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Review

Treating nausea and vomiting in palliative care: a review

, , &
Pages 243-259 | Published online: 12 Sep 2011

References

  • BainesMJABC of palliative care Nausea, vomiting, and intestinal obstructionBMJ19973157116114811509374893
  • PeroutkaSJSnyderSHAntiemetics: neurotransmitter receptor binding predicts therapeutic actionsLancet1982182736586596121969
  • GrunbergSMHeskethPJControl of chemotherapy-induced emesisN Engl J Med199332924179017968232489
  • SteadmanKFranksAA woman with malignant bowel obstruction who did not want to die with tubesLancet199634790069448598760
  • CleelandCSBennettGJDantzerRAre the symptoms of cancer and cancer treatment due to a shared biologic mechanism? A cytokine-immunologic model of cancer symptomsCancer200397112919292512767108
  • BishopTFMorrisonRSGeriatric palliative care – Part I: pain and symptom managementClin Geriatr20071512532
  • SuttonLMDemark-WahnefriedWClippECManagement of terminal cancer in elderly patientsLancet Oncol20034314915712623360
  • FeuerDJBroadleyKECorticosteroids for the resolution of malignant bowel obstruction in advanced gynaecological and gastrointestinal cancerCochrane Database Syst Rev20003CD00121910796761
  • BarfordKLD’OlimpioJTSymptom management in geriatric oncology: practical treatment considerations and current challengesCurr Treat Options Oncol2008923204214
  • SolanoJPGomesBHigginsonIJA comparison of symptom prevalence in far advanced cancer, AIDS, heart disease, chronic obstructive pulmonary disease and renal diseaseJ Pain Symptom Manage2006311586916442483
  • StephensonJDaviesAAn assessment of aetiology-based guidelines for the management of nausea and vomiting in patients with advanced cancerSupport Care Cancer200614434835316228185
  • BrueraEKuehnNMillerMJSelmserPMacmillanKThe Edmonton Symptom Assessment System (ESAS): a simple method for the assessment of palliative care patientsJ Palliat Care199172691714502
  • PortenoyRKThalerHTKornblithABThe memorial symptom assessment scale: an instrument for the evaluation of symptom prevalence, characteristics and distressEur J Cancer199430A9132613367999421
  • MelzackRRosbergerZHollingsworthMLThirlwellMNew approaches to measuring nauseaCMAJ198513387557584042058
  • SigurdardottirKRHaugenDFPrevalence of distressing symptoms in hospitalised patients on medical wards: a cross-sectional studyBMC Palliat Care200871618808724
  • SeowHBarberaLSutradharRTrajectory of performance status and symptom scores for patients with cancer during the last six months of lifeJ Clin Oncol20112991151115821300920
  • YatesPClinical and patient perspectives on factors contributing to nausea in advanced cancerOncol Nurs Forum2006332468469
  • ChangVTHwangSSKasimisBThalerHTShorter symptom assessment instruments: the Condensed Memorial Symptom Assessment Scale (CMSAS)Cancer Invest200422452653615565810
  • VentafriddaVDe ConnoFRipamontiCGambaATamburiniMQuality-of-life assessment during a palliative care programmeAnn Oncol1990164154201707297
  • DonnellySWalshDRybickiLThe symptoms of advanced cancer: identification of clinical and research priorities by assessment of prevalence and severityJ Palliat Care199511127327751982
  • VainioAAuvinenAPrevalence of symptoms among patients with advanced cancer: an international collaborative study. Symptom Prevalence GroupJ Pain Symptom Manage19961213108718910
  • ReubenDBMorVNausea and vomiting in terminal cancer patientsArch Intern Med198614610202120233767547
  • CoyleNAdelhardtJFoleyKMPortenoyRKCharacter of terminal illness in the advanced cancer patient: pain and other symptoms during the last four weeks of lifeJ Pain Symptom Manage19905283932348092
  • FainsingerRMillerMJBrueraEHansonJMaceachernTSymptom control during the last week of life on a palliative care unitJ Palliat Care199171511
