Determinants Of Antipsychotic Drugs Prescription Among Community-Living Older Adults With Dementia: A Population-Based Study Using Health Information Systems In The Lazio Region, Italy

References

• Greenblatt HK, Greenblatt DJ. Use of antipsychotics for the treatment of behavioral symptoms of dementia. J Clin Pharmacol. 2016;56(9):1048–1057. doi:10.1002/jcph.73126953213
   PubMed Web of Science ®Google Scholar
• Azermai M, Petrovic M, Elseviers MM, Bourgeois J, Van Bortel LM, Vander Stichele RH. Systematic appraisal of dementia guidelines for the management of behavioural and psychological symptoms. Ageing Res Rev. 2012;11(1):78–86. doi:10.1016/j.arr.2011.07.00221856452
   PubMed Web of Science ®Google Scholar
• Ballard C, Waite J, Birks J. The effectiveness of atypical antipsychotics for the treatment of aggression and psychosis in Alzheimer’s disease. Cochrane Database Sys Rev. 2006;(Issue 1):Art. N.: CD003476. doi:10.1002/14651858.CD003476.pub2.
   Web of Science ®Google Scholar
• Vasudev A, Shariff SZ, Liu K, et al. Trends in psychotropic dispensing among older adults with dementia living in long-term care facilities: 2004–2013. Am J Geriatr Psychiatry. 2015;23(12):1259–1269. doi:10.1016/j.jagp.2015.07.00126525997
   PubMed Web of Science ®Google Scholar
• Tampi RR, Tampi DJ, Balachandran S, Srinivasan S. Antipsychotic use in dementia: a systematic review of benefits and risks from meta-analyses. Ther Adv Chron Dis. 2016;7:229–245. doi:10.1177/2040622316658463
   PubMed Web of Science ®Google Scholar
• Ivers NM, Taljaard M, Giannakeas V, Reis C, Williams E, Bronskill S. Public reporting of antipsychotic prescribing in nursing homes: population-based interrupted time series analyses. BMJ Qual Saf. 2019;28(2):121–131. doi:10.1136/bmjqs-2018-007840
   Web of Science ®Google Scholar
• Wang PS, Schneeweiss S, Avorn J, et al. Risk of death in elderly users of conventional vs. Atypical Antipsychotic Medications. N Engl J Med. 2005;353(22):2335–2341. doi:10.1056/NEJMoa05282716319382
   PubMed Web of Science ®Google Scholar
• Jalbert JJ, Eaton CB, Miller SC, Lapane KL. Antipsychotic use and the risk of hip fracture among older adults afflicted with dementia. J Am Med Die Assoc. 2010;11(2):120–127. doi:10.1016/j.jamda.2009.10.001
   PubMed Web of Science ®Google Scholar
• Maust DT, Kim HM, Seyfried LS, et al. Antipsychotics, other psychotropics, and the risk of death in patients with dementia: number needed to harm. JAMA Psychiatry. 2015;72(5):438–445. doi:10.1001/jamapsychiatry.2014.301825786075
   PubMed Web of Science ®Google Scholar
• Sacchetti E, Turrina C, Valsecchi P. Cerebrovascular accidents in elderly people treated with antipsychotic drugs: a systematic review. Drug Saf. 2010;33(4):273–288. doi:10.2165/11319120-000000000-0000020297860
   PubMed Web of Science ®Google Scholar
• National Institute for Health and Care Excellence (NICE) Guidelines. Dementia: assessment, management and support for people living with dementia and their caregivers guideline [NG97]. Published 6 2018.
