A Real-World Data Study on the Healthcare Resource Use for Uncontrolled Moderate-to-Severe Atopic Dermatitis in Secondary Care in the United Kingdom Prior to the Introduction of Biologic Treatment

References

• Simpson EL, Bieber T, Eckert L, et al. Patient burden of moderate to severe atopic dermatitis (AD): Insights from a phase 2b clinical trial of dupilumab in adults. J Am Acad Dermatol. 2016;74(3):491–498. doi:10.1016/j.jaad.2015.10.043
   PubMed Web of Science ®Google Scholar
• Eichenfield LF, Tom WL, Chamlin SL, et al. Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis. J Am Acad Dermatol. 2014;70(2):338–351. doi:10.1016/j.jaad.2013.10.010
   PubMed Web of Science ®Google Scholar
• Kowalska-Olędzka E, Czarnecka M, Baran A. Epidemiology of atopic dermatitis in Europe. J Drug Assess. 2019;8(1):126–128. doi:10.1080/21556660.2019.1619570
   PubMed Web of Science ®Google Scholar
• NHS. Atopic Eczema; 2019. Available from: https://www.nhs.uk/conditions/atopic-eczema/. Accessed March 18, 2022.
   Google Scholar
• Abuabara K, Yu AM, Okhovat J-P, Allen IE, Langan SM. The prevalence of atopic dermatitis beyond childhood: a systematic review and meta-analysis of longitudinal studies. Allergy. 2018;73(3):696–704. doi:10.1111/all.13320
   PubMed Web of Science ®Google Scholar
• Nettis E, Ortoncelli M, Pellacani G, et al. A multicenter study on the prevalence of clinical patterns and clinical phenotypes in adult atopic dermatitis. J Investig Allergol Clin Immunol. 2020;30(6):448–450. doi:10.18176/jiaci.0519
   PubMed Web of Science ®Google Scholar
• Barbarot S, Auziere S, Gadkari A, et al. Epidemiology of atopic dermatitis in adults: results from an international survey. Allergy. 2018;73(6):1284–1293. doi:10.1111/all.13401
   PubMed Web of Science ®Google Scholar
• França K, Lotti T. Complementary medicine and the role of integrative dermatology for the treatment of atopic dermatitis. Dermatol Ther.2017;30(4):e12469–12461.
   Web of Science ®Google Scholar
• Dattola A, Bennardo L, Silvestri M, Nisticò SP. What’s new in the treatment of atopic dermatitis? Dermatol Ther. 2019;32(2):e12787. doi:10.1111/dth.12787
   PubMed Web of Science ®Google Scholar
• Shalom G, Babaev M, Kridin K, et al. Healthcare service utilization by 116,816 patients with atopic dermatitis in Israel. Acta Derm Venereol. 2019;99(4):370–374. doi:10.2340/00015555-3117
   PubMed Web of Science ®Google Scholar
• Sicras-Mainar A, Navarro-Artieda R, Carrascosa Carrillo JM. Economic impact of atopic dermatitis in adults: a Population-Based Study (IDEA Study). Actas Dermosifiliogr. 2018;109(1):35–46. doi:10.1016/j.ad.2017.09.003
   PubMed Web of Science ®Google Scholar
• Armstrong AW, Huang A, Wang L, et al. Real-world utilization patterns of systemic immunosuppressants among US adult patients with atopic dermatitis. PLoS One. 2019;14(1):e0210517. doi:10.1371/journal.pone.0210517
   PubMed Web of Science ®Google Scholar
• Igarashi A, Fujita H, Arima K, et al. Health-care resource use and current treatment of adult atopic dermatitis patients in Japan: a retrospective claims database analysis. J Dermatol. 2019;46(8):652–661. doi:10.1111/1346-8138.14947
   PubMed Web of Science ®Google Scholar
• Silverwood RJ, Forbes HJ, Abuabara K, et al. Severe and predominantly active atopic eczema in adulthood and long term risk of cardiovascular disease: population based cohort study. BMJ. 2018;361:k1786. doi:10.1136/bmj.k1786
   PubMed Web of Science ®Google Scholar
• Silverberg JI, Gelfand JM, Margolis DJ, et al. Health utility scores of atopic dermatitis in US adults. J Allergy Clin Immunol Pract. 2019;7(4):1246–1252. doi:10.1016/j.jaip.2018.11.043
   PubMed Web of Science ®Google Scholar
• NICE. Dupilumab for treating moderate to severe atopic dermatitis; 2018. Available from: https://www.nice.org.uk/guidance/ta534. Accessed March 18, 2022.