  • ConillCVergerEHenriquezISymptom prevalence in the last week of lifeJ Pain Symptom Manage19971463283319409097
  • MercadanteSCasuccioAFulfaroFThe course of symptom frequency and intensity in advanced cancer patients followed at homeJ Pain Symptom Manage200020210411210989248
  • BrueraENeumannCBrenneisCQuanHFrequency of symptom distress and poor prognostic indicators in palliative cancer patients admitted to a tertiary palliative care unit, hospices, and acute care hospitalsJ Palliat Care2000163162111019503
  • ReubenDNausea and vomiting in terminal cancer patientsArch Intern Med198614610202120233767547
  • GreavesJGlarePKristjansonLJStocklerMTattersallMHUndertreatment of nausea and other symptoms in hospitalized cancer patientsSupport Care Cancer200917446146418931863
  • CheungWYLeLWZimmermannCSymptom clusters in patients with advanced cancersSupport Care Cancer20091791223123019184126
  • QuigleyEMHaslerWLParkmanHPAGA technical review on nausea and vomitingGastroenterology2001120126328611208736
  • Meineche-SchmidtVChristensenEClassification of dyspepsia. Identification of independent symptom components in 7270 consecutive, unselected dyspepsia patients from general practiceScand J Gastroenterol19983312126212729930389
  • TalleyNJPhillipsSFNon-ulcer dyspepsia: potential causes and pathophysiologyAnn Intern Med198810868658793285748
  • BrueraEBelzileMNeumannCHarsanyiZBabulNDarkeAA double-blind, crossover study of controlled-release metoclopramide and placebo for the chronic nausea and dyspepsia of advanced cancerJ Pain Symptom Manage200019642743510908823
  • American Gastroenterological AssociationMedical position statement: nausea and vomitingGastroenterology2001120126126311208735
  • GanTJMeyerTApfelCCConsensus guidelines for managing postoperative nausea and vomitingAnesth Analg2003971627112818945
  • JordanKSippelCSchmollHJGuidelines for antiemetic treatment of chemotherapy-induced nausea and vomiting: past, present, and future recommendationsOncologist20071291143115017914084
  • LichterINausea and vomiting in patients with cancerHematol Oncol Clin North Am19961012072208821568
  • BentleyABoydKUse of clinical pictures in the management of nausea and vomiting: a prospective auditPalliat Med200115324725311407196
  • WalshDDonnellySRybickiLThe symptoms of advanced cancer: relationship to age, gender, and performance status in 1,000 patientsSupport Care Cancer20008317517910789956
  • MoritaTTsunodaJInoueSChiharaSContributing factors to physical symptoms in terminally-ill cancer patientsJ Pain Symptom Manage199918533834610584457
  • MercadanteSFulfaroFCasuccioAThe impact of home palliative care on symptoms in advanced cancer patientsSupport Care Cancer20008430731010923771
  • MeuserTPietruckCRadbruchLStutePLehmannKAGrondSSymptoms during cancer pain treatment following WHO guidelines: a longitudinal follow-up study of symptom prevalence, severity and etiologyPain200193324725711514084
  • TurnerJZapartSPedersenKRankinNLuxfordKFletcherJClinical practice guidelines for the psychosocial care of adults with cancerPsychooncology200514315917315669019
  • HeskethPJChemotherapy-induced nausea and vomitingN Engl J Med2008358232482249418525044
  • LichterIResults of antiemetic management in terminal illnessJ Palliat Care19939219218397302
  • BrueraEDMacEachernTJSpachynskiKAComparison of the efficacy, safety, and pharmacokinetics of controlled release and immediate release metoclopramide for the management of chronic nausea in patients with advanced cancerCancer19947412320432117982184
  • BrueraESeifertLWatanabeSChronic nausea in advanced cancer patients: a retrospective assessment of a metoclopramide-based antiemetic regimenJ Pain Symptom Manage19961131471538851371
