References
- DelmasPDTreatment of postmenopausal osteoporosisLancet200235993222018202612076571
- Tranquilli LealiPMuresuFMelisARuggiuAZachosACarlo DoriaCSkeletal fragility definitionClin Cases Miner Bone Metab201182111322461808
- JohnellOKanisJAn estimate of the worldwide prevalence and disability associated with osteoporotic fracturesOsteoporos Int200617121726173316983459
- OkaHYoshimuraNKinoshitaHSaigaAKawaguchiHNakamuraKDecreased activities of daily living and associations with bone loss among aged residents in a rural Japanese community: the Miyama StudyJ Bone Miner Metab200624430731316816925
- MeltonLJAtkinsonEJO’ConnorMKO’FallonWMRiggsBLBone density and fracture risk in menJ Bone Miner Res19981312191519239844110
- MeltonJLPerspectives: how many women have osteoporosis now?J Bone Miner Res19951021751777754796
- KanisJJohnellOOdenALong-term risk of osteoporotic fracture in MalmöOsteoporos Int200011866967411095169
- RiggsBLKhoslaSMeltonLJ3rdSex steroids and the construction and conservation of the adult skeletonEndocr Rev200223327930212050121
- CenterJRNguyenTVSchneiderDSambrookPNEismanJAMortality after all major types of osteoporotic fracture in men and women: an observational studyLancet1999353915687888210093980
- BliucDNguyenNDMilchVENguyenTVEismanJACenterJRMortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and womenJAMA2009301551352119190316
- LeeJ-KKhirASMThe incidence of hip fracture in Malaysians above 50 years of age: variation in different ethnic groupsAPLAR J Rheum2007104300305
- ChinK-YSoelaimanI-NMohamedINSex hormones in Malay and Chinese men in Malaysia: are there age and race differences?Clinics (Sao Paulo)201368215916623525310
- RossRWSmallEJOsteoporosis in men treated with androgen deprivation therapy for prostate cancerJ Urol200216751952195611956415
- DiamondTHHiganoCSSmithMRGuiseTASingerFROsteoporosis in men with prostate carcinoma receiving androgen-deprivation therapy: recommendations for diagnosis and therapiesCancer2004100589289914983482
- VanderschuerenDLaurentMRClaessensFSex steroid actions in male boneEndocr Rev201435690696025202834
- ChinKYIma-NirwanaSSex steroids and bone health status in menInt J Endocrinol2012201220871923150727
- KaufmanJMVermeulenAThe decline of androgen levels in elderly men and its clinical and therapeutic implicationsEndocr Rev200526683387615901667
- LabrieFCusanLGomezJLComparable amounts of sex steroids are made outside the gonads in men and women: strong lesson for hormone therapy of prostate and breast cancerJ Steroid Biochem Mol Biol20091131525619073258
- FraiettaRZylberstejnDSEstevesSCHypogonadotropic hypogonadism revisitedClinics (Sao Paulo)201368Suppl 1818823503957
- TorjesenPASandnesLSerum testosterone in women as measured by an automated immunoassay and a RIAClin Chem200450367867914981046
- PhillipMMaorGAssaSSilbergeldASegevYTestosterone stimulates growth of tibial epiphyseal growth plate and insulin-like growth factor-1 receptor abundance in hypophysectomized and castrated ratsEndocrine20011611611822821
- RenSGMalozowskiSSanchezPSweetDELoriauxDLCassorlaFDirect administration of testosterone increases rat tibial epiphyseal growth plate widthActa Endocrinol198912134014052800918
- FinkelsteinJSNeerRMBillerBMCrawfordJDKlibanskiAOsteopenia in men with a history of delayed pubertyN Engl J Med199232696006041734250
- AndersonFFrancisRSelbyPCooperCSex hormones and osteoporosis in menCalcif Tissue Int19986231851889501948
- AlbrightFReifensteinECMetabolic bone disease: osteoporosisAlbrightFReifensteinECThe parathyroid glands and metabolic bone diseaseBaltimoreWilliams and Wilkins1948145204
- GennariLNutiRBilezikianJPAromatase activity and bone homeostasis in menJ Clin Endocrinol Metab200489125898590715579733
- KhoslaSMeltonLJIIIRiggsBLEstrogen and the male skeletonJ Clin Endocrinol Metab20028741443145011932262
- SmithRCorticosteroids and osteoporosisThorax19904585735782205946
- CaraniCQinKSimoniMEffect of testosterone and estradiol in a man with aromatase deficiencyN Engl J Med1997337291959211678
- BraidmanIPHaineyLBatraGSelbyPLSaundersPTHoylandJALocalization of estrogen receptor β protein expression in adult human boneJ Bone Miner Res200116221422011204421
- GruberRCzerwenkaKWolfFHoG-MWillheimMPeterlikMExpression of the vitamin D receptor, of estrogen and thyroid hormone receptor α- and β-isoforms, and of the androgen receptor in cultures of native mouse bone marrow and of stromal/osteoblastic cellsBone199924546547310321906
- van der EerdenBvan TilNBrinkmannALowikCWitJKarperienMGender differences in expression of androgen receptor in tibial growth plate and metaphyseal bone of the ratBone200230689189612052459
