Identification of Frailty and Its Risk Factors in Elderly Hospitalized Patients from Different Wards: A Cross-Sectional Study in China

References

• Beard JR, Officer A, de Carvalho IA, et al. The world report on ageing and health: a policy framework for healthy ageing. Lancet. 2016;387(10033):2145–2154. doi:10.1016/S0140-6736(15)00516-426520231
   PubMed Web of Science ®Google Scholar
• National Bureau of Statistics of China Available from: http://data.stats.gov.cn/easyquery.htm?cn=C01. Accessed 615, 2019.
   Google Scholar
• Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381(9868):752–762. doi:10.1016/S0140-6736(12)62167-923395245
   PubMed Web of Science ®Google Scholar
• Ethun CG, Bilen MA, Jani AB, Maithel SK, Ogan K, Master VA. Frailty and cancer: implications for oncology surgery, medical oncology, and radiation oncology. CA Cancer J Clin. 2017;67(5):362–377. doi:10.3322/caac.2140628731537
   PubMed Web of Science ®Google Scholar
• Apostolo J, Cooke R, Bobrowicz-Campos E, et al. Effectiveness of interventions to prevent pre-frailty and frailty progression in older adults: a systematic review. JBI Database System Rev Implement Rep. 2018;16(1):140–232. doi:10.11124/JBISRIR-2017-003382
   PubMedGoogle Scholar
• Puts MTE, Toubasi S, Andrew MK, et al. Interventions to prevent or reduce the level of frailty in community-dwelling older adults: a scoping review of the literature and international policies. Age Ageing. 2017;46(3):383–392. doi:10.1093/ageing/afw24728064173
   PubMed Web of Science ®Google Scholar
• Hassler AP, Menasalvas E, Garcia-Garcia FJ, Rodriguez-Manas L, Holzinger A. Importance of medical data preprocessing in predictive modeling and risk factor discovery for the frailty syndrome. BMC Med Inform Decis Mak. 2019;19(1):33. doi:10.1186/s12911-019-0747-630777059
   PubMed Web of Science ®Google Scholar
• Holzinger A, Langs G, Denk H, Zatloukal K, Müller H. Causability and explainabilty of artificial intelligence in medicine. Wiley Interdiscip Rev Data Min Knowl Discov. 2019;e1312.
   Web of Science ®Google Scholar
• Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol a Biol Sci Med Sci. 2001;56(3):M146–M156. doi:10.1093/gerona/56.3.M14611253156
   PubMed Web of Science ®Google Scholar
• Jones DM, Song X, Rockwood K. Operationalizing a frailty index from a standardized comprehensive geriatric assessment. J Am Geriatr Soc. 2004;52(11):1929–1933. doi:10.1111/jgs.2004.52.issue-1115507074
   PubMed Web of Science ®Google Scholar
• Rolfson DB, Majumdar SR, Tsuyuki RT, Tahir A, Rockwood K. Validity and reliability of the edmonton frail scale. Age Ageing. 2006;35(5):526–529. doi:10.1093/ageing/afl04116757522
   PubMed Web of Science ®Google Scholar
• Rockwood K. A global clinical measure of fitness and frailty in elderly people. Can Med Assoc J. 2005;173(5):489–495. doi:10.1503/cmaj.05005116129869
   PubMed Web of Science ®Google Scholar
• Morley JE, Malmstrom TK, Miller DK. A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans. J Nutr Health Aging. 2012;16(7):601–608. doi:10.1007/s12603-012-0084-222836700
   PubMed Web of Science ®Google Scholar
• He B, Ma Y, Wang C, et al. Prevalence and risk factors for frailty among community-dwelling older people in China: a systematic review and meta-analysis. J Nutr Health Aging. 2019;23:442–450. doi:10.1007/s12603-019-1179-931021361
   PubMed Web of Science ®Google Scholar
• Yang Y, Hao Q, Flaherty JH, et al. Comparison of procalcitonin, a potentially new inflammatory biomarker of frailty, to interleukin-6 and C-reactive protein among older Chinese hospitalized patients. Aging Clin Exp Res. 2018;30:1459–1464. doi:10.1007/s40520-018-0964-329777476
   PubMed Web of Science ®Google Scholar
• Hao Q, Zhou L, Dong B, Yang M, Dong B, Weil Y. The role of frailty in predicting mortality and readmission in older adults in acute care wards: a prospective study. Sci Rep. 2019;9(1):1207. doi:10.1038/s41598-018-38072-730718784
   PubMed Web of Science ®Google Scholar