   Google Scholar
• Reus VI, Fochtmann LJ, Eyler AE, et al. The American Psychiatric Association practice guideline on the use of antipsychotics to treat agitation or psychosis in patients with dementia. Am J Psychiatry. 2016;173(5):543–546. doi:10.1176/appi.ajp.2015.17350127133416
   PubMed Web of Science ®Google Scholar
• de Mauleon A, Sourdet S, Renom-Guiteras A, et al. Associated factors with antipsychotic use in long-term institutional care in eight European countries: results from the right time place care study. J Am Med Dir Assoc. 2014;15(11):812–818. doi:10.1016/j.jamda.2014.06.01525129474
   PubMed Web of Science ®Google Scholar
• Sultana J, Fontana A, Giorgianni F, et al. The effect of safety warnings on antipsychotic drug prescribing in elderly persons with dementia in the United Kingdom and Italy: a population-based study. CNS Drugs. 2016;30(11):1097–1109. doi:10.1007/s40263-016-0366-z27423216
   PubMed Web of Science ®Google Scholar
• Hessmann P, Dodel R, Baum E, et al. Antipsychotic treatment of community-dwelling and institutionalised patients with dementia in Germany. Int J Psychiatry Clin Pract. 2018;22(3):232–239. doi:10.1080/13651501.2017.141426929235398
   PubMed Web of Science ®Google Scholar
• Tifratene K, Manera V, Fabre R, et al. Antipsychotic prescribing for Alzheimer’s disease and related disorders in specialized settings from 2010 to 2014 in France: a repeated cross-sectional study. Alzheimers Res Ther. 2017;9(1):34–44. doi:10.1186/s13195-017-0256-828446209
   PubMed Web of Science ®Google Scholar
• Italian Medicines Agency. The medicines utilization monitoring centre. National Report on Medicines use in Italy. 2017 Available from: http://wwwaifa.gov.it/sites/default/files/Rapporto_OsMed_2017_AIFA.pdf.
   Google Scholar
• Bharmal MF, Weiner M, Sands LP, Xu H, Craig BA, Thomas J. Impact of patient selection criteria on prevalence estimates and prevalence of diagnosed dementia in a medicaid population. Alzheimer Dis Assoc Disord. 2007;21(2):92–100. doi:10.1097/WAD.0b013e31805c083517545733
   PubMed Web of Science ®Google Scholar
• Francesconi P, Gini R, Roti L, Bartolacci S, Corsi A, Buiatti E. The tuscany experimental registry for Alzheimer’s disease and other dementias: how many demented people does in capture? Aging Clin Exp Res. 2007;19(5):390–393. doi:10.1007/BF332471918007117
   PubMed Web of Science ®Google Scholar
• Barnes TR, Banerjee S, Collins N, Treloar A, McIntyre SM, Paton C. Antipsychotics in dementia: prevalence and quality of antipsychotic drug prescribing in UK mental health services. Br J Psychiatry. 2012;201(3):221–226. doi:10.1192/bjp.bp.111.10763122790679
   PubMed Web of Science ®Google Scholar
• Boucherie Q, Gentile G, Chalançon C, et al. Long-term use of antipsychotics in community-dwelling dementia patients: prevalence and profile accounting for unobservable time bias because of hospitalization. Int Clin Psychopharmacol. 2017;32(1):13–19. doi:10.1097/YIC.000000000000015027741029
   PubMed Web of Science ®Google Scholar
• Kirkham J, Sherman C, Velkers C, et al. Antipsychotic use in dementia is there a problem and are there solutions? Can J Psychiatry. 2017;62(3):170–181. doi:10.1177/070674371667332128212496
   PubMed Web of Science ®Google Scholar
• Dennis M, Shine L, John A, et al. Risk of adverse outcomes for older people with dementia prescribed antipsychotic medication: a population based e-cohort study. Neurol Ther. 2017;6(1):57–77. doi:10.1007/s40120-016-0060-6
   Web of Science ®Google Scholar
• Ralph SJ, Espinet AJ. Increased all-cause mortality by antipsychotic drugs: updated review and meta-analysis in dementia and general mental health care. J Alzheimers Dis Rep. 2018;2(1):1–26. doi:10.3233/ADR-17004230480245
   PubMedGoogle Scholar
• Koponen M, Taipalea H, Tanskanend A, et al. Long-term use of antipsychotics among community-dwelling persons with Alzheimer’s disease: a nation wide register-based study. Eur Neuropsychopharmacol. 2015;25(10):1706–1713. doi:10.1016/j.euroneuro.2015.07.00826233607
   PubMed Web of Science ®Google Scholar
• Puyat JA, Law MR, Wong ST, Sutherland JM, Morgan SG, Essential T. Potentially inappropriate use of antipsychotics across income groups: an analysis of linked administrative data. Can J Psychiatry. 2012;57(8):488–495. doi:10.1177/07067437120570080722854031
   PubMed Web of Science ®Google Scholar
• Vasudev A. Trends in psychotropic dispensing among older adults with dementia living in longterm care facilities: 2004–2013. Am J Geriatr Psychiatry. 2016. doi:10.1016/j.jagp.2015.07.001.
