Cost-Effectiveness and Budget Impact of Comprehensive Anemia Management, The First Pillar of Patient Blood Management, on the Turkish Healthcare System

References

• Althoff FC, Neb H, Herrmann E, et al. Multimodal patient blood management program based on a three-pillar strategy: a systematic review and meta-analysis. Ann Surg. 2019;269(5):794–804. doi:10.1097/SLA.0000000000003095
   PubMed Web of Science ®Google Scholar
• Freedman J, Luke K, Escobar M, Vernich L, Chiavetta JA. Experience of a network of transfusion coordinators for blood conservation (Ontario Transfusion Coordinators [ONTraC]). Transfusion. 2008;48(2):237–250. doi:10.1111/j.1537-2995.2007.01515.x
   PubMed Web of Science ®Google Scholar
• Liumbruno GM, Grazzini G, Rafanelli D. Post-operative blood salvage in patient blood management: is it really cost-effective and safe? Blood Transfus. 2013;11(2):175–177. doi:10.2450/2013.0001-13
   PubMed Web of Science ®Google Scholar
• Abdullah HR, Ang AL, Froessler B, et al. Getting patient blood management Pillar 1 right in the Asia-Pacific: a call for action. Singapore Med J. 2020;61(6):287–296. doi:10.11622/smedj.2019037
   PubMed Web of Science ®Google Scholar
• Bernard AC, Davenport DL, Chang PK, Vaughan TB, Zwischenberger JB. Intraoperative transfusion of 1 U to 2 U packed red blood cells is associated with increased 30-day mortality, surgical-site infection, pneumonia, and sepsis in general surgery patients. J Am Coll Surg. 2009;208(5):931–937. doi:10.1016/j.jamcollsurg.2008.11.019
   PubMed Web of Science ®Google Scholar
• Chatterjee S, Wetterslev J, Sharma A, Lichstein E, Mukherjee D. Association of blood transfusion with increased mortality in myocardial infarction: a meta-analysis and diversity-adjusted study sequential analysis. JAMA Intern Med. 2013;173(2):132–139. doi:10.1001/2013.jamainternmed.1001
   PubMed Web of Science ®Google Scholar
• Jakobsen CJ, Ryhammer PK, Tang M, Andreasen JJ, Mortensen PE. Transfusion of blood during cardiac surgery is associated with higher long-term mortality in low-risk patients. Eur J Cardiothorac Surg. 2012;42(1):114–120. doi:10.1093/ejcts/ezr242
   PubMed Web of Science ®Google Scholar
• Kleineruschkamp A, Meybohm P, Straub N, Zacharowski K, Choorapoikayil S. A model-based cost-effectiveness analysis of patient blood management. Blood Transfus. 2019;17(1):16–26. doi:10.2450/2018.0213-17
   PubMed Web of Science ®Google Scholar
• Hofmann A, Ozawa S, Farrugia A, Farmer SL, Shander A. Economic considerations on transfusion medicine and patient blood management. Best Pract Res Clin Anaesthesiol. 2013;27(1):59–68. doi:10.1016/j.bpa.2013.02.001
   PubMedGoogle Scholar
• Meybohm P, Herrmann E, Steinbicker AU, et al. Patient blood management is associated with a substantial reduction of red blood cell utilization and safe for patient’s outcome: a prospective, multicenter cohort study with a noninferiority design. Ann Surg. 2016;264(2):203–211. doi:10.1097/SLA.0000000000001747
   PubMed Web of Science ®Google Scholar
• Musallam KM, Tamim HM, Richards T, et al. Preoperative anaemia and postoperative outcomes in non-cardiac surgery: a retrospective cohort study. Lancet. 2011;378(9800):1396–1407. doi:10.1016/S0140-6736(11)61381-0
   PubMed Web of Science ®Google Scholar
• Kurian DJ, Guinn NR, Hunting J, Kurian DJ, Guinn NR, Hunting Jet al. Preoperative blood management strategy for elective hip and knee arthroplasty. J Healthc Qual. 2019;41(6):376–383. doi:10.1097/JHQ.0000000000000207
   PubMed Web of Science ®Google Scholar
• World Health Organisation. Sixty-third world health assembly - availability, safety and quality of blood products, WHA63.12; 2010. Available from: https://apps.who.int/gb/ ebwha/ pdf_files/ WHA63/ A63_R12- en.pdf. Accessed May 23, 2022.