  • MystakidouKBefonSLiossiCVlachosLComparison of the efficacy and safety of tropisetron, metoclopramide, and chlorpromazine in the treatment of emesis associated with far advanced cancerCancer1998836121412239740088
  • PerkinsPDormanSHaloperidol for the treatment of nausea and vomiting in palliative care patientsCochrane Database Syst Rev20092CD00627119370630
  • EzzoJMRichardsonMAVickersAAcupuncture-point stimulation for chemotherapy-induced nausea or vomitingCochrane Database Syst Rev20062CD00228516625560
  • ClarkKAgarMRCurrowDMetoclopramide for chronic nausea in adult palliative care patients with advanced cancer (Protocol)Cochrane Database Syst Rev20102
  • WalkembachJBrussMUrbanBWBarannMInteractions of metoclopramide and ergotamine with human 5-HT(3 A) receptors and human 5-HT reuptake carriersBr J Pharmacol2005146454355216041395
  • De MaeyerJHLefebvreRASchuurkesJA5-HT4 receptor agonists: similar but not the sameNeurogastroenterol Motil20082029911218199093
  • CuomoRVandaelePCoulieBInfluence of motilin on gastric fundus tone and on meal-induced satiety in man: role of cholinergic pathwaysAm J Gastroenterol2006101480481116635226
  • SchuurkesJAJHelsenLFMGhoosECREelenJGMGvan NuetenJMStimulation of gastroduodenal motor activity: dopaminergic and cholinergic modulationDrug Dev Res1986814233241
  • MagueurEHagegeHAttaliPSinglasEEtienneJPTaburetAMPharmacokinetics of metoclopramide in patients with liver cirrhosisBr J Clin Pharmacol19913121851872049236
  • BatemanDNGokalRDoddTRBlainPGThe pharmacokinetics of single doses of metoclopramide in renal failureEur J Clin Pharmacol19811964374417250177
  • SantucciGMackJWCommon gastrointestinal symptoms in pediatric palliative care: nausea, vomiting, constipation, anorexia, cachexiaPediatr Clin North Am200754567368917933617
  • HardyJDalySMcQuadeBA double-blind, randomised, parallel group, multinational, multicentre study comparing a single dose of ondansetron 24 mg p.o. with placebo and metoclopramide 10 mg t.d.s. p.o. in the treatment of opioid-induced nausea and emesis in cancer patientsSupport Care Cancer200210323123611904788
  • CorliOCozzolinoABattaiottoLEffectiveness of levosulpiride versus metoclopramide for nausea and vomiting in advanced cancer patients: a double-blind, randomized, crossover studyJ Pain Symptom Manage19951075215268537694
  • KimSWShinISKimJMMirtazapine for severe gastroparesis unresponsive to conventional prokinetic treatmentPsychosomatics200647544044216959934
  • KoutsoumbiPEpanomeritakisETsiaoussisJThe effect of erythromycin on human esophageal motility is mediated by serotonin receptorsAm J Gastroenterol200095123388339211151866
  • AbrahamssonHTreatment options for patients with severe gastroparesisGut200756687788317519490
  • BaroneJADomperidone: a peripherally acting dopamine2-receptor antagonistAnn Pharmacother199933442944010332535
  • OsborneRJSlevinMLHunterRWHamerJCardiotoxicity of intravenous domperidoneLancet1985284513852862531
  • PuisieuxFLAdamantidisMMDumotierBMDupuisBACisapride-induced prolongation of cardiac action potential and early after depolarizations in rabbit Purkinje fibresBr J Pharmacol19961177137713798730728
  • EngerCCaliCWalkerAMSerious ventricular arrhythmias among users of cisapride and other QT-prolonging agents in the United StatesPharmacoepidemiol Drug Saf200211647748612426932
  • StacherGGaupmannGSteinringerHEffects of cisapride on postcibal jejunal motor activityDig Dis Sci1989349140514102766908
  • TwycrossRWilcockACharlesworthSDickmanAPalliative care formulary2nd edOxford UKRadcliffe Medical Press2002
  • McCallumRWPrakashCCampoli-RichardsDMGoaKLCisapride. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use as a prokinetic agent in gastrointestinal motility disordersDrugs19883666526813065057
  • RichelsonEPharmacology of neuroleptics in use in the United StatesJ Clin Psychiatry1985468 Pt 28142862140
