218
Views
12
CrossRef citations to date
0
Altmetric
Commentary

The LipiDiDiet trial: what does it add to the current evidence for Fortasyn Connect in early Alzheimer’s disease?

Pages 1481-1492 | Published online: 15 Aug 2019

References

  • Kennedy EP, Weiss SB. The function of cytidine coenzymes in the biosynthesis of phospholipids. J Biol Chem. 1956;222(1):193–214.13366993
  • Wurtman RJ, Cansev M, Sakamoto T, Ulus IH. Use of phosphatide precursors to promote synaptogenesis. Annu Rev Nutr. 2009;29:59–87. doi:10.1146/annurev-nutr-080508-14105919400698
  • van Wijk N, Broersen LM, de Wilde MC, et al. Targeting synaptic dysfunction in Alzheimer’s disease by administering a specific nutrient combination. J Alzheimer’s Dis. 2014;38(3):459–479. doi:10.3233/JAD-13099823985420
  • Jicha GA, Markesbery WR. Omega-3 fatty acids: potential role in the management of early Alzheimer’s disease. Clin Interv Aging. 2010;5:45–61. doi:10.2147/CIA.S523120396634
  • Smach MA, Jacob N, Golmard J-L, et al. Folate and homocysteine in the cerebrospinal fluid of patients with Alzheimer’s disease or dementia: a case control study. Eur Neurol. 2011;65(5):270–278. doi:10.1159/00032630121474939
  • Glasø M, Nordbø G, Diep L, Bøhmer T. Reduced concentrations of several vitamins in normal weight patients with late-onset dementia of the Alzheimer type without vascular disease. J Nutr Health Aging. 2004;8(5):407–413.15359361
  • Olde Rikkert MG, Verhey FR, Sijben JW, et al. Differences in nutritional status between very mild Alzheimer’s disease patients and healthy controls. J Alzheimers Dis. 2014;(41):261–271. doi:10.3233/JAD-131892
  • Cohen BM, Renshaw PF, Stoll AL, Wurtman RJ, Yurgelun-Todd D, Babb SM. Decreased brain choline uptake in older adults. An in vivo proton magnetic resonance spectroscopy study. JAMA. 1995;274(11):902–907.doi:10.1001/jama.1995.035301100640377674505
  • Soininen H, Solomon A, Visser PJ, et al. LipiDiDiet clinical study group. 24-month intervention with a specific multinutrient in people with prodromal Alzheimer’s disease (LipiDiDiet): a randomised, double-blind, controlled trial. Lancet Neurol. 2017;16(12):965–975. doi:10.1016/S1474-4422(17)30332-029097166
  • Broersen LM, Kuipers AA, Balvers M, et al. A specific multi-nutrient diet reduces alzheimer-like pathology in young adult AbetaPPswe/PS1dE9 mice. J Alzheimers Dis. 2013;33(1):177–190. doi:10.3233/JAD-2012-11203922914588
  • Koivisto H, Grimm MO, Rothhaar TL, et al. Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer’s disease independent of brain amyloid deposition. J Nutr Biochem. 2014;25(2):157–169. doi:10.1016/j.jnutbio.2013.09.01524445040
  • Zerbi V, Jansen D, Wiesmann M, et al. Multinutrient diets improve cerebral perfusion and neuroprotection in a murine model of Alzheimer’s disease. Neurobiol Aging. 2014;35(3):600–613. doi:10.1016/j.neurobiolaging.2013.09.03824210253
  • Holguin S, Martinez J, Chow C, Wurtman R. Dietary uridine enhances the improvement in learning and memory produced by administering DHA to gerbils. FASEB J. 2008;22(11):3938–3946. doi:10.1096/fj.08-11242518606862
  • Jansen D, Zerbi V, Arnoldussen IA, et al. Effects of specific multi-nutrient enriched diets on cerebral metabolism, cognition and neuropathology in AbetaPPswe-PS1dE9 mice. PLoS One. 2013;8(9):e75393. doi:10.1371/journal.pone.007539324086523
  • Cansev M, van Wijk N, Turkyilmaz M, Orhan F, Sijben JW, Broersen LM. Specific multi-nutrient enriched diet enhances hippocampal cholinergic transmission in aged rats. Neurobiol Aging. 2015;36(1):344–351. doi:10.1016/j.neurobiolaging.2014.07.02125146455
  • Janickova H, Rudajev V, Dolejsi E, et al. Lipid-based diets improve muscarinic neurotransmission in the hippocampus of transgenic APPswe/PS1dE9 Mice. Curr Alzheimer Res. 2015;12(10):923–931. doi:10.2174/156720501266615102713035026502816
  • Dubois B, Feldman HH, Jacova C, et al. Research criteria for the diagnosis of Alzheimer’s disease: revising the NINCDS-ADRDA criteria. Lancet Neurol. 2007;6(8):734–746. doi:10.1016/S1474-4422(07)70178-317616482