   Web of Science ®Google Scholar
• Maguire A, Hughes C, Cardwell C, O’Reilly D. Psychotropic medications and the transition into care: a national data linkage study. J Am Geriatr Soc. 2013;61:215–221. doi:10.1111/jgs.2013.61.issue-223320828
   PubMed Web of Science ®Google Scholar
• Trifirò G, Spina E, Brignoli O, Sessa E, Caputi AP, Mazzaglia G. Antipsychotic prescribing pattern among Italian general practitioners: a population-based study during the years 1999-2002. Eur J Clin Pharmacol. 2005;61(1):47–53. doi:10.1007/s00228-004-0868-315666172
   PubMed Web of Science ®Google Scholar
• Chiu YW, Huang CW, Chena PJ, et al. Trends and factors associated with antipsychotic use among elderly patients with dementia in Taiwan from 2005 to 2013: a population-based study. Int Clin Psychopharmacol. 2017;32(5):262–270. doi:10.1097/YIC.000000000000018128542035
   PubMed Web of Science ®Google Scholar
• Wattmo C, Londos E, Minthon L. Solitary living in Alzheimer’s disease over 3 years: association between cognitive and functional impairment and community-based services. Clin Interv Aging. 2014;9:1951–1962. doi:10.2147/CIA.S7170925484578
   PubMed Web of Science ®Google Scholar
• Xiong GL, Filshtein T, Beckett LA, Hinton L. Antipsychotic use in a diverse population with dementia: a retrospective review of the National Alzheimer’s coordinating center database. J Neuropsychiatry Clin Neurosci. 2015;27:326–332. doi:10.1176/appi.neuropsych.1501002026488486
   PubMed Web of Science ®Google Scholar
• Kim S, Choi H, Yoo J, Kim S, Kim BS, Won C. Factors correlated with initiating antipsychotics among dementia patients in Korean long-term care facilities: National Health Insurance service-senior cohort (2002–2013). J Clin Gerontol Geriatrics. 2017;8(4):114–122.
   Web of Science ®Google Scholar
• Trenaman SC, Rideout M, Andrew MK. Sex and gender differences in polypharmacy in persons with dementia: a scoping review. SAGE Open Med. 2019;7:1–10. doi:10.1177/2050312119845715
   Web of Science ®Google Scholar
• Kales HC, Zivin K, Kim HM, et al. Trends in antipsychotic use in dementia 1999–2007. Arch Gen Psychiatry. 2011;68(2):190–197. doi:10.1001/archgenpsychiatry.2010.20021300946
   PubMed Web of Science ®Google Scholar
• Stocks JS, Kontopantelis E, Webb RT, Avery AJ, Burns A, Ashcroft DM. Antipsychotic prescribing to patients diagnosed with dementia without a diagnosis of psychosis in the context of national guidance and drug safety warnings: longitudinal study in UK general practice. Drug Saf. 2017;40(8):679–692. doi:10.1007/s40264-017-0538-x28439716
   PubMed Web of Science ®Google Scholar
• Wastesson JW, Ringbäck Weitoft G, Johnell K. Educational disparities in antipsychotic drug use among older people with and without dementia in Sweden. Acta Psychiatr Scand. 2015;132(1):20–28. doi:10.1111/acps.2015.132.issue-125532774
   PubMed Web of Science ®Google Scholar
• Sivananthan SN, Lavergne MR, McGrail KM. Caring for dementia: a population-based study examining variations in guideline-consistent medical care. Alzheimers Dement. 2015;11(8):906–916. doi:10.1016/j.jalz.2015.02.00825956989
   PubMed Web of Science ®Google Scholar
• Bunn F, Burn AM, Goodman C, et al. Comorbidity and dementia: a scoping review of the literature. BMC Med. 2014;12:192–207. doi:10.1186/s12916-014-0192-425358236
   PubMed Web of Science ®Google Scholar
• Clague F, Mercer SW, Mclean G, Reynish E, Guthrie B. Comorbidity and polypharmacy in people with dementia: insights from a large, population-based cross-sectional analysis of primary care data. Age Ageing. 2017;46(1):33–39. doi:10.1093/ageing/afw17628181629
   PubMed Web of Science ®Google Scholar
• Bagnall AM, Jones L, Ginnelly L, et al. A systematic review of atypical antipsychotic drugs in schizophrenia. Health Technol Assess. 2003;7(13):1–193. doi:10.3310/hta7130
   PubMedGoogle Scholar