  • KudoSIshizakiTPharmacokinetics of haloperidol: an updateClin Pharmacokinet199937643543610628896
  • SkinnerJSkinnerALevomepromazine for nausea and vomiting in advanced cancerHosp Med199960856857010621811
  • PattRBProperGReddySThe neuroleptics as adjuvant analgesicsJ Pain Symptom Manage1994974464537822884
  • DahlSGPharmacokinetics of methotrimeprazine after single and multiple dosesClin Pharmacol Ther19761944354421269194
  • BymasterFPCalligaroDOFalconeJFRadioreceptor binding profile of the atypical antipsychotic olanzapineNeuropsychopharmacology199614287968822531
  • CallaghanJTBergstromRFPtakLRBeasleyCMOlanzapine: pharmacokinetic and pharmacodynamic profileClin Pharmacokinet199937317719310511917
  • PassikSDLundbergJKirschKLA pilot exploration of the antiemetic activity of olanzapine for the relief of nausea in patients with advanced cancer and painJ Pain Symp Manage2002236526532
  • MeltzerHYFibigerCOlanzapine: a new atypical antipsychotic drugNeuropsychopharmacology199614283858822530
  • BhanaNFosterRHOlneyRPloskerGLOlanzapine: an updated review of its use in the management of schizophreniaDrugs200161111116111217867
  • GrallaRJItriLMPiskoSEAntiemetic efficacy of high-dose metoclopramide: randomized trials with placebo and prochlorperazine in patients with chemotherapy-induced nausea and vomitingN Engl J Med1981305169059097024807
  • CritchleyPPlachNGranthamMEfficacy of haloperidol in the treatment of nausea and vomiting in the palliative patient: a systematic reviewJ Pain Symptom Manage200122263163411503632
  • HardyJRO’SheaAWhiteCGilshenanKWelchLDouglasCThe efficacy of haloperidol in the management of nausea and vomiting in patients with cancerJ Pain Symptom Manage201040111111620619214
  • ButtnerMWalderBvon ElmETramerMRIs low-dose haloperidol a useful antiemetic?: a meta-analysis of published and unpublished randomized trialsAnesthesiology200410161454146315564955
  • PassikSDLundbergJKirshKLA pilot exploration of the antiemetic activity of olanzapine for the relief of nausea in patients with advanced cancer and painJ Pain Symptom Manage200223652653212067777
  • TwycrossRBankbyGHallowoodJThe use of low-dose methotrimeprazine (levomepromazine) in the management of nausea and vomitingProg Palliat Care199754953
  • MannixKAPalliation of nausea and vomitingDoyleDHanksGChernyNICalmanKOxford Textbook of Palliative Medicine3rd edOxford, UKOxford University Press2004
  • WoodCDCramerDBGraybielAAntimotion sickness drug efficacyOtolaryngol Head Neck Surg1981896104110446121316
  • TwycrossRWilcockAThorpSPCF1. Palliative Care FormularyLondon, UKRadcliffe Medical Press1998
  • GlarePADunwoodieDClarkKTreatment of nausea and vomiting in terminally ill cancer patientsDrugs200868182575259019093700
  • TanLBBryantSMurrayRGDetrimental haemodynamic effects of cyclizine in heart failureLancet1988185855605612894494
  • FickDMCooperJWWadeWEWallerJLMacleanJRBeersMHUpdating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of expertsArch Intern Med2003163222716272414662625
  • KeeleyPWNausea and vomiting in people with cancer and other chronic diseasesClin Evid (Online)2009 2009
  • GregoryREEttingerDS5-HT3 receptor antagonists for the prevention of chemotherapy-induced nausea and vomiting. A comparison of their pharmacology and clinical efficacyDrugs19985521731899506240
  • FiggWDDukesGEPritchardJFPharmacokinetics of ondansetron in patients with hepatic insufficiencyJ Clin Pharmacol19963632062158690814
  • GrallaRJOsobaDKrisMGRecommendations for the use of antiemetics: evidence-based, clinical practice guidelines. American Society of Clinical OncologyJ Clin Oncol19991792971299410561376
  • CurrowDCCoughlanMFardellBCooneyNJUse of ondansetron in palliative medicineJ Pain Symptom Manage19971353023079185436