- CarrascosaAAudiLFerrandezMBallabrigaABiological effects of androgens and identification of specific dihydrotestosterone-binding sites in cultured human fetal epiphyseal chondrocytesJ Clin Endocrinol Metab19907011341402294127
- Ben-HurHTholeHMashiahAEstrogen, progesterone and testosterone receptors in human fetal cartilaginous tissue: immunohistochemical studiesCalcif Tissue Int19976065205269164826
- BordSHornerABeavanSCompstonJEstrogen receptors α and β are differentially expressed in developing human bone 1J Clin Endocrinol Metab20018652309231411344243
- NilssonLOBomanASävendahlLDemonstration of estrogen receptor-β immunoreactivity in human growth plate cartilageJ Clin Endocrinol Metab19998413703739920110
- FengXMcDonaldJMDisorders of bone remodelingAnnu Rev Pathol2011612114520936937
- HadjidakisDJAndroulakisIIBone remodelingAnn N Y Acad Sci20061092138539617308163
- KarsentyGTranscriptional control of skeletogenesisAnnu Rev Genomics Hum Genet2008918319618767962
- RaggattLJPartridgeNCCellular and molecular mechanisms of bone remodelingJ Biol Chem201028533251032510820501658
- CorralDAAmlingMPriemelMDissociation between bone resorption and bone formation in osteopenic transgenic miceProc Natl Acad Sci U S A1998952313835138409811887
- GoriFHofbauerLCDunstanCRSpelsbergTCKhoslaSRiggsBLThe expression of osteoprotegerin and RANK ligand and the support of osteoclast formation by stromal-osteoblast lineage cells is developmentally regulated 1Endocrinology2000141124768477611108292
- KomoriTYagiHNomuraSTargeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblastsCell19978957557649182763
- ColvardDSEriksenEFKeetingPEIdentification of androgen receptors in normal human osteoblast-like cellsProc Natl Acad Sci U S A19898638548572915981
- KasperkCHelmboldtABörcsökISkeletal site-dependent expression of the androgen receptor in human osteoblastic cell populationsCalcif Tissue Int19976164644739383273
- DamienEPriceJLanyonLMechanical strain stimulates osteoblast proliferation through the estrogen receptor in males as well as femalesJ Bone Miner Res200015112169217711092397
- NakanoYMorimotoIIshidaOThe receptor, metabolism and effects of androgen in osteoblastic MC3T3-E1 cellsBone Miner19942632452597819831
- AlmeidaMHanLAmbroginiEBartellSMManolagasSCOxidative stress stimulates apoptosis and activates NF-κB in osteoblastic cells via a PKCβ/p66shc signaling cascade: counter regulation by estrogens or androgensMol Endocrinol201024102030203720685851
- WirenKMToombsARSemiraleAAZhangXOsteoblast and osteocyte apoptosis associated with androgen action in bone: requirement of increased Bax/Bcl-2 ratioBone200638563765116413235
- KeetingPERifasLHarrisSAEvidence for interleukin-1β production by cultured normal human osteoblast-like cellsJ Bone Miner Res1991688278331785373
- KasperkCFitzsimmonsRStrongDStudies of the mechanism by which androgens enhance mitogenesis and differentiation in bone cellsJ Clin Endocrinol Metab1990715132213292229290
- KasperkCHWergedalJEFarleyJRLinkhartTATurnerRTBaylinkDJAndrogens directly stimulate proliferation of bone cells in vitroEndocrinology19891243157615782521824
- KasperkCHWakleyGKHierlTZieglerRGonadal and adrenal androgens are potent regulators of human bone cell metabolism in vitroJ Bone Miner Res19971234644719076590
- HofbauerLCHicokKCKhoslaSEffects of gonadal and adrenal androgens in a novel androgen-responsive human osteoblastic cell lineJ Cell Biochem1998711961089736458
- ChinK-YSoelaimanINThe effects of orchidectomy and supraphysiological testosterone administration on trabecular bone structure and gene expression in ratsAging Male2015181606625166624
- SudaTTakahashiNUdagawaNJimiEGillespieMTMartinTJModulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand familiesEndocr Rev199920334535710368775
- HofbauerLCHicokKCChenDKhoslaSRegulation of osteoprotegerin production by androgens and anti-androgens in human osteoblastic lineage cellsEur J Endocrinol2002147226927312153751
- ClarkeBLKhoslaSAndrogens and boneSteroids200974329630518992761
- HuberDMBendixenACPathrosePAndrogens suppress osteoclast formation induced by RANKL and macrophage-colony stimulating factorEndocrinology200114293800380811517156
- PalumboCA three-dimensional ultrastructural study of osteoid-osteocytes in the tibia of chick embryosCell Tissue Res198624611251313779795
- BonewaldLFOsteocytes as dynamic multifunctional cellsAnn N Y Acad Sci20071116128129017646259
- KamiokaHHonjoTTakano-YamamotoTA three-dimensional distribution of osteocyte processes revealed by the combination of confocal laser scanning microscopy and differential interference contrast microscopyBone200128214514911182371
