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Original Research

Cost-Effectiveness Analysis of Fracture Liaison Services Compared with Standard of Care in the Secondary Prevention of Fragility Fractures in Spain

ORCID Icon, ORCID Icon, , &
Pages 249-264 | Published online: 22 Apr 2022

References

  • NICE. NICEimpact. Falls and fragility fractures; 2018. Available from: https://www.nice.org.uk/media/default/about/what-we-do/into-practice/measuring-uptake/nice-impact-falls-and-fragility-fractures.pdf. Accessed May 31, 2021.
  • Sanfélix-Genovés J, Reig-Molla B, Sanfélix-Gimeno G, et al. The population-based prevalence of osteoporotic vertebral fracture and densitometric osteoporosis in postmenopausal women over 50 in Valencia, Spain (the FRAVO Study). Bone. 2010;47(3):610–616. doi:10.1016/j.bone.2010.06.015
  • Montoya-García MJ, Giner M, Marcos R, et al. Fragility fractures and imminent fracture risk in the spanish population: a retrospective observational cohort study. J Clin Med. 2021;10(5):1082. doi:10.3390/jcm10051082
  • International Osteoporosis Fundation (IOF). Broken bones, broken lives: a roadmap to solve the fragility fracture crisis in Spain. Available from: https://share.osteoporosis.foundation/EU-6-Material/Reports/IOFReport_SPAIN.pdf. Accessed July 9, 2021.
  • British Orthopaedic Association. The Care of Patients with Fragility Fracture: The ‘Blue Book. British Orthopaedic Association; 2007.
  • Cooper C. Epidemiology and definition of osteoporosis. In: Compston JE, editor. Osteoporosis: New Perspectives on Causes, Prevention and Treatment. London: Royal College of Physicians of London; 1996.
  • Department of Health. National service framework for older people. London: Department of Health; 2001. Available from: https://www.gov.uk/government/publications/quality-standards-for-care-services-for-older-people. Accessed May 31, 2021.
  • Scottish Executive. Adding life to years: report of the expert group on healthcare of older people. Edinburgh: Scottish Executive; 2002. Available from: https://www.sehd.scot.nhs.uk/publications/alty/alty.pdf. Accessed May 31, 2021.
  • Nikitovic M, Wodchis WP, Krahn MD, Cadarette SM. Direct health-care costs attributed to hip fractures among seniors: a matched cohort study. Osteoporos Int. 2013;24(2):659–669. doi:10.1007/s00198-012-2034-6
  • Naranjo A, Ojeda-Bruno S, Bilbao-Cantarero A, Quevedo-Abeledo JC, Diaz-González BV, Rodríguez-Lozano C. Two-year adherence to treatment and associated factors in a fracture liaison service in Spain. Osteoporos Int. 2015;26(11):2579–2585. doi:10.1007/s00198-015-3185-z
  • Caeiro JR, Bartra A, Mesa-Ramos M, et al. Burden of first osteoporotic hip fracture in Spain: a prospective, 12-month, observational study. Calcif Tissue Int. 2017;100(1):29–39. doi:10.1007/s00223-016-0193-8
  • Bliuc D, Nguyen ND, Milch VE, Nguyen TV, Eisman JA, Center JR. Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women. JAMA. 2009;301(5):513. doi:10.1001/jama.2009.50
  • Pisani P, Renna MD, Conversano F, et al. Major osteoporotic fragility fractures: risk factor updates and societal impact. World J Orthop. 2016;7(3):171. doi:10.5312/wjo.v7.i3.171
  • Curtis EM, Moon RJ, Harvey NC, Cooper C. Reprint of: the impact of fragility fracture and approaches to osteoporosis risk assessment worldwide. Int J Orthopaed Trauma Nurs. 2017;26:7–17. doi:10.1016/j.ijotn.2017.04.004
  • McLellan AR, Gallacher SJ, Fraser M, McQuillian C. The fracture liaison service: success of a program for the evaluation and management of patients with osteoporotic fracture. Osteoporos Int. 2003;14(12):1028–1034. doi:10.1007/s00198-003-1507-z