   Google Scholar
• Leahy MF, Roberts H, Mukhtar SA, et al. A pragmatic approach to embedding patient blood management in a tertiary hospital. Transfusion. 2014;54(4):1133–1145. doi:10.1111/trf.12362
   PubMed Web of Science ®Google Scholar
• Leahy MF, Hofmann A, Towler S, et al. Improved outcomes and reduced costs associated with a health-system-wide patient blood management program: a retrospective observational study in four major adult tertiary-care hospitals. Transfusion. 2017;57(6):1347–1358. doi:10.1111/trf.14006
   PubMed Web of Science ®Google Scholar
• Theusinger OM, Kind SL, Seifert B, Borgeat L, Gerber C, Spahn DR. Patient blood management in orthopaedic surgery: a four-year follow-up of transfusion requirements and blood loss from 2008 to 2011 at the Balgrist University Hospital in Zurich, Switzerland. Blood Transfus. 2014;12(2):195–203. doi:10.2450/2014.0306-13
   PubMed Web of Science ®Google Scholar
• Meybohm P, Straub N, Fullenbach C, et al. Health economics of patient blood management: a cost-benefit analysis based on a meta-analysis. Vox Sang. 2020;115(2):182–188. doi:10.1111/vox.12873
   Web of Science ®Google Scholar
• Drabinski T, Zacharowski K, Meybohm P, Ruger AM, Ramirez de Arellano A. Estimating the epidemiological and economic impact of implementing preoperative anaemia measures in the German healthcare system: the health economic footprint of patient blood management. Adv Ther. 2020;37(8):3515–3536. doi:10.1007/s12325-020-01372-4
   PubMed Web of Science ®Google Scholar
• Turkish Ministry of Health and European Union. Technical assistance for improving the blood transfusion management system in Turkey; 2019. Available from: https://hastakanyonetimi.saglik.gov.tr/. Accessed May 10, 2022.
   Google Scholar
• Ertugay S, Kudsioglu T, Sen T, Patient Blood Management Study Group Members. Consensus report on patient blood management in cardiac surgery by Turkish Society of Cardiovascular Surgery (TSCVS), Turkish Society of Cardiology (TSC), and Society of Cardio-Vascular-Thoracic Anaesthesia and Intensive Care (SCTAIC). Turk Gogus Kalp Damar Cerrahisi Derg. 2019;27(4):429–450. doi:10.5606/tgkdc.dergisi.2019.01902
   PubMed Web of Science ®Google Scholar
• Unal D, Senayli Y, Polat R, et al. Peri-operative blood transfusion in elective major surgery: incidence, indications and outcome - an observational multicentre study. Blood Transfus. 2020;18(4):261–279. doi:10.2450/2020.0011-20
   PubMed Web of Science ®Google Scholar
• Budak AB, McCusker K, Gunaydin S, A cardiopulmonary bypass based blood management strategy in adult cardiac surgery. Heart Surg Forum. 2017;20(5):E195–E198. doi:10.1532/hsf.1792
   PubMed Web of Science ®Google Scholar
• Gunaydin S, Spahn DR, Ozisik K, et al. Building a patient blood management program in a large-volume tertiary hospital setting: problems and solutions. Turk Gogus Kalp Damar Cerrahisi Derg. 2020;28(3):560–569. doi:10.5606/tgkdc.dergisi.2020.19701
   PubMed Web of Science ®Google Scholar
• Lafci A, Gokcinar D, Dag O, Gunertem E, Gunaydin S. The effect of “patient blood management” education on the number of red blood cell transfusions in patients undergoing cardiac surgery: a 5-year retrospective study. Turk J Clin Lab. 2019;1:98–103.