• Zou C, Chen S, Shen J, et al. Prevalence and associated factors of depressive symptoms among elderly inpatients of a Chinese tertiary hospital. Clin Interv Aging. 2018;13:1755–1762. doi:10.2147/CIA.S17034630271130
   PubMed Web of Science ®Google Scholar
• Zhang N, Zhu WL, Liu XH, et al. A cross-sectional study on the association between frailty and muscular performances in hospitalized elder patients with coronary artery disease. Zhonghua Nei Ke Za Zhi. 2019;58(4):265–269. doi:10.3760/cma.j.issn.0578-1426.2019.04.00630917418
   PubMedGoogle Scholar
• Yang F, Chen QW. Evaluation of frailty and influencing factors in old people in hospital institution: evidence for a phenotype of frailty. Medicine. 2018;97(3):e9634. doi:10.1097/MD.000000000000963429504994
   PubMed Web of Science ®Google Scholar
• Wei Y, Cao Y, Yang X, Xu Y. Investigation on the frailty status of the elderly inpatients in Shanghai using the FRAIL (fatigue, resistance, ambulation, illness, and loss) questionnaire. Medicine. 2018;97(18):e0581. doi:10.1097/MD.000000000001058129718855
   PubMed Web of Science ®Google Scholar
• Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)–a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377–381. doi:10.1016/j.jbi.2008.08.01018929686
   PubMed Web of Science ®Google Scholar
• Yang L, Bao LH, Zhou Q, Wang CZ, Ma SY. Reliability and validity of edmonton frail scale. Int J Geriatr. 2016;3:135–137.
   Google Scholar
• Searle SD, Mitnitski A, Gahbauer EA, Gill TM, Rockwood K. A standard procedure for creating a frailty index. BMC Geriatr. 2008;8:24. doi:10.1186/1471-2318-8-2418826625
   PubMedGoogle Scholar
• Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW. Studies of illness in the aged. The index of ADL: a standardized measure of biological and psychosocial function. JAMA. 1963;185:914–919. doi:10.1001/jama.1963.0306012002401614044222
   PubMed Web of Science ®Google Scholar
• Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969;9(3):179–186. doi:10.1093/geront/9.3_Part_1.1795349366
   PubMed Web of Science ®Google Scholar
• Hoyl MT, Alessi CA, Harker JO, et al. Development and testing of a five-item version of the geriatric depression scale. J Am Geriatr Soc. 1999;47(7):873–878. doi:10.1111/jgs.1999.47.issue-710404935
   PubMed Web of Science ®Google Scholar
• Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67(6):361–370. doi:10.1111/acp.1983.67.issue-66880820
   PubMed Web of Science ®Google Scholar
• Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189–198. doi:10.1016/0022-3956(75)90026-61202204
   PubMed Web of Science ®Google Scholar
• Soldatos CR, Dikeos DG, Paparrigopoulos TJ. Athens insomnia scale: validation of an instrument based on ICD-10 criteria. J Psychosom Res. 2000;48(6):555–560. doi:10.1016/S0022-3999(00)00095-711033374
   PubMed Web of Science ®Google Scholar
• Pablo AMR, Izaga MA, Alday LA. Assessment of nutritional status on hospital admission: nutritional scores. Eur J Clin Nutr. 2003;57(7):824–831. doi:10.1038/sj.ejcn.160161612821882
   PubMed Web of Science ®Google Scholar
• Hong X, Yan J, Xu L, Shen S, Zeng X, Chen L. Relationship between nutritional status and frailty in hospitalized older patients. Clin Interv Aging. 2019;14:105–111. doi:10.2147/CIA.S18904030666096
   PubMed Web of Science ®Google Scholar
• Chong E, Ho E, Baldevarona-Llego J, Chan M, Wu L, Tay L. Frailty and risk of adverse outcomes in hospitalized older adults: a comparison of different frailty measures. J Am Med Dir Assoc. 2017;18(7):638.e637–638.e611. doi:10.1016/j.jamda.2017.04.011
   Web of Science ®Google Scholar
• Chong E, Ho E, Baldevarona-Llego J, et al. Frailty in hospitalized older adults: comparing different frailty measures in predicting short- and long-term patient outcomes. J Am Med Dir Assoc. 2018;19(5):450–457.e453. doi:10.1016/j.jamda.2017.10.00629153536
   PubMed Web of Science ®Google Scholar
• Sze S, Pellicori P, Zhang J, Weston J, Clark AL. Identification of frailty in chronic heart failure. JACC Heart Fail. 2019;7(4):291–302. doi:10.1016/j.jchf.2018.11.01730738977