  • FeuerDJBroadleyKECorticosteroids for the resolution of malignant bowel obstruction in advanced gynaecological and gastrointestinal cancerCochrane Database Syst Rev20002CD00121910796761
  • CzockDKellerFRascheFMHausslerUPharmacokinetics and pharmacodynamics of systemically administered glucocorticoidsClin Pharmacokinet2005441619815634032
  • RipamontiCTwycrossRBainesMClinical-practice recommendations for the management of bowel obstruction in patients with end-stage cancerSupport Care Cancer20019422323311430417
  • MaurerRGaehwilerBHBuescherHHHillRCRoemerDOpiate antagonistic properties of an octapeptide somatostatin analogProc Natl Acad Sci U S A19827915481548176126877
  • MartinBRWileyJLMechanism of action of cannabinoids: how it may lead to treatment of cachexia, emesis, and painJ Supp Oncol200424305316
  • BagshawSMHagenNAMedical efficacy of cannabinoids and marijuana: a comprehensive review of the literatureJ Palliat Care200218211112212164099
  • WalshDNelsonKAMahmoudFAEstablished and potential therapeutic applications of cannabinoids in oncologySupport Care Cancer200311313714312618922
  • BealJEOlsonRLefkowitzLLong-term efficacy and safety of dronabinol for acquired immunodeficiency syndrome-associated anorexiaJ Pain Symptom Manage19971417149223837
  • RhodesVAMcDanielRWNausea, vomiting, and retching: complex problems in palliative careCA Cancer J Clin200151423224811577489
  • BrueraEStrasserFPalmerJLEffect of fish oil on appetite and other symptoms in patients with advanced cancer and anorexia/cachexia: a double-blind, placebo-controlled studyJ Clin Oncol200321112913412506181
  • Van FleetSRelaxation and imagery for symptom management: improving patient assessment and individualizing treatmentOncol Nurs Forum200027350151010785903
  • ArakawaSRelaxation to reduce nausea, vomiting, and anxiety induced by chemotherapy in Japanese patientsCancer Nurs19972053423499394056
  • MolassiotisAA pilot study of the use of progressive muscle relaxation training in the management of post-chemotherapy nausea and vomitingEur J Cancer Care (Engl)20009423023411829370
  • MundyEADuHamelKNMontgomeryGHThe efficacy of behavioral interventions for cancer treatment-related side effectsSemin Clin Neuropsychiatry20038425327514613052
  • AhlesTATopeDMPinksonBMassage therapy for patients undergoing autologous bone marrow transplantationJ Pain Symptom Manage199918315716310517036
  • GrealishLLomasneyAWhitemanBFoot massage. A nursing inter-vention to modify the distressing symptoms of pain and nausea in patients hospitalized with cancerCancer Nurs200023323724310851775
  • PanCXMorrisonRSNessJFugh-BermanALeipzigRMComplementary and alternative medicine in the management of pain, dyspnea, and nausea and vomiting near the end of life. A systematic reviewJ Pain Symptom Manage200020537438711068159
  • HickokJTRoscoeJAMorrowGRRyanJLA Phase II/III randomized, placebo-controlled, double-blind clinical trial of ginger (Zingiber officinale) for nausea caused by chemotherapy for cancer: a currently accruing URCC CCOP Cancer Control StudySupport Cancer Ther20074424725018632524
  • StoreyPSObstruction of the GI tractAm J Hosp Palliat Care19918351718351
  • PothuriBMeyerLGerardiMBarakatRRChiDSReoperation for palliation of recurrent malignant bowel obstruction in ovarian carcinomaGynecol Oncol200495119319515385131
  • PothuriBMontemaranoMGerardiMPercutaneous endoscopic gastrostomy tube placement in patients with malignant bowel obstruction due to ovarian carcinomaGynecol Oncol200596233033415661217
  • CunninghamMJBrombergCKredentserDCCollinsMBMalfetanoJHPercutaneous gastrostomy for decompression in patients with advanced gynecologic malignanciesGynecol Oncol19955922732767590486
