Geroprotectors as a therapeutic strategy for COPD – where are we now?

References

• AgustiASobradilloPCelliBAddressing the complexity of chronic obstructive pulmonary disease: from phenotypes and biomarkers to scale-free networks, systems biology, and P4 medicineAm J Respir Crit Care Med201118391129113721169466
   PubMed Web of Science ®Google Scholar
• ItoKMercadoNSTOP accelerating lung aging for the treatment of COPDExp Gerontol201459212724709339
   PubMed Web of Science ®Google Scholar
• BarnesPJCelliBRSystemic manifestations and comorbidities of COPDEur Respir J20093351165118519407051
   PubMed Web of Science ®Google Scholar
• ItoKBarnesPJCOPD as a disease of accelerated lung agingChest2009135117318019136405
   PubMed Web of Science ®Google Scholar
• WillemseBWMten HackenNHTRutgersBLesman-LeegteIGATPostmaDSTimensWEffect of 1-year smoking cessation on airway inflammation in COPD and asymptomatic smokersEur Respir J200526583584516264044
   PubMed Web of Science ®Google Scholar
• MillerMChoJYPhamAFriedmanPJRamsdellJBroideDHPersistent airway inflammation and emphysema progression on CT scan in ex-smokers observed for 4 yearsChest201113961380138720966041
   PubMed Web of Science ®Google Scholar
• FletcherCPetoRThe natural history of chronic airflow obstructionBr Med J19771607716451648871704
   PubMed Web of Science ®Google Scholar
• LiuSFKuoHCTsengCWLeukocyte mitochondrial DNA copy number is associated with chronic obstructive pulmonary diseasePLoS One2015109e013871626394041
   PubMed Web of Science ®Google Scholar
• CunninghamTJFordESRolleIVWheatonAGCroftJBAssociations of self-reported cigarette smoking with chronic obstructive pulmonary disease and co-morbid chronic conditions in the United StatesCOPD201512327628625207639
   PubMedGoogle Scholar
• de Matos CavalcanteAGde BruinPFCde BruinVMSMelatonin reduces lung oxidative stress in patients with chronic obstructive pulmonary disease: a randomized, double-blind, placebo-controlled studyJ Pineal Res201253323824422507631
   PubMed Web of Science ®Google Scholar
• VanfleterenLEGWSpruitMAGroenenMClusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2013187772873523392440
   PubMed Web of Science ®Google Scholar
• FuJJMcDonaldVMGibsonPGSimpsonJLSystemic inflammation in older adults with asthma-COPD overlap syndromeAllergy Asthma Immunol Res20146431632424991455
   PubMed Web of Science ®Google Scholar
• Garcia-AymerichJGómezFPBenetMIdentification and prospective validation of clinically relevant chronic obstructive pulmonary disease (COPD) subtypesThorax201166543043721177668
   PubMed Web of Science ®Google Scholar
• ItoKColleyTMercadoNGeroprotectors as a novel therapeutic strategy for COPD, an accelerating aging diseaseInt J Chron Obstruct Pulmon Dis2012764165223055713
   PubMed Web of Science ®Google Scholar
• PanicNLeonciniEde BelvisGRicciardiWBocciaSEvaluation of the endorsement of the preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement on the quality of published systematic review and meta-analysesPLoS One20138e8313824386151
   PubMed Web of Science ®Google Scholar
• RachmaniRSlavachevskiILeviZZadokBKedarYRavidMMetformin in patients with type 2 diabetes mellitus: reconsideration of traditional contraindicationsEur J Intern Med200213742812384131
   PubMedGoogle Scholar
• LaiSWLiaoKFChenPCTsaiPYHsiehDPHChenCCAntidiabetes drugs correlate with decreased risk of lung cancer: a population-based observation in TaiwanClin Lung Cancer201213214314822129971
   PubMed Web of Science ®Google Scholar
• BodmerMBeckerCJickSSMeierCRMetformin does not alter the risk of lung cancer: a case-control analysisLung Cancer Amst Neth2012782133137
   PubMed Web of Science ®Google Scholar
• GarnettJPBakerEHNaikSMetformin reduces airway glucose permeability and hyperglycaemia-induced Staphylococcus aureus load independently of effects on blood glucoseThorax201368983584523709760
   PubMed Web of Science ®Google Scholar
