Epilepsy-Related Direct Medical and Direct Non-Medical Cost in Adult Patients Living with Epilepsy at a Tertiary Neurology Center in Rwanda

References

• Saxena S, Li S. Defeating epilepsy: a global public health commitment. Epilepsia Open. 2017;2(2):153–155. doi:10.1002/epi4.12010
   PubMedGoogle Scholar
• Owolabi LF, Owolabi SD, Adamu B, Jibo AM, Alhaji ID. Epilepsy treatment gap in Sub-Saharan Africa: meta-analysis of community-based studies. Acta Neurol Scand. 2020;142(1):3–13. doi:10.1111/ane.13246
   PubMed Web of Science ®Google Scholar
• Ngugi AK, Kariuki SM, Bottomley C, Kleinschmidt I, Sander JW, Newton CR. Incidence of epilepsy: a systematic review and meta-analysis. Neurology. 2011;77(10):1005–1012. doi:10.1212/WNL.0b013e31822cfc90
   PubMed Web of Science ®Google Scholar
• Ngugi AK, Bottomley C, Kleinschmidt I, Sander JW, Newton CR. Estimation of the burden of active and life-time epilepsy: a meta-analytic approach. Epilepsia. 2010;51(5):883–890. doi:10.1111/j.1528-1167.2009.02481.x
   PubMed Web of Science ®Google Scholar
• Yemadje LP, Houinato D, Quet F, Druet-Cabanac M, Preux PM. Understanding the differences in prevalence of epilepsy in tropical regions. Epilepsia. 2011;52(8):1376–1381. doi:10.1111/j.1528-1167.2011.03099.x
   PubMed Web of Science ®Google Scholar
• Sebera F, Munyandamutsa N, Teuwen DE, et al. Addressing the treatment gap and societal impact of epilepsy in Rwanda--results of a survey conducted in 2005 and subsequent actions. Epilepsy Behav. 2015;46:126–132. doi:10.1016/j.yebeh.2015.03.028
   PubMed Web of Science ®Google Scholar
• Dedeken P, Sebera F, Mutungirehe S, et al. High prevalence of epilepsy in Northern Rwanda: exploring gender differences. Brain Behav. 2021;11(11):e2377. doi:10.1002/brb3.2377
   PubMed Web of Science ®Google Scholar
• Health service packages for public health facilities. Rwanda; 2017. Available from: https://www.moh.gov.rw/fileadmin/user_upload/Moh/Publications/Legal_Framework/Public_health_Facilities_service_packages_in_Rwanda-1.pdf. Accessed December, 2020.
   Google Scholar
• Van Steenkiste F, Sebera F, Nsanzabaganwa W, et al. An ambispective cohort study on treatment outcomes of patients with epilepsy in a tertiary epilepsy center in Rwanda and recommendations for improved epilepsy care. Epilepsia Open. 2019;4(1):123–132. doi:10.1002/epi4.12304
   PubMedGoogle Scholar
• Rabarison KM, Bish CL, Massoudi MS, Giles WH. Economic evaluation enhances public health decision making. Front Public Health. 2015;3:164. doi:10.3389/fpubh.2015.00164
   PubMed Web of Science ®Google Scholar
• Wibecan L, Fink G, Tshering L, et al. The economic burden of epilepsy in Bhutan. Trop Med Int Health. 2018;23(4):342–358. doi:10.1111/tmi.13035
   PubMed Web of Science ®Google Scholar
• Hong Z, Qu B, Wu XT, Yang TH, Zhang Q, Zhou D. Economic burden of epilepsy in a developing country: a retrospective cost analysis in China. Epilepsia. 2009;50(10):2192–2198. doi:10.1111/j.1528-1167.2009.02185.x
   PubMed Web of Science ®Google Scholar
• Wagner RG, Bertram MY, Gómez-Olivé FX, et al. Health care utilization and out-patient, out-of-pocket costs for active convulsive epilepsy in rural northeastern South Africa: a cross-sectional survey. BMC Health Serv Res. 2016;16:208. doi:10.1186/s12913-016-1460-0
   PubMed Web of Science ®Google Scholar
• Nsengiyumva G, Druet-Cabanac M, Nzisabira L, Preux PM, Vergnenègre A. Economic evaluation of epilepsy in Kiremba (Burundi): a case-control study. Epilepsia. 2004;45(6):673–677. doi:10.1111/j.0013-9580.2004.36303.x
   PubMed Web of Science ®Google Scholar
• Kissani N, Benkhadda S, Arkha S, Louhab N. Le coût de l’épilepsie dans la ville de Marrakech et sa région [the cost of epilepsy in Marrakech city and its area]. AMEEJ. 2016;5(1):21–24.