  • Wu CH, Kao IJ, Hung WC, et al. Economic impact and cost-effectiveness of fracture liaison services: a systematic review of the literature. Osteoporos Int. 2018;29(6):1227–1242. doi:10.1007/s00198-018-4411-2
  • Marsh D, Åkesson K, Beaton DE, et al. Coordinator-based systems for secondary prevention in fragility fracture patients. Osteoporos Int. 2011;22(7):2051–2065. doi:10.1007/s00198-011-1642-x
  • Naranjo A, Fernández-Conde S, Ojeda S, et al. Preventing future fractures: effectiveness of an orthogeriatric fracture liaison service compared to an outpatient fracture liaison service and the standard management in patients with hip fracture. Arch Osteoporos. 2017;12(1):3–7. doi:10.1007/s11657-017-0373-9
  • Naranjo A, Ojeda-Bruno S, Saavedra A, Molina A, Negrín M. Impact of the implementation of a Fracture Liaison Service on pharmaceutical expenses for osteoporosis compared to an area without an FLS. Expert Rev Pharmacoecon Outcomes Res. 2019;19(1):81–87. doi:10.1080/14737167.2018.1513791
  • Ojeda-Bruno S, Naranjo A, Francisco-Hernández F, et al. Secondary prevention program for osteoporotic fractures and long-term adherence to bisphosphonates. Osteoporos Int. 2011;22(6):1821–1828. doi:10.1007/s00198-010-1414-z
  • García Renedo RJ, Mella Sousa M, Anaya Rojas M, et al. Estudio epidemiológico de factores de riesgo asociados a refractura en mujeres con fractura vertebral osteoporótica durante 10 años de seguimiento. [Epidemiological study of risk factors associated to refracture in women osteoporotic vertebral fracture during a 10-year follow-up]. Revista Española de Enfermedades Metabólicas Óseas. 2009;18(4):85–89. doi:10.1016/S1132-8460(09)73463-4
  • Martín-Merino E, Huerta-álvarez C, Prieto-Alhambra D, Montero-Corominas D. Cessation rate of anti-osteoporosis treatments and risk factors in Spanish primary care settings: a population-based cohort analysis. Arch Osteoporos. 2017;12(1). doi:10.1007/s11657-017-0331-6
  • Skjødt MK, Khalid S, Ernst M, et al. Secular trends in the initiation of therapy in secondary fracture prevention in Europe: a multi-national cohort study including data from Denmark, Catalonia, and the United Kingdom. Osteoporos Int. 2020;31(8):1535–1544. doi:10.1007/s00198-020-05358-4
  • INE (Instituto Nacional de Estadística). Tablas de mortalidad por año, sexo, edad y funciones. [Population mortality tables for Spain by year, sex, age and functions]; 2020. Available from: https://www.ine.es/. Accessed January 7, 2020.
  • Solomon DH, Patrick AR, Schousboe J, Losina E. The potential economic benefits of improved postfracture care: a cost-effectiveness analysis of a fracture liaison service in the US health-care system. J Bone Mineral Res. 2014;29(7):1667–1674. doi:10.1002/jbmr.2180
  • Cooper MS, Palmer AJ, Seibel MJ. Cost-effectiveness of the Concord Minimal Trauma Fracture Liaison service, a prospective, controlled fracture prevention study. Osteoporos Int. 2012;23(1):97–107. doi:10.1007/s00198-011-1802-z
  • Jonsson E, Borgström F, Ström O. Cost effectiveness evaluation of fracture liaison services for the management of osteoporosis in Sweden. Value Health. 2016;19(7):A612. doi:10.1016/j.jval.2016.09.1529
  • McLellan AR, Wolowacz SE, Zimovetz EA, et al. Fracture liaison services for the evaluation and management of patients with osteoporotic fracture: a cost-effectiveness evaluation based on data collected over 8 years of service provision. Osteoporos Int. 2011;22(7):2083–2098. doi:10.1007/s00198-011-1534-0
  • Ortega Eslava A, Marín Gil R, Fraga Fuentes MD, López-Briz E. Guía de Evaluación Económica e Impacto Presu-Puestario En Los Informes de Evaluación de Medicamentos [Economic Evaluation and Budgetary Impact Guidelines for Assessment Reports on Medicinal Products]. 2016.