   PubMed Web of Science ®Google Scholar
• Afilalo J, Lauck S, Kim D, et al. Frailty in older adults undergoing aortic valve replacement: the FRAILTY-AVR study. J Am Coll Cardiol. 2017;70(6):689–700. doi:10.1016/j.jacc.2017.06.02428693934
   PubMed Web of Science ®Google Scholar
• Ritt M, Bollheimer LC, Sieber CC, Gassmann KG. Prediction of one-year mortality by five different frailty instruments: a comparative study in hospitalized geriatric patients. Arch Gerontol Geriatr. 2016;66:66–72. doi:10.1016/j.archger.2016.05.00427259029
   PubMed Web of Science ®Google Scholar
• Dokuzlar O, Soysal P, Isik AT. Association between serum vitamin B12 level and frailty in older adults. North Clin Istanb. 2017;4(1):22–28. doi:10.14744/nci.2017.8278728752139
   PubMed Web of Science ®Google Scholar
• Eyigor S, Kutsal YG, Duran E, et al. Frailty prevalence and related factors in the older adult-frailTURK project. Age (Dordr). 2015;37(3):9791. doi:10.1007/s11357-015-9791-z25948502
   PubMedGoogle Scholar
• Bonaga B, Sanchez-Jurado PM, Martinez-Reig M, et al. Frailty, polypharmacy, and health outcomes in older adults: the frailty and dependence in albacete study. J Am Med Dir Assoc. 2018;19(1):46–52. doi:10.1016/j.jamda.2017.07.00828899661
   PubMed Web of Science ®Google Scholar
• Harper PL, Theakston E, Ahmed J, Ockelford P. D-dimer concentration increases with age reducing the clinical value of the D-dimer assay in the elderly. Intern Med J. 2007;37(9):607–613. doi:10.1111/imj.2007.37.issue-917543005
   PubMed Web of Science ®Google Scholar
• Tita-Nwa F, Bos A, Adjei A, Ershler WB, Longo DL, Ferrucci L. Correlates of D-dimer in older persons. Aging Clin Exp Res. 2010;22(1):20–23. doi:10.1007/BF332481020305364
   PubMed Web of Science ®Google Scholar
• Reiner AP, Aragaki AK, Gray SL, et al. Inflammation and thrombosis biomarkers and incident frailty in postmenopausal women. Am J Med. 2009;122(10):947–954. doi:10.1016/j.amjmed.2009.04.01619682668
   PubMed Web of Science ®Google Scholar
• Romero-Ortuno R, Cogan L, O’Shea D, Lawlor BA, Kenny RA. Orthostatic haemodynamics may be impaired in frailty. Age Ageing. 2011;40(5):576–583. doi:10.1093/ageing/afr07621749997
   PubMed Web of Science ®Google Scholar
• Shaw BH, Borrel D, Sabbaghan K, et al. Relationships between orthostatic hypotension, frailty, falling and mortality in elderly care home residents. BMC Geriatr. 2019;19(1):80. doi:10.1186/s12877-019-1082-630866845
   PubMed Web of Science ®Google Scholar
• Palatini P, Dorigatti F, Zaetta V, et al. Heart rate as a predictor of development of sustained hypertension in subjects screened for stage 1 hypertension: the HARVEST study. J Hypertens. 2006;24(9):1873–1880. doi:10.1097/01.hjh.0000242413.96277.5b16915038
   PubMed Web of Science ®Google Scholar
• Jensen MT, Suadicani P, Hein HO, Gyntelberg F. Elevated resting heart rate, physical fitness and all-cause mortality: a 16-year follow-up in the copenhagen male study. Heart. 2013;99(12):882–887. doi:10.1136/heartjnl-2012-30337523595657
   PubMed Web of Science ®Google Scholar
• Legeai C, Jouven X, Tafflet M, et al. Resting heart rate, mortality and future coronary heart disease in the elderly: the 3C study. Eur J Cardiovasc Prev Rehabil. 2011;18(3):488–497. doi:10.1177/174182671038936521450655
   PubMedGoogle Scholar
• Jensen MT, Wod M, Galatius S, Hjelmborg JB, Jensen GB, Christensen K. Heritability of resting heart rate and association with mortality in middle-aged and elderly twins. Heart. 2018;104(1):30–36. doi:10.1136/heartjnl-2016-31098628637897
   PubMed Web of Science ®Google Scholar
• Levine HJ. Rest heart rate and life expectancy. J Am Coll Cardiol. 1997;30(4):1104–1106. doi:10.1016/s0735-1097(97)00246-59316546
   PubMed Web of Science ®Google Scholar
• Wod M, Jensen MT, Galatius S, Hjelmborg JB, Jensen GB, Christensen K. Resting heart rate and mortality in the very old. Scand J Clin Lab Invest. 2019;1–6.
   Web of Science ®Google Scholar