  • CampagnuttaECannizzaroRGalloAPalliative treatment of upper intestinal obstruction by gynecological malignancy: the usefulness of percutaneous endoscopic gastrostomyGynecol Oncol19966211031058690280
  • HermanLLHoskinsWJShikeMPercutaneous endoscopic gastrostomy for decompression of the stomach and small bowelGastrointest Endosc19923833143181607082
  • CampagnuttaECannizzaroRPercutaneous endoscopic gastrostomy (PEG) in palliative treatment of non-operable intestinal obstruction due to gynecologic cancer: a reviewEur J Gynaecol Oncol200021439740211055494
  • GuitronAAdalidRHuertaFMaciasMSanchez-NavarreteMPalliative treatment of esophageal cancer with transendoscopic injection of alcoholRev Gastroenterol Mex1996613208211 Spanish9102742
  • NwokoloCUPayne-JamesJJSilkDBMisiewiczJJLoftDEPalliation of malignant dysphagia by ethanol induced tumour necrosisGut19943532993037512062
  • AhlquistDAGostoutCJViggianoTREndoscopic laser palliation of malignant dysphagia: a prospective studyMayo Clin Proc198762108678742443772
  • BrennanFNMcCarthyJHLaurenceBHEndoscopic Nd-YAG laser therapy for palliation of upper gastrointestinal malignancyMed J Aust1990153127311696349
  • DallalHJSmithGDGrieveDCGhoshSPenmanIDPalmerKRA randomized trial of thermal ablative therapy versus expandable metal stents in the palliative treatment of patients with esophageal carcinomaGastrointest Endosc200154554955711677469
  • CostamagnaGShahSKTringaliAMutignaniMPerriVRiccioniMEProspective evaluation of a new self-expanding plastic stent for inoperable esophageal stricturesSurg Endosc200317689189512618935
  • DormannAJEisendrathPWigginghausBHuchzermeyerHDeviereJPalliation of esophageal carcinoma with a new self-expanding plastic stentEndoscopy200335320721112584638
  • DeckerPLipplerJDeckerDHirnerAUse of the Polyflex stent in the palliative therapy of esophageal carcinoma: results in 14 cases and review of the literatureSurg Endosc20011512144147
  • De PalmaGDdi MatteoERomanoGFimmanoARondinoneGCatanzanoCPlastic prosthesis versus expandable metal stents for palliation of inoperable esophageal thoracic carcinoma: a controlled prospective studyGastrointest Endosc19964354784828726762
  • MoscaFConsoliAStracqualursiAPersiALipariGPortaleTROur experience with the use of a plastic prosthesis and self-expanding stents in the palliative treatment of malignant neoplastic stenoses of the esophagus and cardia. Comparative analysis of resultsChir Ital2002543341350 Italian12192930
  • KnyrimKWagnerHJBethgeNKeymlingMVakilNA controlled trial of an expansile metal stent for palliation of esophageal obstruction due to inoperable cancerN Engl J Med199332918130213077692297
  • MoscaFConsoliAStracqualursiAPersiAPortaleTRComparative retrospective study on the use of plastic prostheses and self-expanding metal stents in the palliative treatment of malignant strictures of the esophagus and cardiaDis Esophagus200316211912512823210
  • ShimiSMSelf-expanding metallic stents in the management of advanced esophageal cancer: reviewSemin Laparosc Surg20007192110735913
  • DormannAMeisnerSVerinNWenk LangASelf-expanding metal stents for gastroduodenal malignancies: systematic review of their clinical effectivenessEndoscopy200436654355015202052
  • LelcukSMerhavAKlausnerJMGutmanMGreifFRozinRRectoscopic decompression of acute recto-sigmoid obstructionEndoscopy19871952092103678163
  • XinopoulosDDimitroulopoulosDTheodosopoulosTStenting or stoma creation for patients with inoperable malignant colonic obstructions? Results of a study and cost-effectiveness analysisSurg Endosc200418342142614735348
  • CarnePWFryeJNRobertsonGMFrizelleFAStents or open operation for palliation of colorectal cancer: a retrospective, cohort study of perioperative outcome and long-term survivalDis Colon Rectum20044791455146115486741
  • DalalKimberly MooreGollubMarc JMinerThomas JManagement of patients with malignant bowel obstruction and stage IV colorectal cancerJournal of Palliative Medicine201114782282821595546