  • López Bastida J, Oliva J, Antoñanzas F, et al. Propuesta de guía para la evaluación económica aplicada a las tecnologías sanitarias. [A proposed guideline for economic evaluation of health technologies]. Gaceta Sanitaria. 2010;24(2):154–170. doi:10.1016/j.gaceta.2009.07.011
  • Puig-Junoy J, Oliva-Moreno J, Trapero-Bertrán M, et al. Guía y recomendaciones para la realización y presentación de evaluaciones económicas y análisis de impacto presupuestario de medicamentos en el ámbito del CatSalut [Guidelines and recommendations to conduct and present economic assessments and budget impact analysis of medicines to the CatSalut setting]. Generalitat de Catalunya Dept de Salut Servei Català de la Salut. 2014;2014:9–11.
  • Hiligsmann M, Reginster JY, Tosteson ANA, et al. Recommendations for the conduct of economic evaluations in osteoporosis: outcomes of an experts’ consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and. Osteoporos Int. 2019;30(1):45–57. doi:10.1007/s00198-018-4744-x
  • Naranjo A, Ojeda-Bruno S, Bilbao Cantarero A, Quevedo Abeledo JC, Henríquez-Hernández LA, Rodríguez-Lozano C. Resultados de un modelo de prevención secundaria de fractura osteoporótica coordinado por reumatología centrado en la enfermera y el médico de atención primaria [Results of a model of secondary prevention for osteoporotic fracture coordinated by rheumatology and focused on the nurse and primary care physicians]. Reumatol Clin. 2014;10(5):299–303. doi:10.1016/j.reuma.2013.12.007
  • Rubiño F, Ojeda S, Molina A, Naranjo A. Application of the recommendations of the Spanish Society of Rheumatology on osteoporosis in a Fracture Liaison Service unit. Reumatología Clínica. 2021;17(2):122–123. doi:10.1016/j.reumae.2019.03.011
  • INE (Instituto Nacional de Estadística). Encuesta Nacional de Salud [National Health Survey]; 2014. Available from: https://www.ine.es/. Accessed January 7, 2020.
  • Hiligsmann M, Ethgen O, Richy F, Reginster JY. Utility values associated with osteoporotic fracture: a systematic review of the literature. Calcif Tissue Int. 2008;82(4):288–292. doi:10.1007/s00223-008-9117-6
  • CIMA-AEMPS (Centro de Información online de Medicamentos de la Agencia Española de Medicamentos y Productos Sanitarios). Buscador de medicamentos [Medicines browser for healthcare professionals]. Available from: https://cima.aemps.es/cima/publico/home.html. Accessed July 6, 2020.
  • Naranjo A, Molina A, Sepúlveda C, Rubiño FJ, Martín N, Ojeda S. The evolution of an FLS in search of excellence: the experience of Gran Canaria. Arch Osteoporos. 2020;15(1):108. doi:10.1007/s11657-020-00729-0
  • MSCyBS (Ministerio de Sanidad Consumo y Bienestar Social). Registro de Actividad de Atención Especializada – RAE-CMBD [Registry of Specialized Healthcare Activity - RAE-CMBD]. Available from: https://pestadistico.inteligenciadegestion.mscbs.es/publicoSNS/S/rae-cmbd. Accessed May 13, 2021.
  • Gisbert R, Brosa M. Spanish Health Costs and cost-effectiveness ratios database: eSalud. Barcelona: Oblikue Consulting, S.L; 2007. Available from: http://www.oblikue.com/bddcostes/. Accessed May 13, 2021.
  • Sacristán JA, Oliva J, Del Llano J, Prieto L, Pinto JL. ¿Qué es una tecnología sanitaria eficiente en España? [What is an efficient health technology in Spain?]. Gaceta Sanitaria. 2002;16(4):334–343. doi:10.1016/S0213-9111(02)71933-X
  • Vallejo-Torres L, Garcia-Lorenzo B, Garcia-Pérez L, Linertová R, Serrano-Aguilar P. Disponibilidad a Pagar de La Sociedad Española Por Un Año de Vida Ajustado Por Calidad [Spannish Society Willingness-To-Pay for One Quality-Adjusted Life Year]. Ministerio de Sanidad, Servicios Sociales e Igualdad. Servicio de Evaluación del Servicio Canario de la Salud; 2017.