   Google Scholar
• Hanifin J, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol. 1980;22(92):44–47.
   Google Scholar
• Leshem YA, Hajar T, Hanifin JM, Simpson EL. What the eczema area and severity index score tells us about the severity of atopic dermatitis: an interpretability study. Br J Dermatol. 2015;172(5):1353–1357. doi:10.1111/bjd.13662
   PubMed Web of Science ®Google Scholar
• Langan SM, Thomas KS, Williams HC. What is meant by a “flare” in atopic dermatitis?: a systematic review and proposal. Arch Dermatol. 2006;142(9):1190–1196. doi:10.1001/archderm.142.9.1190
   PubMedGoogle Scholar
• Drucker AM, Qureshi AA, Amand C, et al. Health care resource utilization and costs among adults with atopic dermatitis in the United States: a claims-based analysis. J Allergy Clin Immunol Pract. 2018;6(4):1342–1348. doi:10.1016/j.jaip.2017.10.024
   PubMed Web of Science ®Google Scholar
• Eckert L, Gupta S, Amand C, Gadkari A, Mahajan P, Gelfand JM. The burden of atopic dermatitis in US adults: health care resource utilization data from the 2013 National Health and Wellness Survey. J Am Acad Dermatol. 2018;78(1):54–61. doi:10.1016/j.jaad.2017.08.002
   PubMed Web of Science ®Google Scholar
• Megna M, Napolitano M, Patruno C, et al. Systemic treatment of adult atopic dermatitis: a review. Dermatol Ther. 2017;7(1):1–23. doi:10.1007/s13555-016-0170-1
   PubMed Web of Science ®Google Scholar
• Simpson EL, Bruin-Weller M, Flohr C, et al. When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council. J Am Acad Dermatol. 2017;77(4):623–633. doi:10.1016/j.jaad.2017.06.042
   PubMed Web of Science ®Google Scholar
• Wollenberg A, Oranje A, Deleuran M, et al. ETFAD/EADV Eczema task force 2015 position paper on diagnosis and treatment of atopic dermatitis in adult and paediatric patients. J Eur Acad Dermatol Venereol. 2016;30(5):729–747. doi:10.1111/jdv.13599
   PubMed Web of Science ®Google Scholar
• Boguniewicz M, Alexis AF, Beck LA, et al. Expert perspectives on management of moderate-to-severe atopic dermatitis: a multidisciplinary consensus addressing current and emerging therapies. J Allergy Clin Immunol Pract. 2017;5(6):1519–1531. doi:10.1016/j.jaip.2017.08.005
   PubMed Web of Science ®Google Scholar
• Taylor K, Swan DJ, Affleck A, Flohr C, Reynolds NJ. Treatment of moderate-to-severe atopic eczema in adults within the U.K.: results of a national survey of dermatologists. Br J Dermatol. 2017;176(6):1617–1623. doi:10.1111/bjd.15235
   PubMed Web of Science ®Google Scholar
• Chernyshov PV, Tomas-Aragones L, Manolache L, et al. Quality of life measurement in atopic dermatitis. Position Paper of the European Academy of Dermatology and Venereology (EADV) task force on quality of life. J Eur Acad Dermatol Venereol. 2017;31(4):576–593. doi:10.1111/jdv.14058
   PubMed Web of Science ®Google Scholar
• Vakharia PP, Cella D, Silverberg JI. Patient-reported outcomes and quality of life measures in atopic dermatitis. Clin Dermatol. 2018;36(5):616–630. doi:10.1016/j.clindermatol.2018.05.011
   PubMed Web of Science ®Google Scholar
• National Institute for Health and Care Excellence. Frequency of application of topical corticosteroids for atopic eczema guidance and guidelines; 2004.
   Google Scholar
• National Institute for Health and Care Excellence. Tacrolimus and pimecrolimus for atopic eczema guidance and guidelines; 2004.
   Google Scholar
• Retzler J, Smith A, Reaney M, Rout R, Hudson R. Process utilities for topical treatment in atopic dermatitis. Quality Life Res. 2019;28(9):2373–2381. doi:10.1007/s11136-019-02174-0
   PubMed Web of Science ®Google Scholar