74
Views
0
CrossRef citations to date
0
Altmetric
Letter

PD-1 immune checkpoint blockade may be viable for the prevention and treatment of elderly patients with POCD [Letter]

, &
Pages 689-691 | Published online: 17 Apr 2019

References

  • Kotekar N, Shenkar A, Nagaraj R. Postoperative cognitive dysfunction – current preventive strategies. Clin Interv Aging. 2018;13:2267–2273. doi:10.2147/CIA.S13389630519008
  • Skvarc DR, Berk M, Byrne LK, et al. Post-operative cognitive dysfunction: an exploration of the inflammatory hypothesis and novel therapies. Neurosci Biobehav Rev. 2018;84:116–133. doi:10.1016/j.neubiorev.2017.11.01129180259
  • Leslie M. The post-op brain. Science. 2017;356(6341):898–900. doi:10.1126/science.356.6341.89828572347
  • Zhu H, Liu W, Fang H. Inflammation caused by peripheral immune cells across into injured mouse blood brain barrier can worsen postoperative cognitive dysfunction induced by isoflurane. BMC Cell Biol. 2018;19(1):23. doi:10.1186/s12860-018-0172-130268095
  • Terrando N, Eriksson LI, Ryu JK, et al. Resolving postoperative neuroinflammation and cognitive decline. Ann Neurol. 2011;70(6):986–995. doi:10.1002/ana.2266422190370
  • Murray C, Sanderson DJ, Barkus C, et al. Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium. Neurobiol Aging. 2012;33(3):603–616.e3. doi:10.1016/j.neurobiolaging.2010.04.00220471138
  • Marsh SE, Abud EM, Lakatos A, et al. The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function. Proc Natl Acad Sci U S A. 2016;113(9):E1316–E1325. doi:10.1073/pnas.152546611326884167
  • Huang C, Irwin MG, Wong GTC, Chang RCC. Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model. J Neuroinflammation. 2018;15(1):147. doi:10.1186/s12974-018-1220-729776428
  • Baruch K, Rosenzweig N, Kertser A, et al. Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer’s disease pathology. Nat Commun. 2015;6:7967. doi:10.1038/ncomms896726284939
  • Baruch K, Deczkowska A, Rosenzweig N, et al. PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer’s disease. Nat Med. 2016;22(2):135–137. doi:10.1038/nm.402226779813