  • Borgström F, Karlsson L, Ortsäter G, et al. Fragility fractures in Europe: burden, management and opportunities. Arch Osteoporos. 2020;15(1). doi:10.1007/s11657-020-0706-y
  • Royal College of Physicians. Fracture Liaison Service Database (FLS-DB) Annual Report. Leading FLS Improvement: Secondary Fracture Prevention in the NHS. London: Royal College of Physicians; 2017.
  • Huntjens KMB, van Geel TA, van den Bergh JPW, et al. Fracture liaison service: impact on subsequent nonvertebral fracture incidence and mortality. J Bone Joint Surg. 2014;96(4):e29. doi:10.2106/JBJS.L.00223
  • International Osteoporosis Fundation (IOF). Capture de Fracture Partnership. The need for secondary fracture prevention. Available from: https://www.osteoporosis.foundation/sites/iofbonehealth/files/2021-01/CTFslidekit1_updated_280820.pdf. Accessed July 14, 2021.
  • Catalá-López F, Tobías A, Roqué M. Conceptos básicos del metaanálisis en red. [Basic concepts for network meta-analysis]. Atención Primaria. 2014;46(10):573–581. doi:10.1016/j.aprim.2014.01.006
  • University of Sheffield. FRAX. Fracture risk assessment tool; 2008. Available from: https://www.sheffield.ac.uk/FRAX/index.aspx. Accessed November 5, 2021.
  • Geiger I, Kammerlander C, Höfer C, et al. Implementation of an integrated care programme to avoid fragility fractures of the hip in older adults in 18 Bavarian hospitals – study protocol for the cluster-randomised controlled fracture liaison service FLS-CARE. BMC Geriatr. 2021;21(1):43. doi:10.1186/s12877-020-01966-1
  • Naranjo A, Molina A, Quevedo A, et al. Fracture liaison service model: treatment persistence 5 years later. Arch Osteoporos. 2021;16(1):60. doi:10.1007/s11657-021-00925-6
  • Olmo-Montes FJ, Hernández-Cruz B, Miranda MJ, et al. The fracture liaison service of the virgen macarena university hospital reduces the gap in the management of osteoporosis, particularly in men. It meets the international osteoporosis foundation quality standards. J Clin Med. 2021;10(18):1–17. doi:10.3390/jcm10184220
  • Inderjeeth CA, Raymond W, Geelhoed E, et al. THU0465 fracture liaison service reduces re-fracture rate, cost-effective and cost saving in Western Australia. Ann Rheum Dis. 2016;75(Suppl2):360.2–360. doi:10.1136/annrheumdis-2016-eular.2137
  • Yates CJ, Chauchard MA, Liew D, Bucknill A, Wark JD. Bridging the osteoporosis treatment gap: performance and cost-effectiveness of a fracture liaison service. J Clin Densitomet. 2015;18(2):150–156. doi:10.1016/j.jocd.2015.01.003
  • Yong JHE, Masucci L, Hoch JS, Sujic R, Beaton D. Cost-effectiveness of a fracture liaison service—a real-world evaluation after 6 years of service provision. Osteoporos Int. 2016;27(1):231–240. doi:10.1007/s00198-015-3280-1
  • Moriwaki K, Noto S. Economic evaluation of osteoporosis liaison service for secondary fracture prevention in postmenopausal osteoporosis patients with previous hip fracture in Japan. Osteoporos Int. 2017;28(2):621–632. doi:10.1007/s00198-016-3777-2
  • Majumdar SR, Johnson JA, Lier DA, et al. Persistence, reproducibility, and cost-effectiveness of an intervention to improve the quality of osteoporosis care after a fracture of the wrist: results of a controlled trial. Osteoporos Int. 2007;18(3):261–270. doi:10.1007/s00198-006-0248-1
  • Majumdar SR, Lier DA, Beaupre LA, et al. Osteoporosis case manager for patients with hip fractures. Arch Intern Med. 2009;169(1):25. doi:10.1001/archinte.169.1.25