   Google Scholar
• Krishnan A, Sahariah SU, Kapoor SK. Cost of epilepsy in patients attending a secondary-level hospital in India. Epilepsia. 2004;45(3):289–291. doi:10.1111/j.0013-9580.2004.63102.x
   PubMed Web of Science ®Google Scholar
• Nyandwi A, Umuhoza S, Uwaliraye P, Musange SF. Towards sustainability if the community-based health insurance in Rwanda: successes, challenges, and opportunities. SPARC Africa; 2021. Available from: https://sparc.africa/2021/09/towards-sustainability-of-The-community-based-health-insurance-in-rwanda-successes-challenges-and-opportunities/. Accessed November 25, 2022.
   Google Scholar
• Lu C, Chin B, Lewandowski JL, et al. Towards universal health coverage: an evaluation of Rwanda Mutuelles in its first eight years. PLoS One. 2012;7(6):e39282. doi:10.1371/journal.pone.0039282
   PubMed Web of Science ®Google Scholar
• Woldemichael A, Gurara D, Shimeles A. The impact of community based health insurance schemes on out-of-pocket healthcare spending: evidence from Rwanda. IMF WORKING PAPERS; 2019. Available from: https://www.imf.org/-/media/Files/Publications/WP/2019/WPIEA2019038.ashx. Accessed November 25, 2022.
   Google Scholar
• Ezeala-Adikaibe B, Onwuekwe I, Ekenze S, Achor J, Onwukwe. J. Estimated direct cost of treating epilepsy per month in Southeast Nigeria. Internet J Neurol. 2009;13:1.
   Google Scholar
• Siewe Fodjo JN, Mandro M, Wonya’rossi D, et al. Economic burden of epilepsy in rural Ituri, democratic Republic of Congo. EClinicalMedicine. 2019;9:60–66. doi:10.1016/j.eclinm.2019.03.010
   PubMedGoogle Scholar
• Liu J, Liu Z, Meng F. The economic burden of epilepsy in a sample of people with epilepsy in China. Epilepsy Res. 2013;103(2–3):288–293. doi:10.1016/j.eplepsyres.2012.07.015
   PubMed Web of Science ®Google Scholar
• Fisher RS, Cross JH, D’Souza C, et al. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia. 2017;58(4):531–542. doi:10.1111/epi.13671
   PubMed Web of Science ®Google Scholar
• Fisher RS, Cross JH, French JA, et al. Operational classification of seizure types by the international league against epilepsy: position paper of the ILAE commission for classification and terminology. Epilepsia. 2017;58(4):522–530. doi:10.1111/epi.13670
   PubMed Web of Science ®Google Scholar
• Pato Pato A, Cebrián Pérez E, Cimas Hernando I, Lorenzo González JR, Rodríguez Constenla I, Gude Sampedro F. Analysis of direct, indirect, and intangible costs of epilepsy. Neurologia. 2011;26(1):32–38. doi:10.1016/j.nrl.2010.10.002
   PubMed Web of Science ®Google Scholar
• Chin JH. Epilepsy treatment in sub-Saharan Africa: closing the gap. Afr Health Sci. 2012;12(2):186–192. doi:10.4314/ahs.v12i2.17
   PubMed Web of Science ®Google Scholar
• World Bank GDP per Capita; 2020 Available from: https://data.worldbank.org/country/rwanda?view=chart. Accessed November 25, 2020.
   Google Scholar
• Rwembeho S. Goat meat prices up. New Times; December 03, 2014. Available from: https://www.newtimes.co.rw/article/113868/News/goat-meat-prices-up#:~:text=A%20medium%2Dsized%20goat%20is,most%20places%20in%20the%20province. Accessed December, 2020.
   Google Scholar
• Sanya EO, Kolo PM, Adekeye A, Mustapha K, Ademiluyi BA, Ajayi K. Cost of epilepsy care in a Nigerian tertiary hospital. Niger Postgrad Med J. 2013;20(4):266–271.