   Google Scholar
• Sert GS, Cavus M, Kemerci P, et al. The results of cardiac surgery in terms of patient blood management in our hospital. Turk J Anaesthesiol Reanim. 2019;47(5):402–406. doi:10.5152/TJAR.2019.02058
   PubMed Web of Science ®Google Scholar
• Bisbe E, Basora M, Colomina MJ, Spanish Best Practice in Peri-operative Anaemia Optimisation Panel. Peri-operative treatment of anaemia in major orthopaedic surgery: a practical approach from Spain. Blood Transfus. 2017;15(4):296–306. doi:10.2450/2017.0177-16
   PubMed Web of Science ®Google Scholar
• Calleja JL, Delgado S, Del Val A, et al. Ferric carboxymaltose reduces transfusions and hospital stay in patients with colon cancer and anemia. Int J Colorectal Dis. 2016;31(3):543–551. doi:10.1007/s00384-015-2461-x
   PubMed Web of Science ®Google Scholar
• Cladellas M, Farre N, Comin-Colet J, et al. Effects of preoperative intravenous erythropoietin plus iron on outcome in anemic patients after cardiac valve replacement. Am J Cardiol. 2012;110(7):1021–1026. doi:10.1016/j.amjcard.2012.05.036
   PubMed Web of Science ®Google Scholar
• Munoz M, Gomez-Ramirez S, Martin-Montanez E, Naveira E, Seara J, Pavia J. Cost of post-operative intravenous iron therapy in total lower limb arthroplasty: a retrospective, matched cohort study. Blood Transfus. 2014;12(1):40–49. doi:10.2450/2013.0088-13
   PubMed Web of Science ®Google Scholar
• Marseille E, Larson B, Kazi DS, Kahn JG, Rosen S. Thresholds for the cost-effectiveness of interventions: alternative approaches. Bull World Health Organ. 2015;93(2):118–124. doi:10.2471/BLT.14.138206
   PubMed Web of Science ®Google Scholar
• Turkiye iStatistik Kurumu. Periodic gross domestic product. Available from: https:// www.tuik.gov.tr/. Accessed May 10, 2022.
   Google Scholar
• Goodnough LT, Shander A, Riou B. Patient blood management. Anesthesiology. 2012;116(6):1367–1376. doi:10.1097/ALN.0b013e318254d1a3
   PubMed Web of Science ®Google Scholar
• Vamvakas EC, Blajchman MA. Transfusion-related mortality: the ongoing risks of allogeneic blood transfusion and the available strategies for their prevention. Blood. 2009;113(15):3406–3417. doi:10.1182/blood-2008-10-167643
   PubMed Web of Science ®Google Scholar
• Perkins HA, Busch MP. Transfusion-associated infections: 50 years of relentless challenges and remarkable progress. Transfusion. 2010;50(10):2080–2099. doi:10.1111/j.1537-2995.2010.02851.x
   PubMed Web of Science ®Google Scholar
• Shander A, Hofmann A, Ozawa S, Theusinger OM, Gombotz H, Spahn DR. Activity-based costs of blood transfusions in surgical patients at four hospitals. Transfusion. 2010;50(4):753–765. doi:10.1111/j.1537-2995.2009.02518.x
   PubMed Web of Science ®Google Scholar
• Shander A, Fink A, Javidroozi M, et al. Appropriateness of allogeneic red blood cell transfusion: the international consensus conference on transfusion outcomes. Transfus Med Rev. 2011;25(3):232–246 e253. doi:10.1016/j.tmrv.2011.02.001
   PubMed Web of Science ®Google Scholar
• Vamvakas EC. Establishing causation in transfusion medicine and related tribulations. Transfus Med Rev. 2011;25(2):81–88. doi:10.1016/j.tmrv.2010.11.010
