153
Views
39
CrossRef citations to date
0
Altmetric
Review

Animal models of frailty: current applications in clinical research

, , , , &
Pages 1519-1529 | Published online: 26 Oct 2016

References

  • CollardRMBoterHSchoeversRAOude VoshaarRCPrevalence of frailty in community-dwelling older persons: a systematic reviewJ Am Geriatr Soc20126081487149222881367
  • CleggAYoungJFrailty and organization of health and social careRockwoodKTheouOFrailty in Aging: Biological, Clinical and Social ImplicationsBaselKarger2015161173
  • de VriesNMStaalJBvan RavensbergCDHobbelenJSOlde RikkertMGNijhuis-van der SandenMWOutcome instruments to measure frailty: a systematic reviewAgeing Res Rev201110110411420850567
  • FriedLPTangenCMWalstonJCardiovascular Health Study Collaborative Research GroupFrailty in older adults: evidence for a phenotypeJ Gerontol A Biol Sci Med Sci2001563M146M15611253156
  • MitnitskiABMogilnerAJRockwoodKAccumulation of deficits as a proxy measure of agingScientificWorldJournal2001132333612806071
  • MitnitskiABMogilnerAJMacKnightCRockwoodKThe mortality rate as a function of accumulated deficits in a frailty indexMech Ageing Dev2002123111457146012425952
  • RockwoodKMitnitskiAFrailty in relation to the accumulation of deficitsJ Gerontol A Biol Sci Med Sci200762772272717634318
  • CollertonJMartin-RuizCDaviesKFrailty and the role of inflammation, immunosenescence and cellular ageing in the very old: cross-sectional findings from the Newcastle 85+ StudyMech Ageing Dev2012133645646622663935
  • WalstonJFedarkoNYangHThe physical and biological characterization of a frail mouse modelJ Gerontol A Biol Sci Med Sci200863439139818426963
  • MohlerMJFainMJWertheimerAMNajafiBNikolich-ŽugichJThe frailty syndrome: clinical measurements and basic underpinnings in humans and animalsExp Gerontol20145461324503059
  • HubbardRETheouOFrailty: enhancing the known knownsAge Ageing201241557457522780984
  • TheouOStathokostasLRolandKPThe effectiveness of exercise interventions for the management of frailty: a systematic reviewJ Aging Res2011201156919421584244
  • CadoreELRodríguez-MañasLSinclairAIzquierdoMEffects of different exercise interventions on risk of falls, gait ability, and balance in physically frail older adults: a systematic reviewRejuvenation Res201316210511423327448
  • TjiaJVeltenSJParsonsCValluriSBriesacherBAStudies to reduce unnecessary medication use in frail older adults: a systematic reviewDrugs Aging201330528530723475597
  • Giné-GarrigaMRoqué-FígulsMColl-PlanasLSitjà-RabertMSalvàAPhysical exercise interventions for improving performance-based measures of physical function in community-dwelling, frail older adults: a systematic review and meta-analysisArch Phys Med Rehabil2014954753.e3769.e324291597
  • BibasLLeviMBendayanMMullieLFormanDEAfilaloJTherapeutic interventions for frail elderly patients: part I. Published randomised trialsProg Cardiovasc Dis201457213414325216612
  • JohnstonCHilmerSNMcLachlanAJMatthewsSTCarrollPRKirkpatrickCMThe impact of frailty on pharmacokinetics in older people: using gentamicin population pharmacokinetic modeling to investigate changes in renal drug clearance by glomerular filtrationEur J Clin Pharmacol201470554955524522409
  • HubbardREO’MahonyMSWoodhouseKWMedication prescribing in frail older peopleEur J Clin Pharmacol201369331932622965651
  • PartridgeJSHarariDDhesiJKFrailty in the older surgical patient: a reviewAge Ageing201241214214722345294
  • HarrisRDysonERecruitment of frail older people to research: lessons learnt through experienceJ Adv Nurs200136564365111737496
  • MitchellSJScheibye-KnudsenMLongoDLde CaboRAnimal models of aging research: implications for human aging and age-related diseasesAnnu Rev Anim Biosci2015328330325689319
  • SeldeenKLPangMTroenBRMouse models of frailty: an emerging fieldCurr Osteoporos Rep201513528028626243670
  • RennickDDavidsonNBergDInterleukin-10 gene knock-out mice: a model of chronic inflammationClin Immunol Immunopathol1995763 Pt 2S174S1787554464
  • WalstonJMcBurnieMANewmanACardiovascular Health StudyFrailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health StudyArch Intern Med2002162202333234112418947
  • KoFYuQXueQLInflammation and mortality in a frail mouse modelAge (Dodr)2012343705715
  • BristolIJMahlerMEdwardHInterleukin-10 gene targeted mutationJAX Notes1997 Available from: https://www.jax.org/news-and-insights/1997/october/il10-tm1cgn-an-interleukin-10-gene-targeted-mutationAccessed September 30, 2016
  • ParksRJFaresEMacdonaldJKA procedure for creating a frailty index based on deficit accumulation in aging miceJ Gerontol A Biol Sci Med Sci201267321722722021390
  • RiddaILindleyRMacIntyreRCThe challenges of clinical trials in the exclusion zone: the case of the frail elderlyAustralas J Ageing2008272616618713194
  • WhiteheadJCHildebrandBASunMA clinical frailty index in aging mice: comparisons with frailty index data in humansJ Gerontol A Biol Sci Med Sci201469662163224051346