- VerborgtOTattonNAMajeskaRJSchafflerMBSpatial distribution of Bax and Bcl-2 in osteocytes after bone fatigue: complementary roles in bone remodeling regulation?J Bone Miner Res200217590791412009022
- VerborgtOGibsonGJSchafflerMBLoss of osteocyte integrity in association with microdamage and bone remodeling after fatigue in vivoJ Bone Miner Res2000151606710646115
- AguirreJIPlotkinLIGortazarARA novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransductionJ Biol Chem200728235255012550817609204
- TomkinsonAReeveJShawRNobleBThe death of osteocytes via apoptosis accompanies estrogen withdrawal in human bone 1J Clin Endocrinol Metab1997829312831359284757
- VanderschuerenDVandenputLBoonenSLindbergMKBouillonROhlssonCAndrogens and boneEndocr Rev200425338942515180950
- VandenputLBoonenSVan HerckESwinnenJBouillonRVanderschuerenDEvidence from the aged orchidectomized male rat model that 17β-estradiol is a more effective bone-sparing and anabolic agent than 5α-dihydrotestosteroneJ Bone Miner Res200217112080208612412816
- ModderURiggsBLSpelsbergTCDose-response of estrogen on bone versus the uterus in ovariectomized miceEur J Endocrinol2004151450351015476452
- VidalOLindbergMKHollbergKEstrogen receptor specificity in the regulation of skeletal growth and maturation in male miceProc Natl Acad Sci U S A200097105474547910805804
- LindbergMKMovérareSSkrticSTwo different pathways for the maintenance of trabecular bone in adult male miceJ Bone Miner Res200217455556211918213
- KeHBrownTQiHThe role of estrogen receptor-b in the early age-related bone gain and later age-related bone loss in female miceJ Musculoskelet Neuronal Interact20022547948815758417
- KaufmanJJohnellOAbadieEBackground for studies on the treatment of male osteoporosis: state of the artAnn Rheum Dis2000591076577211005775
- HannanMTFelsonDTAndersonJJBone mineral density in elderly men and women: results from the Framingham osteoporosis studyJ Bone Miner Res1992755475531615761
- RiggsBLKhoslaSMeltonLJA unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging menJ Bone Miner Res19981357637739610739
- BurgerHde LaetCvan DaelePRisk factors for increased bone loss in an elderly population the rotterdam studyAm J Epidemiol199814798718799583718
- CawthonPMEwingSKMcCullochCELoss of hip BMD in older men: the osteoporotic fractures in men (MrOS) studyJ Bone Miner Res200924101728173519419308
- LeBlancESNielsonCMMarshallLMThe effects of serum testosterone, estradiol, and sex hormone binding globulin levels on fracture risk in older menJ Clin Endocrinol Metab20099493337334619584177
- WooJKwokTLeungJCOhlssonCVandenputLLeungPCSex steroids and bone health in older Chinese menOsteoporos Int20122351553156221318439
- MeierCNguyenTVHandelsmanDJEndogenous sex hormones and incident fracture risk in older men: the Dubbo Osteoporosis Epidemiology StudyArch Intern Med20081681475418195195
- MellstromDVandenputLMallminHOlder men with low serum estradiol and high serum SHBG have an increased risk of fracturesJ Bone Miner Res200823101552156018518773
- LorentzonMSwansonCAnderssonNMellströmDOhlssonCFree testosterone is a positive, whereas free estradiol is a negative, predictor of cortical bone size in young Swedish men: the GOOD studyJ Bone Miner Res20052081334134116007330
- VanbillemontGLapauwBBogaertVSex hormone-binding globulin as an independent determinant of cortical bone status in men at the age of peak bone massJ Clin Endocrinol Metab20109541579158620133463
- KhoslaSAminSSinghRJAtkinsonEJMeltonLJ3rdRiggsBLComparison of sex steroid measurements in men by immunoassay versus mass spectroscopy and relationships with cortical and trabecular volumetric bone mineral densityOsteoporos Int200819101465147118338096
- DaniellHWDunnSRFergusonDWLomasGNiaziZStrattePTProgressive osteoporosis during androgen deprivation therapy for prostate cancerJ Urol2000163118118610604342
- LederBZLeBlancKMSchoenfeldDAEastellRFinkelsteinJSDifferential effects of androgens and estrogens on bone turnover in normal menJ Clin Endocrinol Metab200388120421012519853
- Falahati-NiniARiggsBLAtkinsonEJO’FallonWMEastellRKhoslaSRelative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly menJ Clin Invest2000106121553156011120762
- LederBZFinkelsteinJSEffect of aromatase inhibition on bone metabolism in elderly hypogonadal menOsteoporos Int200516121487149415856361
- Burnett-BowieS-AMMcKayEALeeHLederBZEffects of aromatase inhibition on bone mineral density and bone turnover in older men with low testosterone levelsJ Clin Endocrinol Metab200994124785479219820017