically ventilated adults in intensive care units: a systematic review. Health Technol Assess. 2016;20(25):v–xx, 1–117. doi:10.3310/hta20250
   Web of Science ®Google Scholar
• Riker RR, Fraser GL. Altering intensive care sedation paradigms to improve patient outcomes. Crit Care Clin. 2009;25(3):527–538, viii–ix. doi:10.1016/j.ccc.2009.05.004
   Web of Science ®Google Scholar
• Thoma BN, Li J, McDaniel CM, Wordell CJ, Cavarocchi N, Pizzi LT. Clinical and economic impact of substituting dexmedetomidine for propofol due to a US drug shortage: examination of coronary artery bypass graft patients at an urban medical centre. Pharmaco Economics. 2014;32(2):149–157. doi:10.1007/s40273-013-0116-8
   Web of Science ®Google Scholar
• Nguyen J, Nacpil N. Effectiveness of dexmedetomidine versus propofol on extubation times, length of stay and mortality rates in adult cardiac surgery patients: a systematic review and meta-analysis. Joanna Briggs Inst Database Sys Rev Impl Rep. 2018;16(5):1220–1239. doi:10.11124/JBISRIR-2017-003488
   Google Scholar
• Critical Care Statistics. Society of critical care medicine. Available from: http://www.sccm.org/Communications/Critical-Care-Statistics. Accessed October 20, 2018.
   Google Scholar
• Fraind DB, Slagle JM, Tubbesing VA, Hughes SA, Weinger MB. Reengineering intravenous drug and fluid administration processes in the operating room: step one: task analysis of existing processes. Anesthesiology. 2002;97(1):139–147. doi:10.1097/00000542-200207000-00020
   PubMed Web of Science ®Google Scholar
• Centers for medicare & medicaid services. Clin Lab Fee Schedule. 2018.
   Google Scholar
• Centers for medicare & medicaid services. Phy Fee Schedule. 2018.
   Google Scholar
• Park JH, Jeong JH. A cost-minimization analysis comparing dexmedetomidine with midazolam and propofol for sedation in mechanically ventilated intensive care unit patients. J Health Technol Assess. 2016;4(2):75–81. doi:10.34161/johta.2016.4.2.006
   Google Scholar
• Bureau of Labor Statistics. Consumer Price Index-All Urban Consumers (Current Series). 2018.
   Google Scholar
• Corbett SM, Rebuck JA, Greene CM, et al. Dexmedetomidine does not improve patient satisfaction when compared with propofol during mechanical ventilation. Crit Care Med. 2005;33(5):940–945. doi:10.1097/01.CCM.0000162565.18193.E5
   Web of Science ®Google Scholar
• Dasta JF, Kane-Gill SL, Pencina M, et al. A cost-minimization analysis of dexmedetomidine compared with midazolam for long-term sedation in the intensive care unit. Crit Care Med. 2010;38(2):497–503. doi:10.1097/CCM.0b013e3181bc81c9
   PubMed Web of Science ®Google Scholar
• Athanazio R, Maldini P, Roa S, Turunen H, Silva C. Cost-minimisation analysis of dexmedetomidine versus propofol in mechanical ventilated patients at ICU. Value Health. 2015;18(7):A842843. doi:10.1016/j.jval.2015.09.385
   Web of Science ®Google Scholar
• Turunen H, Jakob SM, Ruokonen E, et al. Dexmedetomidine versus standard care sedation with propofol or midazolam in intensive care: an economic evaluation. Critical Care. 2015;19:67. doi:10.1186/s13054-015-0787-y
   Web of Science ®Google Scholar
• Lachaine J, Beauchemin C. Economic evaluation of dexmedetomidine relative to midazolam for sedation in the intensive care unit. Can J Hosp Pharm. 2012;65(2):103–110. doi:10.4212/cjhp.v65i2.1116
   Google Scholar
• Patanwala AE, Erstad BL. Comparison of dexmedetomidine versus propofol on hospital costs and length of stay. J Intensive Care Med. 2016;31(7):466–470. doi:10.1177/0885066614544452
   Web of Science ®Google Scholar
• Shehabi Y, Howe BD, Bellomo R, et al. Early sedation with dexmedetomidine in critically Il patients. New Eng J Med. 2019;380(26):2506–2517. doi:10.1056/NEJMoa1904710
   Web of Science ®Google Scholar
• National Health Expenditure Projections. Centers for Medicare & Medicaid Services; 2017.
   Google Scholar
• Halpern NA, Pastores SM. Critical care medicine in the United States 2000-2005: an analysis of bed numbers, occupancy rates, payer mix, and costs. Crit Care Med. 2010;38(1):65–71. doi:10.1097/CCM.0b013e3181b090d0
   PubMed Web of Science ®Google Scholar