• HitchingsAWArcherJRHSrivastavaSABakerEHSafety of metformin in patients with chronic obstructive pulmonary disease and type 2 diabetes mellitusCOPD201512212613125938184
   PubMedGoogle Scholar
• AnisimovVNMetforminCell Cycle201312223483348924189526
   PubMed Web of Science ®Google Scholar
• SextonPMetcalfPKolbeJRespiratory effects of insulin sensitisation with metformin: a prospective observational studyCOPD201411213314223848509
   PubMedGoogle Scholar
• HalvaniAMohsenpourFNasirianiKEvaluation of exogenous melatonin administration in improvement of sleep quality in patients with chronic obstructive pulmonary diseaseTanaffos2013122915
   Google Scholar
• NunesDMMotaRMSMachadoMOPereiraEDBde BruinVMSde BruinPFCEffect of melatonin administration on subjective sleep quality in chronic obstructive pulmonary diseaseBraz J Med Biol Res2008411092693119030713
   PubMed Web of Science ®Google Scholar
• GumralNNazirogluMOngelKAntioxidant enzymes and melatonin levels in patients with bronchial asthma and chronic obstructive pulmonary disease during stable and exacerbation periodsCell Biochem Funct200927527628319475625
   PubMed Web of Science ®Google Scholar
• ShinISShinNRParkJWMelatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signalingJ Pineal Res2015581506025388990
   PubMed Web of Science ®Google Scholar
• KimGDLeeSEKimTHJinYHParkYSParkCSMelatonin suppresses acrolein-induced IL-8 production in human pulmonary fibroblastsJ Pineal Res201252335636421951103
   PubMed Web of Science ®Google Scholar
• HalesCAMustoSWJanssensSSmoke aldehyde component influences pulmonary edemaJ Appl Physiol1992725555611559932
   PubMed Web of Science ®Google Scholar
• FinkelsteinEINardiniMVan Der VlietAInhibition of neutrophil apoptosis by acrolein: a mechanism of tobaccorelated lung disease?Am J Physiol Lung Cell Mol Physiol2001281L732L73911504702
   PubMed Web of Science ®Google Scholar
• PartridgeLAlicNBjedovIPiperMDWAgeing in drosophila: the role of the insulin/Igf and TOR signalling networkExp Gerontol201146537638120849947
   PubMed Web of Science ®Google Scholar
• HaroonMFitzgeraldOVitamin D and its emerging role in immunopathologyClin Rheumatol201231219920222020389
   PubMed Web of Science ®Google Scholar
• GarlandCFGarlandFCGorhamEDThe role of vitamin D in cancer preventionAm J Public Health200696225226116380576
   PubMed Web of Science ®Google Scholar
• GindeAAMansbachJMCamargoCAAssociation between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination SurveyArch Intern Med2009169438439019237723
   PubMed Web of Science ®Google Scholar
• ZhuBZhuBXiaoCZhengZVitamin D deficiency is associated with the severity of COPD: a systematic review and meta-analysisInt J Chron Obstruct Pulmon Dis2015101907191626392765
   PubMed Web of Science ®Google Scholar
• KunisakiKMNiewoehnerDEConnettJECOPD Clinical Research Network. Vitamin D levels and risk of acute exacerbations of chronic obstructive pulmonary disease: a prospective cohort studyAm J Respir Crit Care Med2012185328629022077070
   PubMed Web of Science ®Google Scholar
• QuintJKDonaldsonGCWassefNHurstJRThomasMWedzichaJA25-hydroxyvitamin D deficiency, exacerbation frequency and human rhinovirus exacerbations in chronic obstructive pulmonary diseaseBMC Pulm Med2012122822726649
   PubMed Web of Science ®Google Scholar
• LehouckAMathieuCCarremansCHigh doses of vitamin D to reduce exacerbations in chronic obstructive pulmonary disease: a randomized trialAnn Intern Med2012156210511422250141
   PubMed Web of Science ®Google Scholar
• HornikxMVan RemoortelHLehouckAVitamin D supplementation during rehabilitation in COPD: a secondary analysis of a randomized trialRespir Res20121318423006613
   PubMed Web of Science ®Google Scholar
• BjerkSMEdgingtonBDRectorTSKunisakiKMSupplemental vitamin D and physical performance in COPD: a pilot randomized trialInt J Chron Obstruct Pulmon Dis201389710423430315
   PubMed Web of Science ®Google Scholar