   PubMed Web of Science ®Google Scholar
• Glance LG, Dick AW, Mukamel DB, et al. Association between intraoperative blood transfusion and mortality and morbidity in patients undergoing noncardiac surgery. Anesthesiology. 2011;114(2):283–292. doi:10.1097/ALN.0b013e3182054d06
   PubMed Web of Science ®Google Scholar
• Goodnough LT, Shieh L, Hadhazy E, Cheng N, Khari P, Maggio P. Improved blood utilization using real-time clinical decision support. Transfusion. 2014;54(5):1358–1365. doi:10.1111/trf.12445
   PubMed Web of Science ®Google Scholar
• Trentino KM, Mace HS, Symons K, et al. Screening and treating pre-operative anaemia and suboptimal iron stores in elective colorectal surgery: a cost effectiveness analysis. Anaesthesia. 2021;76(3):357–365. doi:10.1111/anae.15240
   PubMed Web of Science ®Google Scholar
• Vigna-Taglianti F, Basso L, Rolfo P, et al. Tranexamic acid for reducing blood transfusions in arthroplasty interventions: a cost-effective practice. Eur J Orthop Surg Traumatol. 2014;24(4):545–551. doi:10.1007/s00590-013-1225-y
   PubMedGoogle Scholar
• Wan S, Sparring V, Cabrales DA, Jansson KA, Wikman A. Clinical and budget impact of treating preoperative anemia in major orthopedic surgery-a retrospective observational study. J Arthroplasty. 2020;35(11):3084–3088. doi:10.1016/j.arth.2020.06.018
   PubMed Web of Science ®Google Scholar
• Gross I, Seifert B, Hofmann A, Spahn DR. Patient blood management in cardiac surgery results in fewer transfusions and better outcome. Transfusion. 2015;55(5):1075–1081. doi:10.1111/trf.12946
   PubMed Web of Science ®Google Scholar
• Rognoni C, Gerzeli S. Ferric carboxymaltose for patients with heart failure and iron deficiency in Italy: cost-effectiveness and budget impact. J Comp Eff Res. 2019;8(13):1099–1110. doi:10.2217/cer-2019-0074
   PubMed Web of Science ®Google Scholar
• Kotze A, Carter LA, Scally AJ. Effect of a patient blood management programme on preoperative anaemia, transfusion rate, and outcome after primary hip or knee arthroplasty: a quality improvement cycle. Br J Anaesth. 2012;108(6):943–952. doi:10.1093/bja/aes135
   PubMed Web of Science ®Google Scholar
• Froessler B, Rueger AM, Connolly MP. Assessing the costs and benefits of perioperative iron deficiency anemia management with ferric carboxymaltose in Germany. Risk Manag Healthc Policy. 2018;11:77–82. doi:10.2147/RMHP.S157379
   PubMed Web of Science ®Google Scholar
• Basora M, Pereira A, Coca M, Tio M, Lozano L. Cost-effectiveness analysis of ferric carboxymaltose in pre-operative haemoglobin optimisation in patients undergoing primary knee arthroplasty. Blood Transfus. 2018;16(5):438–442. doi:10.2450/2018.0031-18
   PubMed Web of Science ®Google Scholar
• Mehra T, Seifert B, Bravo-Reiter S, et al. Implementation of a patient blood management monitoring and feedback program significantly reduces transfusions and costs. Transfusion. 2015;55(12):2807–2815. doi:10.1111/trf.13260
   PubMed Web of Science ®Google Scholar
• Sosyal Guvenlik Kurumu. Republic of Turkey Social Security Institution. Available from: http:// www.sgk.gov.tr/ wps/ portal/ sgk/ en/detail/social_security_system. Accessed May 10, 2022.
   Google Scholar