  • Scheltens P, Kamphuis PJ, Verhey FR, et al. Efficacy of a medical food in mild Alzheimer’s disease: a randomized, controlled trial. Alzheimers Dement. 2010;6(1):1–10.e1. doi:10.1016/j.jalz.2009.10.00320129316
  • Scheltens P, Twisk JW, Blesa R, et al. Efficacy of Souvenaid in mild Alzheimer’s disease: results from a randomized, controlled trial. J Alzheimers Dis. 2012;31(1):225–236. doi:10.3233/JAD-2012-12118922766770
  • Olde Rikkert MG, Verhey FR, Blesa R, et al. Tolerability and safety of Souvenaid in patients with mild Alzheimer’s disease: results of multi-center, 24-week, open-label extension study. J Alzheimers Dis. 2015;44(2):471–480. doi:10.3233/JAD-14130525322923
  • Shah RC, Kamphuis PJ, Leurgans S, et al. The S-Connect study: results from a randomized, controlled trial of Souvenaid in mild-to-moderate Alzheimer’s disease. Alzheimers Res Ther. 2013;5(6):59. doi:10.1186/alzrt22424280255
  • Pardini M, Serrato C, Guida S, et al. Souvenaid reduces behavioral deficits and improves social cognition skills in frontotemporal dementia: a proof-of-concept study. Neurodegener Dis. 2015;15(1):58–62. doi:10.1159/00036981125592742
  • de Waal H, Stam CJ, Lansbergen MM, et al. The effect of souvenaid on functional brain network organisation in patients with mild Alzheimer’s disease: a randomised controlled study. PLoS One. 2014;9(1):e86558. doi:10.1371/journal.pone.008655824475144
  • Podhorna J, Krahnke T, Shear M, Harrison JE. Alzheimer’s Disease Neuroimaging Initiative. Alzheimer’s Disease Assessment Scale–cognitive subscale variants in mild cognitive impairment and mild Alzheimer’s disease: change over time and the effect of enrichment strategies. Alzheimer’s Res Ther. 2016;8:8. doi:10.1186/s13195-016-0170-526868820
  • Samtani MN, Raghavan N, Novak G, Nandy P, Narayan VA. Disease progression model for Clinical Dementia Rating–Sum of Boxes in mild cognitive impairment and Alzheimer’s subjects from the Alzheimer’s Disease Neuroimaging Initiative. Neuropsychiatr Dis Treat. 2014;10:929–952. doi:10.2147/NDT.S6232324926196
  • Cummings J, Scheltens P, McKeith I, et al. Effect size analyses of Souvenaid in patients with Alzheimer’s disease. J Alzheimers Dis. 2017;55(3):1131–1139. doi:10.3233/JAD-16074527767993
  • Rockwood K. Size of the treatment effect on cognition of cholinesterase inhibition in Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 2004;75(5):677–685. doi:10.1136/jnnp.2003.02907415090558
  • Douaud G, Refsum H, de Jager CA, et al. Preventing Alzheimer’s disease-related gray matter atrophy by B-vitamin treatment. Proc Natl Acad Sci USA. 2013;110(23):9523–9528. doi:10.1073/pnas.130181611023690582
  • Dubois B, Feldman HH, Jacova C, et al. Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria. Lancet Neurol. 2014;13(6):614–629. doi:10.1016/S1474-4422(14)70090-024849862
  • Seshadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer’s disease. N Engl J Med. 2002;346(7):476–483. doi:10.1056/NEJMoa01161311844848
  • Kivipelto M, Solomon A, Ahtiluoto S, et al. The Finnish Geriatric Intervention Study to prevent cognitive impairment and disability (FINGER): study design and progress. Alzheimers Dement. 2013;9(6):657–665. doi:10.1016/j.jalz.2012.09.01223332672
  • Gillette-Guyonnet S, Andrieu S, Dantoine T, Dartigues JF, Touchon J, Vellas B; MAPT Study Group. Commentary on “A roadmap for the prevention of dementia II. Leon Thal Symposium 2008.” The Multidomain Alzheimer Preventive Trial (MAPT): a new approach to the prevention of Alzheimer’s disease. Alzheimers Dement. 2009;5(2):114–121. doi:10.1016/j.jalz.2009.01.00819328438
  • Lehtisalo J, Levälahti E, Lindström J, et al. Dietary changes and cognition over 2 years within a multidomain intervention trial-The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER). Alzheimers Dement. 2019;15(3):410–417. doi:10.1016/j.jalz.2018.10.00130527596
  • Rosenberg A, Ngandu T, Rusanen M, et al. Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: the FINGER trial. Alzheimers Dement. 2018;14(3):263–270. doi:10.1016/j.jalz.2017.09.00629055814