• MartineauARJamesWYHooperRLVitamin D3 supplementation in patients with chronic obstructive pulmonary disease (ViDiCO): a multicentre, double-blind, randomised controlled trialLancet Respir Med20153212013025476069
   PubMed Web of Science ®Google Scholar
• ZendedelAGholamiMAnbariKGhanadiKBachariECAzargonAEffects of vitamin D intake on FEV1 and COPD exacerbation: a randomized clinical trial studyGlob J Health Sci20157424324825946929
   PubMedGoogle Scholar
• Pedro-BotetJClimentEChillarónJJToroRBenaigesDFlores- Le RouxJAStatins for primary cardiovascular prevention in the elderlyJ Geriatr Cardiol201512443143826345308
   PubMedGoogle Scholar
• McFarlaneSIMuniyappaRFranciscoRSowersJRClinical review 145: Pleiotropic effects of statins: lipid reduction and beyondJ Clin Endocrinol Metab20028741451145811932263
   PubMed Web of Science ®Google Scholar
• YoungRPHopkinsRJUpdate on the potential role of statins in chronic obstructive pulmonary disease and its co-morbiditiesExpert Rev Respir Med20137553354424138695
   PubMed Web of Science ®Google Scholar
• CarlsonAASmithEAReidDJThe stats are in: an update on statin use in COPDInt J Chron Obstruct Pulmon Dis2015102277228426543360
   PubMed Web of Science ®Google Scholar
• LeeTMLinMSChangNCUsefulness of C-reactive protein and interleukin-6 as predictors of outcomes in patients with chronic obstructive pulmonary disease receiving pravastatinAm J Cardiol2008101453053518312772
   PubMed Web of Science ®Google Scholar
• ManeechotesuwanKWongkajornsilpAAdcockIMBarnesPJSimvastatin suppresses airway IL-17 and upregulates IL-10 in patients with stable COPDChest201514851164117626043025
   PubMed Web of Science ®Google Scholar
• MrozRMLisowskiPTycinskaAAnti-inflammatory effects of atorvastatin treatment in chronic obstructive pulmonary disease. a controlled pilot studyJ Physiol Pharmacol201566111112825716971
   PubMed Web of Science ®Google Scholar
• CaoCWuYXuZThe effect of statins on chronic obstructive pulmonary disease exacerbation and mortality: a systematic review and meta-analysis of observational researchSci Rep201551646126553965
   PubMed Web of Science ®Google Scholar
• WangMTLoYWTsaiCLStatin use and risk of COPD exacerbation requiring hospitalizationAm J Med20131267598606.e223684060
   PubMed Web of Science ®Google Scholar
• IngebrigtsenTSMarottJLVestboJCharacteristics of under-treatment in COPD in the general populationChest201314461811181823989916
   PubMed Web of Science ®Google Scholar
• LawesCMMThornleySYoungRStatin use in COPD patients is associated with a reduction in mortality: a national cohort studyPrim Care Respir J2012211354022218819
   PubMedGoogle Scholar
• ShengXMurphyMJMacDonaldTMEffect of statins on total cholesterol concentrations, cardiovascular morbidity, and all-cause mortality in chronic obstructive pulmonary disease: a population-based cohort studyClin Ther201234237438422244052
   PubMed Web of Science ®Google Scholar
• BartziokasKPapaioannouAIMinasMStatins and outcome after hospitalization for COPD exacerbation: a prospective studyPulm Pharmacol Ther201124562563121729761
   PubMed Web of Science ®Google Scholar
• HuangCCChanWLChenYCStatin use and hospitalization in patients with chronic obstructive pulmonary disease: a nationwide population-based cohort study in TaiwanClin Ther201133101365137021962452
   PubMed Web of Science ®Google Scholar
• LahousseLLothDWJoosGFStatins, systemic inflammation and risk of death in COPD: the Rotterdam studyPulm Pharmacol Ther201326221221723142156
   PubMed Web of Science ®Google Scholar
• CrinerGJConnettJEAaronSDSimvastatin for the prevention of exacerbations in moderate-to-severe COPDN Engl J Med2014370232201221024836125
   PubMed Web of Science ®Google Scholar
• NeukammAHøisethADEinvikGRosuvastatin treatment in stable chronic obstructive pulmonary disease (RODEO): a randomized controlled trialJ Intern Med20152781596725495178
   PubMed Web of Science ®Google Scholar