   PubMedGoogle Scholar
• Ughasoro MD, Onwujekwe OE, Ojinnaka NC. Economic cost of treatment of childhood epilepsy in Enugu, southeast Nigeria. Int J Technol Assess Health Care. 2014;30(4):469–474. doi:10.1017/S0266462314000518
   PubMed Web of Science ®Google Scholar
• Fandiño-Franky J, Silfvenius H. World-wide disparities in epilepsy care: a Latin American outlook. Epilepsia. 1999;40(Suppl 8):48–54. doi:10.1111/j.1528-1157.1999.tb00948.x
   PubMedGoogle Scholar
• Wagner RG, Kabudula CW, Forsgren L, et al. Epilepsy care cascade, treatment gap and its determinants in rural South Africa. Seizure. 2020;80:175–180. doi:10.1016/j.seizure.2020.06.013
   PubMed Web of Science ®Google Scholar
• Gustavsson A, Svensson M, Jacobi F, et al. Cost of disorders of the brain in Europe 2010. Eur Neuropsychopharmacol. 2011;21(10):718–779. doi:10.1016/j.euroneuro.2011.08.008
   PubMed Web of Science ®Google Scholar
• Guerrini R, Battini R, Ferrari AR, et al. The costs of childhood epilepsy in Italy: comparative findings from three health care settings. Epilepsia. 2001;42(5):641–646. doi:10.1046/j.1528-1157.2001.27300.x
   PubMed Web of Science ®Google Scholar
• Quintana M, Fonseca E, Sánchez-López J, et al. The economic burden of newly diagnosed epilepsy in Spain. Epilepsy Behav. 2021;125:108395. doi:10.1016/j.yebeh.2021.108395
   PubMed Web of Science ®Google Scholar
• Begley C, Wagner RG, Abraham A, et al. The global cost of epilepsy: a systematic review and extrapolation. Epilepsia. 2022;63(4):892–903. doi:10.1111/epi.17165
   PubMed Web of Science ®Google Scholar
• Haroon A, Tripathi M, Khanam R, Vohora D. Antiepileptic drugs prescription utilization behavior and direct costs of treatment in a national hospital of India. Ann Indian Acad Neurol. 2012;15(4):289–293. doi:10.4103/0972-2327.104338
   PubMed Web of Science ®Google Scholar
• Sarangi SC, Kaur N, Tripathi M. Need for pharmacoeconomic consideration of antiepileptic drugs monotherapy treatment in persons with epilepsy. Saudi Pharm J. 2020;28(10):1228–1237. doi:10.1016/j.jsps.2020.08.013
   PubMed Web of Science ®Google Scholar
• Beghi E, Garattini L, Ricci E, Cornago D, Parazzini F; EPICOS Group. Direct cost of medical management of epilepsy among adults in Italy: a prospective cost-of-illness study (EPICOS). Epilepsia. 2004;45(2):171–178. doi:10.1111/j.0013-9580.2004.14103.x
   PubMed Web of Science ®Google Scholar
• Guekht A, Mizinova M, Kaimovsky I, Danilenko O, Bianchi E, Beghi E. The direct costs of epilepsy in Russia. A prospective cost-of-illness study from a single center in Moscow. Epilepsy Behav. 2016;64:122–126. doi:10.1016/j.yebeh.2016.08.031
   PubMed Web of Science ®Google Scholar
• Rutebemberwa E, Ssemugabo C, Tweheyo R, Turyagaruka J, Pariyo GW. Biomedical drugs and traditional treatment in care seeking pathways for adults with epilepsy in Masindi district, Western Uganda: a household survey. BMC Health Serv Res. 2020;20(1):17. doi:10.1186/s12913-019-4879-2
   PubMed Web of Science ®Google Scholar
• Esan O, Appiah-Poku J, Othieno C, et al. A survey of traditional and faith healers providing mental health care in three sub-Saharan African countries. Soc Psychiatry Psychiatr Epidemiol. 2019;54(3):395–403. doi:10.1007/s00127-018-1630-y
   PubMed Web of Science ®Google Scholar
• Anand P, Othon GC, Sakadi F, et al. Guinea epilepsy project. Epilepsy and traditional healers in the Republic of Guinea: a mixed methods study. Epilepsy Behav. 2019;92:276–282. doi:10.1016/j.yebeh.2019.01.017
   PubMed Web of Science ®Google Scholar
• Kissani N, Cherkaoui Rhazouani O, Souirti Z, et al. Epilepsy in Morocco: realities, pitfalls and prospects. Epilepsia Open. 2020;6(1):13–21. doi:10.1002/epi4.12440
   PubMedGoogle Scholar
• Chao J, Lu B, Zhang H, Zhu L, Jin H, Liu P. Healthcare system responsiveness in Jiangsu Province, China. BMC Health Serv Res. 2017;17(1):31. doi:10.1186/s12913-017-1980-2
   PubMedGoogle Scholar
• Moura LMVR, Karakis I, Zack MM, Tian N, Kobau R, Howard D. Drivers of US health care spending for persons with seizures and/or epilepsies, 2010–2018. Epilepsia. 2022;63:2144–2154. doi:10.1111/epi.17305
   PubMed Web of Science ®Google Scholar
• Tulleners R, Blythe R, Dionisio S, Carter H. Resource use and costs associated with epilepsy in the Queensland hospital system: protocol for a population-based data linkage study. BMJ Open. 2021;11(12):e050070. doi:10.1136/bmjopen-2021-050070
   PubMed Web of Science ®Google Scholar