  • WoodruffRPalliative medicine: evidence-based symptomatic and supportive care for patients with advanced cancer4th edMelbourne, AustraliaOxford University Press2004
  • DahlSGStrandjordREPharmacokinetics of chlorpromazine after single and chronic dosageClin Pharmacol Ther1977214437448849674
  • GriffinDSBaseltRCBlood and urine concentrations of cyclizine by nitrogen-phosphorus gas-liquid chromatographyJ Anal Toxicol19848297996716982
  • HeykantsJHendriksRMeuldermansWMichielsMScheygrondHReyntjensHOn the pharmacokinetics of domperidone in animals and man. IV. The pharmacokinetics of intravenous domperidone and its bioavailability in man following intramuscular, oral and rectal administrationEur J Drug Metab Pharmacokinet19816161707250152
  • HuangYCColaizziJLBiermanRHWoestenborghsRHeykantsJJPharmacokinetics and dose proportionality of domperidone in healthy volunteersJ Clin Pharmacol19862686286323793955
  • EbertUSiepmannMOertelRWesnesKAKirchWPharmacokinetics and pharmacodynamics of scopolamine after subcutaneous administrationJ Clin Pharmacol19983887207269725548
  • BatemanDNClinical pharmacokinetics of metoclopramideClin Pharmacokinet1983865235296360466
  • KutzKNueschERosenthalerJPharmacokinetics of SMS201–995 in healthy subjectsScand J Gastroenterol Suppl198611965722876508
  • ChansonPTimsitJHarrisAGClinical pharmacokinetics of octreotide. Therapeutic applications in patients with pituitary tumoursClin Pharmacokinet19932553753918287633
  • CallaghanJTBergstromRFPtakLRBeasleyCMOlanzapine. Pharmacokinetic and pharmacodynamic profileClin Pharmacokinet199937317719310511917
  • IsahAORawlinsMDBatemanDNClinical pharmacology of prochlorperazine in healthy young malesBr J Clin Pharmacol19913266776841768559
  • TaylorWBBatemanDNPreliminary studies of the pharmacokinetics and pharmacodynamics of prochlorperazine in healthy volunteersBr J Clin Pharmacol19872321371423828192
  • TaylorGHoustonJBShafferJMawerGPharmacokinetics of promethazine and its sulphoxide metabolite after intravenous and oral administration to manBr J Clin Pharmacol19831532872936849764
  • PatonDMWebsterDRClinical pharmacokinetics of H1-receptor antagonists (the antihistamines)Clin Pharmacokinet19851064774972866055
  • DimmitDCChooYSMartinLAArumughamTHahaneWFWeirSJIntravenous pharmacokinetics and absolute oral bioavailability of dolasetron in healthy volunteers: part 1Biopharm Drug Dispos1999201293910086835
  • LermanJSimsCSikichNPharmacokinetics of the active metabolite (MDL 74,156) of dolasetron mesylate after oral or intravenous administration to anesthetized childrenClin Pharmacol Ther19966054854928941021
  • PloskerGLGoaKLGranisetron. A review of its pharmacological properties and therapeutic use as an antiemeticDrugs19914258058241723376
  • RoilaFDel FaveroAOndansetron clinical pharmacokineticsClin Pharmacokinet1995292951097586904
  • SimpsonKHHicksFMClinical pharmacokinetics of ondansetron. A reviewJ Pharm Pharmacol19964887747818887724
  • WildeMIMarkhamAOndansetron. A review of its pharmacology and preliminary clinical findings in novel applicationsDrugs19965257737949118822
  • StoltzRCyongJCShahAParisiSPharmacokinetic and safety evaluation of palonosetron, a 5-hydroxytryptamine-3 receptor antagonist, in US and Japanese healthy subjectsJ Clin Pharmacol200444552053115102873
  • HuntTLGallagherSCCullenMTJrShahAKEvaluation of safety and pharmacokinetics of consecutive multiple-day dosing of palonosetron in healthy subjectsJ Clin Pharmacol200545558959615831783
  • de BruijnKMTropisetron. A review of the clinical experienceDrugs199243Suppl 311221380428
  • LeeCRPloskerGLMcTavishDTropisetron. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential as an antiemeticDrugs19934659259437507039