  • MitnitskiASongXSkoogIRelative fitness and frailty of elderly men and women in developed countries and their relationship with mortalityJ Am Geriatr Soc200553122184218916398907
  • FeridooniHASunMHRockwoodKHowlettSEReliability of a frailty index based on the clinical assessment of health deficits in male C57BL/6J miceJ Gerontol A Biol Sci Med Sci201570668669325205762
  • KaneAEHilmerSNHuizer-PajkosAFactors that impact on interrater reliability of the mouse clinical frailty indexJ Gerontol A Biol Sci Med Sci201570669469525838548
  • GraberTGFerguson-StegallLKimJHThompsonLVC57BL/6 neuromuscular healthspan scoring systemJ Gerontol A Biol Sci Med Sci201368111326133623585418
  • JanssenIHeymsfieldSBRossRLow relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disabilityJ Am Geriatr Soc200250588989612028177
  • LiuHGraberTGFerguson-StegallLThompsonLVClinically relevant frailty index for miceJ Gerontol A Biol Sci Med Sci201369121485148924336799
  • CleggAYoungJIliffeSRikkertMORockwoodKFrailty in elderly peopleLancet2013381986875276223395245
  • SinghMStewartRWhiteHImportance of frailty in patients with cardiovascular diseaseEur Heart J201435261726173124864078
  • SikkaaGMillerKLSteppanJInterleukin 10 knockout frail mice develop cardiac and vascular dysfunction with increased ageExp Gerontol201348212813523159957
  • AkkiAYangHGuptaASkeletal muscle ATP kinetics are impaired in frail miceAge (Dodr)20143612130
  • KoFAbadirPMarxRImpaired mitochondrial degradation by autophagy in the skeletal muscle of the aged female interleukin 10 null mouseExp Gerontol201673232726596403
  • KaneAEMitchellSJMachJAcetaminophen hepatotoxicity in mice: effect of age, frailty and exposure typeExp Gerontol2016739510626615879
  • SchalkBWVisserMDeegDJBouterLMLower levels of serum albumin and total cholesterol and future decline in functional performance in older persons: the Longitudinal Aging Study AmsterdamAge Ageing200433326627215082432
  • KitamuraKNakamuraKNishiwakiTUenoKNakazawaAHasegawaMDetermination of whether the association between serum albumin and activities of daily living in frail elderly people is causalEnviron Health Prev Med201217216416821861116
  • WangBYangGLiangXZhuMDuMGrape seed extract prevents skeletal muscle wasting in interleukin 10 knockout miceBMC Complement Altern Med20141416224884473
  • LinCHYangHXueQLLosartan improves measures of activity, inflammation, and oxidative stress in older miceExp Gerontol20145817417825077714
  • GraberTGFerguson-StegallLLiuHThompsonLVVoluntary aerobic exercise reverses frailty in old miceJ Gerontol A Biol Sci Med Sci20157091045105825271307
  • KaneAEHilmerSNBoyerDImpact of longevity interventions on a validated mouse clinical frailty indexJ Gerontol A Biol Sci Med Sci201671333333925711530
  • RichardsonAFischerKESpeakmanJRMeasures of healthspan as indices of aging in mice – a recommendationJ Gerontol A Biol Sci Med Sci201571442743026297941
  • Huizer-PajkosAKaneAEHowlettSEAdverse geriatric outcomes secondary to polypharmacy in a mouse model: the influence of agingJ Gerontol Biol Sci Med Sci2016715571577
  • HorgasALTsaiPFAnalgesic drug prescription and use in cognitively impaired nursing home residentsNurs Res19984742352429683119
  • WonABLapaneKLVallowSScheinJMorrisJNLipsitzLAPersistent nonmalignant pain and analgesic prescribing patterns in elderly nursing home residentsJ Am Geriatr Soc200452686787415161448
  • LangilleMGIMeehanCJKoenigJEMicrobial shifts in the aging mouse gutMicrobiome201425025520805
  • IngramDKAge-related decline in physical activity: generalization to nonhumansMed Sci Sports Exerc20003291623162910994915
  • SindlerALFleenorBSCalvertJWNitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with agingAging Cell201110342943721276184
  • RowlattCChestermanFCSheriffMULifespan, age changes and tumour incidence in an ageing C57BL mouse colonyLab Anim19761010419442979138
  • TurturroADuffyPHassBKodellRHartRSurvival characteristics and age-adjusted disease incidences in C57BL/6 mice fed a commonly used cereal-based diet modulated by dietary restrictionJ Gerontol A Biol Sci Med Sci20025711B379B38912403793
  • GoodrickCLLife-span and the inheritance of longevity of inbred miceJ Gerontol19753032572631120887
  • ForsterMJMorrisPSohalRSGenotype and age influence the effect of caloric intake on mortality in miceFASEB J200317669069212586746
  • LiaoCYRikkeBAJohnsonTEDiazVNelsonJFGenetic variation in the murine lifespan response to dietary restriction: from life extension to life shorteningAging Cell201091929519878144
  • MitchellSJMadrigal-MatuteJScheibye-KnudsenMEffects of sex, strain, and energy intake on hallmarks of aging in miceCell Metab20162361093111227304509
  • SearleSDMitnitskiAGahbauerEAGillTMRockwoodKA standard procedure for creating a frailty indexBMC Geriatr200882418826625
  • WillottJFBrossLSMcFaddenSAmeliorative effects of exposing DBA/2J mice to an augmented acoustic environment on histological changes in the cochlea and anteroventral cochlear nucleusJ Assoc Res Otolaryngol20056323424315983726
  • HubbardRSex differences in frailtyInterdiscip Top Gerontol Geriatr201541415326301978